Abstract:
BACKGROUND:Some studies suggest that the orbicularis oculi is resistant to neuromuscular blocking drugs and behaves like laryngeal muscles. Others report little or no difference between the orbicularis oculi and the adductor pollicis. These discrepancies could be related to the exact site of recording. The purpose of this study was to compare two monitoring sites around the eye with the adductor pollicis and the laryngeal adductor muscles. METHODS:After institutional approval and informed consent, the evoked response to train-of-four stimulation was measured in 12 patients by acceleromyography at the thumb (adductor pollicis), the eyelid (orbicularis oculi), and the superciliary arch (corrugator supercilii) after 0.5 mg/kg rocuronium during propofol-fentanyl-nitrous oxide anesthesia. In 12 other patients, laryngeal adductor neuromuscular blockade was assessed via the cuff of the tracheal tube and compared with the adductor pollicis and the corrugator supercilii after 0.6 mg/kg rocuronium. RESULTS:After 0.5 mg/kg, maximum blockade (%T1, mean +/- SD) was less at the corrugator supercilii (80+/-20%) than at the adductor pollicis (100+/-1%) and the orbicularis oculi (93+/-8%) (P < 0.01). Clinical duration (25%T1) was shorter at the corrugator supercilii (12+/-7 min) than at the adductor pollicis (25+/-4 min) and orbicularis oculi (24+/-10 min) (P < 0.01). After 0.6 mg/kg, maximum blockade was similar at the corrugator supercilii (88+/-8%) and the laryngeal adductor muscles (89+/-11%). Clinical duration at the corrugator supercilii and the laryngeal adductors was 17+/-7 and 17+/-10 min, respectively. CONCLUSIONS:Muscles around the eye vary in their response to rocuronium. The response of the superciliary arch (corrugator supercilii) reflects blockade of laryngeal adductor muscles. However, the eyelid (orbicularis oculi) and thumb (adductor pollicis) have similar sensitivities.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Plaud B,Debaene B,Donati Fdoi
10.1097/00000542-200107000-00019subject
Has Abstractpub_date
2001-07-01 00:00:00pages
96-101issue
1eissn
0003-3022issn
1528-1175journal_volume
95pub_type
临床试验,杂志文章相关文献
ANESTHESIOLOGY文献大全abstract:BACKGROUND:Recent studies have questioned the importance of the gravitational model of pulmonary perfusion. Because low levels of positive end-expiratory pressure (PEEP) are commonly used during anesthesia, the authors studied the distribution of pulmonary blood flow with low levels of PEEP using a high spatial resolut...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199805000-00021
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Transcranial motor-evoked potentials (TcMEPs) monitor spinal cord motor tract integrity. Using a swine model, the authors studied the effects of vasodilatory hypotension, hemorrhage, and various resuscitation efforts on TcMEP responses. METHODS:Twelve pigs were anesthetized with constant infusions of propof...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e31829d4a92
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Perfluorocarbon (PFC) liquids are known to improve gas exchange and pulmonary function in various models of acute respiratory failure. Vaporization has been recently reported as a new method of delivering PFC to the lung. Our aim was to study the effect of PFC vapor on the ventilation/perfusion (VA/Q) matchi...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200112000-00021
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Mild hypothermia is accompanied by metabolic changes. Epidural local anesthetic agents attenuate the surgical stress response, but it is not known whether they modulate thermal stress. METHODS:Thirty patients undergoing colorectal surgery, performed by one surgical team, received epidural 0.5% bupivacaine t...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199805000-00011
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:The authors developed a measure to determine whether maternal motivation to be present during induction (Motivation for Parental Presence during Induction of Anesthesia [MPPIA]) is related to children's anxiety during the induction process. METHODS:Mothers and children (aged 2-12 yr) undergoing outpatient, ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200509000-00008
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Due to potential neurologic sequelae, the risk:benefit ratio of thoracic epidural analgesia is controversial. Surprisingly, however, few available data address neurologic complications. The incidence of neurologic complications occurring after thoracic epidural catheterization was studied in patients schedul...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199701000-00009
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Nonsteroidal antiinflammatory drugs are commonly used to treat postoperative and chronic pain. Animal studies suggest that these drugs act, in part, by blocking prostaglandin production in the spinal cord. The authors tested intrathecal ketorolac in patients with chronic or postoperative pain. METHODS:After...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/ALN.0b013e3181d94dc0
