Cerebral and systemic effects of hypotension induced by adenosine or ATP in dogs.

abstract：:Thirty-six halogenated Me Et ethers have been synthesized for evaluation as volatile anesthetics. Eleven of the ethers were too unstable to test, and, of the remaining 25, 13 had promising anesthetic properties in mice and are suitable for study in larger animals. Those ethers having one H with at least 2 halogens oth...

journal_title：Anesthesiology

authors： Terrell RC

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The tube of the intubating laryngeal mask (ILM) is more rigid than the standard laryngeal mask airway (LMA), and the authors have tested the hypothesis that pharyngeal mucosal pressures, airway sealing pressures, and fiberoptic position are different when the two devices are compared. METHODS:Twenty anesthe...

journal_title：Anesthesiology

authors： Keller C,Brimacombe J

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:The study was designed to compare the effects of equimolar concentrations of racemic bupivacaine, levobupivacaine, and ropivacaine on ventricular conduction, anisotropy, duration and homogeneity of refractoriness, and wavelengths, and to provide a potency ratio for effects on conduction velocity. METHODS:Is...

journal_title：Anesthesiology

authors： Aya AG,de la Coussaye JE,Robert E,Ripart J,Cuvillon P,Mazoit JX,Jeannes P,Fabbro-Péray P,Eledjam JJ

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Obesity is an important risk factor for surgical site infections. The incidence of surgical wound infections is directly related to tissue perfusion and oxygenation. Fat tissue mass expands without a concomitant increase in blood flow per cell, which might result in a relative hypoperfusion with decreased ti...

journal_title：Anesthesiology

authors： Kabon B,Nagele A,Reddy D,Eagon C,Fleshman JW,Sessler DI,Kurz A

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:The aim of this study was to characterize cervical cord, root, and bony spine claims in the American Society of Anesthesiologists Closed Claims database to formulate hypotheses regarding mechanisms of injury. METHODS:All general anesthesia claims (1970-2007) in the Closed Claims database were searched to id...

journal_title：Anesthesiology

authors： Hindman BJ,Palecek JP,Posner KL,Traynelis VC,Lee LA,Sawin PD,Tredway TL,Todd MM,Domino KB

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:The authors sought to determine whether subjects with pathophysiological conditions that are characterized by increased concentrations of aldosterone have increased susceptibility to the side effects of neonatal anesthesia with sevoflurane. METHODS:Postnatal day 4-20 (P4-P20) rats were exposed to sevofluran...

journal_title：Anesthesiology

authors： Cao W,Pavlinec C,Gravenstein N,Seubert CN,Martynyuk AE

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:The rate of administration of an intravenous anesthetic induction agent is an important variable determining the total dose required to reach a given endpoint, such as loss of consciousness (LOC). The influence of infusion rate on the dose-response relationship has not been described rigorously. In this stud...

journal_title：Anesthesiology

authors： Gentry WB,Krejcie TC,Henthorn TK,Shanks CA,Howard KA,Gupta DK,Avram MJ

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Preterm and ex-preterm infants are at risk for life-threatening apnea after general anesthesia. The authors attempted to define the postconceptual age beyond which apnea is less likely to occur and to identify the factors that predispose to postanesthetic apnea. METHODS:Ninety-one infants younger than 60 we...

journal_title：Anesthesiology

authors： Malviya S,Swartz J,Lerman J

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Intensive care unit (ICU) patients often need blood transfusion, but no reliable predictors of transfusion requirements are available at ICU admission. The authors hypothesized that ICU patients with functional iron deficiency may be at higher risk for developing anemia, requiring blood transfusion. Their ob...

journal_title：Anesthesiology

authors： Fernandez R,Tubau I,Masip J,Muñoz L,Roig I,Artigas A

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Malignant hyperthermia is associated with mutations within the gene encoding the skeletal muscle ryanodine receptor, the calcium channel that releases Ca from sarcoplasmic reticulum stores triggering muscle contraction, and other metabolic activities. More than 200 variants have been identified in the ryanod...

journal_title：Anesthesiology

authors： Sato K,Pollock N,Stowell KM

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Reduction of nocturnal obstructive events during lateral position in patients with obstructive sleep apnea was previously reported. However, little information is available regarding mechanisms of the improvement and the precise pharyngeal site influenced by the lateral position. The authors tested the hypot...

