Chemokine (C-C motif) receptor 5 is an important pathological regulator in the development and maintenance of neuropathic pain.


BACKGROUND:The chemokine family has been revealed to be involved in the pathogenesis of neuropathic pain. In this study, the authors investigated the role of chemokine (C-C motif) ligand 3 and its receptors chemokine (C-C motif) receptor 1 and chemokine (C-C motif) receptor (CCR) 5 in neuropathic pain. METHODS:A spinal nerve injury model was established in adult male Wistar rats. The von Frey test and hot plate test were performed to evaluate neuropathic pain behavior, and real-time quantitative reverse transcription polymerase chain reaction, in situ hybridization, and immunohistochemistry were performed to understand the molecular mechanisms. RESULTS:The expression levels of chemokine (C-C motif) ligand 3 and CCR5 messenger RNA in the spinal cord were up-regulated after nerve injury, which was possibly due to CD11b-positive microglia. Single intrathecal administration of recombinant chemokine (C-C motif) ligand 3 produced biphasic tactile allodynia; each phase of pain behavior was induced by different receptors. Intrathecal injection of CCR5 antagonist suppressed the development of tactile allodynia (12.81 ± 1.33 g vs. 3.52 ± 0.41 g [mean ± SEM, drug vs. control in paw-withdrawal threshold]; P < 0.05, n = 6 each) and could reverse established tactile allodynia (10.87 ± 0.91 g vs. 3.43 ± 0.28 g; P < 0.05, n = 8 and 7). Furthermore, Oral administration of CCR5 antagonist could reverse established tactile allodynia (8.20 ± 1.27 g vs. 3.18 ± 0.46 g; P < 0.05, n = 4 each). CONCLUSIONS:Pharmacological blockade of CCR5 was effective in the treatment of the development and maintenance phases of neuropathic pain. Thus, CCR5 antagonists may be potential new drugs for the treatment of neuropathic pain.






Matsushita K,Tozaki-Saitoh H,Kojima C,Masuda T,Tsuda M,Inoue K,Hoka S




Has Abstract


2014-06-01 00:00:00












  • Sub-Tenon anesthesia: a prospective study of 6,000 blocks.

    abstract:BACKGROUND:An initial pilot study of 300 sub-Tenon local anesthetic blocks (STBs) for intraocular surgery established the effectiveness and patient acceptability of the technique. Following this, a decision was made in 1995 to change from sharp needle techniques to STB for all eye surgeries performed during local anest...


    pub_type: 临床试验,杂志文章


    authors: Guise PA

    更新日期:2003-04-01 00:00:00

  • Adrenergic vasoconstriction in peripheral nerves of the rabbit.

    abstract::The blood flow in the sciatic nerve of the rabbit was estimated from the wash out of intraneurally injected 133Xe. To avoid diffusion of the tracer into the surrounding muscular tissue, the nerve was covered by a gas-tight plastic film. Using this technique, the basal blood flow in the sciatic nerve was estimated to 3...


    pub_type: 杂志文章


    authors: Selander D,Månsson LG,Karlsson L,Svanvik J

    更新日期:1985-01-01 00:00:00

  • Sodium channel in human malignant hyperthermia.

    abstract:BACKGROUND:The abundance of a specific sodium channel subunit (SkM2) appeared to be altered in vitro in cell cultures from persons susceptible to malignant hyperthermia. This study sought to determine whether these findings are artifacts of cell culture or whether they may be relevant to malignant hyperthermia. METHOD...


    pub_type: 杂志文章


    authors: Fletcher JE,Wieland SJ,Karan SM,Beech J,Rosenberg H

    更新日期:1997-05-01 00:00:00

  • Diagnostic Accuracy of Respiratory Distress Observation Scales as Surrogates of Dyspnea Self-report in Intensive Care Unit Patients.

    abstract:BACKGROUND:Dyspnea, like pain, can cause major suffering in intensive care unit (ICU) patients. Its evaluation relies on self-report; hence, the risk of being overlooked when verbal communication is impaired. Observation scales incorporating respiratory and behavioral signs (respiratory distress observation scales [RDO...


    pub_type: 杂志文章


    authors: Persichini R,Gay F,Schmidt M,Mayaux J,Demoule A,Morélot-Panzini C,Similowski T

    更新日期:2015-10-01 00:00:00

  • Ideal permissive hypotension to resuscitate uncontrolled hemorrhagic shock and the tolerance time in rats.

    abstract:BACKGROUND:Studies have shown that permissive hypotension for uncontrolled hemorrhagic shock can result in good resuscitation outcome. The ideal target mean arterial pressure (MAP) and the tolerance time for permissive hypotension have not been determined. METHODS:To elucidate the ideal target MAP and tolerance time f...


