Weak polar interactions confer albumin binding site selectivity for haloether anesthetics.

abstract：BACKGROUND:Because the nuclear factor-κB (NF-κB) coupled pathway is believed to amplify inflammation prevailing in sepsis, the authors tested the hypotheses that the insertion-deletion polymorphism (-94ins/delATTG) (1) alters nuclear translocation of nuclear factor-κB and activator protein-1 (NF-κB1) in monocytes after...

journal_title：Anesthesiology

authors： Adamzik M,Schäfer S,Frey UH,Becker A,Kreuzer M,Winning S,Frede S,Steinmann J,Fandrey J,Zacharowski K,Siffert W,Peters J,Hartmann M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The authors developed a measure to determine whether maternal motivation to be present during induction (Motivation for Parental Presence during Induction of Anesthesia [MPPIA]) is related to children's anxiety during the induction process. METHODS:Mothers and children (aged 2-12 yr) undergoing outpatient, ...

journal_title：Anesthesiology

authors： Caldwell-Andrews AA,Kain ZN,Mayes LC,Kerns RD,Ng D

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:The local anesthetic bupivacaine exists in two stereoisomeric forms, R(+)- and S(-)-bupivacaine. Because of its lower cardiac and central nervous system toxicity, attempts were made recently to introduce S(-)-bupivacaine into clinical anesthesia. We investigated stereoselective actions of R(+)-and S(-)-bupiv...

journal_title：Anesthesiology

authors： Nau C,Vogel W,Hempelmann G,Bräu ME

更新日期：1999-09-01 00:00:00

abstract：:Carotid endarterectomy requires temporary surgical occlusion of the involved carotid artery. During occlusion, the minimally acceptable (critical) internal carotid artery stump pressure is reported to be 50 torr, whereas for regional cerebral blood flow (rCBF), a critical range is reported to be 18-24 ml/100 g/min. Du...

journal_title：Anesthesiology

authors： McKay RD,Sundt TM,Michenfelder JD,Gronert GA,Messick JM,Sharbrough FW,Piepgras DG

更新日期：1976-10-01 00:00:00

abstract：BACKGROUND:General anesthetics may modify airway responsiveness. The authors investigated the effect of thiopental, propofol, and etomidate on airway smooth muscle. METHODS:Contraction experiments were done in human airway rings that were either normal or passively sensitized with asthmatic serum. The effect of propof...

journal_title：Anesthesiology

authors： Ouedraogo N,Roux E,Forestier F,Rossetti M,Savineau JP,Marthan R

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Inhaled nitric oxide (NO), a selective vasodilator, improves oxygenation in many patients with adult respiratory distress syndrome (ARDS). Vasoconstrictors may also improve oxygenation, possibly by enhancing hypoxic pulmonary vasoconstriction. This study compared the effects of phenylephrine, NO, and their c...

journal_title：Anesthesiology

authors： Doering EB,Hanson CW 3rd,Reily DJ,Marshall C,Marshall BE

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:This study was design to assess clinical agitation, electroencephalogram (EEG) and autonomic cardiovascular activity changes in children during induction of anesthesia with sevoflurane compared with halothane using noninvasive recording of EEG, heart rate, and finger blood pressure. METHODS:Children aged 2-...

journal_title：Anesthesiology

authors： Constant I,Dubois MC,Piat V,Moutard ML,McCue M,Murat I

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Optimal analgesia for total knee arthroplasty remains challenging. Many modalities have been used, including peripheral nerve block, periarticular infiltration, and epidural analgesia. However, the relative efficacy of various modalities remains unknown. The authors aimed to quantify and rank order the effic...

journal_title：Anesthesiology

authors： Terkawi AS,Mavridis D,Sessler DI,Nunemaker MS,Doais KS,Terkawi RS,Terkawi YS,Petropoulou M,Nemergut EC

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The mechanisms of amino-amide local anesthetic agent-induced vasoconstriction remain unclear. The current study was designed to examine the roles of the protein kinase C (PKC), Rho kinase, and p44/42 mitogen-activated protein kinase (p44/42 MAPK) signaling pathways in calcium (Ca2+)-sensitization mechanisms ...

journal_title：Anesthesiology

authors： Yu J,Tokinaga Y,Kuriyama T,Uematsu N,Mizumoto K,Hatano Y

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:To minimize the risk of pneumonia, many anesthesiologists delay anesthesia-requiring procedures when patients exhibit signs of viral upper respiratory tract infection. Postinfluenza secondary bacterial pneumonias (SBPs) are a major cause of morbidity and mortality. An increased host susceptibility to SBP pos...

