Abstract:
BACKGROUND:The results of sevoflurane biotransformation (fluoromethyl-1,1,1,3,3,3,-hexafluoro-2-propyl ether) to inorganic fluoride have been examined. However, these investigations have lacked a simplified assay for determining the primary organic metabolite, hexafluoroisopropanol. Previous attempts have involved extensive extraction steps, complicated derivatization techniques, or sophisticated detectors. METHODS:After enzymatic hydrolysis of conjugates, hexafluoroisopropanol is detected readily using a head space gas chromatographic analysis with a flame ionization detector. RESULTS:The gas chromatographic technique was linear from 10 to 800 microM with a correlation coefficient of 0.999. The detection limit was 10 microM in urine and 25 microM in blood. CONCLUSIONS:This simplified approach does not require the extraction, derivatization, or mass spectrometric detectors of previous methods. As sevoflurane utilization and research increases, this assay should allow for a variety of laboratory and clinical disposition studies to be performed.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Morgan SE,Frink EJ,Gandolfi AJdoi
10.1097/00000542-199401000-00027subject
Has Abstractpub_date
1994-01-01 00:00:00pages
201-5issue
1eissn
0003-3022issn
1528-1175journal_volume
80pub_type
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