Chemokine (C-C motif) receptor 5 is an important pathological regulator in the development and maintenance of neuropathic pain.

abstract：:The antinociceptive interaction on the tail flick (TF) and hot plate (HP) tests between opioid analgesics and medetomidine after intravenous (iv) or intrathecal administration were examined by isobolographic analysis. Male Sprague-Dawley rats received fixed ratios of medetomidine to morphine, fentanyl, and meperidine ...

journal_title：Anesthesiology

authors： Ossipov MH,Harris S,Lloyd P,Messineo E,Lin BS,Bagley J

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:The number of pregnancy-related deaths and severe maternal complications continues to rise in the United States, and the quality of obstetrical care across U.S. hospitals is uneven. Providing hospitals with performance feedback may help reduce the rates of severe complications in mothers and their newborns. ...

journal_title：Anesthesiology

authors： Glance LG,Hasley S,Glantz JC,Stevens TP,Faden E,Kreso MA,Pyne SG,Wissler RN,Fichter J,Gloff MS,Dick AW

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:The impact on the endothelial glycocalyx for the extravasation of colloidal infusion solutions has not been investigated sufficiently. METHODS:Isolated guinea pig hearts were perfused with Krebs-Henseleit buffer in a Langendorff mode. Solutions of 0.9% saline, 5% albumin (70 kd), or 6% hydroxyethyl starch (...

journal_title：Anesthesiology

authors： Rehm M,Zahler S,Lötsch M,Welsch U,Conzen P,Jacob M,Becker BF

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Protamine causes multiple adverse reactions. Heparinase I, a specific enzyme that inactivates heparin, is a possible alternative to protamine. In this study, the authors examined the efficacy of heparinase I to reverse heparin-induced anticoagulation in vitro and compared heparinase I to protamine as an anta...

journal_title：Anesthesiology

authors： Michelsen LG,Kikura M,Levy JH,Lee MK,Lee KC,Zimmermann JJ,Szlam F

更新日期：1996-08-01 00:00:00

abstract：:The authors hypothesized that relaxation of airway smooth muscle by halothane lessens the dependence of airway resistance on lung volume, and that halothane alters the relationship between pulmonary resistance and lung volume by changing both the airway and tissue components of pulmonary resistance. The relationship a...

journal_title：Anesthesiology

authors： Joyner MJ,Warner DO,Rehder K

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:Ca2+-permeable non-N-methyl-D-aspartate receptors are found in the spinal dorsal horn and represent a presumptive target for glutamatergic transmission in nociceptive processing. This study characterized the analgesic profile associated with the blockade of these spinal receptors by intrathecally delivered a...

journal_title：Anesthesiology

authors： Sorkin LS,Yaksh TL,Doom CM

更新日期：2001-10-01 00:00:00

abstract：:The effects of epinephrine 1/200,000 as an adjuvant to epidural morphine were investigated in three healthy male volunteers, during 26-h observation sessions. Peak blood concentrations of morphine were 44 +/- 12.9 ng/ml after plain morphine and 13.7 +/- 6.7 ng/ml after epinephrine-morphine. Cutaneous hypalgesia was mo...

journal_title：Anesthesiology

authors： Bromage PR,Camporesi EM,Durant PA,Nielsen CH

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND:Autoregressive modeling with exogenous input of middle latency auditory evoked potentials (A-Line autoregressive index [AAI]) has been proposed for monitoring depth of anesthesia in adults. The aim of this study was to evaluate the performance of the AAI during induction of anesthesia with sevoflurane and re...

journal_title：Anesthesiology

authors： Weber F,Bein T,Hobbhahn J,Taeger K

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Some inhalation anesthetics increase apoptotic cell death in the developing brain. Xenon, an inhalation anesthetic, increases neuroprotection when combined with therapeutic hypothermia after hypoxic-ischemic brain injury in newborn animals. The authors, therefore, examined whether there was any neuroapoptoti...

journal_title：Anesthesiology

authors： Sabir H,Bishop S,Cohen N,Maes E,Liu X,Dingley J,Thoresen M

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:The authors investigated the efficacy of bilateral suprazygomatic maxillary nerve block (SMB) for postoperative pain relief in infants undergoing cleft palate repair. METHODS:In this prospective, double-blind, single-site, randomized, and parallel-arm controlled trial, 60 children were assigned to undergo b...