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Previously, the authors found that anesthetized diabetic dogs had increased cerebral blood flow (CBF) and oxygen consumption (CMRO2). These results may have been influenced by anesthesia or surgery. The aim of this study was to determine whether CBF and CMRO2 are increased in the awake or anesthetized state ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199311000-00020
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Aprotinin has been reported to reduce blood loss and transfusion requirements in patients having major orthopedic operations. Data on whether epsilon amino-caproic acid (EACA) is effective in this population are sparse. METHODS:Sixty-nine adults with malignancy scheduled for either pelvic, extremity or spin...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200302000-00011
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:Chronic pain is associated with depression. In rodents, pain is often assessed by sensory hypersensitivity, which does not sufficiently measure affective responses. Low-dose ketamine has been used to treat both pain and depression, but it is not clear whether ketamine can relieve depression associated with c...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e31822f16ae
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Single lung transplantation has become a viable therapy for treatment of end-stage pulmonary disease. We previously observed that left lung autotransplantation (LLA) results in a chronic increase in pulmonary vascular resistance and enhanced pulmonary vascular reactivity to sympathetic alpha adrenoreceptor a...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199609000-00019
更新日期:1996-09-01 00:00:00
abstract::Thiopental was used in long-term infusion (3-4.5 mg . kg-1 . h-1 during 4-8 days) to protect the brain from injury following trauma. Thiopental plasma concentrations were measured during infusion (48 patients) and after infusion (14 patients) to determine the kinetics of the drug in continuous infusion. All mean value...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198507000-00007
更新日期:1985-07-01 00:00:00
abstract:BACKGROUND:The anticonvulsant gabapentin, proven effective for neuropathic pain in two large, placebo-controlled clinical trials, is widely used for treatment of chronic pain. Preclinical studies have demonstrated analgesic and antiallodynic effects in models involving neuronal sensitization and nerve injury, without a...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200207000-00015
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:General anesthetics reduce neuronal death caused by focal cerebral ischemia in rodents and by in vitro ischemia in cultured neurons and brain slices. However, in intact animals, the protective effect may enhance neuronal survival for only several days after an ischemic injury, possibly because anesthetics pr...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200201000-00033
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Blood conservation techniques are being increasingly used because of the increased cost and lack of availability of allogeneic blood. Cell salvage offers great blood savings opportunities but is thought to be contraindicated in a number of areas (e.g., blood contaminated with bacteria). Several outcome studi...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200309000-00021
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:The mechanisms of action of general anesthetics are not completely understood. Many general anesthetics are reported to potentiate gamma-aminobutyric acid (GABAA) and glycine receptors in the central nervous system (CNS) and to inhibit the muscle-type nicotinic acetylcholine receptor (nAChR). The effects of ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199704000-00016
更新日期:1997-04-01 00:00:00
abstract::Magnesium plays a fundamental role in many cellular functions, and thus there is increasing interest in its role in clinical medicine. Although numerous experimental studies indicate positive effects of magnesium in a variety of disease states, large clinical trials often give conflicting results. However, there is cl...
journal_title:Anesthesiology
pub_type: 杂志文章,评审
doi:10.1097/ALN.0b013e318210483d
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Selective breeding produces animal strains with varying anesthetic sensitivity. It thus seems unlikely that various human ethnicities have identical anesthetic requirements. Therefore, the authors tested the hypothesis that the minimum alveolar concentration of sevoflurane differs significantly as a function...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.anes.0000267534.31668.62
更新日期:2007-07-01 00:00:00
abstract::Postoperative itching is an important problem in the postoperative care unit. Pruritus after surgery may be drug induced (including intrathecal opioids) or secondary to a preexisting systemic disease. Mechanisms of itching are complex and not completely understood. The purpose of this review is to highlight new discov...
