Bayesian modeling of muscle biopsy contracture testing for malignant hyperthermia susceptibility.

abstract：:The duration of action and the pharmacokinetics of vecuronium were compared in patients with and without renal function. Twenty patients were studied: 12 with renal failure who were to receive kidney transplants from cadaveric donors, and eight with normal renal function. After oral premedication with diazepam, 10 mg,...

journal_title：Anesthesiology

authors： Lynam DP,Cronnelly R,Castagnoli KP,Canfell PC,Caldwell J,Arden J,Miller RD

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND:Combined spinal-epidural anesthesia is a technique growing in popularity. However, there have been no attempts to investigate the risk of epidural drug reaching the subarachnoid space in high concentration by passing through the meningeal hole left by the spinal needle. This study begins to address this ques...

journal_title：Anesthesiology

authors： Bernards CM,Kopacz DJ,Michel MZ

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:Dexmedetomidine is an alpha 2 agonist with potential utility in clinical anesthesia for both its sedative and sympatholytic properties. METHODS:The pharmacokinetics and hemodynamic changes that occurred in ten healthy male volunteers were determined after administration of dexmedetomidine 2 micrograms/kg by...

journal_title：Anesthesiology

authors： Dyck JB,Maze M,Haack C,Vuorilehto L,Shafer SL

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Glutamate has been implicated in the pathophysiology of neuronal injury associated with cerebral hypoxia-ischemia. A model using chronic in utero microdialysis was developed to sample the extracellular space of the fetal brain. Using this model, we tested the hypothesis that glutamate efflux from the parasag...

journal_title：Anesthesiology

authors： Penning DH,Chestnut DH,Dexter F,Hrdy J,Poduska D,Atkins B

更新日期：1995-02-01 00:00:00

abstract：:Halothane-induced lipid peroxidation was studied in microsomes from phenobarbital-pretreated male rats at defined steady state oxygen partial pressures (PO2). At PO2 less than 10 mmHg on addition of halothane to NADPH-reduced microsomes, significant increases in malondialdehyde (MDA) formation, oxygen uptake, and conj...

journal_title：Anesthesiology

authors： de Groot H,Noll T

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:The mechanisms of ventilator-induced lung injury, an iatrogenic inflammatory condition induced by mechanical ventilation, are not completely understood. Toll-like receptor 4 (TLR4) signaling via the adaptor protein myeloid differentiation factor 88 (MyD88) is proinflammatory and plays a critical role in host...

journal_title：Anesthesiology

authors： Li H,Su X,Yan X,Wasserloos K,Chao W,Kaynar AM,Liu ZQ,Leikauf GD,Pitt BR,Zhang LM

更新日期：2010-09-01 00:00:00

abstract：:The effects of halothane on uptake and phosphorylation of uridine, and on cellular ATP content were studied in Tetrahymena pyriformis, a ciliate protozoan. Exposure to halothane inhibited the accumulation of 14C-uridine into the following acid-soluble intracellular pools: UTP, UDP, UMP, and an unidentified compound. H...

journal_title：Anesthesiology

authors： Conklin KA,Lau SS

更新日期：1984-07-01 00:00:00

abstract：:The authors determined the effect of profound induced hypotension (i.e., mean arterial blood pressure less than 50 mmHg) during craniotomy for cerebral aneurysm on cerebral blood flow and cerebral metabolic rate for oxygen before, during, and after (20 min and 40 min after) the hypotensive period. The study was perfor...

journal_title：Anesthesiology

authors： Pinaud M,Souron R,Lelausque JN,Gazeau MF,Lajat Y,Dixneuf B

更新日期：1989-02-01 00:00:00

abstract：:Exposure of resting rat diaphragm for one hour in vitro to halothane (1-1.5, 2-2.5 and 4-4.5 per cent in oxygen) produced significant alterations of intracellular glucose disposition. Glycolysis (as measured by lactate production) increased, while glycogen formation was inhibited in a dose-related fashion. Net glucose...

journal_title：Anesthesiology

authors： Rosenberg H,Haugaard N,Haugaard ES

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND:The spinal delivery of the cholinesterase inhibitor neostigmine yields analgesia in rats and augments the analgesic effects of alpha 2 agonists in sheep. To assess its activity in humans, preclinical toxicology studies to define its safety were required in two species. METHODS:Rats with chronic intrathecal ...

journal_title：Anesthesiology

authors： Yaksh TL,Grafe MR,Malkmus S,Rathbun ML,Eisenach JC

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Mask ventilation is an essential element of airway management that has rarely been studied as the primary outcome. The authors sought to determine the incidence and predictors of difficult and impossible mask ventilation. METHODS:A four-point scale to grade difficulty in performing mask ventilation (MV) is ...

