Biotransformation of isoflurane: urinary and serum fluoride ion and organic fluorine.

abstract：BACKGROUND:The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtype of glutamate receptor mediates fast excitatory neurotransmission in the central nervous system. Many general anesthetics inhibit AMPA receptors in vitro; however, it is not certain if this inhibition contributes to the behavioral pro...

journal_title：Anesthesiology

authors： Joo DT,Gong D,Sonner JM,Jia Z,MacDonald JF,Eger EI 2nd,Orser BA

更新日期：2001-03-01 00:00:00

abstract：:The metabolism of alfentanil was studied in three healthy subjects after a 1-h infusion of 2.5 mg alfentanil-3H. One of the subjects was a poor hydroxylator of debrisoquine. Pharmacokinetic parameters were similar in the three subjects and were in the same range as those reported for volunteers. The majority of the ad...

journal_title：Anesthesiology

authors： Meuldermans W,Van Peer A,Hendrickx J,Woestenborghs R,Lauwers W,Heykants J,Vanden Bussche G,Van Craeyvelt H,Van der Aa P

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND:Epidural morphine yields postoperative pain relief and hemodynamic stability. However, the effects of epidural morphine on sympathetic tone are unclear. This study was designed to elucidate the effects of epidural morphine on cardiac (CSNA) and renal (RSNA) sympathetic nerve activity by direct measurement in...

journal_title：Anesthesiology

authors： Mori T,Nishikawa K,Terai T,Yukioka H,Asada A

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Patient blood management combines the use of several transfusion alternatives. Integrated use of erythropoietin, cell saver, and/or postoperative drain reinfusion devices on allogeneic erythrocyte use was evaluated using a restrictive transfusion threshold. METHODS:In a factorial design, adult elective hip-...

journal_title：Anesthesiology

authors： So-Osman C,Nelissen RG,Koopman-van Gemert AW,Kluyver E,Pöll RG,Onstenk R,Van Hilten JA,Jansen-Werkhoven TM,van den Hout WB,Brand R,Brand A

更新日期：2014-04-01 00:00:00

abstract：:Eighty-three ASA Physical Status 1-2 patients were orally premedicated with triazolam (0.125, 0.25, or 0.5 mg), diazepam (5, 10, or 15 mg), or placebo to evaluate the effectiveness of these drugs and doses in reducing preoperative anxiety, providing sedation, and producing amnesia. The drug treatments were administere...

journal_title：Anesthesiology

authors： Baughman VL,Becker GL,Ryan CM,Glaser M,Abenstein JP

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Diffusion of nitrous oxide into the cuff of the endotracheal tube results in an increase in cuff pressure. Excessive endotracheal tube cuff pressure may impair tracheal mucosal perfusion and cause tracheal damage and sore throat. Filling the cuff of the endotracheal tube with saline instead of air prevents t...

journal_title：Anesthesiology

authors： Combes X,Schauvliege F,Peyrouset O,Motamed C,Kirov K,Dhonneur G,Duvaldestin P

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:The long-lasting high-affinity opioid buprenorphine has complex pharmacology, including ceiling effects with respect to analgesia and respiratory depression. Plasma concentrations of the major buprenorphine metabolites norbuprenorphine, buprenorphine-3-glucuronide, and norbuprenorphine-3-glucuronide approxim...

journal_title：Anesthesiology

authors： Brown SM,Holtzman M,Kim T,Kharasch ED

更新日期：2011-12-01 00:00:00

abstract：:Despite evidence from animal experiments to the contrary, nitrous oxide (N2O) reportedly does not induce myocardial ischemia when used as an adjunct to fentanyl anesthesia in patients with coronary artery disease who have well-preserved left ventricular (LV) function. However, the incidence of ischemia with N2O admini...

journal_title：Anesthesiology

authors： Mitchell MM,Prakash O,Rulf EN,van Daele ME,Cahalan MK,Roelandt JR

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively....

journal_title：Anesthesiology

authors： Klinger RY,James OG,Borges-Neto S,Bisanar T,Li YJ,Qi W,Berger M,Terrando N,Newman MF,Doraiswamy PM,Mathew JP,Alzheimer’s Disease Neuroimaging Initiative (ADNI) Study Group.,Neurologic Outcomes Research Group (NORG).

