Abstract:
BACKGROUND:Neuropathic pain is a condition resulting from injury to the peripheral and/or central nervous system. Despite extensive research over the last several decades, neuropathic pain remains difficult to manage. METHODS:The authors conducted a randomized, placebo-controlled, double-blinded, and crossover clinical trial to examine the effect of 1.5% topical diclofenac (TD) on neuropathic pain. The authors hypothesized that 1.5% TD would reduce the visual pain score and improve both quantitative sensory testing and functional status in subjects with neuropathic pain. The authors recruited subjects with postherpetic neuralgia and complex regional pain syndrome. The primary outcome was subject's visual pain score. RESULTS:Twenty-eight subjects completed the study (12 male and 16 female) with the mean age of 48.8 yr. After 2 weeks of topical application, subjects in 1.5% TD group showed lower overall visual pain score compared with placebo group (4.9 [1.9] vs. 5.6 [2.1], difference: 0.8; 95% CI, 0.1 to 1.3; P = 0.04) as well as decreased burning pain (2.9 [2.6] vs. 4.3 [2.8], difference, 1.4; 95% CI, 0.2 to 2.6; P = 0.01). There were no statistical differences in constant pain, shooting pain, or hypersensitivity over the painful area between the groups. This self-reported improvement of pain was corroborated by the decreased pain summation detected by quantitative sensory testing. There were no statistically significant changes in functional status in these subjects. There were no complications in both groups. CONCLUSION:The findings indicate that 1.5% TD may serve as an effective treatment option for patients with neuropathic pain from postherpetic neuralgia and complex regional pain syndrome.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Ahmed SU,Zhang Y,Chen L,Cohen A,St Hillary K,Vo T,Houghton M,Mao Jdoi
10.1097/ALN.0000000000000693subject
Has Abstractpub_date
2015-07-01 00:00:00pages
191-8issue
1eissn
0003-3022issn
1528-1175journal_volume
123pub_type
杂志文章,随机对照试验相关文献
ANESTHESIOLOGY文献大全abstract:BACKGROUND:Dysrhythmias and death occur in patients with acquired long QT syndrome (LQTS). Little information exists regarding interactions between anesthetics and drugs that prolong ventricular repolarization. Therefore the effects of three commonly used intravenous anesthetics on ventricular repolarization were inves...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199711000-00022
更新日期:1997-11-01 00:00:00
abstract::This study was designed to test the hypothesis that the volatile anesthetics directly affect cardiac contractile proteins. For this purpose, the effects of various anesthetic doses of halothane, enflurane, and isoflurane on myocardial calcium sensitivity and maximal calcium-activated force were examined in rat cardiac...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198812000-00015
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:The impact on the endothelial glycocalyx for the extravasation of colloidal infusion solutions has not been investigated sufficiently. METHODS:Isolated guinea pig hearts were perfused with Krebs-Henseleit buffer in a Langendorff mode. Solutions of 0.9% saline, 5% albumin (70 kd), or 6% hydroxyethyl starch (...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200405000-00025
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:Preoperative anemia is frequent in patients undergoing orthopedic surgery. The purpose of this study was to assess the preoperative increase of hemoglobin in iron deficiency anemia patients treated with intravenous iron. METHODS:After obtaining written informed consent, 20 patients with iron deficiency anem...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/01.anes.0000291441.10704.82
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:A primary source of calcium (Ca2+) necessary for excitation contraction in vascular smooth muscle (VSM) is influx via voltage-dependent Ca2+ channels. Thus, force generation in VSM is coupled closely to resting transmembrane potential, which itself is primarily a function of potassium conductance. Previously...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199903000-00021
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:During muscular exercise, a negative correlation has been demonstrated between the value of mixed venous oxygen saturation (SvO2) and the level of muscular work, expressed at each level as the ratio of oxygen uptake (VO2) to each subject's maximal oxygen uptake (VO2max). Because the immediate postoperative p...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199402000-00007
更新日期:1994-02-01 00:00:00
abstract::In MH, skeletal muscle acutely and unexpectedly increases its oxygen consumption and lactate production, resulting in greater heat production, respiratory and metabolic acidosis, muscle ridigity, sympathetic stimulation, and increased cellular permeability. The best-accepted theory is that MH is due to an inability to...
