Pharyngeal mucosal pressures, airway sealing pressures, and fiberoptic position with the intubating versus the standard laryngeal mask airway.

Abstract:

BACKGROUND:The tube of the intubating laryngeal mask (ILM) is more rigid than the standard laryngeal mask airway (LMA), and the authors have tested the hypothesis that pharyngeal mucosal pressures, airway sealing pressures, and fiberoptic position are different when the two devices are compared. METHODS:Twenty anesthetized, paralyzed adults were randomly allocated to receive either the LMA or ILM for airway management. Microchip sensors were attached to the size 5 LMA or ILM at locations corresponding to the pyriform fossa, hypopharynx, base of tongue, posterior pharynx, and distal and proximal oropharynx. Mucosal pressures, airway sealing pressures, and fiberoptic positioning were recorded during inflation of the cuff from 0 to 40 ml in 10-ml increments. RESULTS:Airway sealing pressures were higher for the ILM (30 vs. 23 cm H2O), but epiglottic downfolding was more common (56% vs. 26%). Pharyngeal mucosal pressures were much higher for the ILM at five of six locations. Mean mucosal pressures in the distal oropharynx for the ILM were always greater than 157 cm H2O, regardless of cuff volume. There was no correlation between mucosal pressures and airway sealing pressures at any location for the LMA, but there was a correlation at three of six locations for the ILM. CONCLUSIONS:The ILM provides a more effective seal than the LMA, but pharyngeal mucosal pressures are higher and always exceed capillary perfusion pressure. The ILM is unsuitable for use as a routine airway and should be removed after its use as an airway intubator.

journal_name

Anesthesiology

journal_title

Anesthesiology

authors

Keller C,Brimacombe J

doi

10.1097/00000542-199904000-00012

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

1001-6

issue

4

eissn

0003-3022

issn

1528-1175

journal_volume

90

pub_type

临床试验,杂志文章,随机对照试验
  • 18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.

    abstract:BACKGROUND:Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively....

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000002103

    authors: Klinger RY,James OG,Borges-Neto S,Bisanar T,Li YJ,Qi W,Berger M,Terrando N,Newman MF,Doraiswamy PM,Mathew JP,Alzheimer’s Disease Neuroimaging Initiative (ADNI) Study Group.,Neurologic Outcomes Research Group (NORG).

    更新日期:2018-04-01 00:00:00

  • Anesthetic influence on arteriolar diameters and tissue oxygen tension in hemorrhaged rats.

    abstract::Arteriolar diameters and tissue oxygen tensions were measured in the cremaster muscles of 68 hemorrhaged rats which were anesthetized with either intramuscular ketamine, 125 mg/kg, plus 30 mg/kg supplements as needed, or enflurane, 2.2% inspired. Animals breathed room air, or room air plus enflurane, throughout the ex...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198209000-00006

    authors: Longnecker DE,Ross DC,Silver IA

    更新日期:1982-09-01 00:00:00

  • Population pharmacokinetics and pharmacodynamics of thiopental: the effect of age revisited.

    abstract::The authors have previously attributed the mechanism for the 50-67% decrease in the required dose of thiopental for induction of anesthesia in aged human patients to a decrease in the initial distribution volume for thiopental. Using a larger group of patients and volunteers studied in the laboratory, the authors have...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199003000-00003

    authors: Stanski DR,Maitre PO

    更新日期:1990-03-01 00:00:00

  • Incidence of neurologic complications related to thoracic epidural catheterization.

    abstract:BACKGROUND:Due to potential neurologic sequelae, the risk:benefit ratio of thoracic epidural analgesia is controversial. Surprisingly, however, few available data address neurologic complications. The incidence of neurologic complications occurring after thoracic epidural catheterization was studied in patients schedul...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199701000-00009

    authors: Giebler RM,Scherer RU,Peters J

    更新日期:1997-01-01 00:00:00

  • Alfentanil pharmacokinetics and metabolism in humans.

