The effect of halothane on the steady-state levels of high-energy phosphates in the neonatal heart.

abstract：BACKGROUND:Lamotrigine is a sodium channel blocker that inhibits the neuronal release of glutamate. Systemic administration of lamotrigine induces analgesia in short- and long-term models of hyperalgesia in rats. Considering the key role of N-methyl-D-aspartate receptors in the sensitization of dorsal horn neurons that...

journal_title：Anesthesiology

authors： Klamt JG

更新日期：1998-02-01 00:00:00

abstract：:The authors investigated the value of high-dose thiopental (TH) therapy after 16-min complete global brain ischemia (GBI) in three groups of pigtailed monkeys, using a neck cuff model of GBI with 96 h intensive care postischemia (PI). Control group (n18): Normotension was restored within 2 min PI; paralysis/controlled...

journal_title：Anesthesiology

authors： Gisvold SE,Safar P,Hendrickx HH,Rao G,Moossy J,Alexander H

更新日期：1984-02-01 00:00:00

abstract：:The effect of pertussis toxin on opioid antinociception was studied in rats. Intrathecal injection of a single dose of pertussis toxin reduced the antinociceptive effect of PL017, a highly selective mu-opioid agonist, in a dose- and time-dependent manner. The maximal effective dose of pertussis toxin was 1 microgram, ...

journal_title：Anesthesiology

authors： Wong CS,Su YF,Chang KJ,Watkins WD

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:The diagnosis of acute life-threatening allergic reactions during anesthesia relies on clinical signs, histamine and/or tryptase measurements, and allergic testing. In patients who die after the reaction, skin tests cannot be performed, and the effect of resuscitation manoeuvres on mediator concentrations is...

journal_title：Anesthesiology

authors： Laroche D,Gomis P,Gallimidi E,Malinovsky JM,Mertes PM

更新日期：2014-08-01 00:00:00

abstract：:In order to elucidate the possible mechanism(s) by which opiates may affect cerebral and spinal circulation, and cerebral metabolism, cerebral blood flow (CBF) and spinal cord blood flow (SCBF) were measured simultaneously following intravenous or subarachnoid administration of morphine in dogs lightly anesthetized wi...

journal_title：Anesthesiology

authors： Matsumiya N,Dohi S

更新日期：1983-09-01 00:00:00

abstract：:Systemic pretreatment with ketanserin, a relatively specific type-2 serotonin receptor antagonist, significantly attenuated the muscle rigidity produced in rats by the potent short-acting opiate agonist alfentanil. Following placement of subcutaneous electrodes in each animal's left gastrocnemius muscle, rigidity was ...

journal_title：Anesthesiology

authors： Weinger MB,Cline EJ,Smith NT,Koob GF

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND:Norepinephrine has been investigated as a potential alterative to phenylephrine for maintaining blood pressure during spinal anesthesia for cesarean delivery with the advantage of less depression of maternal heart rate and cardiac output. However, the relative potencies of these two vasopressors have not bee...

journal_title：Anesthesiology

authors： Ngan Kee WD

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine whether combination of 1-5 microg intrathecal neostigmine would enhance analgesia from a fixed intrathecal dose of morphine. METHODS:A total of 60 patients undergoing gynecologic surgery were randomized to one of five groups. Patients received 15 mg bupivacaine plu...

journal_title：Anesthesiology

authors： Almeida RA,Lauretti GR,Mattos AL

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Halothane induces negative inotropic and lusitropic effects in myocardium. It has been suggested that halothane potentiates beta-adrenoceptor stimulation. However, its effects on the inotropic response to alpha-adrenoceptor stimulation and its effects on the lusitropic effects of alpha- and beta-adrenoceptor...

journal_title：Anesthesiology

authors： Hanouz JL,Riou B,Massias L,Lecarpentier Y,Coriat P

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Recent evidence implicates nitric oxide (*NO) in the pathogenesis of preeclampsia. The authors tested the hypothesis that administration of low-dose endotoxin to pregnant rats mimics the signs of preeclampsia in humans and that *NO and *NO-derived species play a role in that animal model. METHODS:Endotoxin ...

journal_title：Anesthesiology

authors： Sakawi Y,Tarpey M,Chen YF,Calhoun DA,Connor MG,Chestnut DH,Parks DA

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:The Bispectral Index (BIS) and the Patient State Index (PSI) quantify depth of anesthesia by analyzing the electroencephalogram. The authors examined the response of BIS and PSI to sevoflurane anesthesia. METHODS:In 22 patients, sevoflurane anesthesia was induced by inhalation with a tight-fitting facemask ...