journal_title:Anesthesiology
pub_type: 杂志文章,评审
doi:10.1097/00000542-198011000-00007
更新日期:1980-11-01 00:00:00
abstract::Neurophysiologic studies indicate that local anesthetic-induced seizures are generated in subcortical brain structures. The authors utilized a quantitative autoradiographic technique to measure cerebral metabolism during lidocaine-induced seizure activity in rats anesthetized with nitrous oxide. Local cerebral metabol...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198101000-00007
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Postoperative delirium is one of the most common complications in the elderly surgical population. However, its long-term outcomes remain largely to be determined. Therefore a prospective cohort study was conducted to determine the association between postoperative delirium and long-term decline in activitie...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002849
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Previous studies reported that thoracic epidural anesthesia (TEA) protected against a decrease in gastric intramucosal pH, suggesting that TEA increased gut mucosal perfusion. The current study examines the effects of TEA on ileal mucosa using intravital microscopy in anesthetized rats. METHODS:Nineteen rat...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200009000-00036
更新日期:2000-09-01 00:00:00
abstract::The authors evaluated the systemic and cerebral hemodynamic and metabolic effects of 1 h of hypotension to a mean arterial pressure of either 50 mmHg or 40 mmHg induced by intravenous adenosine or ATP in dogs maintained on 70% nitrous oxide and 0.1% halothane. Following the hypotensive period, brain biopsy specimens w...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198504000-00010
更新日期:1985-04-01 00:00:00
abstract::This study was performed to determine if direct arterial dilating actions of propofol contribute to the drug's hypotensive actions. The effects of propofol were compared with those of thiopental on isolated vascular ring preparations from rat thoracic aorta and pulmonary artery. Thoracic aortic ring responses were eva...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199211000-00019
更新日期:1992-11-01 00:00:00
abstract:WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Ketamine is an N-methyl-D-aspartate receptor antagonist that reduces temporal summation of pain and modulates antinociception. Ketamine infusions can produce significant relief of neuropathic pain, but the treatment is resource i...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002417
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:The surface membrane Ca(2+)-adenosine triphosphatase and Na(+)-Ca(2+) exchanger transport Ca(2+) out of the ventricular myocyte, competing for cytosolic Ca(2+) with the Ca(2+)-adenosine triphosphatase located in the sarcoplasmic reticulum. In this study the authors examined the effects of halothane, isoflura...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200206000-00027
更新日期:2002-06-01 00:00:00
abstract::Depressive effect of halothane on carotid sinus baroreceptor function may be due to direct local action, in the CNS, or both. Paris of dogs were anesthetized with pentobarbital and ventilated with oxygen. The carotid sinus of the recipient dog was isolated and perfused with blood from the common carotid artery of the ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198408000-00009
更新日期:1984-08-01 00:00:00
abstract:BACKGROUND:Propofol can be associated with delayed awakening after prolonged infusion. The aim of this study was to characterize the preclinical pharmacology of AZD-3043, a positive allosteric modulator of the γ-aminobutyric acid type A (GABA(A)) receptor containing a metabolically labile ester moiety. The authors post...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e31825685a6
更新日期:2012-06-01 00:00:00
abstract::Cardiac output and myocardial blood flow decrease dramatically in a dose-dependent pattern in the young lamb during isoflurane anesthesia. This raises important questions about the ability of the young lamb to increase myocardial performance if oxygen delivery were compromised by a decrease in oxygen content during an...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198911000-00020
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:Cerebral embolization is a primary cause of cardiac surgical neurologic morbidity. During cardiopulmonary bypass (CPB), there are well-defined periods of embolic risk. In theory, cerebral embolization might be reduced by an increase in pump flow during these periods. The purpose of this study was to determin...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199911000-00031
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Propofol is short-acting intravenous general anesthetics that reduces cardiovascular hemodynamics. The effects of propofol on intrinsic myocardial contractility, however, remain debatable. The aim of the current study was to test the hypothesis that inhibitory effects of propofol on left ventricular (LV) con...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200410000-00012
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:The relative contributions of intraoperative and postoperative hypotension to perioperative morbidity remain unclear. We determined the association between hypotension and a composite of 30-day myocardial infarction and death over three periods: (1) intraoperative, (2) remaining day of surgery, and (3) durin...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/ALN.0000000000001985
更新日期:2018-02-01 00:00:00
abstract::EEG amplitude dominance in awake man is posterior. During EEG monitoring in patients, the authors observed the abrupt appearance of anterior amplitude dominance during induction of anesthesia with halothane, enflurane, or thiopental. This EEG change is coincident with loss of eyelid reflex and loss of ability to respo...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197704000-00005
更新日期:1977-04-01 00:00:00
abstract:BACKGROUND:Age is a known risk factor for postoperative complications, but the genetic factors that account for variability in age at presentation for surgery have not been characterized. Because thrombosis is a critical process in the development of coronary syndromes, the authors hypothesized that patients bearing th...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200312000-00009
更新日期:2003-12-01 00:00:00
abstract::An important guideline for anesthesia in patients with ischemic heart disease is the effect on myocardial oxygen demand. Therefore, this investigation evaluated commonly used myocardial oxygen demand formulas for clinical application. The study was performed on patients undergoing coronary bypass surgery (n = 62). Mea...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199107000-00009
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Densities in dependent lung regions worsen oxygenation in patients with acute respiratory distress syndrome. Identification of these densities requires examination using computed tomography (CT). In this study, the authors evaluated the use of transesophageal echocardiography (TEE) to estimate densities in t...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200105000-00017
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Several beneficial effects of local anesthetics (LAs) were shown to be due to inhibition of G protein-coupled receptor signaling. Differences in exposure time might explain discrepancies in concentrations of LAs required to achieve these protective effects in vivo and in vitro (approximately 100-fold higher)...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200404000-00015
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Xenon has been shown to be neuroprotective in several models of in vitro and in vivo neuronal injury. However, its putative neuroprotective properties have not been evaluated in focal cerebral ischemia. The purpose of this study was to determine if xenon offers neuroprotection in a mouse model of middle cere...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200310000-00020
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers improve cognitive function. The authors therefore tested the primary hypothesis that preoperative use of angiotensin inhibitors is associated with less delirium in critical care patients. Post hoc, the association between postoperativ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000003329
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Both esophagectomy and pulmonary resection are associated with postoperative cardiac complications, partly because of autonomic perturbations involving the heart. This study was undertaken to determine whether heart rate variability (HRV), employed as an index of cardiac autonomic function, changes in patien...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199605000-00008
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:This study was design to assess clinical agitation, electroencephalogram (EEG) and autonomic cardiovascular activity changes in children during induction of anesthesia with sevoflurane compared with halothane using noninvasive recording of EEG, heart rate, and finger blood pressure. METHODS:Children aged 2-...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199912000-00010
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Chronic use of μ-opioid receptor agonists paradoxically causes both hyperalgesia and the loss of analgesic efficacy. Opioid treatment increases presynaptic N-methyl-D-aspartate receptor activity to potentiate nociceptive input to spinal dorsal horn neurons. However, the mechanism responsible for this opioid-...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002648
更新日期:2019-05-01 00:00:00