journal_title：Anesthesiology

authors： Chiono J,Raux O,Bringuier S,Sola C,Bigorre M,Capdevila X,Dadure C

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:In cardiac patients, pulmonary capillary wedge pressure (PCWP) is estimated using color M-mode Doppler study of left ventricular filling and Doppler tissue imaging. The goal of this study was to assess whether echocardiography accurately estimates PCWP in critically ill patients. METHODS:Sixty ventilated pa...

journal_title：Anesthesiology

authors： Bouhemad B,Nicolas-Robin A,Benois A,Lemaire S,Goarin JP,Rouby JJ

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Mice lacking calsequestrin-1 (CASQ1-null), a Ca-binding protein that modulates the activity of Ca release in the skeletal muscle, exhibit lethal hypermetabolic episodes that resemble malignant hyperthermia in humans when exposed to halothane or heat stress. METHODS:Because oxidative species may play a criti...

journal_title：Anesthesiology

authors： Michelucci A,Paolini C,Canato M,Wei-Lapierre L,Pietrangelo L,De Marco A,Reggiani C,Dirksen RT,Protasi F

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Propofol is an alternative to thiopental as an intravenous induction agent for cesarean section. Because it has relaxant effects on vascular and other smooth muscles, the authors set out to determine whether propofol has any effect on pregnant human uterine smooth muscle in an isolated preparation. METHODS:...

journal_title：Anesthesiology

authors： Shin YK,Kim YD,Collea JV

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Some studies suggest that the orbicularis oculi is resistant to neuromuscular blocking drugs and behaves like laryngeal muscles. Others report little or no difference between the orbicularis oculi and the adductor pollicis. These discrepancies could be related to the exact site of recording. The purpose of t...

journal_title：Anesthesiology

authors： Plaud B,Debaene B,Donati F

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Perioperative beta-blockade has been shown to improve long-term cardiac outcome in noncardiac surgical patients. A possible mechanism for the reduced risk of perioperative myocardial infarction is the attenuation of the excitotoxic effects of catecholamine surges by beta-blockade. It was hypothesized that be...

journal_title：Anesthesiology

authors： Zaugg M,Tagliente T,Lucchinetti E,Jacobs E,Krol M,Bodian C,Reich DL,Silverstein JH

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:The health-related effects of the operating room environment are unclear. The authors compared mortality risks of anesthesiologists to those of internal medicine physicians between 1979 and 1995. METHODS:The Physician Master File database, a listing of all US physicians, was used to identify anesthesiologis...

journal_title：Anesthesiology

authors： Alexander BH,Checkoway H,Nagahama SI,Domino KB

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:In children with a history of significant obstructive sleep apnea who undergo adenotonsillectomy, postsurgical administration of opiates has been alleged to be associated with an increased risk for respiratory complications, including respiratory depression. The authors hypothesize that this association is d...

journal_title：Anesthesiology

authors： Moss IR,Brown KA,Laferrière A

更新日期：2006-10-01 00:00:00

abstract：:The teratogenic potential of subanesthetic and anesthetic exposure to halothane was studied in Swiss/ICR mice. Two treatment regimens were employed: daily exposure of males and females for nine weeks prior to conception and on days 1 through 17 of pregnancy; and exposure of females only on days 6 through 15 of pregnan...

journal_title：Anesthesiology

authors： Wharton RS,Wilson AI,Mazze RI,Baden JM,Rice SA

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:The mechanism by which barbiturates protect neurons against ischemia is unclear, particularly when they are given after ischemia or reperfusion begins. Because an excess release of excitatory neurotransmitters causes postsynaptic membrane depolarization, which triggers neuronal damage in ischemia, the effect...

journal_title：Anesthesiology

authors： Amakawa K,Adachi N,Liu K,Ikemune K,Fujitani T,Arai T

更新日期：1996-12-01 00:00:00

abstract：:The effects of increased intracranial pressure (ICP) and increased cardiac output (QT) on the pulmonary vascular response to regional alveolar hypoxia were compared in pentobarbital-anesthetized, closed-chested dogs. A bronchial divider was inserted, the right lung (RL) was continuously ventilated with 100% O2, and th...