journal_title：Anesthesiology

authors： Kheterpal S,Han R,Tremper KK,Shanks A,Tait AR,O'Reilly M,Ludwig TA

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:To assess the performance of transcranial Doppler (TCD) in predicting neurologic worsening after mild to moderate traumatic brain injury. METHODS:The authors conducted a prospective observational study across 17 sites. TCD was performed upon admission in 356 patients (Glasgow Coma Score [GCS], 9 to 15) with...

journal_title：Anesthesiology

authors： Bouzat P,Almeras L,Manhes P,Sanders L,Levrat A,David JS,Cinotti R,Chabanne R,Gloaguen A,Bobbia X,Thoret S,Oujamaa L,Bosson JL,Payen JF,Asehnoune K,Pes P,Lefrant JY,Mirek S,Albasini F,Scrimgeour C,Thouret JM,Char

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Hypoalbuminemia may increase the risk of acute kidney injury (AKI). The authors investigated whether the immediate preoperative administration of 20% albumin solution affects the incidence of AKI after off-pump coronary artery bypass surgery. METHODS:In this prospective, single-center, randomized, parallel-...

journal_title：Anesthesiology

authors： Lee EH,Kim WJ,Kim JY,Chin JH,Choi DK,Sim JY,Choo SJ,Chung CH,Lee JW,Choi IC

更新日期：2016-05-01 00:00:00

abstract：:The effects of halothane, tetrodotoxin (TTX), veratridine (VTD), and alterations of extracellular calcium ion concentration [Ca++]0) on regional differences of canine Purkinje fiber action potential duration (APD50 and APD90) were investigated in vitro at a paced rate of 75 beats per min. Under control conditions (n =...

journal_title：Anesthesiology

authors： Turner LA,Marijic J,Kampine JP,Bosnjak ZJ

更新日期：1990-12-01 00:00:00

abstract：:Because propofol has cerebral effects similar to those observed for barbiturates, we postulated that it too might offer protection against a focal cerebral ischemic insult. Spontaneously hypertensive male rats were anesthetized with halothane (in 50% O2/balance N2), and their tracheas were intubated and their lungs me...

journal_title：Anesthesiology

authors： Ridenour TR,Warner DS,Todd MM,Gionet TX

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Liver damage by ischemia and reperfusion injury is a risk factor for morbidity and mortality after liver surgery. Postoperative oxygen treatment is routinely applied in the postanesthesia and intensive care unit after liver surgery. The risks of aggravating the injury by increasing inspiratory oxygen from 21...

journal_title：Anesthesiology

authors： Zangl Q,Martignoni A,Jackson SH,Ohta A,Klaunberg B,Kaufmann I,Lukashev D,Ward JM,Sitkovsky M,Thiel M,Choukèr A

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Neurally adjusted ventilatory assist (NAVA) is a new mode of mechanical ventilation that delivers ventilatory assist in proportion to the electrical activity of the diaphragm. This study aimed to compare the ventilatory and gas exchange effects between NAVA and pressure support ventilation (PSV) during the w...

journal_title：Anesthesiology

authors： Coisel Y,Chanques G,Jung B,Constantin JM,Capdevila X,Matecki S,Grasso S,Jaber S

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Glucose-insulin-potassium (GIK) administration during cardiac surgery inconsistently improves myocardial function, perhaps because hyperglycemia negates the beneficial effects of GIK. The hyperinsulinemic normoglycemic clamp (HNC) technique may better enhance the myocardial benefits of GIK. The authors exten...

journal_title：Anesthesiology

authors： Duncan AE,Kateby Kashy B,Sarwar S,Singh A,Stenina-Adognravi O,Christoffersen S,Alfirevic A,Sale S,Yang D,Thomas JD,Gillinov M,Sessler DI

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Excessive intraoperative bleeding is associated with significant morbidity and mortality. The authors and others have shown that fibrin monomer allows preoperative risk stratification for intraoperative blood loss, likely due to an imbalance between available factor XIII and prothrombin conversion. The autho...

journal_title：Anesthesiology

authors： Korte WC,Szadkowski C,Gähler A,Gabi K,Kownacki E,Eder M,Degiacomi P,Zoller N,Devay J,Lange J,Schnider T

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Cardiac preconditioning, including that induced by halogenated anesthetics, is an innate protective mechanism against ischemia-reperfusion injury. The adenosine triphosphate-sensitive potassium (K(ATP)) channels are considered essential in preconditioning mechanism. However, it is unclear whether K(ATP) chan...