journal_title：Anesthesiology

authors： MacDonald BA,Chakravarthy KV,Davidson BA,Mullan BA,Alluri R,Hakansson AP,Knight PR

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Intraspinally administered alpha 2-adrenergic agonists may relieve pain in sympathetically maintained pain (SMP) syndromes, such as reflex sympathetically dystrophy (RSD), by spinal, peripheral, and central nervous system actions. This study examined analgesic efficacy and side effects of epidurally administ...

journal_title：Anesthesiology

authors： Rauck RL,Eisenach JC,Jackson K,Young LD,Southern J

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Because tactile evaluation is the most common form of clinical neuromuscular monitoring, this study examines the relative efficacy of antagonizing residual block at different levels of recovery of the tactile train-of-four (TOF) response. METHODS:Anesthesia was induced in 64 adults with 2-5 microg/kg fentan...

journal_title：Anesthesiology

authors： Kirkegaard H,Heier T,Caldwell JE

更新日期：2002-01-01 00:00:00

abstract：:The authors determined the effect of profound induced hypotension (i.e., mean arterial blood pressure less than 50 mmHg) during craniotomy for cerebral aneurysm on cerebral blood flow and cerebral metabolic rate for oxygen before, during, and after (20 min and 40 min after) the hypotensive period. The study was perfor...

journal_title：Anesthesiology

authors： Pinaud M,Souron R,Lelausque JN,Gazeau MF,Lajat Y,Dixneuf B

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Inhaled nitric oxide (NO) may be useful in the treatment of adult respiratory distress syndrome and other diseases characterized by pulmonary hypertension and hypoxemia. NO is rapidly converted to nitrogen dioxide (NO2) in oxygen (O2) environments. We hypothesized that in patients whose lungs are mechanicall...

journal_title：Anesthesiology

authors： Nishimura M,Hess D,Kacmarek RM,Ritz R,Hurford WE

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Malignant hyperthermia is associated with mutations within the gene encoding the skeletal muscle ryanodine receptor, the calcium channel that releases Ca from sarcoplasmic reticulum stores triggering muscle contraction, and other metabolic activities. More than 200 variants have been identified in the ryanod...

journal_title：Anesthesiology

authors： Sato K,Pollock N,Stowell KM

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:This study investigated the ability of the modified continual reassessment method (MCRM) to determine the maximum tolerated dose of the opioid antagonist nalmefene, which does not reverse analgesia in an acceptable number of postoperative patients receiving epidural fentanyl in 0.075% bupivacaine. METHODS:I...

journal_title：Anesthesiology

authors： Dougherty TB,Porche VH,Thall PF

更新日期：2000-04-01 00:00:00

abstract：:I653 is a new volatile anesthetic structurally similar to enflurane and isoflurane. Since enflurane can induce convulsions, whereas isoflurane progressively depresses cortical electrical activity, the authors believed it important to assess the effect of I653 on the EEG (in both the "time" and "frequency" domain). The...

journal_title：Anesthesiology

authors： Rampil IJ,Weiskopf RB,Brown JG,Eger EI 2nd,Johnson BH,Holmes MA,Donegan JH

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:The authors investigated the efficacy of bilateral suprazygomatic maxillary nerve block (SMB) for postoperative pain relief in infants undergoing cleft palate repair. METHODS:In this prospective, double-blind, single-site, randomized, and parallel-arm controlled trial, 60 children were assigned to undergo b...

journal_title：Anesthesiology

authors： Chiono J,Raux O,Bringuier S,Sola C,Bigorre M,Capdevila X,Dadure C

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Spinal adenosine receptor agonists exert antinociception in animal models of acute and chronic pain, but adenosine itself has not been examined. The authors tested the antinociceptive and antihypersensitivity interactions of intrathecal adenosine and its interactions with intrathecal clonidine and neostigmin...

journal_title：Anesthesiology

authors： Chiari AI,Eisenach JC

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Propofol is an alternative to thiopental as an intravenous induction agent for cesarean section. Because it has relaxant effects on vascular and other smooth muscles, the authors set out to determine whether propofol has any effect on pregnant human uterine smooth muscle in an isolated preparation. METHODS:...

