Taming the ketamine tiger. 1965.

abstract：BACKGROUND:Ketamine is a potent bronchodilator that, in clinically used concentrations, relaxes airway smooth muscle in part by a direct effect. This study explored the role of calcium concentration (Ca2+) in this relaxation. METHODS:Canine trachea smooth muscle strips were loaded with the fluorescent probe fura-2 and...

journal_title：Anesthesiology

authors： Pabelick CM,Jones KA,Street K,Lorenz RR,Warner DO

更新日期：1997-05-01 00:00:00

abstract：INTRODUCTION:The current investigation aimed to study the efficacy of hemostatic therapy guided either by conventional coagulation analyses or point-of-care (POC) testing in coagulopathic cardiac surgery patients. METHODS:Patients undergoing complex cardiac surgery were assessed for eligibility. Those patients in whom...

journal_title：Anesthesiology

authors： Weber CF,Görlinger K,Meininger D,Herrmann E,Bingold T,Moritz A,Cohn LH,Zacharowski K

更新日期：2012-09-01 00:00:00

abstract：:Medical records of 38 patients undergoing anesthesia and surgery for removal of an insulinoma were reviewed to determine 1) the safety of avoiding intraoperative glucose, 2) the appropriate frequency of plasma glucose analysis, and 3) the accuracy of using rebound hyperglycemia as an indication of tumor removal. Plasm...

journal_title：Anesthesiology

authors： Muir JJ,Endres SM,Offord K,van Heerden JA,Tinker JH

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:Dexmedetomidine is an alpha 2 agonist with potential utility in clinical anesthesia for both its sedative and sympatholytic properties. METHODS:The pharmacokinetics and hemodynamic changes that occurred in ten healthy male volunteers were determined after administration of dexmedetomidine 2 micrograms/kg by...

journal_title：Anesthesiology

authors： Dyck JB,Maze M,Haack C,Vuorilehto L,Shafer SL

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Although respiratory depression is the most well-known and dangerous side effect of opioids, no pharmacokinetic-pharmacodynamic model exists for its quantitative analysis. The development of such a model was the aim of this study. METHODS:After institutional approval approval and informed consent were obtai...

journal_title：Anesthesiology

authors： Bouillon T,Schmidt C,Garstka G,Heimbach D,Stafforst D,Schwilden H,Hoeft A

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Persistent postsurgical pain is common and affects quality of life. The hypothesis was that use of pregabalin and ketamine would prevent persistent pain after cardiac surgery. METHODS:This randomized, double-blind, placebo-controlled trial was undertaken at two cardiac surgery centers in the United Kingdom....

journal_title：Anesthesiology

authors： Anwar S,Cooper J,Rahman J,Sharma C,Langford R

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:This series investigated the quality of analgesia and the incidence and severity of side effects of intrathecal morphine for post-cesarean analgesia administered over a dose range of 0.0-0.5 mg. METHODS:ONE hundred eight term parturients undergoing cesarean delivery at term and given spinal anesthesia were ...

journal_title：Anesthesiology

authors： Palmer CM,Emerson S,Volgoropolous D,Alves D

更新日期：1999-02-01 00:00:00

abstract：:The effects of halothane, tetrodotoxin (TTX), veratridine (VTD), and alterations of extracellular calcium ion concentration [Ca++]0) on regional differences of canine Purkinje fiber action potential duration (APD50 and APD90) were investigated in vitro at a paced rate of 75 beats per min. Under control conditions (n =...

journal_title：Anesthesiology

authors： Turner LA,Marijic J,Kampine JP,Bosnjak ZJ

更新日期：1990-12-01 00:00:00

abstract：:EEG amplitude dominance in awake man is posterior. During EEG monitoring in patients, the authors observed the abrupt appearance of anterior amplitude dominance during induction of anesthesia with halothane, enflurane, or thiopental. This EEG change is coincident with loss of eyelid reflex and loss of ability to respo...

journal_title：Anesthesiology

authors： Tinker JH,Sharbrough FW,Michenfelder JD

更新日期：1977-04-01 00:00:00

abstract：:Administration of the oxidant lipid peroxide tertiary butyl hydroperoxide (t-bu-OOH) in the isolated rabbit lung leads to acute pulmonary vasoconstriction, which is caused by the synthesis of thromboxane. The inhalational anesthetics, halothane, nitrous oxide, and cyclopropane, markedly enhance t-bu-OOH-induced pulmon...

journal_title：Anesthesiology

authors： McShane AJ,Crowley K,Shayevitz JR,Michael JR,Adkinson NF Jr,Traystman RJ,Gurtner GH

