Comparative effects of propofol and halothane on outcome from temporary middle cerebral artery occlusion in the rat.

abstract：BACKGROUND:Ca is the dominant second messenger in primary sensory neurons. In addition, disrupted Ca signaling is a prominent feature in pain models involving peripheral nerve injury. Standard cytoplasmic Ca recording techniques use high K or field stimulation and dissociated neurons. To compare findings in intact dors...

journal_title：Anesthesiology

authors： Gemes G,Rigaud M,Koopmeiners AS,Poroli MJ,Zoga V,Hogan QH

更新日期：2010-07-01 00:00:00

abstract：:Recent reports have described resistance to pancuronium-induced neuromuscular blockade in patients chronically receiving anticonvulsants. This study examines the pharmacokinetics and pharmacodynamics of metocurine (MTC) in 12 patients undergoing craniotomy--six on chronic phenytoin therapy and six comparable controls....

journal_title：Anesthesiology

authors： Ornstein E,Matteo RS,Young WL,Diaz J

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:A focal cortical cryogenic brain injury has been reported to reduce the brain pentobarbital concentrations needed to prevent movement in response to pain in rats. This occurred despite any apparent behavioral changes in the awake animals. To determine whether this was true with other anesthetics, the authors...

journal_title：Anesthesiology

authors： Todd MM,Weeks JB,Warner DS

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Anesthetic preconditioning (APC) with sevoflurane reduces myocardial ischemia-reperfusion injury. The authors tested whether two brief exposures to sevoflurane would lead to a better preconditioning state than would a single longer exposure and whether dual exposure to a lower (L) concentration of sevofluran...

journal_title：Anesthesiology

authors： Riess ML,Kevin LG,Camara AK,Heisner JS,Stowe DF

更新日期：2004-03-01 00:00:00

abstract：:The safety and efficacy of epidural morphine injected into the caudal space for control of postoperative pain following open cardiac surgery in children was studied. Thirty-two children between the ages of 2-12 yr for whom early postoperative tracheal extubation was anticipated were randomly assigned to control and st...

journal_title：Anesthesiology

authors： Rosen KR,Rosen DA

更新日期：1989-03-01 00:00:00

abstract：:Using the technique of ventriculocisternal perfusion, resistance to reabsorption of cerebrospinal fluid (Ra) was calculated from determinations of the rate of reabsorption of cerebrospinal fluid (Va) at differing cerebrospinal fluid pressures in dogs. Ra was examined during prolonged anesthesia (5.0-6.0 h) with enflur...

journal_title：Anesthesiology

authors： Artru AA

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:Selective breeding produces animal strains with varying anesthetic sensitivity. It thus seems unlikely that various human ethnicities have identical anesthetic requirements. Therefore, the authors tested the hypothesis that the minimum alveolar concentration of sevoflurane differs significantly as a function...

journal_title：Anesthesiology

authors： Ezri T,Sessler D,Weisenberg M,Muzikant G,Protianov M,Mascha E,Evron S

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Awake tracheal intubation may evoke reflex bronchoconstriction in asthmatics. Whether this effect is altered by the choice of the local anesthetic used or by pretreatment with a beta2-adrenoceptor agonist is unknown. Therefore, we assessed the effect of awake fiberoptic intubation after lidocaine or dyclonin...

journal_title：Anesthesiology

authors： Groeben H,Schlicht M,Stieglitz S,Pavlakovic G,Peters J

更新日期：2002-12-01 00:00:00

abstract：:The effects of halothane on the beating response of rat heart cells in tissue culture were studied using an optical-electronic monitoring device. A dose-response curve was obtained over a concentration range to as much as 5 vol per cent halothane. The clinical dosage of 1 vol per cent halothane decreased the inotropic...

journal_title：Anesthesiology

authors： Stong LJ,Hartzell CR,McCarl RL

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:Adaptive support ventilation can speed weaning after coronary artery surgery compared with protocolized weaning using other modes. There are no data to support this mode of weaning after cardiac valvular surgery. Furthermore, control group weaning times have been long, suggesting that the results may reflect...

journal_title：Anesthesiology

authors： Zhu F,Gomersall CD,Ng SK,Underwood MJ,Lee A

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The authors conducted a randomized, controlled, parallel-arm, superiority study to test the hypothesis that a continuous adductor canal block decreases the time to attain four discharge criteria compared with a continuous femoral nerve block after tricompartment knee arthroplasty. METHODS:Subjects undergoin...