    pub_type: 杂志文章


    authors: Li T,Zhu Y,Hu Y,Li L,Diao Y,Tang J,Liu L

    更新日期:2011-01-01 00:00:00

  • Perioperative β-blockade: atenolol is associated with reduced mortality when compared to metoprolol.

    abstract:BACKGROUND:The Atenolol study of 1996 provided evidence that perioperative β-blockade reduced postsurgical mortality. In 1998, the indications for perioperative β-blockade were codified as the Perioperative Cardiac Risk Reduction protocol and implemented at the San Francisco Veterans Affairs Medical Center. The current...


    pub_type: 杂志文章


    authors: Wallace AW,Au S,Cason BA

    更新日期:2011-04-01 00:00:00

  • Variations in pancuronium requirement, plasma concentration, and urinary excretion induced by cardiopulmonary bypass with hypothermia.

    abstract::To determine the effects of cardiopulmonary bypass (CPB) and hypothermia on the neuromuscular blockade produced by pancuronium, this relaxant was infused intravenously into 10 anesthetized patients to produce and maintain 90% depression of the twitch tension of the adductor pollicis muscle following supramaximal ulnar...


    pub_type: 杂志文章


    authors: d'Hollander AA,Duvaldestin P,Henzel D,Nevelsteen M,Bomblet JP

    更新日期:1983-06-01 00:00:00

  • Adsorption characteristics of volatile anesthetics on activated carbons and performance of carbon canisters.

    abstract::The adsorption characteristics, such as the adsorption capacity, the nature of the mass transfer zone, and heats of adsorption, are important for evaluating the performances of carbon canisters for removal of waste anesthetic vapors. The adsorption capacities and the natures of the mass transfer zones were measured fo...


    pub_type: 杂志文章


    authors: Kim BM,Sircar S

    更新日期:1977-03-01 00:00:00

  • Population pharmacokinetics and pharmacodynamics of thiopental: the effect of age revisited.

    abstract::The authors have previously attributed the mechanism for the 50-67% decrease in the required dose of thiopental for induction of anesthesia in aged human patients to a decrease in the initial distribution volume for thiopental. Using a larger group of patients and volunteers studied in the laboratory, the authors have...


    pub_type: 杂志文章


    authors: Stanski DR,Maitre PO

    更新日期:1990-03-01 00:00:00

  • The effect of clonidine on cerebral blood flow velocity, carbon dioxide cerebral vasoreactivity, and response to increased arterial pressure in human volunteers.

    abstract:BACKGROUND:Because patients may be taking clonidine chronically or may be receiving it as a premedication before surgery, the authors investigated its effect on cerebral hemodynamics. METHODS:In nine volunteers, middle cerebral artery mean blood flow velocity (Vm) was measured using transcranial Doppler ultrasonograph...


    pub_type: 杂志文章


    authors: Lee HW,Caldwell JE,Dodson B,Talke P,Howley J

    更新日期:1997-09-01 00:00:00

  • Hepatic oxygen supply during halothane or isoflurane anesthesia in guinea pigs.

    abstract::The present study was designed to determine changes in hepatic oxygen supply in guinea pigs during halothane or isoflurane anesthesia. Twenty-seven guinea pigs were randomly divided into three equal groups: control (no anesthesia) group, and animals anesthetized with halothane or isoflurane to decrease mean arterial p...


    pub_type: 杂志文章


    authors: Hursh D,Gelman S,Bradley EL Jr

    更新日期:1987-11-01 00:00:00

  • Safety and efficacy of the cyclooxygenase-2 inhibitors parecoxib and valdecoxib after noncardiac surgery.

    abstract:BACKGROUND:Valdecoxib and its intravenous prodrug parecoxib are reported to increase thromboembolic risk after coronary artery bypass grafting. The authors conducted a randomized trial to examine their safety and analgesic efficacy in patients recovering from major noncardiac surgical procedures. METHODS:The trial was...


    pub_type: 杂志文章,随机对照试验


    authors: Nussmeier NA,Whelton AA,Brown MT,Joshi GP,Langford RM,Singla NK,Boye ME,Verburg KM

    更新日期:2006-03-01 00:00:00

  • Efficacy of tactile-guided reversal from cisatracurium-induced neuromuscular block.

    abstract:BACKGROUND:Because tactile evaluation is the most common form of clinical neuromuscular monitoring, this study examines the relative efficacy of antagonizing residual block at different levels of recovery of the tactile train-of-four (TOF) response. METHODS:Anesthesia was induced in 64 adults with 2-5 microg/kg fentan...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kirkegaard H,Heier T,Caldwell JE

    更新日期:2002-01-01 00:00:00

  • Influence of erythrocyte concentrate storage time on postsurgical morbidity in cardiac surgery patients.

