Alpha(2A) adrenoceptors contribute to feedback inhibition of capsaicin-induced hyperalgesia.

abstract：BACKGROUND:Inflammation is a key element in the pathophysiology of cerebral ischemia. This study investigated the role of N-Myc downstream-regulated gene-2 in nuclear transcription factor κB-mediated inflammation in ischemia models. METHODS:Mice (n = 6 to 12) with or without nuclear transcription factor κB inhibitor p...

journal_title：Anesthesiology

authors： Deng YL,Ma YL,Zhang ZL,Zhang LX,Guo H,Qin P,Hou YS,Gao ZJ,Hou WG

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") can mediate acute toxic effects such as muscle rigidity, metabolic acidosis, and hyperthermia. Because of close clinical similarities, an association between MDMA intoxication and malignant hyperthermia (MH) was suggested. The aim of this study was to inves...

journal_title：Anesthesiology

authors： Fiege M,Wappler F,Weisshorn R,Gerbershagen MU,Menge M,Schulte Am Esch J

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Percutaneous cannulation of the internal jugular vein in infants is technically more difficult and carries a higher risk of carotid artery puncture than in older children and adults. In this prospective study, the authors tested their hypothesis that using an ultrasound scanner would increase the success of ...

journal_title：Anesthesiology

authors： Verghese ST,McGill WA,Patel RI,Sell JE,Midgley FM,Ruttimann UE

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:The linearity of cisatracurium elimination and its concentration-effect relation were determined as part of a traditional rich data study with three dose levels in patients receiving balanced anesthesia. METHODS:Forty-eight adults with American Society of Anesthesiologists status I-II were randomized to rec...

journal_title：Anesthesiology

authors： Bergeron L,Bevan DR,Berrill A,Kahwaji R,Varin F

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:In the partial CO(2) rebreathing method, monitored changes in CO(2) elimination and end-tidal CO(2) in response to a brief rebreathing period are used to estimate cardiac output. However, dynamic changes in CO(2) production during ischemia and reperfusion may affect the accuracy of these estimates. This stud...

journal_title：Anesthesiology

authors： Kotake Y,Moriyama K,Innami Y,Shimizu H,Ueda T,Morisaki H,Takeda J

更新日期：2003-08-01 00:00:00

abstract：:To determine whether disuse atrophy of skeletal muscle results in resistance to pancuronium, the dose response to pancuronium was determined simultaneously in both gastrocnemius muscles of six dogs that had one hind limb immobilized in a plaster cast for one month. Muscle responses were evoked during pentobarbital-nit...

journal_title：Anesthesiology

authors： Gronert GA

更新日期：1981-11-01 00:00:00

abstract：BACKGROUND:Intrathecal clonidine reduces tactile allodynia in animal models of neuropathic pain, and this effect is blocked by atropine. However, the role of tonic spinal cholinergic activity and its interaction with alpha2-adrenergic systems in normal and neuropathic conditions and to different sensory methods has not...

journal_title：Anesthesiology

authors： Paqueron X,Conklin D,Eisenach JC

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Experimental and clinical studies have shown reduction in intrapulmonary shunt with improved oxygenation by spontaneous breathing with airway pressure release ventilation (APRV) in acute lung injury. The mechanisms of these findings are not clear. The authors hypothesized that spontaneous breathing results i...

journal_title：Anesthesiology

authors： Wrigge H,Zinserling J,Neumann P,Defosse J,Magnusson A,Putensen C,Hedenstierna G

更新日期：2003-08-01 00:00:00

abstract：:Fourteen cases of sudden cardiac arrest in healthy patients who received spinal anesthesia were discovered in a preliminary review of 900 closed insurance claims for major anesthetic mishaps. All patients were resuscitated from the intraoperative cardiac arrest, but six suffered such severe neurologic injury that they...

journal_title：Anesthesiology

authors： Caplan RA,Ward RJ,Posner K,Cheney FW

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:No externally validated risk score for postoperative pulmonary complications (PPCs) is currently available. The authors tested the generalizability of the Assess Respiratory Risk in Surgical Patients in Catalonia risk score for PPCs in a large European cohort (Prospective Evaluation of a RIsk Score for posto...