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:In the event of trauma, emergency reversal of anticoagulation therapy may be required. However, no specific reversal agents are routinely available for the direct oral anticoagulants such as dabigatran. The authors investigated four-factor prothrombin complex concentrate (PCC) for treating dabigatran-induced...

journal_title：Anesthesiology

authors： Honickel M,Braunschweig T,van Ryn J,Ten Cate H,Spronk HM,Rossaint R,Grottke O

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Perfluorocarbon liquids are being used experimentally and in clinical trials for the treatment of acute lung injury. Their resemblance to inhaled anesthetic agents suggests the possibility of application by vaporization. The authors' aim was to develop the technical means for perfluorocarbon vaporization and...

journal_title：Anesthesiology

authors： Bleyl JU,Ragaller M,Tschö U,Regner M,Kanzow M,Hübler M,Rasche S,Albrecht M

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Sevoflurane administered to neonatal rats induces neurobehavioral abnormalities and epigenetic reprogramming of their germ cells; the latter can pass adverse effects of sevoflurane to future offspring. As germ cells are susceptible to reprogramming by environmental factors across the lifespan, the authors hy...

journal_title：Anesthesiology

authors： Ju LS,Yang JJ,Xu N,Li J,Morey TE,Gravenstein N,Seubert CN,Setlow B,Martynyuk AE

更新日期：2019-11-01 00:00:00

abstract：:The neonatal heart is especially vulnerable to cardiac depression caused by halothane. The cause of this sensitivity is uncertain. Isolated, perfused, isovolumic, contracting neonatal rabbit hearts were studied using 31P NMR to determine whether changes in concentrations of high energy phosphates (HEP) or intracellula...

journal_title：Anesthesiology

authors： McAuliffe JJ,Hickey PR

更新日期：1987-08-01 00:00:00

abstract：:Sevoflurane, 1.4 per cent (MAC), was administered to groups of Fischer 344 rats for 10 hours, 4 hours, or 1 hour; additional rats received 0.5 per cent methoxyflurane for 3 hours or 1 hour. Urinary inorganic fluoride excretion of sevoflurane in vivo was a third to a fourth that of methoxyflurane. However, using hepati...

journal_title：Anesthesiology

authors： Cook TL,Beppu WJ,Hitt BA,Kosek JC,Mazze RI

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND:Patients with brain injury are at high risk of extubation failure. METHODS:We conducted a prospective observational cohort study in four intensive care units of three university hospitals. The aim of the study was to create a score that could predict extubation success in patients with brain injury. RESULT...

journal_title：Anesthesiology

authors： Asehnoune K,Seguin P,Lasocki S,Roquilly A,Delater A,Gros A,Denou F,Mahé PJ,Nesseler N,Demeure-Dit-Latte D,Launey Y,Lakhal K,Rozec B,Mallédant Y,Sébille V,Jaber S,Le Thuaut A,Feuillet F,Cinotti R,ATLANREA group.

更新日期：2017-08-01 00:00:00

abstract：:Recent reports have described resistance to pancuronium-induced neuromuscular blockade in patients chronically receiving anticonvulsants. This study examines the pharmacokinetics and pharmacodynamics of metocurine (MTC) in 12 patients undergoing craniotomy--six on chronic phenytoin therapy and six comparable controls....

journal_title：Anesthesiology

authors： Ornstein E,Matteo RS,Young WL,Diaz J

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:Midazolam and alfentanil are desirable anesthetic adjuncts for cardiac anesthesia. They are metabolized by cytochrome P450 3A (CYP3A) enzymes. These isozymes are inhibited by concurrent medications, including the calcium channel antagonist diltiazem, which may have an effect on recovery from anesthesia. MET...

journal_title：Anesthesiology

authors： Ahonen J,Olkkola KT,Salmenperä M,Hynynen M,Neuvonen PJ

更新日期：1996-12-01 00:00:00

abstract：:The authors evaluated the systemic and cerebral hemodynamic and metabolic effects of 1 h of hypotension to a mean arterial pressure of either 50 mmHg or 40 mmHg induced by intravenous adenosine or ATP in dogs maintained on 70% nitrous oxide and 0.1% halothane. Following the hypotensive period, brain biopsy specimens w...

journal_title：Anesthesiology

authors： Newberg LA,Milde JH,Michenfelder JD

更新日期：1985-04-01 00:00:00

abstract：:Arterial and peripheral venous plasma levels of bupivacaine were determined in 30 patients following epidural anesthesia using 150 and 225 mg, as well as following intercostal nerve block with 400 mg. Arterial levels were consistently higher than levels in simultaneously sampled venous blood, and the highest levels oc...