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Chronic neck pain after whiplash injury is caused by cervical zygapophysial joints in 50% of patients. Diagnostic blocks of nerves supplying the joints are performed using fluoroscopy. The authors' hypothesis was that the third occipital nerve can be visualized and blocked with use of an ultrasound-guided te...

journal_title：Anesthesiology

authors： Eichenberger U,Greher M,Kapral S,Marhofer P,Wiest R,Remonda L,Bogduk N,Curatolo M

更新日期：2006-02-01 00:00:00

abstract：:The effect of liposome encapsulation on the analgesia produced by intrathecally administered alfentanil was examined in the rat. In rats prepared with chronic intrathecal catheters, alfentanil in doses of 1-50 micrograms was administered intrathecally in either saline or in multilamellar liposomes (dipalmitoylphosphat...

journal_title：Anesthesiology

authors： Bernards CM,Luger TJ,Malmberg AB,Hill HF,Yaksh TL

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:High-frequency oscillatory ventilation (HFOV) at higher frequencies minimizes the tidal volume. However, whether increased frequencies during HFOV can reduce ventilator-induced lung injury remains unknown. METHODS:After the induction of acute respiratory distress syndrome in the model by repeated lavages, 2...

journal_title：Anesthesiology

authors： Liu S,Yi Y,Wang M,Chen Q,Huang Y,Liu L,Xie J,Zhou D,Qiu H

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Moxonidine, a novel imidazoline-alpha2-adrenergic receptor-selective analgesic, was recently identified as antinociceptive but has yet to be evaluated in neuropathic pain models. alpha2-adrenergic receptor-selective analgesics, and high-efficacy opioids, effectively inhibit neuropathic pain behaviors in rode...

journal_title：Anesthesiology

authors： Fairbanks CA,Nguyen HO,Grocholski BM,Wilcox GL

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Chronic use of μ-opioid receptor agonists paradoxically causes both hyperalgesia and the loss of analgesic efficacy. Opioid treatment increases presynaptic N-methyl-D-aspartate receptor activity to potentiate nociceptive input to spinal dorsal horn neurons. However, the mechanism responsible for this opioid-...

journal_title：Anesthesiology

authors： Deng M,Chen SR,Chen H,Pan HL

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:To assess the performance of transcranial Doppler (TCD) in predicting neurologic worsening after mild to moderate traumatic brain injury. METHODS:The authors conducted a prospective observational study across 17 sites. TCD was performed upon admission in 356 patients (Glasgow Coma Score [GCS], 9 to 15) with...

journal_title：Anesthesiology

authors： Bouzat P,Almeras L,Manhes P,Sanders L,Levrat A,David JS,Cinotti R,Chabanne R,Gloaguen A,Bobbia X,Thoret S,Oujamaa L,Bosson JL,Payen JF,Asehnoune K,Pes P,Lefrant JY,Mirek S,Albasini F,Scrimgeour C,Thouret JM,Char

更新日期：2016-08-01 00:00:00

abstract：:Cardiac output and myocardial blood flow decrease dramatically in a dose-dependent pattern in the young lamb during isoflurane anesthesia. This raises important questions about the ability of the young lamb to increase myocardial performance if oxygen delivery were compromised by a decrease in oxygen content during an...

journal_title：Anesthesiology

authors： Brett CM,Teitel DF,Heymann MA,Rudolph AM

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Activation of the complement system is one component of the inflammatory response. Various components of the complement system participate in killing foreign organisms, recruiting immune cells, enhancing edema, and stimulating cytokine formation. Complement-mediated enhancement of the inflammation surroundin...

journal_title：Anesthesiology

authors： Clark JD,Qiao Y,Li X,Shi X,Angst MS,Yeomans DC

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:In acute lung injury positive end-expiratory pressure (PEEP) and recruitment maneuver are proposed to optimize arterial oxygenation. The aim of the study was to evaluate the impact of such a strategy on lung histological inflammation and hyperinflation in pigs with acid aspiration-induced lung injury. METHO...

journal_title：Anesthesiology

authors： Ambrosio AM,Luo R,Fantoni DT,Gutierres C,Lu Q,Gu WJ,Otsuki DA,Malbouisson LM,Auler JO Jr,Rouby JJ,Experimental ARDS Study Group.

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Inhaled nitric oxide (NO) may be useful in the treatment of adult respiratory distress syndrome and other diseases characterized by pulmonary hypertension and hypoxemia. NO is rapidly converted to nitrogen dioxide (NO2) in oxygen (O2) environments. We hypothesized that in patients whose lungs are mechanicall...

journal_title：Anesthesiology

authors： Nishimura M,Hess D,Kacmarek RM,Ritz R,Hurford WE

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Optimal risk adjustment is a requisite precondition for monitoring quality of care and interpreting public reports of hospital outcomes. Current risk-adjustment measures have been criticized for including baseline variables that are difficult to obtain and inadequately adjusting for high-risk patients. The a...