journal_title：Anesthesiology

authors： Soehle M,Ellerkmann RK,Grube M,Kuech M,Wirz S,Hoeft A,Bruhn J

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:The authors evaluated optimal adrenergic support using norepinephrine, dopamine, and dobutamine in a clinically relevant model of septic shock. METHODS:Twenty-eight mature, female, anesthetized sheep (weight, 30.5 +/- 3.6 kg) underwent cecal ligation and perforation and were randomized into four groups of s...

journal_title：Anesthesiology

authors： Sun Q,Tu Z,Lobo S,Dimopoulos G,Nagy N,Rogiers P,De Backer D,Vincent JL

更新日期：2003-04-01 00:00:00

abstract：:Although suppression of thermoregulatory mechanisms by anesthetics is generally assumed, the extent to which thermoregulation is active during general anesthesia is not known. The only thermoregulatory responses available to anesthetized, hypothermic patients are vasoconstriction and non-shivering thermogenesis. To te...

journal_title：Anesthesiology

authors： Sessler DI,Olofsson CI,Rubinstein EH,Beebe JJ

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:There is little information concerning the carbon dioxide-related effects on respiratory mechanics in anesthetized, paralyzed subjects; however, hypocapnia or hypercapnia is often permitted in patients with severe brain injury or acute respiratory distress syndrome. Therefore, the carbon dioxide dependence o...

journal_title：Anesthesiology

authors： D'Angelo E,Calderini IS,Tavola M

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:Frailty is associated with adverse postoperative outcomes, but it remains unclear which measure of frailty is best. This study compared two approaches: the Modified Frailty Index, which is a deficit accumulation model (number of accumulated deficits), and the Hopkins Frailty Score, which is a phenotype model...

journal_title：Anesthesiology

authors： Sonny A,Kurz A,Skolaris LA,Boehm L,Reynolds A,Cummings KC 3rd,Makarova N,Yang D,Sessler DI

更新日期：2020-01-01 00:00:00

abstract：:Changes in hepatic plasma flow (HPF) during sodium nitroprusside (SNP) induced hypotension were studied in 14 patients undergoing intracranial aneurysm surgery under neurolept anesthesia. Patients were monitored with the use of a radial artery catheter and a thermistor-tipped Swan-Ganz catheter. Hypotension was induce...

journal_title：Anesthesiology

authors： Chauvin M,Bonnet F,Montembault C,Lafay M,Curet P,Viars P

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:Medical errors exact an inordinate toll on healthcare costs. One of the most publicized and analyzed type of medical error is wrong-site surgery. Yet, despite the burgeoning number of procedures performed, no literature exists on wrong-site pain management injections. The purpose of this study was to estimat...

journal_title：Anesthesiology

authors： Cohen SP,Hayek SM,Datta S,Bajwa ZH,Larkin TM,Griffith S,Hobelmann G,Christo PJ,White R

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Up to 84% of women who undergo operative vaginal delivery receive neuraxial analgesia. However, little is known about the association between neuraxial analgesia and neonatal morbidity in women who undergo operative vaginal delivery. The authors hypothesized that neuraxial analgesia is associated with a redu...

journal_title：Anesthesiology

authors： Butwick AJ,Wong CA,Lee HC,Blumenfeld YJ,Guo N

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Insufficient data exist on the production of compound A during closed-system sevoflurane administration with newer carbon dioxide absorbents. METHODS:A modified PhysioFlex apparatus (Dräger, Lübeck, Germany) was connected to an artificial test lung (inflow at the top of the bellow approximately/= 160 ml/min...

journal_title：Anesthesiology

authors： Versichelen LF,Bouche MP,Rolly G,Van Bocxlaer JF,Struys MM,De Leenheer AP,Mortier EP

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Perioperative thoracic epidural analgesia reduces stress response and pain scores and may improve outcome after cardiac surgery. This prospective, randomized trial was designed to compare the effectiveness of patient-controlled thoracic epidural analgesia with patient-controlled analgesia with intravenous mo...