journal_title：Anesthesiology

authors： Mazo V,Sabaté S,Canet J,Gallart L,de Abreu MG,Belda J,Langeron O,Hoeft A,Pelosi P

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Halothane has been previously shown in vitro to decrease both the inward calcium current in isolated cells and the density of calcium antagonist binding sites in cardiac sarcolemmal membranes prepared from several species, including humans, presumably contributing to the negative inotropic effects seen with ...

journal_title：Anesthesiology

authors： Lee DL,Zhang J,Blanck TJ

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:General anesthetics are thought to produce their hypnotic effects mainly by acting at ligand-gated ionic channels in the central nervous system (CNS). Although it is well established that volatile anesthetics significantly modify the activity of the acetylcholine nicotinic receptors of the neuromuscular junc...

journal_title：Anesthesiology

authors： Salord F,Keita H,Lecharny JB,Henzel D,Desmonts JM,Mantz J

更新日期：1997-03-01 00:00:00

abstract：:The authors sought to determine if isoflurane would attenuate effects of three different types of vasoconstrictors on isolated segments of canine epicardial coronary arteries removed from healthy dogs. As the endothelium has a major role in regulating epicardial coronary artery tone, and as it modulates the effect of ...

journal_title：Anesthesiology

authors： Blaise G,Sill JC,Nugent M,Van Dyke RA,Vanhoutte PM

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:Phantom and stump pains, common sequelae of limb amputations, are significant impediments to rehabilitation of amputees. The pathophysiology and optimal treatment of postamputation pain states are unclear. While stump pain may result from neuromas in the stump, phantom pain is thought to be related to cortic...

journal_title：Anesthesiology

authors： Wu CL,Tella P,Staats PS,Vaslav R,Kazim DA,Wesselmann U,Raja SN

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:The pharmacokinetics of epidurally administered drugs has been the subject of many studies, yet drug concentration in the epidural space has never been measured. This study was undertaken to characterize the epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidurally administered opioids on the ...

journal_title：Anesthesiology

authors： Bernards CM,Shen DD,Sterling ES,Adkins JE,Risler L,Phillips B,Ummenhofer W

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Some patients develop recrudescence after a malignant hyperthermia (MH) reaction, but it is not clear which patients are at risk. The authors analyzed clinical variables associated with recrudescence after a clinical MH episode. METHODS:Data were obtained from Adverse Metabolic Reaction to Anesthesia report...

journal_title：Anesthesiology

authors： Burkman JM,Posner KL,Domino KB

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Anesthetics are believed to alter functional connectivity across brain regions. However, network-level analyses of anesthesia, particularly in humans, are sparse. The authors hypothesized that propofol-induced loss of consciousness results in functional disconnection of human sensorimotor cortices underlying...

journal_title：Anesthesiology

authors： Malekmohammadi M,AuYong N,Price CM,Tsolaki E,Hudson AE,Pouratian N

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Acid aspiration into one lung causes contralateral lung injury and systemic organ injury; this injury is thought to be mediated by the sequestration of activated neutrophils. Recombinant human soluble complement receptor 1 (sCR1) inhibits both the classical and alternative complement pathways; this study inv...

journal_title：Anesthesiology

authors： Nishizawa H,Yamada H,Miyazaki H,Ohara M,Kaneko K,Yamakawa T,Wiener-Kronish J,Kudoh I

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Previous experimental and clinical studies have shown that anesthetic agents have varying effects on cancer prognosis; however, the results were inconsistent among these studies. The authors compared overall and recurrence-free survival in patients given volatile or intravenous anesthesia for digestive tract...

journal_title：Anesthesiology

authors： Makito K,Matsui H,Fushimi K,Yasunaga H

更新日期：2020-10-01 00:00:00

abstract：:Previous investigators have identified an aortic-to-radial artery pressure gradient thought to develop during rewarming and discontinuation of cardiopulmonary bypass. The authors measured mean aortic and radial artery pressures before, during, and after cardiopulmonary bypass in 30 patients, to determine when the pres...

journal_title：Anesthesiology

authors： Rich GF,Lubanski RE Jr,McLoughlin TM

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Sugammadex (Org 25969) forms a complex with steroidal neuromuscular blocking agents, thereby reversing neuromuscular block. This study investigated the dose-response relation, safety, and pharmacokinetics of sugammadex to reverse rocuronium-induced block. METHODS:Twenty-seven male surgical patients aged 18-...

