Effects of halothane and isoflurane on ventilation and occlusion pressure.

Abstract:

BACKGROUND:Isoflurane has been said to be more ventilatory depressant than halothane. However, data for comparing the respiratory effects of halothane and isoflurane in humans are insufficient at this time. The aim of this study was to extend our understanding of the nature of the central, as opposed to peripheral, ventilatory effect of halothane and isoflurane by comparing them at two concentrations. METHODS:Twenty patients were randomly assigned to receive halothane (n = 10) or isoflurane (n = 10). The patients were studied the day before surgery and during anesthesia immediately before surgery. Ventilatory effects were analyzed in terms of breathing pattern, end-tidal carbon dioxide pressure (PETCO2) and inspiratory occlusion pressure. After anesthetic induction and orotracheal intubation with thiopental and succinylcholine patients were allowed to breathe halothane or isoflurane in oxygen spontaneously at 1.2 (low) and 2.0 (high) minimum alveolar concentration (MAC) applied in random order. Inspiratory active impedance during anesthesia was also measured. RESULTS:Significant reduction of minute ventilation between awake and low MAC states was observed for isoflurane (-34.4%; P < 0.001) but not for halothane. Inspiratory occlusion pressure at 100 ms increased significantly between awake and low MAC states, from 1.43 +/- 0.89 to 2.67 +/- 1.05 cmH2O (P < 0.05) for halothane, representing an 87% increase, whereas a nonsignificant increase (16%) was observed for isoflurane. Both anesthetics showed a dose-related ventilatory depressant effect, not attributable to changes in mechanical properties, reflected by significant reductions in minute ventilation (P < 0.001), tidal volume (P < 0.001), and inspiratory occlusion pressure at 100 ms (P < 0.05) and increases in respiratory rate (P < 0.001) and end-tidal carbon dioxide pressure (P < 0.01) when concentration was increased. However, at the higher concentration a significantly greater reduction of minute ventilation (P < 0.01) was observed for isoflurane (-25.6%) than for halothane (-9.4%). We did not observe differences in respiratory rate between the two anesthetics. Significant differences in inspiratory occlusion pressure wave were observed, characterized by a concave-upward tendency for isoflurane and for high concentration. CONCLUSIONS:Our study confirms the stronger ventilatory depression induced by isoflurane compared with that induced by halothane and indicates that halothane at 1.2 MAC induces significantly less ventilatory depression than expected.

journal_name

Anesthesiology

journal_title

Anesthesiology

authors

Canet J,Sanchis J,Zegrí A,Llorente C,Navajas D,Casan P

doi

10.1097/00000542-199409000-00007

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

563-71

issue

3

eissn

0003-3022

issn

1528-1175

journal_volume

81

pub_type

临床试验,杂志文章,随机对照试验
  • Halothane-induced changes in the release and disposition of norepinephrine at adrenergic nerve endings in dog saphenous vein.

    abstract::The effect of halothane on the release and metabolism of norepinephrine during resting conditions and in response to electrical stimulation at 2 Hz was studied in isolated superfused segments od dog saphenous vein. Liquid chromatography with electrochemical detection was used to measure endogenous norepinephrine overf...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198410000-00004

    authors: Lunn JJ,Rorie DK

    更新日期:1984-10-01 00:00:00

  • Moderate exposure to allogeneic blood products is not associated with reduced long-term survival after surgery for coronary artery disease.

    abstract:BACKGROUND:It has been suggested that blood transfusion has an adverse effect on long-term health, mainly through immune modulation and tumor promotion. To further assess this concern, the authors have performed a prospective observational study with the hypothesis that after taking perioperative risk factors relevant ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e3181ab6743

    authors: Weightman WM,Gibbs NM,Sheminant MR,Newman MA,Grey DE

    更新日期:2009-08-01 00:00:00

  • Predicting difficult intubation with indirect laryngoscopy.