    abstract:BACKGROUND:The transfusion of erythrocytes that have been stored for long periods of time can produce visceral ischemia and favor the acquisition of postsurgical infections. To estimate the role of the duration of storage of erythrocytes on morbidity in cardiac surgery, we performed an observational study. METHODS:All...


    pub_type: 临床试验,杂志文章


    authors: Leal-Noval SR,Jara-López I,García-Garmendia JL,Marín-Niebla A,Herruzo-Avilés A,Camacho-Laraña P,Loscertales J

    更新日期:2003-04-01 00:00:00

  • Separate lung blood flow in anesthetized dogs: a comparative study between electromagnetometry and SF6 and CO2 elimination.

    abstract::Anesthetized, prone dogs were intubated with a double-lumen endobronchial tube, and the lungs were ventilated independently. Three methods of recording differential blood flow were compared during unilateral lung hypoxia: electromagnetic flow measurement, flow probes being fitted onto each main pulmonary artery after ...


    pub_type: 杂志文章


    authors: Carlsson AJ,Hedenstierna G,Blomqvist H,Strandberg A

    更新日期:1987-08-01 00:00:00

  • Effects of desflurane in senescent rat myocardium.

    abstract:BACKGROUND:The myocardial negative inotropic effects of desflurane are less pronounced than those of other halogenated anesthetics, partly because of intramyocardial catecholamine store release. However, the effects of desflurane on aging myocardium are unknown, whereas aging is known to be associated with an attenuati...


    pub_type: 杂志文章


    authors: Rozenberg S,Besse S,Amour J,Vivien B,Tavernier B,Riou B

    更新日期:2006-11-01 00:00:00

  • Mortality experience among anesthesiologists, 1954-1976.

    abstract::To determine whether anesthesiologists, because of prolonged exposure to halothane or other inhalational anesthetics, might have higher death rates from all causes, from cancer, and from hepatic or renal disease than other physicians, the mortality rates of male and female members of the American Society of Anesthesio...


    pub_type: 杂志文章


    authors: Lew EA

    更新日期:1979-09-01 00:00:00

  • Direct assessments of the antioxidant effects of propofol medium chain triglyceride/long chain triglyceride on the brain of stroke-prone spontaneously hypertensive rats using electron spin resonance spectroscopy.

    abstract:BACKGROUND:Antioxidant anesthetics such as propofol (2,6-diisopropylphenol) directly inhibit lipid peroxidation via the generation of reactive oxygen species. Currently, there are no other studies regarding the direct effects of propofol medium chain triglyceride/long chain triglyceride (MCT/LCT) on reactive oxygen spe...


    pub_type: 杂志文章


    authors: Kobayashi K,Yoshino F,Takahashi SS,Todoki K,Maehata Y,Komatsu T,Yoshida K,Lee MC

    更新日期:2008-09-01 00:00:00

  • A comparative evaluation of the effects of multiple vasodilators on human internal mammary artery.

    abstract:BACKGROUND:Vasospasm of arterial grafts represents an unpredictable complication of coronary artery surgery and may compromise myocardial revascularization, and treatment is based on empirical therapy with nitroglycerin. Because of the potential for tolerance to nitroglycerin to occur, the authors studied different vas...


    pub_type: 杂志文章


    authors: Huraux C,Makita T,Montes F,Szlam F,Levy JH

    更新日期:1998-06-01 00:00:00

  • Presynaptic inhibition in man during anesthesia and sleep.

    abstract::The slow positive (P2) wave of the evoked electrospinogram was recorded from the dorsal epidural space in man. The waveform characteristics of the P2 wave were similar to those of the dorsal cord positive wave (P wave), which is believed to be caused by the primary afferent depolarization (PAD) and to be related to pr...


    pub_type: 杂志文章


    authors: Shimoji K,Ito Y,Oama K,Sawa T,Ikezono E

    更新日期:1975-10-01 00:00:00

  • Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning.

    abstract:BACKGROUND:Anesthetic preconditioning (APC) is a clinically important phenomenon in which volatile anesthetics (VAs) protect tissues such as heart against ischemic injury. The mechanism of APC is thought to involve K channels encoded by the Slo gene family, and the authors showed previously that slo-2 is required for A...


    pub_type: 杂志文章


    authors: Wojtovich AP,Smith CO,Urciuoli WR,Wang YT,Xia XM,Brookes PS,Nehrke K

    更新日期:2016-05-01 00:00:00

  • Agent-selective effects of volatile anesthetics on GABAA receptor-mediated synaptic inhibition in hippocampal interneurons.

    abstract:BACKGROUND:A relatively small number of inhibitory interneurons can control the excitability and synchronization of large numbers of pyramidal cells in hippocampus and other cortical regions. Thus, anesthetic modulation of interneurons could play an important role for the maintenance of anesthesia. The aim of this stud...


