Intrathecal pertussis toxin treatment attenuates opioid antinociception and reduces high-affinity state of opioid receptors.

abstract：BACKGROUND:Anesthetics inhibit airway smooth muscle contraction in part by a direct effect on the smooth muscle cell. This study tested the hypothesis that the anesthetics halothane and hexanol, which both relax airway smooth muscle in vitro, inhibit acetylcholine-promoted nucleotide exchange at the alpha subunit of th...

journal_title：Anesthesiology

authors： Sakihara C,Perkins WJ,Warner DO,Jones KA

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Vascular endothelium plays an important role in the regulation of vascular tone. Volatile anesthetics have been shown to attenuate endothelium-mediated relaxation in conductance arteries, such as aorta. However, significant differences in volatile anesthetic pharmacology between these large vessels and the s...

journal_title：Anesthesiology

authors： Akata T,Nakashima M,Kodama K,Boyle WA 3rd,Takahashi S

更新日期：1995-01-01 00:00:00

abstract：:This study was performed to determine the potency of succinylcholine using the single-dose technique, and to test the ability of the cumulative dose technique for generating dose-response data. Thirty-eight adult patients received single doses (n = 18), cumulative doses (n = 10), or cumulative doses of succinylcholine...

journal_title：Anesthesiology

authors： Smith CE,Donati F,Bevan DR

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:An animal experimental model of acute lung injury after intratracheal instillation of acidified milk products has been recently demonstrated. Exogenous administration of surfactant has proved to be successful treatment for acute lung injury induced by many causes including acid aspiration. The authors conduc...

journal_title：Anesthesiology

authors： Nishina K,Mikawa K,Takao Y,Maekawa N,Obara H

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Recent advances have indicated a complex interplay between the autonomic nervous system and the innate immune system. Targeting neural networks for the treatment of sepsis is being developed as a therapeutic strategy. Because electroacupuncture at select acupoints can modulate activities of the autonomic ner...

journal_title：Anesthesiology

authors： Song JG,Li HH,Cao YF,Lv X,Zhang P,Li YS,Zheng YJ,Li Q,Yin PH,Song SL,Wang HY,Wang XR

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:During laparoscopic surgery utilizing carbon dioxide as the insufflating agent, nitrous oxide will diffuse into the peritoneal cavity if it is used as part of the anesthetic. Bowel perforation and the subsequent release of volatile bowel gas could create a explosion hazard. METHODS:Two related studies were ...

journal_title：Anesthesiology

authors： Neuman GG,Sidebotham G,Negoianu E,Bernstein J,Kopman AF,Hicks RG,West ST,Haring L

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Lactate has been shown to be a prognostic biomarker in trauma. Although lactate clearance has already been proposed as an intermediate endpoint in randomized trials, its precise role in trauma patients remains to be determined. METHODS:Blood lactate levels and lactate clearance (LC) were calculated at admis...

journal_title：Anesthesiology

authors： Régnier MA,Raux M,Le Manach Y,Asencio Y,Gaillard J,Devilliers C,Langeron O,Riou B

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the relationship of four postanesthesia care unit (PACU) cardiovascular events to long-term outcomes (unplanned critical care admission or mortality) and to evaluate the contribution of anesthetic management compared with other perioperative factors in predicting th...

journal_title：Anesthesiology

authors： Rose DK,Cohen MM,DeBoer DP

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Enflurane and isoflurane are structural isomers with different anesthetic potencies and side effects. It is not clear whether these differences are produced by differing occupancy of common protein binding sites or by occupancy of different sites, but the very similar molecular properties make the latter pos...

journal_title：Anesthesiology

authors： Liu R,Eckenhoff RG

更新日期：2005-04-01 00:00:00

abstract：:Vastus lateralis muscle was excised from normal pigs and from pigs susceptible to malignant hyperthermia. Anesthesia consisted of diazepam, N2O:O2, and a lidocaine field block. In the susceptible (MHS) pigs, respiratory control in mitochondria of excised muscle was normal, while electron transport was accelerated. Glu...

