Resistance to metocurine-induced neuromuscular blockade in patients receiving phenytoin.

abstract：BACKGROUND:Potential deleterious effect of multiple anesthesia exposures on the developing brain remains a clinical concern. We hypothesized that multiple neonatal anesthesia exposures are more detrimental to brain maturation than an equivalent single exposure, with more pronounced long-term behavioral consequences. We...

journal_title：Anesthesiology

authors： Makaryus R,Lee H,Robinson J,Enikolopov G,Benveniste H

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Mutations in the methylenetetrahydrofolate reductase (MTHFR) gene (677C>T, 1298A>C) cause elevated plasma homocysteine concentrations and have been linked to fatal outcomes after nitrous oxide anesthesia. This study tested the hypothesis that patients with common MTHFR 677C>T or 1298A>C mutations develop hig...

journal_title：Anesthesiology

authors： Nagele P,Zeugswetter B,Wiener C,Burger H,Hüpfl M,Mittlböck M,Födinger M

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Suboptimal tissue perfusion and oxygenation during surgery may be responsible for postoperative nausea and vomiting in some patients. This trial tested the hypothesis that muscular tissue oxygen saturation-guided intraoperative care reduces postoperative nausea and vomiting. METHODS:This multicenter, pragma...

journal_title：Anesthesiology

authors： Li G,Tian DD,Wang X,Feng X,Zhang W,Bao J,Wang DX,Ai YQ,Liu Y,Zhang M,Xu M,Mu DL,Zhao X,Dai F,Yang JJ,Che X,Yanez D,Guo X,Meng L,iMODIPONV Research Group.

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Previous clinical evidence and electrophysiologic studies in the authors' laboratory have implicated the dorsal column (DC) as an important pathway for the transmission of visceral colorectal pain. This study examined, behaviorally and electrophysiologically, the role of the DC in mediating epigastric nocice...

journal_title：Anesthesiology

authors： Feng Y,Cui M,Al-Chaer ED,Willis WD

更新日期：1998-08-01 00:00:00

abstract：:Complications after major surgery are a leading cause of morbidity and mortality. The etiology of postoperative complications is complex, but poor cardiorespiratory reserve appears to be a key factor. There is increasing interest in the use of central and mixed venous oxygen saturation to guide therapeutic interventio...

journal_title：Anesthesiology

authors： Shepherd SJ,Pearse RM

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:The results of sevoflurane biotransformation (fluoromethyl-1,1,1,3,3,3,-hexafluoro-2-propyl ether) to inorganic fluoride have been examined. However, these investigations have lacked a simplified assay for determining the primary organic metabolite, hexafluoroisopropanol. Previous attempts have involved exte...

journal_title：Anesthesiology

authors： Morgan SE,Frink EJ,Gandolfi AJ

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:The myocardial negative inotropic effects of desflurane are less pronounced than those of other halogenated anesthetics, partly because of intramyocardial catecholamine store release. However, the effects of desflurane on aging myocardium are unknown, whereas aging is known to be associated with an attenuati...

journal_title：Anesthesiology

authors： Rozenberg S,Besse S,Amour J,Vivien B,Tavernier B,Riou B

更新日期：2006-11-01 00:00:00

abstract：:The hemodynamic effects of prolonged mechanical ventilation with positive end-expiratory pressure (PEEP), with and without blood volume augmentation, were studied in 18 beagles anesthetized with halothane (0.7 per cent end-tidal). Addition of 12 cm H2O PEEP during mechanical ventilation in normavolemic dogs was associ...

journal_title：Anesthesiology

authors： Qvist J,Pontoppidan H,Wilson RS,Lowenstein E,Laver MB

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:The probability of recovering consciousness in acute brain-injured patients depends on central nervous system damage and complications acquired during their stay in the intensive care unit. The objective of this study was to establish a relation between the Bispectral Index (BIS) and other variables derived ...

journal_title：Anesthesiology

authors： Fàbregas N,Gambús PL,Valero R,Carrero EJ,Salvador L,Zavala E,Ferrer E

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:We have previously shown that intralipid (lipid emulsion) protects the heart against ischemia/reperfusion injury and bupivacaine-induced cardiotoxicity. However, the precise underlying mechanisms are not fully understood. Here we explored the hypothesis that free fatty acid receptor-1 or G-protein-coupled re...

journal_title：Anesthesiology

authors： Umar S,Li J,Hannabass K,Vaillancourt M,Cunningham CM,Moazeni S,Mahajan A,Eghbali M