journal_title：Anesthesiology

authors： Machi AT,Sztain JF,Kormylo NJ,Madison SJ,Abramson WB,Monahan AM,Khatibi B,Ball ST,Gonzales FB,Sessler DI,Mascha EJ,You J,Nakanote KA,Ilfeld BM

更新日期：2015-08-01 00:00:00

abstract：:The effect of enflurane (2% and 4% inspired) on left ventricular (LV) function were examined in chronically instrumented dogs, both intact and after isolation of their hearts and lungs from the systemic circulation. Enflurane in the intact dogs increased heart rate (32 +/- 5% with 2% and 41 +/- 4% with 4%) and elicite...

journal_title：Anesthesiology

authors： Zimpfer M,Gilly H,Krösl P,Schlag G,Steinbereithner K

更新日期：1983-02-01 00:00:00

abstract：BACKGROUND:Chronic neck pain after whiplash injury is caused by cervical zygapophysial joints in 50% of patients. Diagnostic blocks of nerves supplying the joints are performed using fluoroscopy. The authors' hypothesis was that the third occipital nerve can be visualized and blocked with use of an ultrasound-guided te...

journal_title：Anesthesiology

authors： Eichenberger U,Greher M,Kapral S,Marhofer P,Wiest R,Remonda L,Bogduk N,Curatolo M

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:There is substantial and growing literature on the actions of general anesthetics on a variety of neurotransmitter-gated ion channels, with the greatest attention being focused on inhibitory gamma-amino butyric acid type A receptors. In contrast, glutamate receptors, the most important class of fast excitato...

journal_title：Anesthesiology

authors： Plested AJ,Wildman SS,Lieb WR,Franks NP

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Mechanical ventilation is crucial for patients with respiratory failure. The mechanical takeover of diaphragm function leads to diaphragm dysfunction and atrophy (ventilator-induced diaphragmatic dysfunction), with an increase in oxidative stress as a major contributor. In most patients, a sedative regimen h...

journal_title：Anesthesiology

authors： Bruells CS,Maes K,Rossaint R,Thomas D,Cielen N,Bergs I,Bleilevens C,Weis J,Gayan-Ramirez G

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Chloroprocaine has been associated with severe back pain after epidural anesthesia. Factors proposed to contribute to this problem are: 1) the preservative disodium ethylenediaminetetraacetic acid (EDTA), 2) large volumes of chloroprocaine, 3) low pH of chloroprocaine, and 4) local infiltration with chloropr...

journal_title：Anesthesiology

authors： Stevens RA,Urmey WF,Urquhart BL,Kao TC

更新日期：1993-03-01 00:00:00

abstract：:Four volunteers judged eight levels of thermal stimuli induced by a Hardy dolorimeter, varying in intensity from extremely painful to a low level seldom even perceived. Half of the 406 stimuli were applied during acupuncture and half either before insertion or after removal of the needles. The experimental design mini...

journal_title：Anesthesiology

authors： Day RL,Kitahata LM,Kao FF,Motoyama EK,Hardy JD

更新日期：1975-11-01 00:00:00

abstract：BACKGROUND:Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury and often leads to multiorgan dysfunction and systemic inflammation. Volatile anesthetics have potent antiinflammatory effects. We aimed to determine whether the representative volatile anesthetic isoflurane protects against acut...

journal_title：Anesthesiology

authors： Kim M,Park SW,Kim M,D'Agati VD,Lee HT

更新日期：2011-02-01 00:00:00

abstract：:Despite evidence from animal experiments to the contrary, nitrous oxide (N2O) reportedly does not induce myocardial ischemia when used as an adjunct to fentanyl anesthesia in patients with coronary artery disease who have well-preserved left ventricular (LV) function. However, the incidence of ischemia with N2O admini...

journal_title：Anesthesiology

authors： Mitchell MM,Prakash O,Rulf EN,van Daele ME,Cahalan MK,Roelandt JR

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:It is not always possible to predict when tracheal intubation will be difficult or impossible. The authors wanted to determine whether indirect laryngoscopy could identify patients in whom intubation was difficult. METHODS:Indirect laryngoscopy was done in 2,504 patients. The Wilson risk sum score and the m...