    abstract::The metabolism of alfentanil was studied in three healthy subjects after a 1-h infusion of 2.5 mg alfentanil-3H. One of the subjects was a poor hydroxylator of debrisoquine. Pharmacokinetic parameters were similar in the three subjects and were in the same range as those reported for volunteers. The majority of the ad...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198810000-00012

    authors: Meuldermans W,Van Peer A,Hendrickx J,Woestenborghs R,Lauwers W,Heykants J,Vanden Bussche G,Van Craeyvelt H,Van der Aa P

    更新日期:1988-10-01 00:00:00

  • Endothelial glycocalyx as an additional barrier determining extravasation of 6% hydroxyethyl starch or 5% albumin solutions in the coronary vascular bed.

    abstract:BACKGROUND:The impact on the endothelial glycocalyx for the extravasation of colloidal infusion solutions has not been investigated sufficiently. METHODS:Isolated guinea pig hearts were perfused with Krebs-Henseleit buffer in a Langendorff mode. Solutions of 0.9% saline, 5% albumin (70 kd), or 6% hydroxyethyl starch (...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200405000-00025

    authors: Rehm M,Zahler S,Lötsch M,Welsch U,Conzen P,Jacob M,Becker BF

    更新日期:2004-05-01 00:00:00

  • Clinician-delivered intervention to facilitate tobacco quitline use by surgical patients.

    abstract:BACKGROUND:Telephone quitlines that provide counseling support are efficacious in helping cigarette smokers quit and have been widely disseminated; currently, they are underused. Surgery represents a teachable moment for smoking cessation, which can benefit surgical outcomes; however, few surgical patients receive smok...

    journal_title:Anesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ALN.0b013e31820d868d

    authors: Warner DO,Klesges RC,Dale LC,Offord KP,Schroeder DR,Shi Y,Vickers KS,Danielson DR

    更新日期:2011-04-01 00:00:00

  • Intrathecal pertussis toxin treatment attenuates opioid antinociception and reduces high-affinity state of opioid receptors.

    abstract::The effect of pertussis toxin on opioid antinociception was studied in rats. Intrathecal injection of a single dose of pertussis toxin reduced the antinociceptive effect of PL017, a highly selective mu-opioid agonist, in a dose- and time-dependent manner. The maximal effective dose of pertussis toxin was 1 microgram, ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199210000-00013

    authors: Wong CS,Su YF,Chang KJ,Watkins WD

    更新日期:1992-10-01 00:00:00

  • Mucociliary clearance in the canine lung during and after general anesthesia.

    abstract::Central and peripheral pulmonary mucociliary clearance was assessed by tantalum bronchography and serial chest roentgenograms in dogs. Thiopental, 25 mg/kg, did not change clearance from awake values. Halothane 1.2 MAC, for six hours, delayed both central and peripheral clearance by at least three hours. After halotha...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-197901000-00006

    authors: Forbes AR,Gamsu G

    更新日期:1979-01-01 00:00:00

  • Influence of polyethylene glycol superoxide dismutase/catalase on altered opioid-induced pial artery dilation after brain injury.

    abstract:BACKGROUND:The current study was designed to investigate the influence of pretreatment with the oxygen radical scavengers polyethylene glycol superoxide dismutase and catalase (SODCAT) on altered opioid-induced pial artery dilation after fluid percussion brain injury (FPI) in the newborn pig. It has been observed previ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199603000-00017

    authors: Thorogood MC,Armstead WM

    更新日期:1996-03-01 00:00:00

  • Opioid-volatile anesthetic synergy: a response surface model with remifentanil and sevoflurane as prototypes.

    abstract:BACKGROUND:Combining a hypnotic and an analgesic to produce sedation, analgesia, and surgical immobility required for clinical anesthesia is more common than administration of a volatile anesthetic alone. The aim of this study was to apply response surface methods to characterize the interactions between remifentanil a...