    abstract:BACKGROUND:It is not always possible to predict when tracheal intubation will be difficult or impossible. The authors wanted to determine whether indirect laryngoscopy could identify patients in whom intubation was difficult. METHODS:Indirect laryngoscopy was done in 2,504 patients. The Wilson risk sum score and the m...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199702000-00007

    authors: Yamamoto K,Tsubokawa T,Shibata K,Ohmura S,Nitta S,Kobayashi T

    更新日期:1997-02-01 00:00:00

  • Evaluation of Seldinger technique emergency cricothyroidotomy versus standard surgical cricothyroidotomy in 200 cadavers.

    abstract:BACKGROUND:Percutaneous cricothyroidotomy is a lifesaving procedure for airway obstruction in trauma victims who need airway establishment and cannot be intubated or in whom intubation has failed. METHODS:The purpose of this study was to examine whether there is a training effect using Seldinger technique emergency cr...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200501000-00005

    authors: Schaumann N,Lorenz V,Schellongowski P,Staudinger T,Locker GJ,Burgmann H,Pikula B,Hofbauer R,Schuster E,Frass M

    更新日期:2005-01-01 00:00:00

  • Resting metabolic rate of the critically ill patient: measured versus predicted.

    abstract::Critically ill patients requiring mechanical ventilation are particularly susceptible to malnutrition. A knowledge of the energy requirements of these patients is essential in designing nutritional regimens. This study examines 45 resting energy-expenditure measurements performed in a group (n = 40) of postoperative, ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198606000-00001

    authors: Weissman C,Kemper M,Askanazi J,Hyman AI,Kinney JM

    更新日期:1986-06-01 00:00:00

  • Perioperative Visual Loss in Spine Fusion Surgery: Ischemic Optic Neuropathy in the United States from 1998 to 2012 in the Nationwide Inpatient Sample.

    abstract:BACKGROUND:Perioperative ischemic optic neuropathy (ION) causes visual loss in spinal fusion. Previous case-control studies are limited by study size and lack of a random sample. The purpose of this study was to study trends in ION incidence in spinal fusion and risk factors in a large nationwide administrative hospita...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000001211

    authors: Rubin DS,Parakati I,Lee LA,Moss HE,Joslin CE,Roth S

    更新日期:2016-09-01 00:00:00

  • Improved postoperative outcomes associated with preoperative statin therapy.

    abstract::Statin therapy is well established for prevention of cardiovascular disease. Statins may also reduce postoperative mortality and morbidity via a pleiotropic (non-lipid-lowering) effect. The authors conducted a meta-analysis to determine the influence of statin treatment on adverse postoperative outcomes in patients un...

    journal_title:Anesthesiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/00000542-200612000-00027

    authors: Hindler K,Shaw AD,Samuels J,Fulton S,Collard CD,Riedel B

    更新日期:2006-12-01 00:00:00

  • Plasma protein binding of thiopental in patients with impaired renal or hepatic function.

    abstract::Binding of thiopental to proteins in plasma from healthy, cirrhotic, and uremic subjects was studied using equilibrium dialysis. In plasma from healthy volunteers 28.0 plus or minus 0.9 per cent of thiopental was unbound. In plasma from patients with hepatic disease 53.0 plus or minus 2.1 per cent was unbound, while i...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-197505000-00007

    authors: Ghoneim MM,Pandya H

    更新日期:1975-05-01 00:00:00

  • Effect of epidural blockade on protein, glucose, and lipid metabolism in the fasted state and during dextrose infusion in volunteers.

    abstract:BACKGROUND:To interpret correctly the results from studies performed during surgery and anesthesia it is necessary to dissect the separate effect of the anesthetic technique itself. The purpose of this study was to investigate the metabolic effects of epidural blockade (T7-S1) with bupivacaine 0.25% after 12 h fasting ...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000542-200001000-00015

    authors: Schricker T,Klubien K,Wykes L,Carli F

    更新日期:2000-01-01 00:00:00

  • Neutrophil adhesion molecule expression is comparable in perinatal rabbits and humans.

