Chemokine (C-C motif) receptor 5 is an important pathological regulator in the development and maintenance of neuropathic pain.


BACKGROUND:The chemokine family has been revealed to be involved in the pathogenesis of neuropathic pain. In this study, the authors investigated the role of chemokine (C-C motif) ligand 3 and its receptors chemokine (C-C motif) receptor 1 and chemokine (C-C motif) receptor (CCR) 5 in neuropathic pain. METHODS:A spinal nerve injury model was established in adult male Wistar rats. The von Frey test and hot plate test were performed to evaluate neuropathic pain behavior, and real-time quantitative reverse transcription polymerase chain reaction, in situ hybridization, and immunohistochemistry were performed to understand the molecular mechanisms. RESULTS:The expression levels of chemokine (C-C motif) ligand 3 and CCR5 messenger RNA in the spinal cord were up-regulated after nerve injury, which was possibly due to CD11b-positive microglia. Single intrathecal administration of recombinant chemokine (C-C motif) ligand 3 produced biphasic tactile allodynia; each phase of pain behavior was induced by different receptors. Intrathecal injection of CCR5 antagonist suppressed the development of tactile allodynia (12.81 ± 1.33 g vs. 3.52 ± 0.41 g [mean ± SEM, drug vs. control in paw-withdrawal threshold]; P < 0.05, n = 6 each) and could reverse established tactile allodynia (10.87 ± 0.91 g vs. 3.43 ± 0.28 g; P < 0.05, n = 8 and 7). Furthermore, Oral administration of CCR5 antagonist could reverse established tactile allodynia (8.20 ± 1.27 g vs. 3.18 ± 0.46 g; P < 0.05, n = 4 each). CONCLUSIONS:Pharmacological blockade of CCR5 was effective in the treatment of the development and maintenance phases of neuropathic pain. Thus, CCR5 antagonists may be potential new drugs for the treatment of neuropathic pain.






Matsushita K,Tozaki-Saitoh H,Kojima C,Masuda T,Tsuda M,Inoue K,Hoka S




Has Abstract


2014-06-01 00:00:00












  • Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale.

    abstract:BACKGROUND:Emergence delirium has been investigated in several clinical trials. However, no reliable and valid rating scale exists to measure this phenomenon in children. Therefore, the authors developed and evaluated the Pediatric Anesthesia Emergence Delirium (PAED) scale to measure emergence delirium in children. M...


    pub_type: 杂志文章


    authors: Sikich N,Lerman J

    更新日期:2004-05-01 00:00:00

  • Isoflurane pretreatment inhibits cytokine-induced cell death in cultured rat smooth muscle cells and human endothelial cells.

    abstract:BACKGROUND:Anesthetics are protective during ischemic-reperfusion injury and associated inflammation; therefore, the authors hypothesized that anesthetic pretreatment may provide protection in culture from cytokine-induced cell death. METHODS:Rat vascular smooth muscle (VSM) cell and human umbilical vascular endotheli...


    pub_type: 杂志文章


    authors: de Klaver MJ,Manning L,Palmer LA,Rich GF

    更新日期:2002-07-01 00:00:00

  • Dexamethasone Dose and Early Postoperative Recovery after Mastectomy: A Double-blind, Randomized Trial.

    abstract:BACKGROUND:Pain and nausea are the most common challenges in postoperative recovery after mastectomy. Preventive measures include multimodal analgesia with preoperative glucocorticoid. The aim of this study was to investigate whether 24 mg of preoperative dexamethasone was superior to 8 mg on early recovery after maste...


    pub_type: 杂志文章,随机对照试验


    authors: Steinthorsdottir KJ,Awada HN,Abildstrøm H,Kroman N,Kehlet H,Kvanner Aasvang E

    更新日期:2020-04-01 00:00:00

  • A two-handed jaw-thrust technique is superior to the one-handed "EC-clamp" technique for mask ventilation in the apneic unconscious person.

    abstract:BACKGROUND:Mask ventilation is considered a "basic" skill for airway management. A one-handed "EC-clamp" technique is most often used after induction of anesthesia with a two-handed jaw-thrust technique reserved for difficult cases. Our aim was to directly compare both techniques with the primary outcome of air exchang...


    pub_type: 杂志文章,随机对照试验


    authors: Joffe AM,Hetzel S,Liew EC

    更新日期:2010-10-01 00:00:00

  • Comparison of the immediate effects of surgical incision on dorsal horn neuronal receptive field size and responses during postnatal development.

    abstract:BACKGROUND:Pain behavior in response to skin incision is developmentally regulated, but little is known about the underlying neuronal mechanisms. The authors hypothesize that the spatial activation and intensity of dorsal horn neuron responses to skin incision differ in immature and adult spinal cord. METHODS:Single w...