    journal_title:Anesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/00000542-200608000-00009

    authors: Manyam SC,Gupta DK,Johnson KB,White JL,Pace NL,Westenskow DR,Egan TD

    更新日期:2006-08-01 00:00:00

  • Dual exposure to sevoflurane improves anesthetic preconditioning in intact hearts.

    abstract:BACKGROUND:Anesthetic preconditioning (APC) with sevoflurane reduces myocardial ischemia-reperfusion injury. The authors tested whether two brief exposures to sevoflurane would lead to a better preconditioning state than would a single longer exposure and whether dual exposure to a lower (L) concentration of sevofluran...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200403000-00016

    authors: Riess ML,Kevin LG,Camara AK,Heisner JS,Stowe DF

    更新日期:2004-03-01 00:00:00

  • Alterations in the functional connectivity of frontal lobe networks preceding emergence delirium in children.

    abstract:BACKGROUND:This study aimed to characterize the electroencephalogram in children who emerged with emergence delirium (ED) compared with children without ED using methods that involved the assessment of cortical functional connectivity. METHODS:Children aged 5 to 15 yr had multichannel electroencephalographic recording...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000000376

    authors: Martin JC,Liley DT,Harvey AS,Kuhlmann L,Sleigh JW,Davidson AJ

    更新日期:2014-10-01 00:00:00

  • Postoperative Delirium Is Associated with Long-term Decline in Activities of Daily Living.

    abstract:BACKGROUND:Postoperative delirium is one of the most common complications in the elderly surgical population. However, its long-term outcomes remain largely to be determined. Therefore a prospective cohort study was conducted to determine the association between postoperative delirium and long-term decline in activitie...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000002849

    authors: Shi Z,Mei X,Li C,Chen Y,Zheng H,Wu Y,Zheng H,Liu L,Marcantonio ER,Xie Z,Shen Y

    更新日期:2019-09-01 00:00:00

  • The minimum alveolar concentration of isoflurane in patients undergoing bilateral tubal ligation in the postpartum period.

    abstract:BACKGROUND:The minimum alveolar concentration (MAC) of volatile anesthetics is decreased during pregnancy, but MAC in the early postpartum period has not been reported. The aim of this study was to determine the MAC of isoflurane and to evaluate the relation between MAC and serum progesterone and beta-endorphin in pati...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199506000-00007

    authors: Zhou HH,Norman P,DeLima LG,Mehta M,Bass D

    更新日期:1995-06-01 00:00:00

  • Long-term pain and activity during recovery from major thoracotomy using thoracic epidural analgesia.

    abstract:BACKGROUND:Pain following thoracotomy can persist for years with an undetermined impact on quality of life. Factors hypothesized to modulate this painful experience include analgesic regimen, gender, and type of incision. METHODS:A total of 157 generally healthy patients of both genders scheduled for segmentectomy, lo...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000542-200211000-00029

    authors: Ochroch EA,Gottschalk A,Augostides J,Carson KA,Kent L,Malayaman N,Kaiser LR,Aukburg SJ

    更新日期:2002-11-01 00:00:00

  • Antinociceptive interaction between opioids and medetomidine: systemic additivity and spinal synergy.

    abstract::The antinociceptive interaction on the tail flick (TF) and hot plate (HP) tests between opioid analgesics and medetomidine after intravenous (iv) or intrathecal administration were examined by isobolographic analysis. Male Sprague-Dawley rats received fixed ratios of medetomidine to morphine, fentanyl, and meperidine ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199012000-00022

    authors: Ossipov MH,Harris S,Lloyd P,Messineo E,Lin BS,Bagley J

    更新日期:1990-12-01 00:00:00

  • Transcutaneous cardiac pacing during thoracic surgery. Feasibility and hemodynamic evaluation by transesophageal echocardiography.

