Abstract:
:The authors determined the effects of intravenous infusion and epidural administration of lidocaine on the control of ventilation in two groups of eight healthy unpremedicated subjects. In the intravenous group, an injection of 1.5 mg/kg lidocaine was followed by an infusion at a rate of 60 micrograms X kg-1 X min-1 for 30 min. The slope of the ventilatory response to CO2 was significantly increased (P less than 0.05) from its control value (2.65 +/- 1.22 1 X min-1 X mmHg-1 [mean +/- SD]) at the end of the infusion (58%), while plasma lidocaine level was at 3.14 +/- 0.82 microgram/ml. The correlation between individual plasma lidocaine levels and the changes in the slope of the ventilatory response to CO2 was significant (r = 0.58, n = 24, P less than 0.01). In the epidural group, after the administration of 5 mg/kg of lidocaine, the slope of the ventilatory response to CO2 increased significantly (P less than 0.05) from its control value (1.52 +/- 0.75 1 X min-1 X mmHg-1) at 15 (+22%) and 25 min (+42%), while plasma lidocaine levels were at 1.79 +/- 0.42 and 2.22 +/- 0.47 microgram/ml, respectively. In both groups, resting minute ventilation and end-tidal CO2 values remained unchanged. These results suggest that epidural lidocaine has a stimulating effect on the ventilatory control mechanisms that results from the systemic effect of the drug.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Labaille T,Clergue F,Samii K,Ecoffey C,Berdeaux Adoi
10.1097/00000542-198508000-00011subject
Has Abstractpub_date
1985-08-01 00:00:00pages
179-83issue
2eissn
0003-3022issn
1528-1175journal_volume
63pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract:BACKGROUND:Hydroxyethyl starch (HES) is commonly used as plasma expander during surgery but may be nephrotoxic as seen in studies in patients with sepsis. The authors hypothesized that the possible nephrotoxicity of 6% HES 130/0.4 could be revealed by measurements of urinary excretion of neutrophil gelatinase-associate...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000000413
更新日期:2014-11-01 00:00:00
abstract::Inorganic fluoride (F-) production and renal function were assessed in six groups of Fischer 344 rats administered either methoxyflurane (MOF) or deuterated methoxyflurane (d4-MOF). One untreated and one phenobarbital (PB)-treated group were exposed for two hours to either air, 0.5 per cent (V/v) MOF, or 0.5 per cent ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198203000-00009
更新日期:1982-03-01 00:00:00
abstract:BACKGROUND:Patient-controlled analgesia (PCA) with intravenous morphine and patient-controlled epidural analgesia (PCEA), using an opioid either alone or in combination with a local anesthetic, are two major advances in the management of pain after major surgery. However, these techniques have been evaluated poorly in ...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200002000-00025
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Morphine-6-glucuronide (M-6-G), a major metabolite of morphine, is reported to be more potent than morphine when administered intrathecally; however, its efficiency remains under debate when administered intravenously. This study was designed to assess the analgesic efficiency of intravenous M-6-G for the tr...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200002000-00015
更新日期:2000-02-01 00:00:00
abstract::The dosage and blood concentration of lidocaine required to produce central nervous and cardiovascular system toxicity in both nonasphyxiated and asphyxiated fetuses were determined in ten pregnant baboons with fetuses of average gestation of 158 days (term, 185 days). Lidocaine was infused into the fetal jugular vein...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198103000-00002
更新日期:1981-03-01 00:00:00
abstract:BACKGROUND:The noble gas xenon (Xe) has been used as an inhalational anesthetic agent in clinical trials with little or no physiologic side effects. Like nitrous oxide, Xe is believed to exert minimal unwanted cardiovascular effects, and like nitrous oxide, the vapor concentration to achieve 1 minimum alveolar concentr...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200002000-00035
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Deep hypothermia has been associated with an increased incidence of postoperative neurologic dysfunction after cardiac surgery in children. Recent studies suggest an excitotoxic mechanism involving overstimulation of glutamate receptors. Extracellular glutamate uptake occurs primarily by astrocytes. Astrocyt...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199912000-00030
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Persistent postsurgical pain is common and affects quality of life. The hypothesis was that use of pregabalin and ketamine would prevent persistent pain after cardiac surgery. METHODS:This randomized, double-blind, placebo-controlled trial was undertaken at two cardiac surgery centers in the United Kingdom....