journal_title：Anesthesiology

authors： Yamamoto K,Tsubokawa T,Shibata K,Ohmura S,Nitta S,Kobayashi T

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Mask ventilation is an essential element of airway management that has rarely been studied as the primary outcome. The authors sought to determine the incidence and predictors of difficult and impossible mask ventilation. METHODS:A four-point scale to grade difficulty in performing mask ventilation (MV) is ...

journal_title：Anesthesiology

authors： Kheterpal S,Han R,Tremper KK,Shanks A,Tait AR,O'Reilly M,Ludwig TA

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Previous studies integrated opioid benefit and harm into one single function-the utility function-to determine the drug toxicity (respiratory depression) in light of its wanted effect (analgesia). This study further refined the concept of the utility function using the respiratory and analgesic effects of th...

journal_title：Anesthesiology

authors： Roozekrans M,van der Schrier R,Aarts L,Sarton E,van Velzen M,Niesters M,Dahan A,Olofsen E

更新日期：2018-05-01 00:00:00

abstract：:The antinociceptive interaction on the tail flick (TF) and hot plate (HP) tests between opioid analgesics and medetomidine after intravenous (iv) or intrathecal administration were examined by isobolographic analysis. Male Sprague-Dawley rats received fixed ratios of medetomidine to morphine, fentanyl, and meperidine ...

journal_title：Anesthesiology

authors： Ossipov MH,Harris S,Lloyd P,Messineo E,Lin BS,Bagley J

更新日期：1990-12-01 00:00:00

abstract：:The effects of increased intracranial pressure (ICP) and increased cardiac output (QT) on the pulmonary vascular response to regional alveolar hypoxia were compared in pentobarbital-anesthetized, closed-chested dogs. A bronchial divider was inserted, the right lung (RL) was continuously ventilated with 100% O2, and th...

journal_title：Anesthesiology

authors： Domino KB,Hlastala MP,Cheney FW

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Inhalation anesthetics may interfere with the synthesis or action of endothelium-derived vasoactive factors. We investigated the effects of desflurane, enflurane, halothane, isoflurane, and sevoflurane on the release of nitric oxide and endothelium-derived hyperpolarizing factor (EDHF) in the isolated endoth...

journal_title：Anesthesiology

authors： Lischke V,Busse R,Hecker M

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Factor VII is the most affected clotting factor during the early phase of warfarin therapy. An international normalized ratio (INR) of more than 1.4 is considered unsafe for epidural catheter placement or removal, according to the American Society of Regional Anesthesia and Pain Medicine. The authors tested ...

journal_title：Anesthesiology

authors： Benzon HT,Avram MJ,Benzon HA,Kirby-Nolan M,Nader A

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtype of glutamate receptor mediates fast excitatory neurotransmission in the central nervous system. Many general anesthetics inhibit AMPA receptors in vitro; however, it is not certain if this inhibition contributes to the behavioral pro...

journal_title：Anesthesiology

authors： Joo DT,Gong D,Sonner JM,Jia Z,MacDonald JF,Eger EI 2nd,Orser BA

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Effects of volatile anesthetic agents on N-methyl-D-aspartate (NMDA) receptor-mediated excitatory synaptic transmission have not been well characterized. The authors compared effects produced by halothane and isoflurane on electrophysiologic properties of NMDA and non-NMDA receptor-mediated synaptic response...

journal_title：Anesthesiology

authors： Nishikawa K,MacIver MB

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Halothane and isoflurane have been shown to differentially effect mechanisms of contraction in working myocardial fibers. The aim of this study was to compare effects of halothane and isoflurane on contractile force (CF) and Ca2+ transients in canine cardiac Purkinje fiber preparations. METHODS:Fiber prepar...

journal_title：Anesthesiology

authors： Stowe DF,Sprung J,Turner LA,Kampine JP,Bosnjak ZJ

更新日期：1994-06-01 00:00:00

abstract：INTRODUCTION:Directional connectivity from anterior to posterior brain regions (or "feedback" connectivity) has been shown to be inhibited by propofol and sevoflurane. In this study the authors tested the hypothesis that ketamine would also inhibit cortical feedback connectivity in frontoparietal networks. METHODS:Sur...

journal_title：Anesthesiology

authors： Lee U,Ku S,Noh G,Baek S,Choi B,Mashour GA

更新日期：2013-06-01 00:00:00