    abstract:BACKGROUND:Occasionally, emergency perioperative pacing is necessary. Transcutaneous cardiac pacing is noninvasive, safe, and readily available. Its feasibility and hemodynamic effects during thoracic surgery and one-lung ventilation have not been established. METHODS:Twenty anesthetized patients (aged 25-70 yr) witho...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000542-199310000-00013

    authors: Amar D,Gross JN,Burt M,Schwinger ME,Rusch VW,Reinsel RA

    更新日期:1993-10-01 00:00:00

  • Initial Experience of an Anesthesiology-based Service for Perioperative Management of Pacemakers and Implantable Cardioverter Defibrillators.

    abstract:BACKGROUND:Management of cardiovascular implantable electronic devices (CIEDs), including pacemakers and implantable cardioverter defibrillators, for surgical procedures is challenging due to the increasing number of patients with CIEDs and limited availability of trained providers. At the authors' institution, a small...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000000838

    authors: Rooke GA,Lombaard SA,Van Norman GA,Dziersk J,Natrajan KM,Larson LW,Poole JE

    更新日期:2015-11-01 00:00:00

  • Diagnostic Accuracy of Respiratory Distress Observation Scales as Surrogates of Dyspnea Self-report in Intensive Care Unit Patients.

    abstract:BACKGROUND:Dyspnea, like pain, can cause major suffering in intensive care unit (ICU) patients. Its evaluation relies on self-report; hence, the risk of being overlooked when verbal communication is impaired. Observation scales incorporating respiratory and behavioral signs (respiratory distress observation scales [RDO...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000000805

    authors: Persichini R,Gay F,Schmidt M,Mayaux J,Demoule A,Morélot-Panzini C,Similowski T

    更新日期:2015-10-01 00:00:00

  • Free Fatty Acid Receptor G-protein-coupled Receptor 40 Mediates Lipid Emulsion-induced Cardioprotection.

    abstract:BACKGROUND:We have previously shown that intralipid (lipid emulsion) protects the heart against ischemia/reperfusion injury and bupivacaine-induced cardiotoxicity. However, the precise underlying mechanisms are not fully understood. Here we explored the hypothesis that free fatty acid receptor-1 or G-protein-coupled re...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000002195

    authors: Umar S,Li J,Hannabass K,Vaillancourt M,Cunningham CM,Moazeni S,Mahajan A,Eghbali M

    更新日期:2018-07-01 00:00:00

  • Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study.

    abstract:BACKGROUND:Patients with initial mild acute respiratory distress syndrome are often underrecognized and mistakenly considered to have low disease severity and favorable outcomes. They represent a relatively poorly characterized population that was only classified as having acute respiratory distress syndrome in the mos...

    journal_title:Anesthesiology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/ALN.0000000000002508

    authors: Pham T,Serpa Neto A,Pelosi P,Laffey JG,De Haro C,Lorente JA,Bellani G,Fan E,Brochard LJ,Pesenti A,Schultz MJ,Artigas A,LUNG SAFE Investigators* and the European Society of Intensive Care Medicine Trials Group.

    更新日期:2019-02-01 00:00:00

  • Ventilatory effects of clonidine alone and in the presence of alfentanil, in human volunteers.

    abstract::Clonidine, an alpha 2-adrenergic agonist, can potentiate opioid-induced analgesia. In a double-blind placebo-controlled study in human volunteers, we sought to determine whether clonidine also potentiates opioid-induced respiratory depression. Hypercapnic ventilatory responses (minute ventilation, mean inspiratory flo...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000542-199206000-00005

    authors: Jarvis DA,Duncan SR,Segal IS,Maze M

    更新日期:1992-06-01 00:00:00

  • Exaggerated anesthetic requirements in the preferentially anesthetized brain.