journal_title：Anesthesiology

authors： Sorgenfrei IF,Norrild K,Larsen PB,Stensballe J,Ostergaard D,Prins ME,Viby-Mogensen J

更新日期：2006-04-01 00:00:00

abstract：:The purpose of this study was to evaluate the analgesic contribution of intravenously administered lidocaine and to correlate it with blood levels of the drug. In a double-blind manner, 14 healthy male volunteers received saline solution or lidocaine, 0.2 per cent, at three increasingly greater rates of infusion on tw...

journal_title：Anesthesiology

authors： Rowlingson JC,DiFazio CA,Foster J,Carron H

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:While electroconvulsive therapy is widely regarded as a lifesaving and safe procedure, evidence regarding its effects on myocardial cell injury is sparse. The objective of this investigation was to determine the incidence and magnitude of new cardiac troponin elevation after electroconvulsive therapy using a...

journal_title：Anesthesiology

authors： Duma A,Pal S,Johnston J,Helwani MA,Bhat A,Gill B,Rosenkvist J,Cartmill C,Brown F,Miller JP,Scott MG,Sanchez-Conde F,Jarvis M,Farber NB,Zorumski CF,Conway C,Nagele P

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Enflurane and isoflurane are structural isomers with different anesthetic potencies and side effects. It is not clear whether these differences are produced by differing occupancy of common protein binding sites or by occupancy of different sites, but the very similar molecular properties make the latter pos...

journal_title：Anesthesiology

authors： Liu R,Eckenhoff RG

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:The study was designed to compare the effects of equimolar concentrations of racemic bupivacaine, levobupivacaine, and ropivacaine on ventricular conduction, anisotropy, duration and homogeneity of refractoriness, and wavelengths, and to provide a potency ratio for effects on conduction velocity. METHODS:Is...

journal_title：Anesthesiology

authors： Aya AG,de la Coussaye JE,Robert E,Ripart J,Cuvillon P,Mazoit JX,Jeannes P,Fabbro-Péray P,Eledjam JJ

更新日期：2002-03-01 00:00:00

abstract：:The effect of hypocapnia on autoregulation of cerebral blood flow (CBF) and the lower limit of autoregulation (LLA) was determined in dogs anesthetized with nitrous oxide (66%) and halothane (0.2%, end-expired concentration). CBF and cerebral vascular resistance (CVR) were determined during both normocapnia and hypoca...

journal_title：Anesthesiology

authors： Artru AA,Katz RA,Colley PS

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Previous studies demonstrated that both edrophonium and neostigmine affect mivacurium's pharmacokinetics, thereby potentially affecting its recovery profile. However, those studies were not clinically relevant because mivacurium was still infused after the antagonists were given. In the present study, the au...

journal_title：Anesthesiology

authors： Szenohradszky J,Fogarty D,Kirkegaard-Nielsen H,Brown R,Sharma ML,Fisher DM

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Isoflurane has been said to be more ventilatory depressant than halothane. However, data for comparing the respiratory effects of halothane and isoflurane in humans are insufficient at this time. The aim of this study was to extend our understanding of the nature of the central, as opposed to peripheral, ven...

journal_title：Anesthesiology

authors： Canet J,Sanchis J,Zegrí A,Llorente C,Navajas D,Casan P

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Tight perioperative control of blood glucose improves the outcome of diabetic patients undergoing cardiac surgery. Because stress response and cardiopulmonary bypass can induce profound hyperglycemia, intraoperative glycemic control may become difficult. The authors undertook a prospective cohort study to de...

journal_title：Anesthesiology

authors： Ouattara A,Lecomte P,Le Manach Y,Landi M,Jacqueminet S,Platonov I,Bonnet N,Riou B,Coriat P

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Exogenous pyruvate and ethyl pyruvate (EP), the key ingredient in a new Ringer's solution in clinical trials, are antioxidants as well as metabolic substrates. In vivo studies show both to be protective in oxidative stress, with EP being better. The authors used an acute rat brain slice preparation to compar...

journal_title：Anesthesiology

authors： Zeng J,Liu J,Yang GY,Kelly MJ,James TL,Litt L

更新日期：2007-10-01 00:00:00