    abstract:BACKGROUND:Human newborns, particularly those born before full term, are more susceptible to bacterial infections as a result of impaired host defense mechanisms. Compared with adults, circulating leukocytes from human newborns (preterm and full-term gestations) and newborn rabbits (full-term gestation) have low restin...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199702000-00017

    authors: Ramamoorthy C,Kovarik WD,Winn RK,Harlan JM,Sharar SR

    更新日期:1997-02-01 00:00:00

  • Dose-response and plasma concentration-response relationships of pancuronium in man.

    abstract::The dose-response and plasma concentration-response relationships for pancuronium in man were studied during its intravenous administration to eight patients at a rate of 1.62 microgram/kg/min. The (log) dose-response relationships resulted in a sigmoid curve that was linear in its central range. At 20, 50 and 80 per ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-197908000-00004

    authors: Shanks CA,Somogyi AA,Triggs EJ

    更新日期:1979-08-01 00:00:00

  • Anesthetic interactions of midazolam and fentanyl: is there acute tolerance to the opioid?

    abstract::The anesthetic effects and interactions of midazolam and fentanyl were determined in terms of their reduction of enflurane MAC in dogs, and the effects of their specific antagonists were also investigated. Control enflurane MAC was determined by the tail clamp method in 18 mongrel dogs. Each animal then received an iv...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198904000-00021

    authors: Schwieger IM,Hall RI,Szlam F,Hug CC Jr

    更新日期:1989-04-01 00:00:00

  • Ionic basis of the differential effects of intravenous anesthetics on erythromycin-induced prolongation of ventricular repolarization in the guinea pig heart.

    abstract:BACKGROUND:Dysrhythmias and death occur in patients with acquired long QT syndrome (LQTS). Little information exists regarding interactions between anesthetics and drugs that prolong ventricular repolarization. Therefore the effects of three commonly used intravenous anesthetics on ventricular repolarization were inves...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199711000-00022

    authors: Morey TE,Martynyuk AE,Napolitano CA,Raatikainen MJ,Guyton TS,Dennis DM

    更新日期:1997-11-01 00:00:00

  • Effect of direct fetal opioid analgesia on fetal hormonal and hemodynamic stress response to intrauterine needling.

    abstract:BACKGROUND:Whether the fetus can experience pain remains controversial. During the last half of pregnancy, the neuroanatomic connections for nociception are in place, and the human fetus mounts sizable stress responses to physical insults. Analgesia has been recommended for intrauterine procedures or late termination, ...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000542-200110000-00008

    authors: Fisk NM,Gitau R,Teixeira JM,Giannakoulopoulos X,Cameron AD,Glover VA

    更新日期:2001-10-01 00:00:00

  • Volume kinetic analysis of the distribution of 0.9% saline in conscious versus isoflurane-anesthetized sheep.

    abstract:BACKGROUND:The distribution and elimination of 0.9% saline given by intravenous infusion has not been compared between the conscious state and during inhalational anesthesia. METHODS:Six adult sheep received an intravenous infusion of 25 ml/kg of 0.9% saline over 20 min in the conscious state and also during isofluran...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200202000-00033

    authors: Brauer KI,Svensén C,Hahn RG,Traber LD,Prough DS

    更新日期:2002-02-01 00:00:00

  • Adsorption characteristics of volatile anesthetics on activated carbons and performance of carbon canisters.

    abstract::The adsorption characteristics, such as the adsorption capacity, the nature of the mass transfer zone, and heats of adsorption, are important for evaluating the performances of carbon canisters for removal of waste anesthetic vapors. The adsorption capacities and the natures of the mass transfer zones were measured fo...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-197703000-00001

    authors: Kim BM,Sircar S

    更新日期:1977-03-01 00:00:00

  • Cardiovascular responses to the induction of mild hypothermia in the presence of epidural anesthesia.