journal_title：Anesthesiology

authors： Isono S,Tanaka A,Nishino T

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Reduced spinal excitability contributes to the suppression of movement responses to noxious stimuli during the anesthetic state. This study examines and compares presynaptic and postsynaptic effects of two anesthetics in the human spinal cord. METHODS:The authors tested two parameters during the administrat...

journal_title：Anesthesiology

authors： Baars JH,Benzke M,von Dincklage F,Reiche J,Schlattmann P,Rehberg B

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:This series investigated the quality of analgesia and the incidence and severity of side effects of intrathecal morphine for post-cesarean analgesia administered over a dose range of 0.0-0.5 mg. METHODS:ONE hundred eight term parturients undergoing cesarean delivery at term and given spinal anesthesia were ...

journal_title：Anesthesiology

authors： Palmer CM,Emerson S,Volgoropolous D,Alves D

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Aqueous suspensions of the local anesthetic n-butyl-p-aminobenzoate (BAB), epidurally applied in terminal cancer patients, resulted in a sensory blockade, lasting up to several months. To investigate the mechanism of action on the cellular level, the effect of 100 microM BAB on Na+ action potentials and on N...

journal_title：Anesthesiology

authors： Van den Berg RJ,Van Soest PF,Wang Z,Grouls RJ,Korsten HH

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Studies on receptor knockout mice have so far shown that of the three alpha2-adrenoceptor subtypes, the alpha(2A) adrenoceptor has a major role in mediating the powerful central analgesia induced by synthetic alpha2-adrenoceptor agonists. However, because a knockout of the gene for the alpha(2A) adrenoceptor...

journal_title：Anesthesiology

authors： Mansikka H,Lähdesmäki J,Scheinin M,Pertovaara A

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Animal studies have provided considerable evidence to support a role of histamine in the central nervous system in thermoregulation, and premedication with a histamine H2 receptor antagonist before general anesthesia is used to reduce the risk of acid aspiration. The authors investigated whether premedicatio...

journal_title：Anesthesiology

authors： Hirose M,Hara Y,Matsusaki M

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:To eliminate the influence of hydrostatic pressure, proper transducer positions for central venous pressure and pulmonary artery wedge pressure are at the uppermost blood levels of right atrium (RA) and left atrium (LA). This study was performed to investigate accurate reference levels of central venous pres...

journal_title：Anesthesiology

authors： Seo JH,Jung CW,Bahk JH

更新日期：2007-08-01 00:00:00

abstract：:The aim of the study was to establish whether there exists a relationship between blood methadone concentration and analgesic response and the intrasubject and intersubject variability in this relationship. Sixteen general surgical (upper abdominal) and orthopedic (spinal fusion) patients were administered methadone (...

journal_title：Anesthesiology

authors： Gourlay GK,Willis RJ,Wilson PR

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:The severity of spontaneous myocardial hypercarbic acidosis during cardiac arrest previously has been predictive of the likelihood of restoring spontaneous circulation. The present study investigated whether hypercarbia itself impairs cardiac resuscitation. Since coronary perfusion pressure is the overriding...

journal_title：Anesthesiology

authors： Maldonado FA,Weil MH,Tang W,Bisera J,Gazmuri RJ,Johnson B,D'Alessio A

更新日期：1993-02-01 00:00:00

abstract：:This study reports effects of halothane on tumor cells in vitro. Cells from the human colon cancer cell line HT-29 were exposed to various concentrations of halothane for 8-72 h. The effect of this exposure on this colon cancer cell line, with and without coincubation with the biologic response modifier gamma-interfer...

journal_title：Anesthesiology

authors： Rudnick S,Stevenson GW,Hall SC,Espinoza-Delgado I,Stevenson HC,Longo DL

更新日期：1991-01-01 00:00:00

abstract：:The effect of halothane on the pressor responses to hypoxia (3% O2, 5% CO2, balance N2) and to Angiotensin II (Ang II) (0.2 microgram) has been compared in an in vitro perfused and ventilated rat lung preparation in the presence and absence of agents known to block the lipoxygenase (BW755C) and/or the cyclooxygenase (...