journal_title：Anesthesiology

authors： Domino KB,Hlastala MP,Cheney FW

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:In the event of trauma, emergency reversal of anticoagulation therapy may be required. However, no specific reversal agents are routinely available for the direct oral anticoagulants such as dabigatran. The authors investigated four-factor prothrombin complex concentrate (PCC) for treating dabigatran-induced...

journal_title：Anesthesiology

authors： Honickel M,Braunschweig T,van Ryn J,Ten Cate H,Spronk HM,Rossaint R,Grottke O

更新日期：2015-12-01 00:00:00

abstract：:The formation of acute edema in the tracheobronchial mucosa following local instillation of hydrochloric acid or gastric juice was studied in rats. Protein extravasation using the Evans blue technique was measured and used to indicate edema formation. A pH dependent Evans blue extravasation was observed whereby pH 2 p...

journal_title：Anesthesiology

authors： Martling CR,Lundberg JM

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:The authors sought to determine whether subjects with pathophysiological conditions that are characterized by increased concentrations of aldosterone have increased susceptibility to the side effects of neonatal anesthesia with sevoflurane. METHODS:Postnatal day 4-20 (P4-P20) rats were exposed to sevofluran...

journal_title：Anesthesiology

authors： Cao W,Pavlinec C,Gravenstein N,Seubert CN,Martynyuk AE

更新日期：2012-10-01 00:00:00

abstract：:Chloroprocaine, 0.5 per cent, with physiologic saline solution, has a specific gravity of 1.007 and a osmolarity of 283 mOsm/l, which increase to a specific gravity of 1.025 and an osmolarity of 542 mOsm/l when chloroprocaine is prepared in dextrose, 5 per cent. Chloroprocaine, 2.7 per cent, shows similar increases in...

journal_title：Anesthesiology

authors： Park YR,Eastwood DW

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND:In this study, the authors determined the success and failure rates for interns learning bag-and-mask ventilation and orotracheal intubation. Their goal was to determine the amount of experience needed to perform these procedures correctly. METHODS:The authors recorded 695 bag-and-mask ventilations and 679 ...

journal_title：Anesthesiology

authors： Komatsu R,Kasuya Y,Yogo H,Sessler DI,Mascha E,Yang D,Ozaki M

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Acute pancreatitis has been linked to intestinal barrier dysfunction and systemic inflammatory response with high mortality. Thoracic epidural analgesia improves intestinal perfusion. The authors hypothesized that thoracic epidural analgesia influences microcirculation injury, inflammatory response, and outc...

journal_title：Anesthesiology

authors： Freise H,Lauer S,Anthonsen S,Hlouschek V,Minin E,Fischer LG,Lerch MM,Van Aken HK,Sielenkämper AW

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Little is known about the influence of liver transplantation on the pharmacokinetics of most anesthetic drugs. The authors determined the pharmacokinetics of rocuronium during liver transplantation and examined whether variability in pharmacokinetics could explain variability in recovery of neuromuscular fun...

journal_title：Anesthesiology

authors： Fisher DM,Ramsay MA,Hein HA,Marcel RJ,Sharma M,Ramsay KJ,Miller RD

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Because patients may be taking clonidine chronically or may be receiving it as a premedication before surgery, the authors investigated its effect on cerebral hemodynamics. METHODS:In nine volunteers, middle cerebral artery mean blood flow velocity (Vm) was measured using transcranial Doppler ultrasonograph...

journal_title：Anesthesiology

authors： Lee HW,Caldwell JE,Dodson B,Talke P,Howley J

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Despite pharmacological treatment, 70-80% of patients report moderate to severe pain after surgery. Because nicotine has been reported to have analgesic properties in animal and human volunteer studies, the authors assessed the analgesic efficacy of a single 3 mg dose of nicotine nasal spray administered bef...

journal_title：Anesthesiology

authors： Flood P,Daniel D

更新日期：2004-12-01 00:00:00

abstract：:This study was designed to define the effects of halothane on the compliance of the trachea. An isolated in-situ tracheal preparation was studied in 14 mongrel dogs anesthetized with pentobarbital. Compliance of the closed tracheal segment was measured with continuous intraluminal pressure recordings during repeated i...

journal_title：Anesthesiology

authors： Palmer SK,Zuperku EJ,Bosnjak Z,Coon RL,Kampine JP

更新日期：1978-10-01 00:00:00