journal_title:Anesthesiology
pub_type: 杂志文章,评审
doi:10.1097/00000542-200507000-00025
更新日期:2005-07-01 00:00:00
abstract::The effects of halothane on uptake and phosphorylation of uridine, and on cellular ATP content were studied in Tetrahymena pyriformis, a ciliate protozoan. Exposure to halothane inhibited the accumulation of 14C-uridine into the following acid-soluble intracellular pools: UTP, UDP, UMP, and an unidentified compound. H...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND:Halogenated anesthetics potentiate the positive inotropic effects of alpha- and beta-adrenoceptor stimulations. Although diabetes mellitus induces significant myocardial abnormalities, the interaction of halogenated anesthetics and adrenoceptor stimulation in diabetic myocardium remains unknown. METHODS:Lef...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200411000-00014
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:The aim of this study was to compare the effects of goal-directed colloid fluid therapy with goal-directed crystalloid and restricted crystalloid fluid therapy on healthy and perianastomotic colon tissue in a pig model of colon anastomosis surgery. METHODS:Pigs (n = 27, 9 per group) were anesthetized and me...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e31819841f6
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:The chemokine family has been revealed to be involved in the pathogenesis of neuropathic pain. In this study, the authors investigated the role of chemokine (C-C motif) ligand 3 and its receptors chemokine (C-C motif) receptor 1 and chemokine (C-C motif) receptor (CCR) 5 in neuropathic pain. METHODS:A spina...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000190
更新日期:2014-06-01 00:00:00
abstract::Thiopental-14C (30 mg and 10 muCi/kg) was injected intravenously into rats 36-48 hours following bilateral nephrectomy and one minute after pretreatment with sulfadimethoxine (30 mg/kg, iv). Control groups of normal and sham-operated animals were used. The distributions of radioactivity in plasma, brain, and heart 1, ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197612000-00008
更新日期:1976-12-01 00:00:00
abstract:BACKGROUND:Epidural morphine has proven analgesic efficacy in the postoperative period and is widely used. This study evaluated the efficacy of extended-release epidural morphine (EREM; DepoDur; Endo Pharmaceuticals Inc., Chadds Ford, PA; SkyePharma, Inc., San Diego, CA) in providing pain relief for 48 h after surgery....
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00000542-200505000-00022
更新日期:2005-05-01 00:00:00
abstract::Blood from 20 ASA physical status I patients collected before and after induction of anesthesia was used in vitro to reexamine the effects of nitrous oxide on the oxyhemoglobin dissociation curve and the response of the oxygen electrode. The preinduction P50 values with and without 70% N2O were 28.4 +/- 0.1 mmHg and 2...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198702000-00015
更新日期:1987-02-01 00:00:00
abstract:BACKGROUND:Morphine is widely used in patients undergoing surgical operations and is also reported to mediate cardioprotection of preconditioning. The current study determined effects of morphine at therapeutic to pharmacologic concentrations on cardiac action potential, L-type Ca2+ current (ICa.L), delayed rectifier K...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200508000-00011
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:Postoperative visual loss after prone spine surgery is increasingly reported in association with ischemic optic neuropathy, but its etiology is unknown. METHODS:To describe the clinical characteristics of these patients, the authors analyzed a retrospectively collected series of 93 spine surgery cases volun...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200610000-00007
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Halothane and isoflurane have been shown to differentially effect mechanisms of contraction in working myocardial fibers. The aim of this study was to compare effects of halothane and isoflurane on contractile force (CF) and Ca2+ transients in canine cardiac Purkinje fiber preparations. METHODS:Fiber prepar...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199406000-00024
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:The authors compared the intubation success rate of straight reinforced tracheal tubes emerging from the Airtraq laryngoscope (Prodol Meditec S.A., Vizcaya, Spain) with standard preformed polyvinyl chloride tracheal tubes in anesthetized patients. METHODS:The authors randomly allocated 347 adult patients to...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0b013e3181c0ad5b
更新日期:2009-12-01 00:00:00