更新日期：2018-07-01 00:00:00

abstract：:To assess depth of anesthesia for intravenous anesthetics using clinical stimuli and observed responses, it is necessary to achieve constant serum concentrations of drug that result in constant biophase or central nervous system concentrations. The goal of this investigation was to use a computer-controlled infusion p...

journal_title：Anesthesiology

authors： Bührer M,Maitre PO,Hung OR,Ebling WF,Shafer SL,Stanski DR

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Neosaxitoxin (NeoSTX) is a site-1 sodium channel blocker that produces prolonged local anesthesia in animals and humans. Under a Food and Drug Administration-approved phase 1 Investigational New Drug trial, the authors evaluated safety and efficacy of NeoSTX alone and combined with 0.2% bupivacaine (Bup) wit...

journal_title：Anesthesiology

authors： Lobo K,Donado C,Cornelissen L,Kim J,Ortiz R,Peake RW,Kellogg M,Alexander ME,Zurakowski D,Kurgansky KE,Peyton J,Bilge A,Boretsky K,McCann ME,Berde CB,Cravero J

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the relationship of four postanesthesia care unit (PACU) cardiovascular events to long-term outcomes (unplanned critical care admission or mortality) and to evaluate the contribution of anesthetic management compared with other perioperative factors in predicting th...

journal_title：Anesthesiology

authors： Rose DK,Cohen MM,DeBoer DP

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:The mechanisms underlying depression-associated pain remain poorly understood. Using a mouse model of depression, the authors hypothesized that the central amygdala-periaqueductal gray circuitry is involved in pathologic nociception associated with depressive states. METHODS:The authors used chronic restrai...

journal_title：Anesthesiology

authors： Yin W,Mei L,Sun T,Wang Y,Li J,Chen C,Farzinpour Z,Mao Y,Tao W,Li J,Xie W,Zhang Z

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:This propensity score-matched cohort study evaluates the effect of anesthetic technique on a 30-day mortality after total hip or knee arthroplasty. METHODS:All patients who had hip or knee arthroplasty between January 1, 2003, and December 31, 2014, were evaluated. The principal exposure was spinal versus g...

journal_title：Anesthesiology

authors： Perlas A,Chan VW,Beattie S

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The lightwand may be useful as an alternative for tracheal intubation during a rapid-sequence induction of anesthesia in the presence of a full stomach. This study was undertaken to assess the effect of application of cricoid pressure on the success of lightwand intubation. METHODS:Sixty adult female patien...

journal_title：Anesthesiology

authors： Hodgson RE,Gopalan PD,Burrows RC,Zuma K

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Pain and nausea are the most common challenges in postoperative recovery after mastectomy. Preventive measures include multimodal analgesia with preoperative glucocorticoid. The aim of this study was to investigate whether 24 mg of preoperative dexamethasone was superior to 8 mg on early recovery after maste...

journal_title：Anesthesiology

authors： Steinthorsdottir KJ,Awada HN,Abildstrøm H,Kroman N,Kehlet H,Kvanner Aasvang E

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Chronic neck pain after whiplash injury is caused by cervical zygapophysial joints in 50% of patients. Diagnostic blocks of nerves supplying the joints are performed using fluoroscopy. The authors' hypothesis was that the third occipital nerve can be visualized and blocked with use of an ultrasound-guided te...

journal_title：Anesthesiology

authors： Eichenberger U,Greher M,Kapral S,Marhofer P,Wiest R,Remonda L,Bogduk N,Curatolo M

更新日期：2006-02-01 00:00:00

abstract：:Low concentrations of ethanol (17 mM) inhibited development of spontaneous mechanical activity (vasomotion) in isolated rat portal veins. Low concentrations of ethanol potentiated, however, contractions induced by epinephrine, but not those induced by angiotensin or potassium. Higher concentrations of ethanol, such as...

journal_title：Anesthesiology

authors： Edgarian H,Altura BM

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:Halothane and isoflurane have been reported to suppress the contraction of vascular smooth muscle, although the exact mechanism has not been explained fully. This study examined the effect of halothane and isoflurane on cytosolic calcium ion (Ca2+) concentrations ([Ca2+]cyt), which was measured simultaneousl...

journal_title：Anesthesiology

authors： Tsuchida H,Namba H,Yamakage M,Fujita S,Notsuki E,Namiki A

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Povidone iodine (PI) solution is used commonly for skin disinfection before epidural and spinal anesthesia. Although there have been reports indicating the presence of microbial contaminants in PI solution, none have evaluated the prevalence of PI contamination. The aims of this study were to assess the freq...