    abstract:BACKGROUND:The combining of epidural anesthesia with general anesthesia impairs central and peripheral thermoregulatory control and therefore is often accompanied by unintended intraoperative hypothermia. However, little is known about the cardiovascular response to hypothermia during combined epidural and general anes...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200104000-00023

    authors: Yoshida M,Shibata K,Itoh H,Yamamoto K

    更新日期:2001-04-01 00:00:00

  • New ultrathin-walled endotracheal tube with a novel laryngeal seal design. Long-term evaluation in sheep.

    abstract:BACKGROUND:A new endotracheal tube (ETT) was fabricated and tested in sheep. It had no tracheal cuff; airway seal was achieved at the level of the glottis through a no-pressure seal made of "gills"; the laryngeal portion was oval-shaped; and the wall thickness was reduced to 0.2 mm. METHODS:Sheep were tracheally intub...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199601000-00019

    authors: Reali-Forster C,Kolobow T,Giacomini M,Hayashi T,Horiba K,Ferrans VJ

    更新日期:1996-01-01 00:00:00

  • Morphologic changes in mouse spermatozoa after exposure to inhalational anesthetics during early spermatogenesis.

    abstract::The authors studied anesthetic mutagenesis following exposure in vivo by use of an adaptation of the mouse spermatozoa morphology assay of Wyrobek and Bruce. The epididymal spermatozoa of (C57B1/C3H)F1 mice were examined for morphologic abnormalities following exposure to near-0.1 MAC and greater concentrations of gen...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198101000-00010

    authors: Land PC,Owen EL,Linde HW

    更新日期:1981-01-01 00:00:00

  • Sedation using propofol induces similar diaphragm dysfunction and atrophy during spontaneous breathing and mechanical ventilation in rats.

    abstract:BACKGROUND:Mechanical ventilation is crucial for patients with respiratory failure. The mechanical takeover of diaphragm function leads to diaphragm dysfunction and atrophy (ventilator-induced diaphragmatic dysfunction), with an increase in oxidative stress as a major contributor. In most patients, a sedative regimen h...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000000125

    authors: Bruells CS,Maes K,Rossaint R,Thomas D,Cielen N,Bergs I,Bleilevens C,Weis J,Gayan-Ramirez G

    更新日期:2014-03-01 00:00:00

  • Continuous interscalene analgesia with ropivacaine 2 mg/ml after major shoulder surgery.

    abstract:BACKGROUND:In this open, randomized study, the pharmacokinetics, clinical efficacy, and safety of a 48-h continuous interscalene infusion of 2 mg/ml ropivacaine for postoperative pain relief were investigated in patients undergoing open major shoulder surgery. METHODS:An initial interscalene block with 30 ml ropivacai...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000542-200301000-00023

    authors: Ekatodramis G,Borgeat A,Huledal G,Jeppsson L,Westman L,Sjövall J

    更新日期:2003-01-01 00:00:00

  • The effects of diazepam on cerebral blood flow and oxygen consumption in rats and its synergistic interaction with nitrous oxide.

    abstract::The effects of diazepam on cerebral blood flow (CBF) and cerebral oxygen uptake (CMRO2) was studied using a 133xenon modification of the Kety-Schmidt (1948) technique in paralyzed, artifically ventilated rats with and without simultaneous administration of 70 per cent nitrous oxide. Diazepam was given iv in doses that...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-197609000-00013

    authors: Carlsson C,Hgerdal M,Kaasik AE,Siesjö BK

    更新日期:1976-09-01 00:00:00

  • Intravenous lidocaine inhibits visceral nociceptive reflexes and spinal neurons in the rat.

    abstract:BACKGROUND:Systemically administered local anesthetics and other sodium channel blockers produce analgesia in patients with hypersensitivity disorders. To assess whether these agents have a role in the treatment of visceral pain, the present study examined the effects of intravenous lidocaine on neuronal and reflex res...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200006000-00028

    authors: Ness TJ

    更新日期:2000-06-01 00:00:00

  • Bayesian modeling of muscle biopsy contracture testing for malignant hyperthermia susceptibility.