    pub_type: 杂志文章


    authors: Ririe DG,Bremner LR,Fitzgerald M

    更新日期:2008-10-01 00:00:00

  • Alcohol consumption alters the pharmacodynamics of alfentanil.

    abstract::Two groups of women, ASA physical status 1, undergoing surgery for primary breast cancer, were studied to assess the effect of alcohol intake on alfentanil pharmacodynamics. Patients in group 1 (n = 6) had an average daily consumption of 20-40 g alcohol. Patients in group 2 (n = 8) were life-long abstainers or drank o...


    pub_type: 杂志文章


    authors: Lemmens HJ,Bovill JG,Hennis PJ,Gladines MP,Burm AG

    更新日期:1989-11-01 00:00:00

  • Days Alive and Out of Hospital: Validation of a Patient-centered Outcome for Perioperative Medicine.

    abstract:BACKGROUND:Days alive and out of hospital is a potentially useful patient-centered quality measure for perioperative care in adult surgical patients. However, there has been very limited prior validation of this endpoint with respect to its ability to capture differences in patient-level risk factor profiles and longer...


    pub_type: 杂志文章


    authors: Jerath A,Austin PC,Wijeysundera DN

    更新日期:2019-07-01 00:00:00

  • Lumbosacral cerebrospinal fluid volume is the primary determinant of sensory block extent and duration during spinal anesthesia.

    abstract:UNLABELLED:BACKGROUND. Injection of local anesthetic into cerebrospinal fluid (CSF) produces anesthesia of unpredictable extent and duration. Although many factors have been identified that affect the extent of spinal anesthesia, correlations are relatively poor and the extent of spread remains unpredictable. This stud...


    pub_type: 杂志文章


    authors: Carpenter RL,Hogan QH,Liu SS,Crane B,Moore J

    更新日期:1998-07-01 00:00:00

  • Isoflurane modulation of neuronal nicotinic acetylcholine receptors expressed in human embryonic kidney cells.

    abstract:BACKGROUND:It is well established that neuronal nicotinic acetylcholine receptors (nAChRs) are sensitive to inhalational anesthetics. The authors previously reported that halothane potently blocked alpha4beta2-type nAChRs of rat cortical neurons. However, the effect of isoflurane, which is widely used clinically, on nA...


    pub_type: 杂志文章


    authors: Yamashita M,Mori T,Nagata K,Yeh JZ,Narahashi T

    更新日期:2005-01-01 00:00:00

  • Use of linear programming to estimate impact of changes in a hospital's operating room time allocation on perioperative variable costs.

    abstract:BACKGROUND:Administrators at hospitals with a fixed annual budget may want to focus surgical services on priority areas to ensure its community receives the best health services possible. However, many hospitals lack the detailed managerial accounting data needed to ensure that such a change does not increase operating...


    pub_type: 杂志文章


    authors: Dexter F,Blake JT,Penning DH,Sloan B,Chung P,Lubarsky DA

    更新日期:2002-03-01 00:00:00

  • Morphine inhibits spontaneous and cytokine-enhanced natural killer cell cytotoxicity in volunteers.

    abstract:BACKGROUND:Opioids are used by patients who have conditions ranging from the acute pain of surgery and chronic cancer pain to substance abuse. Despite their widespread use and considerable experimental data about them, little is known about how opioids may alter in vivo immunity in humans. This study was designed to ev...


    pub_type: 杂志文章


    authors: Yeager MP,Colacchio TA,Yu CT,Hildebrandt L,Howell AL,Weiss J,Guyre PM

    更新日期:1995-09-01 00:00:00

  • Xenon attenuates hippocampal long-term potentiation by diminishing synaptic and extrasynaptic N-methyl-D-aspartate receptor currents.

    abstract:BACKGROUND:The memory-blocking properties of general anesthetics are of high clinical relevance and scientific interest. The inhalational anesthetic xenon antagonizes N-methyl-D-aspartate (NMDA) receptors. It is unknown if xenon affects long-term potentiation (LTP), a cellular correlate for memory formation. In hippoca...


    pub_type: 杂志文章


    authors: Kratzer S,Mattusch C,Kochs E,Eder M,Haseneder R,Rammes G

    更新日期:2012-03-01 00:00:00

  • Effect of flumazenil on ventilatory drive during sedation with midazolam and alfentanil.

    abstract:BACKGROUND:Patients who receive a combination of a benzodiazepine and an opioid for conscious sedation are at risk for developing respiratory depression. While flumazenil effectively antagonizes the respiratory depression associated with a benzodiazepine alone, its efficacy in the presence of both a benzodiazepine and ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gross JB,Blouin RT,Zandsberg S,Conard PF,Häussler J