journal_title：Anesthesiology

authors： Britt BA,Endrenyi L,Cadman DL,Fan HM,Fung HY

更新日期：1975-03-01 00:00:00

abstract：:Eighty-six patients undergoing coronary artery bypass graft (n = 63) or intracardiac (n = 23) surgery were randomly assigned with respect to the target value for PaCO2 during cardiopulmonary bypass. In 44 patients the target PaCO2 was 40 mmHg, measured at the standard electrode temperature of 37 degrees C, while in 42...

journal_title：Anesthesiology

authors： Bashein G,Townes BD,Nessly ML,Bledsoe SW,Hornbein TF,Davis KB,Goldstein DE,Coppel DB

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Alveolar macrophages are a critical part of the defense against pulmonary infection. Thus the authors determined time-dependent changes in alveolar macrophage functions in patients having surgery who were anesthetized with isoflurane or propofol. METHODS:Patients anesthetized with propofol (n = 30) or isofl...

journal_title：Anesthesiology

authors： Kotani N,Hashimoto H,Sessler DI,Kikuchi A,Suzuki A,Takahashi S,Muraoka M,Matsuki A

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:The discrepancy between predicted effect-site concentration and measured bispectral index is problematic during intravenous anesthesia with target-controlled infusion of propofol and remifentanil. We hypothesized that bispectral index during total intravenous anesthesia would be more accurately predicted by ...

journal_title：Anesthesiology

authors： Lee HC,Ryu HG,Chung EJ,Jung CW

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Interscalene nerve blockade remains one of the most commonly used anesthetic and analgesic approaches for shoulder surgery. The high incidence of hemidiaphragmatic paralysis associated with the block, however, precludes its use among patients with compromised pulmonary function. To address this issue, recent...

journal_title：Anesthesiology

authors： Kim DH,Lin Y,Beathe JC,Liu J,Oxendine JA,Haskins SC,Ho MC,Wetmore DS,Allen AA,Wilson L,Garnett C,Memtsoudis SG

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:In 2001, the Centers for Medicare and Medicaid Services issued a rule allowing U.S. states to "opt out" of the regulations requiring physician supervision of nurse anesthetists in an effort to increase access to anesthesia care. Whether "opt out" has successfully achieved this goal remains unknown. METHODS:...

journal_title：Anesthesiology

authors： Sun EC,Dexter F,Miller TR,Baker LC

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Postoperative visual loss after prone spine surgery is increasingly reported in association with ischemic optic neuropathy, but its etiology is unknown. METHODS:To describe the clinical characteristics of these patients, the authors analyzed a retrospectively collected series of 93 spine surgery cases volun...

journal_title：Anesthesiology

authors： Lee LA,Roth S,Posner KL,Cheney FW,Caplan RA,Newman NJ,Domino KB

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Many studies have demonstrated that either glutamate -methyl-d-aspartate (NMDA) receptor antagonists or opioid receptor agonists provide antinociception. Spinal coadministration of an NMDA receptor antagonist and morphine has an additive action for control of various pain states in animal models. The current...

journal_title：Anesthesiology

authors： Lu Y,Vera-Portocarrero LP,Westlund KN

更新日期：2003-03-01 00:00:00

abstract：:The effects of subparalytic doses of succinylcholine and d-tubocurarine on epinephrine-induced cardiac arrhythmias during halothane anesthesia were evaluated in dogs. Succinylcholine markedly increased (P is less than .05) the arrhythmogenicity of epinephrine and d-tubocurarine slightly decreased (P is less than .05) ...

journal_title：Anesthesiology

authors： Tucker WK,Munson ES

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:The effects of triiodothyronine (T3) on systemic hemodynamics, myocardial contractility (preload recruitable stroke work slope; Mw), and left ventricular (LV) isovolumic relaxation (time constant; tau) were examined before and after the development of pacing-induced cardiomyopathy in conscious dogs. METHODS...

journal_title：Anesthesiology

authors： Jamall IN,Pagel PS,Hettrick DA,Lowe D,Kersten JR,Tessmer JP,Warltier DC

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Amitriptyline has been reported to be a more potent local anesthetic than bupivacaine. In keeping with the objective of identifying drugs for prolonged cutaneous analgesia, the authors compared the cutaneous analgesic effectiveness of amitriptyline and bupivacaine in rats. METHODS:Rats were subcutaneously i...