journal_title：Anesthesiology

authors： Dalton JE,Kurz A,Turan A,Mascha EJ,Sessler DI,Saager L

更新日期：2011-06-01 00:00:00

abstract：:Pharmacologic actions of CI-581, a chemical derivative of phencyclidine, were determined in 20 volunteers from a prison population. The results indicate that this drug is an effective analgesic and anesthetic agent in doses of 1.0 to 2.0 mg per kilogram. With intravenous administration the onset of action is within 1 ...

journal_title：Anesthesiology

authors： Domino EF

更新日期：2010-09-01 00:00:00

abstract：WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Ketamine is an N-methyl-D-aspartate receptor antagonist that reduces temporal summation of pain and modulates antinociception. Ketamine infusions can produce significant relief of neuropathic pain, but the treatment is resource i...

journal_title：Anesthesiology

authors： Bosma RL,Cheng JC,Rogachov A,Kim JA,Hemington KS,Osborne NR,Venkat Raghavan L,Bhatia A,Davis KD

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:alpha 2 Agonists are powerful analgesics after spinal delivery. The current work characterizes the dose-dependent antinociception and effects upon respiratory function of dexmedetomidine after intrathecal, epidural, intravenous, and intracisternal delivery in chronically prepared dogs. METHODS:Dogs were pre...

journal_title：Anesthesiology

authors： Sabbe MB,Penning JP,Ozaki GT,Yaksh TL

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Pentobarbital decreases the gain of the baroreceptor reflex on the order of 50%, and this blunting is caused nearly entirely by decreasing cardioinhibitory parasympathetic activity. The most likely site of action of pentobarbital is the gamma-aminobutyric acid type A (GABA(A)) receptor. The authors tested wh...

journal_title：Anesthesiology

authors： Irnaten M,Walwyn WM,Wang J,Venkatesan P,Evans C,Chang KS,Andresen MC,Hales TG,Mendelowitz D

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:The hanging drop technique is used for identifying the cervical epidural space, using its negative pressure. However, it is doubtful whether the epidural space intrinsically exhibits a negative pressure. We designed this study to test the hypothesis that the cervical epidural pressure (CEP) is significantly ...

journal_title：Anesthesiology

authors： Moon JY,Lee PB,Nahm FS,Kim YC,Choi JB

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Intrathecal sufentanil (ITS) is frequently used to provide analgesia during labor. Decreases in blood pressure and sensory changes in this circumstance suggest that ITS may have a local anesthetic effect and thus cause a sympathectomy. To determine whether ITS given to laboring women causes a sympathectomy, ...

journal_title：Anesthesiology

authors： Riley ET,Walker D,Hamilton CL,Cohen SE

更新日期：1997-10-01 00:00:00

abstract：:Postoperative itching is an important problem in the postoperative care unit. Pruritus after surgery may be drug induced (including intrathecal opioids) or secondary to a preexisting systemic disease. Mechanisms of itching are complex and not completely understood. The purpose of this review is to highlight new discov...

journal_title：Anesthesiology

authors： Waxler B,Dadabhoy ZP,Stojiljkovic L,Rabito SF

更新日期：2005-07-01 00:00:00

abstract：:Hepatic venous oxygen saturation (ShvO2) was continuously monitored in 33 consecutive patients undergoing hepatic lobectomy. Fiberoptic pulmonary artery catheters were inserted into the hepatic vein (HV) and in the pulmonary artery through the right internal jugular vein before anesthetic induction. The success rate a...

journal_title：Anesthesiology

authors： Kainuma M,Fujiwara Y,Kimura N,Shitaokoshi A,Nakashima K,Shimada Y

更新日期：1991-01-01 00:00:00

abstract：:The effects of anesthetic drugs on lipid order were evaluated by the fluorescence polarization of the probe molecule, 1,6-diphenyl-1,3,5-hexatriene (DPH) incorporated into vesicles of dimyristoylphosphatidylcholine (DMPC) and DMPC with 10 mol% ganglioside (GD1a). Anesthetics (enflurane, chloroform, diethylether, pento...

journal_title：Anesthesiology

authors： Harris RA,Groh GI

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:The mechanisms of ventilator-induced lung injury, an iatrogenic inflammatory condition induced by mechanical ventilation, are not completely understood. Toll-like receptor 4 (TLR4) signaling via the adaptor protein myeloid differentiation factor 88 (MyD88) is proinflammatory and plays a critical role in host...

journal_title：Anesthesiology

authors： Li H,Su X,Yan X,Wasserloos K,Chao W,Kaynar AM,Liu ZQ,Leikauf GD,Pitt BR,Zhang LM

更新日期：2010-09-01 00:00:00