    更新日期:1996-10-01 00:00:00

  • Cell-based therapy for acute organ injury: preclinical evidence and ongoing clinical trials using mesenchymal stem cells.

    abstract::Critically ill patients often suffer from multiple organ failures involving lung, kidney, liver, or brain. Genomic, proteomic, and metabolomic approaches highlight common injury mechanisms leading to acute organ failure. This underlines the need to focus on therapeutic strategies affecting multiple injury pathways. Th...


    pub_type: 杂志文章,评审


    authors: Monsel A,Zhu YG,Gennai S,Hao Q,Liu J,Lee JW

    更新日期:2014-11-01 00:00:00

  • The actions of halothane, ibuprofen and BW755C on hypoxic pulmonary vasoconstriction.

    abstract::The effect of halothane on the pressor responses to hypoxia (3% O2, 5% CO2, balance N2) and to Angiotensin II (Ang II) (0.2 microgram) has been compared in an in vitro perfused and ventilated rat lung preparation in the presence and absence of agents known to block the lipoxygenase (BW755C) and/or the cyclooxygenase (...


    pub_type: 杂志文章


    authors: Marshall C,Kim SD,Marshall BE

    更新日期:1987-04-01 00:00:00

  • Both local anesthetics and salbutamol pretreatment affect reflex bronchoconstriction in volunteers with asthma undergoing awake fiberoptic intubation.

    abstract:BACKGROUND:Awake tracheal intubation may evoke reflex bronchoconstriction in asthmatics. Whether this effect is altered by the choice of the local anesthetic used or by pretreatment with a beta2-adrenoceptor agonist is unknown. Therefore, we assessed the effect of awake fiberoptic intubation after lidocaine or dyclonin...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Groeben H,Schlicht M,Stieglitz S,Pavlakovic G,Peters J

    更新日期:2002-12-01 00:00:00

  • Intranasal nicotine for postoperative pain treatment.

    abstract:BACKGROUND:Despite pharmacological treatment, 70-80% of patients report moderate to severe pain after surgery. Because nicotine has been reported to have analgesic properties in animal and human volunteer studies, the authors assessed the analgesic efficacy of a single 3 mg dose of nicotine nasal spray administered bef...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Flood P,Daniel D

    更新日期:2004-12-01 00:00:00

  • Alpha 4 beta 2 neuronal nicotinic acetylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but alpha 7-type nicotinic acetylcholine receptors are unaffected.

    abstract:BACKGROUND:The mechanisms of action of general anesthetics are not completely understood. Many general anesthetics are reported to potentiate gamma-aminobutyric acid (GABAA) and glycine receptors in the central nervous system (CNS) and to inhibit the muscle-type nicotinic acetylcholine receptor (nAChR). The effects of ...


    pub_type: 杂志文章


    authors: Flood P,Ramirez-Latorre J,Role L

    更新日期:1997-04-01 00:00:00

  • Regional gas exchange and cellular metabolic activity in ventilator-induced lung injury.

    abstract:BACKGROUND:Alveolar overdistension and repetitive derecruitment-recruitment contribute to ventilator-induced lung injury (VILI). The authors investigated (1) whether inflammatory cell activation due to VILI was assessable by positron emission tomography and (2) whether cell activation due to dynamic overdistension alon...


    pub_type: 杂志文章


    authors: Musch G,Venegas JG,Bellani G,Winkler T,Schroeder T,Petersen B,Harris RS,Melo MF

    更新日期:2007-04-01 00:00:00

  • Site of hemodynamic effects of intrathecal alpha 2-adrenergic agonists.

    abstract::Intrathecally administered alpha 2-adrenergic agonists produce analgesia in humans but may also produce hypotension and bradycardia. To further characterize hemodynamic depression produced by intrathecally administered alpha 2-adrenergic agonists, clonidine (100-1,500 micrograms) was injected into the cervical, thorac...


    pub_type: 杂志文章


    authors: Eisenach JC,Tong CY

    更新日期:1991-04-01 00:00:00

  • Malignant hyperthermia susceptibility in neuroleptic malignant syndrome.

    abstract::The relationship between neuroleptic malignant syndrome (NMS) and malignant hyperthermia (MH) was investigated using the in vitro skeletal muscle contracture test to screen for MH-susceptibility in NMS patients. The maximum contracture tension which developed following exposure to halothane (1-3%), and incremental dos...


    pub_type: 杂志文章


    authors: Caroff SN,Rosenberg H,Fletcher JE,Heiman-Patterson TD,Mann SC

    更新日期:1987-07-01 00:00:00

  • Relationship between anesthetic procedure and contact of anesthesia personnel with patient body fluids.