    pub_type: 杂志文章


    authors: Nishikawa K,MacIver MB

    更新日期:2001-02-01 00:00:00

  • Psychedelic effects of ketamine in healthy volunteers: relationship to steady-state plasma concentrations.

    abstract:BACKGROUND:Ketamine has been associated with a unique spectrum of subjective "psychedelic" effects in patients emerging from anesthesia. This study quantified these effects of ketamine and related them to steady-state plasma concentrations. METHODS:Ketamine or saline was administered in a single-blinded crossover prot...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bowdle TA,Radant AD,Cowley DS,Kharasch ED,Strassman RJ,Roy-Byrne PP

    更新日期:1998-01-01 00:00:00

  • Response to mivacurium in a patient compound heterozygous for a novel and a known silent mutation in the butyrylcholinesterase gene: genotyping by sequencing.

    abstract:BACKGROUND:Patients who are homozygous for the atypical mutation, compound heterozygous for atypical and silent mutations, or homozygous for silent mutations (SS) respond to mivacurium with extensively prolonged neuromuscular block. Although important, exact phenotyping of these patients is difficult. This article pres...


    pub_type: 杂志文章


    authors: Gätke MR,Ostergaard D,Bundgaard JR,Varin F,Viby-Mogensen J

    更新日期:2001-09-01 00:00:00

  • Endothelial glycocalyx as an additional barrier determining extravasation of 6% hydroxyethyl starch or 5% albumin solutions in the coronary vascular bed.

    abstract:BACKGROUND:The impact on the endothelial glycocalyx for the extravasation of colloidal infusion solutions has not been investigated sufficiently. METHODS:Isolated guinea pig hearts were perfused with Krebs-Henseleit buffer in a Langendorff mode. Solutions of 0.9% saline, 5% albumin (70 kd), or 6% hydroxyethyl starch (...


    pub_type: 杂志文章


    authors: Rehm M,Zahler S,Lötsch M,Welsch U,Conzen P,Jacob M,Becker BF

    更新日期:2004-05-01 00:00:00

  • Isoflurane and the pulmonary vascular pressure-flow relation at baseline and during sympathetic alpha- and beta-adrenoreceptor activation in chronically instrumented dogs.

    abstract:BACKGROUND:The extent to which isoflurane anesthesia alters systemic vascular regulation has received considerable attention. In contrast, the pulmonary vascular effects of isoflurane have not been elucidated. Our initial objective was to investigate the net effect of isoflurane on the baseline left pulmonary vascular ...


    pub_type: 杂志文章


    authors: Lennon PF,Murray PA

    更新日期:1995-03-01 00:00:00

  • Anterior shift of the dominant EEG rhytham during anesthesia in the Java monkey: correlation with anesthetic potency.

    abstract::EEG amplitude dominance in awake man is posterior. During EEG monitoring in patients, the authors observed the abrupt appearance of anterior amplitude dominance during induction of anesthesia with halothane, enflurane, or thiopental. This EEG change is coincident with loss of eyelid reflex and loss of ability to respo...


    pub_type: 杂志文章


    authors: Tinker JH,Sharbrough FW,Michenfelder JD

    更新日期:1977-04-01 00:00:00

  • Ketanserin pretreatment reverses alfentanil-induced muscle rigidity.

    abstract::Systemic pretreatment with ketanserin, a relatively specific type-2 serotonin receptor antagonist, significantly attenuated the muscle rigidity produced in rats by the potent short-acting opiate agonist alfentanil. Following placement of subcutaneous electrodes in each animal's left gastrocnemius muscle, rigidity was ...


    pub_type: 杂志文章


    authors: Weinger MB,Cline EJ,Smith NT,Koob GF

    更新日期:1987-09-01 00:00:00

  • Inhibitory effects of thiopental, ketamine, and propofol on voltage-dependent Ca2+ channels in porcine tracheal smooth muscle cells.

    abstract:BACKGROUND:Intravenously administered anesthetics directly inhibit airway smooth muscle contraction. Because many anesthetic agents affect membrane ion channel function and sustained contraction of airway smooth muscle requires the influx of Ca2+ through voltage-dependent Ca2+ channels, it was hypothesized that intrave...


    pub_type: 杂志文章


    authors: Yamakage M,Hirshman CA,Croxton TL

    更新日期:1995-12-01 00:00:00

  • The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice.

    abstract:BACKGROUND:Xenon has been shown to be neuroprotective in several models of in vitro and in vivo neuronal injury. However, its putative neuroprotective properties have not been evaluated in focal cerebral ischemia. The purpose of this study was to determine if xenon offers neuroprotection in a mouse model of middle cere...


    pub_type: 杂志文章


    authors: Homi HM,Yokoo N,Ma D,Warner DS,Franks NP,Maze M,Grocott HP

    更新日期:2003-10-01 00:00:00