journal_title：Anesthesiology

authors： Marinovic J,Bosnjak ZJ,Stadnicka A

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:It should be possible to avoid variations in plasma glucose concentration during anesthesia by adjusting glucose infusion rate to whole-body glucose uptake. To study this hypothesis, we measured glucose utilization and production, before and during halothane anesthesia. METHODS:After an overnight fast, six ...

journal_title：Anesthesiology

authors： Sbaï D,Jouvet P,Soulier A,Pénicaud L,Merckx J,Bresson JL

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:The transfusion of erythrocytes that have been stored for long periods of time can produce visceral ischemia and favor the acquisition of postsurgical infections. To estimate the role of the duration of storage of erythrocytes on morbidity in cardiac surgery, we performed an observational study. METHODS:All...

journal_title：Anesthesiology

authors： Leal-Noval SR,Jara-López I,García-Garmendia JL,Marín-Niebla A,Herruzo-Avilés A,Camacho-Laraña P,Loscertales J

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Acute renal dysfunction (ARD) and subsequent acute renal failure after cardiac surgery are associated with high mortality and morbidity. Early therapeutic or preventive intervention is hampered by the lack of an early biomarker for acute renal injury. Recent studies showed that urinary neutrophil gelatinase-...

journal_title：Anesthesiology

authors： Wagener G,Jan M,Kim M,Mori K,Barasch JM,Sladen RN,Lee HT

更新日期：2006-09-01 00:00:00

abstract：:The formation of acute edema in the tracheobronchial mucosa following local instillation of hydrochloric acid or gastric juice was studied in rats. Protein extravasation using the Evans blue technique was measured and used to indicate edema formation. A pH dependent Evans blue extravasation was observed whereby pH 2 p...

journal_title：Anesthesiology

authors： Martling CR,Lundberg JM

更新日期：1988-03-01 00:00:00

abstract：:The cerebral and systemic hemodynamic and metabolic effects of hypotension induced with desflurane were examined in 11 dogs. During a steady-state baseline period under 1 MAC desflurane (7.2%), the following were measured or derived: arterial, pulmonary artery, and pulmonary artery occlusion pressures; arterial, mixed...

journal_title：Anesthesiology

authors： Milde LN,Milde JH

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:The use of nicotinic agonists for analgesia is limited by their unacceptable side effects. Sazetidine-A is a new partial agonist nicotinic ligand that has very high selectivity for beta2-containing nicotinic acetylcholine receptors. It potently and selectively desensitizes alpha4beta2 nicotinic acetylcholine...

journal_title：Anesthesiology

authors： Cucchiaro G,Xiao Y,Gonzalez-Sulser A,Kellar KJ

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Neuropathic pain is a condition resulting from injury to the peripheral and/or central nervous system. Despite extensive research over the last several decades, neuropathic pain remains difficult to manage. METHODS:The authors conducted a randomized, placebo-controlled, double-blinded, and crossover clinica...

journal_title：Anesthesiology

authors： Ahmed SU,Zhang Y,Chen L,Cohen A,St Hillary K,Vo T,Houghton M,Mao J

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:In airway smooth muscle (ASM), volatile anesthetics deplete sarcoplasmic reticulum (SR) Ca(2+) stores by increasing Ca(2+) "leak." Accordingly, SR replenishment becomes dependent on Ca(2+) influx. Depletion of SR Ca(2+) stores triggers Ca(2+) influx via specific plasma membrane channels, store-operated Ca(2+...

journal_title：Anesthesiology

authors： Pabelick CM,Ay B,Prakash YS,Sieck GC

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:The incidence of awareness has been reported to be higher in children than in adults. Accurately assessing awareness in children is difficult, and the lack of a specific measure of awareness makes it difficult to determine exactly how many and why children are aware. The aim of this study was to determine th...

journal_title：Anesthesiology

authors： Davidson AJ,Sheppard SJ,Engwerda AL,Wong A,Phelan L,Ironfield CM,Stargatt R

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:We evaluated whether spectral entropy (SpE) can measure the depth of hypnosis and the hypnotic drug effect in children during total intravenous anesthesia. METHODS:Sixty healthy children, aged 3-16 yr, were studied. Anesthesia was induced with an increasing target controlled infusion of propofol, and mainta...

journal_title：Anesthesiology

authors： Klockars JG,Hiller A,Münte S,van Gils MJ,Taivainen T

更新日期：2012-02-01 00:00:00