    abstract:BACKGROUND:The brain is assumed to be the site of anesthetic action, but anesthetics have effects elsewhere, such as the spinal cord. A preferentially anesthetized goat brain model was used to determine the importance of anesthetic action in the brain. METHODS:Six goats were anesthetized with isoflurane; after trachea...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199312000-00015

    authors: Antognini JF,Schwartz K

    更新日期:1993-12-01 00:00:00

  • Perioperative Management of the Adult Patient on Venovenous Extracorporeal Membrane Oxygenation Requiring Noncardiac Surgery.

    abstract::The use of venovenous extracorporeal membrane oxygenation is increasing worldwide. These patients often require noncardiac surgery. In the perioperative period, preoperative assessment, patient transport, choice of anesthetic type, drug dosing, patient monitoring, and intraoperative and postoperative management of com...

    journal_title:Anesthesiology

    pub_type: 杂志文章,评审

    doi:10.1097/ALN.0000000000001887

    authors: Fierro MA,Daneshmand MA,Bartz RR

    更新日期:2018-01-01 00:00:00

  • Morphologic changes in mouse spermatozoa after exposure to inhalational anesthetics during early spermatogenesis.

    abstract::The authors studied anesthetic mutagenesis following exposure in vivo by use of an adaptation of the mouse spermatozoa morphology assay of Wyrobek and Bruce. The epididymal spermatozoa of (C57B1/C3H)F1 mice were examined for morphologic abnormalities following exposure to near-0.1 MAC and greater concentrations of gen...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198101000-00010

    authors: Land PC,Owen EL,Linde HW

    更新日期:1981-01-01 00:00:00

  • Intracranial pressure during hypotension and subsequent vasopressor therapy in anesthetized cats.

    abstract::The effects of vasopressor therapy on intracranial pressure (ICP) during hypotension were evaluated in 45 adult cats anesthetized with pentobarbital and hyperventilated via an endotracheal tube with nitrous oxide, 70 per cent, and oxygen, 30 per cent, to maintain Paco2 25 plus or minus 5 torr. Hypotension was induced ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-197504000-00011

    authors: Stullken EH Jr,Sokoll MD

    更新日期:1975-04-01 00:00:00

  • A Central Amygdala-Ventrolateral Periaqueductal Gray Matter Pathway for Pain in a Mouse Model of Depression-like Behavior.

    abstract:BACKGROUND:The mechanisms underlying depression-associated pain remain poorly understood. Using a mouse model of depression, the authors hypothesized that the central amygdala-periaqueductal gray circuitry is involved in pathologic nociception associated with depressive states. METHODS:The authors used chronic restrai...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000003133

    authors: Yin W,Mei L,Sun T,Wang Y,Li J,Chen C,Farzinpour Z,Mao Y,Tao W,Li J,Xie W,Zhang Z

    更新日期:2020-05-01 00:00:00

  • Influence of administration rate on propofol plasma-effect site equilibration.

    abstract:BACKGROUND:The authors hypothesized a difference in plasma-effect site equilibration, depicted by a first-order constant k(e0), depending on the injection rate of propofol. METHODS:Sixty-one patients received 2.5 mg/kg propofol given as a bolus or as a 1-, 2-, or 3-min infusion. The Bispectral Index was used to monito...

    journal_title:Anesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.anes.0000278902.15505.f8

    authors: Struys MM,Coppens MJ,De Neve N,Mortier EP,Doufas AG,Van Bocxlaer JF,Shafer SL

    更新日期:2007-09-01 00:00:00

  • Carcinogen bioassay of enflurane in mice.

    abstract::A carcinogen bioassay of enflurane was performed in Swiss/ICR mice. Two groups of weanling mice, each of 125 males and 125 females, were exposed to eigher a maximum tolerated dose of enflurane, 3000 ppm (0.3 per cent v/v) or compressed air for 4 hs per day, 5 days per week. After 52 weeks exposure, 25 males and 25 fem...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198201000-00003

    authors: Baden JM,Egbert B,Mazze RI

    更新日期:1982-01-01 00:00:00