    abstract:BACKGROUND:Phenotyping malignant hyperthermia (MH) by contracture testing has a low but quantifiable degree of inaccuracy, measured by its sensitivity and specificity. Quantifying the limitations inherent in diagnostic testing for MH can help resolve issues in clinical practice, such as the interpretation of a negative...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199803000-00007

    authors: Loke JC,MacLennan DH

    更新日期:1998-03-01 00:00:00

  • Positive inotropic and lusitropic effects of triiodothyronine in conscious dogs with pacing-induced cardiomyopathy.

    abstract:BACKGROUND:The effects of triiodothyronine (T3) on systemic hemodynamics, myocardial contractility (preload recruitable stroke work slope; Mw), and left ventricular (LV) isovolumic relaxation (time constant; tau) were examined before and after the development of pacing-induced cardiomyopathy in conscious dogs. METHODS...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199707000-00014

    authors: Jamall IN,Pagel PS,Hettrick DA,Lowe D,Kersten JR,Tessmer JP,Warltier DC

    更新日期:1997-07-01 00:00:00

  • Liability associated with obstetric anesthesia: a closed claims analysis.

    abstract:BACKGROUND:Obstetrics carries high medical liability risk. Maternal death and newborn death/brain damage were the most common complications in obstetric anesthesia malpractice claims before 1990. As the liability profile may have changed over the past two decades, the authors reviewed recent obstetric claims in the Ame...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e318190e16a

    authors: Davies JM,Posner KL,Lee LA,Cheney FW,Domino KB

    更新日期:2009-01-01 00:00:00

  • Evaluation of a novel transfusion algorithm employing point-of-care coagulation assays in cardiac surgery: a retrospective cohort study with interrupted time-series analysis.

    abstract:BACKGROUND:Cardiac surgery requiring the use of cardiopulmonary bypass is frequently complicated by coagulopathic bleeding that, largely due to the shortcomings of conventional coagulation tests, is difficult to manage. This study evaluated a novel transfusion algorithm that uses point-of-care coagulation testing. MET...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000000556

    authors: Karkouti K,McCluskey SA,Callum J,Freedman J,Selby R,Timoumi T,Roy D,Rao V

    更新日期:2015-03-01 00:00:00

  • Dose-response relationship of intrathecal morphine for postcesarean analgesia.

    abstract:BACKGROUND:This series investigated the quality of analgesia and the incidence and severity of side effects of intrathecal morphine for post-cesarean analgesia administered over a dose range of 0.0-0.5 mg. METHODS:ONE hundred eight term parturients undergoing cesarean delivery at term and given spinal anesthesia were ...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000542-199902000-00018

    authors: Palmer CM,Emerson S,Volgoropolous D,Alves D

    更新日期:1999-02-01 00:00:00

  • Cardiovascular changes in preterm neonates receiving isoflurane, halothane, fentanyl, and ketamine.

    abstract::Hemodynamic changes during four anesthetic techniques were studied in 80 preterm neonates. Atropine, 0.02 mg/kg, and pancuronium, 0.1 mg/kg, were given intravenously to all patients, who were ventilated with oxygen and air. Each group of 20 patients then received 0.75% isoflurane, 0.5% halothane, 20 micrograms/kg fent...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198602000-00018

    authors: Friesen RH,Henry DB

    更新日期:1986-02-01 00:00:00

  • Volatile anesthetic preconditioning present in the invertebrate Caenorhabditis elegans.

    abstract:BACKGROUND:Volatile anesthetics (VAs) have been found to induce a delayed protective response called preconditioning to subsequent hypoxic/ischemic injury. VA preconditioning has been primarily studied in canine and rodent heart. A more genetically tractable model of VA preconditioning would be extremely useful. Here, ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e318164d013

    authors: Jia B,Crowder CM

    更新日期:2008-03-01 00:00:00