journal_title：Anesthesiology

authors： Shin YK,Kim YD,Collea JV

更新日期：1998-07-01 00:00:00

abstract：:Robert D. Dripps, M.D. (1911 to 1973), helped found academic anesthesiology. Newly reviewed teaching slides from the University of Pennsylvania (Philadelphia, Pennsylvania) contain six anesthesia records from 1965 to 1967 that involved Dripps. They illustrate the clinical philosophy he taught-to consider administratio...

journal_title：Anesthesiology

authors： Johnstone RE,Fleisher LA

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:The neural mechanisms underlying the modulation of pain perception by hypnosis remain obscure. In this study, we used positron emission tomography in 11 healthy volunteers to identify the brain areas in which hypnosis modulates cerebral responses to a noxious stimulus. METHODS:The protocol used a factorial ...

journal_title：Anesthesiology

authors： Faymonville ME,Laureys S,Degueldre C,DelFiore G,Luxen A,Franck G,Lamy M,Maquet P

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:The current study was designed to test the hypothesis that the fibromyalgia survey criteria would be directly associated with increased opioid consumption after hysterectomy even when accounting for other factors previously described as being predictive for acute postoperative pain. METHODS:Two hundred eigh...

journal_title：Anesthesiology

authors： Janda AM,As-Sanie S,Rajala B,Tsodikov A,Moser SE,Clauw DJ,Brummett CM

更新日期：2015-05-01 00:00:00

abstract：:The effects of diazepam on cerebral blood flow (CBF) and cerebral oxygen uptake (CMRO2) was studied using a 133xenon modification of the Kety-Schmidt (1948) technique in paralyzed, artifically ventilated rats with and without simultaneous administration of 70 per cent nitrous oxide. Diazepam was given iv in doses that...

journal_title：Anesthesiology

authors： Carlsson C,Hgerdal M,Kaasik AE,Siesjö BK

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND:Systemic magnesium has been used to minimize postoperative pain with conflicting results by clinical studies. It remains unknown whether the administration of perioperative systemic magnesium can minimize postoperative pain. The objective of the current investigation was to evaluate the effect of systemic ma...

journal_title：Anesthesiology

authors： De Oliveira GS Jr,Castro-Alves LJ,Khan JH,McCarthy RJ

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The authors sought to understand neural correlates of anesthetic-induced unconsciousness. Cortical gamma oscillations have been associated with neural processes supporting conscious perception, but the effect of general anesthesia on these oscillations is controversial. In this study, the authors examined th...

journal_title：Anesthesiology

authors： Imas OA,Ropella KM,Ward BD,Wood JD,Hudetz AG

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:There is substantial and growing literature on the actions of general anesthetics on a variety of neurotransmitter-gated ion channels, with the greatest attention being focused on inhibitory gamma-amino butyric acid type A receptors. In contrast, glutamate receptors, the most important class of fast excitato...

journal_title：Anesthesiology

authors： Plested AJ,Wildman SS,Lieb WR,Franks NP

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:It is not always possible to predict when tracheal intubation will be difficult or impossible. The authors wanted to determine whether indirect laryngoscopy could identify patients in whom intubation was difficult. METHODS:Indirect laryngoscopy was done in 2,504 patients. The Wilson risk sum score and the m...

journal_title：Anesthesiology

authors： Yamamoto K,Tsubokawa T,Shibata K,Ohmura S,Nitta S,Kobayashi T

更新日期：1997-02-01 00:00:00

abstract：:The anesthetic requirements for sevoflurane, isoflurane, and halothane were determined in mongrel dogs. The MACs (minimum alveolar concentration) of sevoflurane, isoflurane, and halothane were 2.36 +/- 0.46% (n = 18), 1.39 +/- 0.25% (n = 10), and 0.89 +/- 0.20% (n = 12), respectively (mean +/- SD). In agreement with s...

journal_title：Anesthesiology

authors： Kazama T,Ikeda K

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:Adding sodium bicarbonate to lidocaine to enhance its efficacy during peripheral nerve block is controversial. The authors studied the effect of adding sodium bicarbonate to lidocaine with and without epinephrine versus equivalent alkalinization by sodium hydroxide (NaOH) on onset, degree, and duration of pe...

journal_title：Anesthesiology

authors： Sinnott CJ,Garfield JM,Thalhammer JG,Strichartz GR

更新日期：2000-10-01 00:00:00