journal_title：Anesthesiology

authors： Moore DC,Mather LE,Bridenbaugh PO,Bridenbaugh LD,Balfour RI,Lysons DF,Horton WG

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND:Phantom and stump pains, common sequelae of limb amputations, are significant impediments to rehabilitation of amputees. The pathophysiology and optimal treatment of postamputation pain states are unclear. While stump pain may result from neuromas in the stump, phantom pain is thought to be related to cortic...

journal_title：Anesthesiology

authors： Wu CL,Tella P,Staats PS,Vaslav R,Kazim DA,Wesselmann U,Raja SN

更新日期：2002-04-01 00:00:00

abstract：:To assess depth of anesthesia for intravenous anesthetics using clinical stimuli and observed responses, it is necessary to achieve constant serum concentrations of drug that result in constant biophase or central nervous system concentrations. The goal of this investigation was to use a computer-controlled infusion p...

journal_title：Anesthesiology

authors： Bührer M,Maitre PO,Hung OR,Ebling WF,Shafer SL,Stanski DR

更新日期：1992-08-01 00:00:00

abstract：:The present study examines the postulate that isoflurane, in contrast to halothane, causes redistribution of blood flow away from an ischemic myocardial region through vasodilation of adjacent normally perfused myocardium. The study was performed in open-chest dogs anesthetized with fentanyl; ischemia was induced by o...

journal_title：Anesthesiology

authors： Moore PG,Kien ND,Reitan JA,White DA,Safwat AM

更新日期：1991-11-01 00:00:00

abstract：:Volatile anesthetics inhibit phagocytic cell function, yet little is known about their effects on target tissues or on the target tissue response to stimulated phagocytes. Experiments were performed to determine how exposure to halothane and isoflurane changes rat pulmonary artery endothelial cell (RPAEC) viability in...

journal_title：Anesthesiology

authors： Shayevitz JR,Varani J,Ward PA,Knight PR

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Volatile anesthetics relax airway smooth muscle (ASM) by altering intracellular Ca2+ concentration ([Ca2+]i). The authors hypothesized that relaxation is produced by decreasing sarcoplasmic reticulum Ca2+ content via increased Ca2+ "leak" through both inositol trisphosphate (IP3) and ryanodine receptor chann...

journal_title：Anesthesiology

authors： Pabelick CM,Prakash YS,Kannan MS,Warner DO,Sieck GC

更新日期：2001-07-01 00:00:00

abstract：:Using the open ventriculocisternal perfusion method, rates of cerebrospinal fluid (CSF) production and reabsorption by bulk flow were examined in dogs anesthetized with either enflurane (2.2%) in nitrogen (60-70%) and oxygen, or nitrous oxide (60-70%) and enflurane (less than 0.2%) in oxygen (controls). The mean rate ...

journal_title：Anesthesiology

authors： Artru AA,Nugent M,Michenfelder JD

更新日期：1982-10-01 00:00:00

abstract：BACKGROUND:Given the current practice environment, it is important to determine the anesthetic technique with the highest patient acceptance and lowest associated costs. The authors compared three commonly used anesthetic techniques for anorectal procedures in the ambulatory setting. METHODS:Ninety-three consenting ad...

journal_title：Anesthesiology

authors： Li S,Coloma M,White PF,Watcha MF,Chiu JW,Li H,Huber PJ Jr

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:A relatively small number of inhibitory interneurons can control the excitability and synchronization of large numbers of pyramidal cells in hippocampus and other cortical regions. Thus, anesthetic modulation of interneurons could play an important role for the maintenance of anesthesia. The aim of this stud...

journal_title：Anesthesiology

authors： Nishikawa K,MacIver MB

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Due to potential neurologic sequelae, the risk:benefit ratio of thoracic epidural analgesia is controversial. Surprisingly, however, few available data address neurologic complications. The incidence of neurologic complications occurring after thoracic epidural catheterization was studied in patients schedul...

journal_title：Anesthesiology

authors： Giebler RM,Scherer RU,Peters J

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Propofol is an intravenous anesthetic agent that may impair host defense system. The aim of this study was to evaluate the effects of propofol on macrophage functions and its possible mechanism. METHODS:Mouse macrophage-like Raw 264.7 cells were exposed to propofol, at 3, 30 (a clinically relevant concentra...

journal_title：Anesthesiology

authors： Chen RM,Wu CH,Chang HC,Wu GJ,Lin YL,Sheu JR,Chen TL

更新日期：2003-05-01 00:00:00