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000002751
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:General anesthetics modify airway responsiveness by several mechanisms, including direct effects on airway smooth muscle and reductions in neural reflex activity. Halothane has been shown to reduce responsiveness through both of these mechanisms. The airway effects of barbiturates are controversial, and the ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199308000-00014
更新日期:1993-08-01 00:00:00
abstract::The authors present a simple and clinically applicable method for the serial monitoring of pulmonary microvascular enzyme function in vivo. This method requires the intravenous injection of trace amounts of a radiolabelled substrate and the collection of a single arterial blood sample. Simultaneous measurement of pulm...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198801000-00008
更新日期:1988-01-01 00:00:00
abstract::The authors sought to determine if isoflurane would attenuate effects of three different types of vasoconstrictors on isolated segments of canine epicardial coronary arteries removed from healthy dogs. As the endothelium has a major role in regulating epicardial coronary artery tone, and as it modulates the effect of ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198710000-00012
更新日期:1987-10-01 00:00:00
abstract:BACKGROUND:Previous studies demonstrated that both edrophonium and neostigmine affect mivacurium's pharmacokinetics, thereby potentially affecting its recovery profile. However, those studies were not clinically relevant because mivacurium was still infused after the antagonists were given. In the present study, the au...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200003000-00015
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Rapid assessment of hepatic function early after reperfusion of the liver graft is of great importance, because it may allow for prompt detection of incipient hepatic graft failure. The current study was undertaken to determine whether the continuous recording of neuromuscular transmission could be used as a...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199407000-00023
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Global cerebral ischemia is associated with delayed neuronal death. Given the role of caspases in apoptosis, caspase inhibitors may provide neuronal protection after cardiac arrest. To this end, the authors generated a transgenic rat line expressing baculovirus p35, a broad-spectrum caspase inhibitor, in cen...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200307000-00020
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Inflammation is a key element in the pathophysiology of cerebral ischemia. This study investigated the role of N-Myc downstream-regulated gene-2 in nuclear transcription factor κB-mediated inflammation in ischemia models. METHODS:Mice (n = 6 to 12) with or without nuclear transcription factor κB inhibitor p...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002044
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Dysrhythmias and death occur in patients with acquired long QT syndrome (LQTS). Little information exists regarding interactions between anesthetics and drugs that prolong ventricular repolarization. Therefore the effects of three commonly used intravenous anesthetics on ventricular repolarization were inves...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199711000-00022
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:The discrepancy between predicted effect-site concentration and measured bispectral index is problematic during intravenous anesthesia with target-controlled infusion of propofol and remifentanil. We hypothesized that bispectral index during total intravenous anesthesia would be more accurately predicted by ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001892
更新日期:2018-03-01 00:00:00
abstract::Evidence of developmental toxicity of clinically used nondepolarizing muscle relaxants was sought in rat embryos grown in culture. Embryos were explanted at 8 AM on day 9 of gestation (presomite stage, plug day = day 0), and were cultured in rotating bottles with medium containing various concentrations of d-tubocurar...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199206000-00021
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:Anesthetics are believed to alter functional connectivity across brain regions. However, network-level analyses of anesthesia, particularly in humans, are sparse. The authors hypothesized that propofol-induced loss of consciousness results in functional disconnection of human sensorimotor cortices underlying...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001940
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Ketamine is a commonly used anesthetic, but the mechanistic basis for its clinically relevant actions remains to be determined. The authors previously showed that HCN1 channels are inhibited by ketamine and demonstrated that global HCN1 knockout mice are twofold less sensitive to hypnotic actions of ketamine...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e318287b7c8
更新日期:2013-04-01 00:00:00
abstract::The effects of continuous positive airway pressure (CPAP) on cardiovascular dynamics and pulmonary shunt (QS/QT) were investigated in 12 dogs before and during sodium nitroprusside infusion that decreased mean arterial blood pressure 40-50 per cent. Before nitroprusside infusion, 5 cm H2O CPAP significantly, P less th...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197705000-00008
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND:Chronic postsurgical pain, a significant public health problem, occurs in 10 to 50% of patients undergoing major surgery. Acute pain induces endogenous analgesia termed conditioned pain modulation (CPM), and the strength of CPM preoperatively predicts the likelihood of chronic postsurgical pain. The relation...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000593
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:To characterize the impact of lung volume changes in the lung function impairment after the surgical repair of congenital heart diseases, combined measurements of functional residual capacity, lung clearance index, and respiratory mechanics were performed in children with hypoperfused lungs (tetralogy of Fal...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181a32887
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Spontaneous breaths during airway pressure release ventilation (APRV) have to overcome the resistance of the artificial airway. Automatic tube compensation provides ventilatory assistance by increasing airway pressure during inspiration and lowering airway pressure during expiration, thereby compensating for...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200108000-00020
更新日期:2001-08-01 00:00:00
abstract::To study the cerebral protective effects of hypothermia in arterial hypoxia, anesthetized (70% N2O), mechanically ventilated rats were cooled to a body temperature of 27 C. Hypoxia was induced by decreasing the oxygen content in the inspired gas mixture either to 6-7 per cent or to 2.5-3 per cent. This reduced mean Pa...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197601000-00006
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Drugs used for sedation in anesthesia and intensive care may cause pharyngeal dysfunction and increased risk for aspiration. In this study, the authors investigate the impact of sedative doses of morphine and midazolam on pharyngeal function during swallowing and coordination of breathing and swallowing. ME...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000657
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:(human ether-a-gogo related gene) encodes the cardiac rapidly activating delayed rectifier potassium currents (I(kr)), which play an important role in cardiac action potential repolarization. General anesthetics, like halothane, can prolong Q-T interval, suggesting that they act on myocellular repolarization...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200210000-00026
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Neuroligin-1 (NL1) forms a complex with the presynaptic neurexin-1β (Nrx1b), regulating clustering of N-methyl-D-aspartate receptors with postsynaptic density-95 (PSD-95) to underlie learning-/memory-associated plasticity. Pain-related spinal neuroplasticity shares several common features with learning-/memo...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000809
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Recent evidence indicates that vascular adenosine triphosphate-sensitive potassium (K(ATP)) channels in vascular smooth muscle cells are critical in the regulation of vascular tonus under both physiologic and pathophysiologic conditions. Studies of the interaction of volatile anesthetics with vascular K(ATP)...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/01.anes.0000265158.47556.73
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Perioperative beta-blockade has been shown to improve long-term cardiac outcome in noncardiac surgical patients. A possible mechanism for the reduced risk of perioperative myocardial infarction is the attenuation of the excitotoxic effects of catecholamine surges by beta-blockade. It was hypothesized that be...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199912000-00020
更新日期:1999-12-01 00:00:00