Abstract:
:Statin therapy is well established for prevention of cardiovascular disease. Statins may also reduce postoperative mortality and morbidity via a pleiotropic (non-lipid-lowering) effect. The authors conducted a meta-analysis to determine the influence of statin treatment on adverse postoperative outcomes in patients undergoing cardiac, vascular, or noncardiovascular surgery. Two independent authors abstracted data from 12 retrospective and 3 prospective trials (n = 223,010 patients). A meta-analysis was performed to evaluate the overall effect of preoperative statin therapy on postoperative outcomes. Preoperative statin therapy was associated with 38% and 59% reduction in the risk of mortality after cardiac (1.9% vs. 3.1%; P = 0.0001) and vascular (1.7% vs. 6.1%; P = 0.0001) surgery, respectively. When including noncardiac surgery, a 44% reduction in mortality (2.2% vs. 3.2%; P = 0.0001) was observed. Preoperative statin therapy may reduce postoperative mortality in patients undergoing surgical procedures. However, the statin associated effects on postoperative cardiovascular morbidity are too variable to draw any conclusion.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Hindler K,Shaw AD,Samuels J,Fulton S,Collard CD,Riedel Bdoi
10.1097/00000542-200612000-00027subject
Has Abstractpub_date
2006-12-01 00:00:00pages
1260-72; quiz 1289-90issue
6eissn
0003-3022issn
1528-1175pii
00000542-200612000-00027journal_volume
105pub_type
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