journal_title：Anesthesiology

authors： Marshall C,Kim SD,Marshall BE

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:CW002 is a neuromuscular blocking drug that is inactivated by endogenous L-cysteine. This study determined the exogenous L-cysteine dose-response relationship for CW002 reversal along with acute cardiovascular effects and organ toxicity in dogs. METHODS:Six dogs were each studied four times during isofluran...

journal_title：Anesthesiology

authors： Sunaga H,Malhotra JK,Yoon E,Savarese JJ,Heerdt PM

更新日期：2010-04-01 00:00:00

abstract：:The need for accurate clinical diagnosis and appropriate intervention requires that a modern blood-gas laboratory have the means to correct for significant discrepancies between patient temperature and the temperature at which in vitro blood samples are analyzed. Recent advances in mini- and microcomputer technology p...

journal_title：Anesthesiology

authors： Andritsch RF,Muravchick S,Gold MI

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND:The current study was designed to investigate the influence of pretreatment with the oxygen radical scavengers polyethylene glycol superoxide dismutase and catalase (SODCAT) on altered opioid-induced pial artery dilation after fluid percussion brain injury (FPI) in the newborn pig. It has been observed previ...

journal_title：Anesthesiology

authors： Thorogood MC,Armstead WM

更新日期：1996-03-01 00:00:00

abstract：UNLABELLED:BACKGROUND. Injection of local anesthetic into cerebrospinal fluid (CSF) produces anesthesia of unpredictable extent and duration. Although many factors have been identified that affect the extent of spinal anesthesia, correlations are relatively poor and the extent of spread remains unpredictable. This stud...

journal_title：Anesthesiology

authors： Carpenter RL,Hogan QH,Liu SS,Crane B,Moore J

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Etomidate is a sedative hypnotic that is often used in critically ill patients because it provides superior hemodynamic stability. However, it also binds with high affinity to 11beta-hydroxylase, potently suppressing the synthesis of steroids by the adrenal gland that are necessary for survival. The authors ...

journal_title：Anesthesiology

authors： Cotten JF,Forman SA,Laha JK,Cuny GD,Husain SS,Miller KW,Nguyen HH,Kelly EW,Stewart D,Liu A,Raines DE

更新日期：2010-03-01 00:00:00

abstract：:Addition of glucose (16.7 mM) to isolated pieces of rat pancreas increased insulin secretion 5.4-fold over basal secretion rates. Ether at 1, 1.5 and 2 MAC inhibited this insulinogenic effect of glucose in a dose-related manner by 5, 18 (P less than 0.01) and 29 (P less than 0.01) per cent, respectively. ...

journal_title：Anesthesiology

authors： Gingerich RL,Paradise RR,Wright PH

更新日期：1979-07-01 00:00:00

abstract：AIMS:Helium protects myocardium by inducing preconditioning in animals. We investigated whether human endothelium is preconditioned by helium inhalation in vivo. METHODS AND RESULTS:Forearm ischemia-reperfusion (I/R) in healthy volunteers (each group n = 10) was performed by inflating a blood pressure cuff for 20 min....

journal_title：Anesthesiology

authors： Smit KF,Oei GT,Brevoord D,Stroes ES,Nieuwland R,Schlack WS,Hollmann MW,Weber NC,Preckel B

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:In cardiac myocytes, lidocaine reduces but mexiletine increases adenosine triphosphate (ATP)-sensitive K+ currents, suggesting that these class Ib antiarrhythmic drugs may differentially modify the activity of ATP-sensitive K+ channels. The effects of lidocaine and mexiletine on arterial relaxations induced ...

journal_title：Anesthesiology

authors： Kinoshita H,Ishikawa T,Hatano Y

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Work suggests the amnesia from dexmedetomidine (an α2-adrenergic agonist) is caused by a failure of information to be encoded into long-term memory and that dexmedetomidine might differentially affect memory for emotionally arousing material. We investigated these issues in humans using event-related neuroim...

journal_title：Anesthesiology

authors： Hayama HR,Drumheller KM,Mastromonaco M,Reist C,Cahill LF,Alkire MT

更新日期：2012-11-01 00:00:00