journal_title：Anesthesiology

authors： Hansdottir V,Philip J,Olsen MF,Eduard C,Houltz E,Ricksten SE

更新日期：2006-01-01 00:00:00

abstract：:The authors determined the thiopental dose needed for satisfactory induction in ten neonates, 0-14 days of age, and 20 infants, 1-6 months of age. A single iv bolus of thiopental was given. Thirty seconds after injection the anesthesia mask was applied and the response was observed during the following 30 s while the ...

journal_title：Anesthesiology

authors： Westrin P,Jonmarker C,Werner O

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:Patients who are homozygous for the atypical mutation, compound heterozygous for atypical and silent mutations, or homozygous for silent mutations (SS) respond to mivacurium with extensively prolonged neuromuscular block. Although important, exact phenotyping of these patients is difficult. This article pres...

journal_title：Anesthesiology

authors： Gätke MR,Ostergaard D,Bundgaard JR,Varin F,Viby-Mogensen J

更新日期：2001-09-01 00:00:00

abstract：:There is controversy about whether N2O increases cerebral blood flow and cortical oxygen consumption (CMRO2) in rats. Cortical and subcortical blood flow and CMRO2 were measured in awake, unrestrained rats while awake and during 70% N2O administration using radioactive microspheres. In the awake state, cortical and su...

journal_title：Anesthesiology

authors： Baughman VL,Hoffman WE,Miletich DJ,Albrecht RF

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:Crystalloid solutions are used to restore intravascular volume in septic patients, but each solution has limitations. The authors compared the effects of three crystalloid solutions on hemodynamics, organ function, microcirculation, and survival in a sepsis model. METHODS:Peritonitis was induced by injectio...

journal_title：Anesthesiology

authors： Orbegozo D,Su F,Santacruz C,He X,Hosokawa K,Creteur J,De Backer D,Vincent JL

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The chemokine family has been revealed to be involved in the pathogenesis of neuropathic pain. In this study, the authors investigated the role of chemokine (C-C motif) ligand 3 and its receptors chemokine (C-C motif) receptor 1 and chemokine (C-C motif) receptor (CCR) 5 in neuropathic pain. METHODS:A spina...

journal_title：Anesthesiology

authors： Matsushita K,Tozaki-Saitoh H,Kojima C,Masuda T,Tsuda M,Inoue K,Hoka S

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The current study was designed to test the hypothesis that the fibromyalgia survey criteria would be directly associated with increased opioid consumption after hysterectomy even when accounting for other factors previously described as being predictive for acute postoperative pain. METHODS:Two hundred eigh...

journal_title：Anesthesiology

authors： Janda AM,As-Sanie S,Rajala B,Tsodikov A,Moser SE,Clauw DJ,Brummett CM

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Previous studies integrated opioid benefit and harm into one single function-the utility function-to determine the drug toxicity (respiratory depression) in light of its wanted effect (analgesia). This study further refined the concept of the utility function using the respiratory and analgesic effects of th...

journal_title：Anesthesiology

authors： Roozekrans M,van der Schrier R,Aarts L,Sarton E,van Velzen M,Niesters M,Dahan A,Olofsen E

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:While persistent opioid use after surgery has been the subject of a large number of studies, it is unknown how much variability in the definition of persistent use impacts the reported incidence across studies. The objective was to evaluate the incidence of persistent use estimated with different definitions...

journal_title：Anesthesiology

authors： Jivraj NK,Raghavji F,Bethell J,Wijeysundera DN,Ladha KS,Bateman BT,Neuman MD,Wunsch H

更新日期：2020-06-01 00:00:00

abstract：:The cerebral and systemic hemodynamic and metabolic effects of hypotension induced with desflurane were examined in 11 dogs. During a steady-state baseline period under 1 MAC desflurane (7.2%), the following were measured or derived: arterial, pulmonary artery, and pulmonary artery occlusion pressures; arterial, mixed...

journal_title：Anesthesiology

authors： Milde LN,Milde JH

更新日期：1991-03-01 00:00:00

abstract：:Whereas opiate receptor agonists have resulted in spinal cord damage; opiate receptor antagonists have demonstrated protection against spinal cord injury. Because opioids are used in clinical anesthesia, the effect of an opiate antagonist was evaluated on neurologic outcome in a rat model of spinal cord injury occurri...

journal_title：Anesthesiology

authors： Cole DJ,Drummond JC,Shapiro HM,Hertzog RE,Brauer FS

更新日期：1989-09-01 00:00:00