Abstract:
:The effects of gamma-aminobutyric acid (GABA) on the induction of convulsions by local anesthetics were investigated in mice and rats. Intraventricular administration of 0.8-1.6 mg GABA protected rats against convulsions induced by procaine, lidocaine, cocaine, and tetracaine in a dose-related manner. Intraperitoneal gamma-acetylenic GABA was also effective against procaine-induced convulsions in mice, but the metabolites of GABA, gamma-hydroxybutyrate, and gamma-butyrolactone were without effect. Intraventricular GABA, 1.6 mg, delayed the onset of convulsions induced by hydrazine, but had no influence on the incidence of convulsions induced by nicotine, pentylenetetrazol, picrotoxin, or strychnine. These results suggest that the GABA system may be involved in the mechanisms of local anesthetic-induced convulsions.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Ikeda M,Dohi T,Tsujimoto Adoi
10.1097/00000542-198205000-00007subject
Has Abstractpub_date
1982-05-01 00:00:00pages
365-8issue
5eissn
0003-3022issn
1528-1175journal_volume
56pub_type
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