journal_title：Anesthesiology

authors： Khan MA,Gerner P,Kuo Wang G

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Povidone iodine (PI) solution is used commonly for skin disinfection before epidural and spinal anesthesia. Although there have been reports indicating the presence of microbial contaminants in PI solution, none have evaluated the prevalence of PI contamination. The aims of this study were to assess the freq...

journal_title：Anesthesiology

authors： Birnbach DJ,Stein DJ,Murray O,Thys DM,Sordillo EM

更新日期：1998-03-01 00:00:00

abstract：:The serum and urinary concentrations of fluorinated metabolites of isoflurane after inhalation of three different concentrations of isoflurane were studied in 18 ASA physical status 1 or 2 patients, scheduled for orthopedic or otolaryngeal surgery. Isoflurane was administered for 60 min during fentanyl-nitrous oxide-o...

journal_title：Anesthesiology

authors： Davidkova T,Kikuchi H,Fujii K,Mukaida K,Sato N,Kawachi S,Morio M

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND:Perfluorocarbon (PFC) liquids are known to improve gas exchange and pulmonary function in various models of acute respiratory failure. Vaporization has been recently reported as a new method of delivering PFC to the lung. Our aim was to study the effect of PFC vapor on the ventilation/perfusion (VA/Q) matchi...

journal_title：Anesthesiology

authors： Hübler M,Souders JE,Shade ED,Polissar NL,Schimmel C,Hlastala MP

更新日期：2001-12-01 00:00:00

abstract：:Fourteen cases of sudden cardiac arrest in healthy patients who received spinal anesthesia were discovered in a preliminary review of 900 closed insurance claims for major anesthetic mishaps. All patients were resuscitated from the intraoperative cardiac arrest, but six suffered such severe neurologic injury that they...

journal_title：Anesthesiology

authors： Caplan RA,Ward RJ,Posner K,Cheney FW

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Although considerable evidence indicates neuronal Ca channels play significant roles in pain perception, their possible importance in hypersensitization after acute inflammation has not been investigated. METHODS:Using carrageenan for inducing hypersensitization, the authors investigated the analgesic effec...

journal_title：Anesthesiology

authors： Yokoyama K,Kurihara T,Makita K,Tanabe T

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Indirect evidence supports a role of spinal cholinergic neurons in tonically reducing response to noxious mechanical stimulation and in effecting analgesia from alpha2-adrenergic agonists. This study directly assessed the role of cholinergic neurons in regulating the level of mechanical allodynia and in part...

journal_title：Anesthesiology

authors： Paqueron X,Li X,Bantel C,Tobin JR,Voytko ML,Eisenach JC

更新日期：2001-06-01 00:00:00

abstract：WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Ketamine is an N-methyl-D-aspartate receptor antagonist that reduces temporal summation of pain and modulates antinociception. Ketamine infusions can produce significant relief of neuropathic pain, but the treatment is resource i...

journal_title：Anesthesiology

authors： Bosma RL,Cheng JC,Rogachov A,Kim JA,Hemington KS,Osborne NR,Venkat Raghavan L,Bhatia A,Davis KD

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Dexmedetomidine is only approved for use in humans as an intravenous medication. An oral formulation may broaden the use and benefits of dexmedetomidine to numerous care settings. The authors hypothesized that oral dexmedetomidine (300 mcg to 700 mcg) would result in plasma concentrations consistent with sed...

journal_title：Anesthesiology

authors： Chamadia S,Pedemonte JC,Hobbs LE,Deng H,Nguyen S,Cortinez LI,Akeju O

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:The knowledge on the mechanism of the postoperative exacerbation of sleep-disordered breathing may direct the perioperative management of patients with obstructive sleep apnea. The objective of this study is to investigate the factors associated with postoperative severity of sleep-disordered breathing. M...

journal_title：Anesthesiology

authors： Chung F,Liao P,Elsaid H,Shapiro CM,Kang W

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:We previously described the use of the nematode Caenorabditis elegans as a genetic model for studying the mechanism of action of volatile anesthetics. All previous strains of C. elegans with altered responses to anesthetics have been identified by screening the response to halothane. The current study was de...

journal_title：Anesthesiology

authors： Morgan PG,Sedensky MM

更新日期：1994-10-01 00:00:00