    abstract::We recorded the frequency with which anesthesia personnel came in contact with patient body fluids in order to provide an empirical basis for the recommendation of relevant precautions. Anesthesia personnel completed a questionnaire when performing a range of standardized procedures. The rate of contact with blood was...


    pub_type: 杂志文章


    authors: Kristensen MS,Sloth E,Jensen TK

    更新日期:1990-10-01 00:00:00

  • Predicting difficult intubation with indirect laryngoscopy.

    abstract:BACKGROUND:It is not always possible to predict when tracheal intubation will be difficult or impossible. The authors wanted to determine whether indirect laryngoscopy could identify patients in whom intubation was difficult. METHODS:Indirect laryngoscopy was done in 2,504 patients. The Wilson risk sum score and the m...


    pub_type: 杂志文章


    authors: Yamamoto K,Tsubokawa T,Shibata K,Ohmura S,Nitta S,Kobayashi T

    更新日期:1997-02-01 00:00:00

  • Propofol-induced Changes in α-β Sensorimotor Cortical Connectivity.

    abstract:BACKGROUND:Anesthetics are believed to alter functional connectivity across brain regions. However, network-level analyses of anesthesia, particularly in humans, are sparse. The authors hypothesized that propofol-induced loss of consciousness results in functional disconnection of human sensorimotor cortices underlying...


    pub_type: 杂志文章


    authors: Malekmohammadi M,AuYong N,Price CM,Tsolaki E,Hudson AE,Pouratian N

    更新日期:2018-02-01 00:00:00

  • Awareness: Monitoring versus remembering what happened.

    abstract:BACKGROUND:Awareness during anesthesia is foremost assessed with postoperative interviews, which may underestimate its incidence. On-line monitors such as the Bispectral Index and patient response to verbal command are not necessarily commonly used. This study investigated response to command during deep sedation (Bisp...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kerssens C,Klein J,Bonke B

    更新日期:2003-09-01 00:00:00

  • Intergenerational Effects of Sevoflurane in Young Adult Rats.

    abstract:BACKGROUND:Sevoflurane administered to neonatal rats induces neurobehavioral abnormalities and epigenetic reprogramming of their germ cells; the latter can pass adverse effects of sevoflurane to future offspring. As germ cells are susceptible to reprogramming by environmental factors across the lifespan, the authors hy...


    pub_type: 杂志文章


    authors: Ju LS,Yang JJ,Xu N,Li J,Morey TE,Gravenstein N,Seubert CN,Setlow B,Martynyuk AE

    更新日期:2019-11-01 00:00:00

  • Propofol anesthesia compared to awake reduces infarct size in rats.

    abstract:BACKGROUND:Propofol has not been studied directly in animals subject to cerebral ischemia in the conscious state. Strokes are usually induced in animals while they are anesthetized, making it difficult to eliminate anesthetic interactions as a complicating factor. Therefore, to compare the neuroprotective effects of pr...


    pub_type: 杂志文章


    authors: Gelb AW,Bayona NA,Wilson JX,Cechetto DF

    更新日期:2002-05-01 00:00:00

  • Presynaptic and postsynaptic effects of the anesthetics sevoflurane and nitrous oxide in the human spinal cord.

    abstract:BACKGROUND:Reduced spinal excitability contributes to the suppression of movement responses to noxious stimuli during the anesthetic state. This study examines and compares presynaptic and postsynaptic effects of two anesthetics in the human spinal cord. METHODS:The authors tested two parameters during the administrat...


    pub_type: 杂志文章


    authors: Baars JH,Benzke M,von Dincklage F,Reiche J,Schlattmann P,Rehberg B

    更新日期:2007-10-01 00:00:00

  • Bacterial reduction by cell salvage washing and leukocyte depletion filtration.

    abstract:BACKGROUND:Blood conservation techniques are being increasingly used because of the increased cost and lack of availability of allogeneic blood. Cell salvage offers great blood savings opportunities but is thought to be contraindicated in a number of areas (e.g., blood contaminated with bacteria). Several outcome studi...


    pub_type: 杂志文章


    authors: Waters JH,Tuohy MJ,Hobson DF,Procop G

    更新日期:2003-09-01 00:00:00

  • Extracellular histones play an inflammatory role in acid aspiration-induced acute respiratory distress syndrome.

    abstract:BACKGROUND:Systemic inflammation is a key feature in acid aspiration-induced acute respiratory distress syndrome (ARDS), but the factors that trigger inflammation are unclear. The authors hypothesize that extracellular histones, a newly identified inflammatory mediator, play important roles in the pathogenesis of ARDS....


    pub_type: 杂志文章


    authors: Zhang Y,Wen Z,Guan L,Jiang P,Gu T,Zhao J,Lv X,Wen T

    更新日期:2015-01-01 00:00:00