journal_title：Anesthesiology

authors： Birnbach DJ,Stein DJ,Murray O,Thys DM,Sordillo EM

更新日期：1998-03-01 00:00:00

abstract：:This study was designed to test the hypothesis that the volatile anesthetics directly affect cardiac contractile proteins. For this purpose, the effects of various anesthetic doses of halothane, enflurane, and isoflurane on myocardial calcium sensitivity and maximal calcium-activated force were examined in rat cardiac...

journal_title：Anesthesiology

authors： Murat I,Ventura-Clapier R,Vassort G

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:Physiologic data that is automatically collected during anesthesia is widely used for medical record keeping and clinical research. These data contain artifacts, which are not relevant in clinical care, but may influence research results. The aim of this study was to explore the effect of different methods o...

journal_title：Anesthesiology

authors： Pasma W,Peelen LM,van Buuren S,van Klei WA,de Graaff JC

更新日期：2020-04-01 00:00:00

abstract：:I653 is a new volatile anesthetic structurally similar to enflurane and isoflurane. Since enflurane can induce convulsions, whereas isoflurane progressively depresses cortical electrical activity, the authors believed it important to assess the effect of I653 on the EEG (in both the "time" and "frequency" domain). The...

journal_title：Anesthesiology

authors： Rampil IJ,Weiskopf RB,Brown JG,Eger EI 2nd,Johnson BH,Holmes MA,Donegan JH

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:During emergence from anesthesia, breathing 100% oxygen is frequently used to provide a safety margin toward hypoxemia in case an airway problem occurs. Oxygen breathing has been shown to cause pulmonary gas exchange disorders in healthy individuals. This study investigates how oxygen breathing during emerge...

journal_title：Anesthesiology

authors： Kleinsasser AT,Pircher I,Truebsbach S,Knotzer H,Loeckinger A,Treml B

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:We evaluated whether spectral entropy (SpE) can measure the depth of hypnosis and the hypnotic drug effect in children during total intravenous anesthesia. METHODS:Sixty healthy children, aged 3-16 yr, were studied. Anesthesia was induced with an increasing target controlled infusion of propofol, and mainta...

journal_title：Anesthesiology

authors： Klockars JG,Hiller A,Münte S,van Gils MJ,Taivainen T

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Catheter-related infection is a serious complication of continuous regional anesthesia. The authors tested the hypothesis that single-dose antibiotic prophylaxis is associated with a lower incidence of catheter-related infections. METHODS:Our analysis was based on cases in the 25-center German Network for R...

journal_title：Anesthesiology

authors： Bomberg H,Krotten D,Kubulus C,Wagenpfeil S,Kessler P,Steinfeldt T,Standl T,Gottschalk A,Stork J,Meissner W,Birnbaum J,Koch T,Sessler DI,Volk T,Raddatz A

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Drugs used for sedation in anesthesia and intensive care may cause pharyngeal dysfunction and increased risk for aspiration. In this study, the authors investigate the impact of sedative doses of morphine and midazolam on pharyngeal function during swallowing and coordination of breathing and swallowing. ME...

journal_title：Anesthesiology

authors： Hårdemark Cedborg AI,Sundman E,Bodén K,Hedström HW,Kuylenstierna R,Ekberg O,Eriksson LI

更新日期：2015-06-01 00:00:00

abstract：:Liver surgery is often accompanied by hepatic hypoperfusion and hypoxia, and it is controversial whether catecholamines increase hepatic blood flow and oxygen supply. The effects of 3 micrograms.kg-1.min-1 dobutamine on hepatic circulation and oxygen balance were examined in patients anesthetized with enflurane, nitro...

journal_title：Anesthesiology

authors： Kainuma M,Kimura N,Nonami T,Kurokawa T,Ito T,Nakashima K,Shimada Y

更新日期：1992-09-01 00:00:00

abstract：:The pharmacokinetics, biodisposition, and neuromuscular blocking properties of 3-desacetylvecuronium were studied in 17 adult cats. Animals were divided into three groups: five cats with kidney failure induced by bilateral ligation of the renal pedicles, six cats with galactosamine-induced fulminant hepatitis, and six...

journal_title：Anesthesiology

authors： Segredo V,Shin YS,Sharma ML,Gruenke LD,Caldwell JE,Khuenl-Brady KS,Agoston S,Miller RD

更新日期：1991-06-01 00:00:00