The corrugator supercilii, not the orbicularis oculi, reflects rocuronium neuromuscular blockade at the laryngeal adductor muscles.


BACKGROUND:Some studies suggest that the orbicularis oculi is resistant to neuromuscular blocking drugs and behaves like laryngeal muscles. Others report little or no difference between the orbicularis oculi and the adductor pollicis. These discrepancies could be related to the exact site of recording. The purpose of this study was to compare two monitoring sites around the eye with the adductor pollicis and the laryngeal adductor muscles. METHODS:After institutional approval and informed consent, the evoked response to train-of-four stimulation was measured in 12 patients by acceleromyography at the thumb (adductor pollicis), the eyelid (orbicularis oculi), and the superciliary arch (corrugator supercilii) after 0.5 mg/kg rocuronium during propofol-fentanyl-nitrous oxide anesthesia. In 12 other patients, laryngeal adductor neuromuscular blockade was assessed via the cuff of the tracheal tube and compared with the adductor pollicis and the corrugator supercilii after 0.6 mg/kg rocuronium. RESULTS:After 0.5 mg/kg, maximum blockade (%T1, mean +/- SD) was less at the corrugator supercilii (80+/-20%) than at the adductor pollicis (100+/-1%) and the orbicularis oculi (93+/-8%) (P < 0.01). Clinical duration (25%T1) was shorter at the corrugator supercilii (12+/-7 min) than at the adductor pollicis (25+/-4 min) and orbicularis oculi (24+/-10 min) (P < 0.01). After 0.6 mg/kg, maximum blockade was similar at the corrugator supercilii (88+/-8%) and the laryngeal adductor muscles (89+/-11%). Clinical duration at the corrugator supercilii and the laryngeal adductors was 17+/-7 and 17+/-10 min, respectively. CONCLUSIONS:Muscles around the eye vary in their response to rocuronium. The response of the superciliary arch (corrugator supercilii) reflects blockade of laryngeal adductor muscles. However, the eyelid (orbicularis oculi) and thumb (adductor pollicis) have similar sensitivities.






Plaud B,Debaene B,Donati F




Has Abstract


2001-07-01 00:00:00












  • Anesthesia with abdominal surgery leads to intense REM sleep during the first postoperative week.

    abstract::Characteristics of nocturnal sleep were investigated in six patients after anesthesia and cholecystectomy and in another six after anesthesia and gastroplasty. All night polysomnographic recordings were obtained while each patient slept in a private surgical ward room through two nights before and five or six nights a...


    pub_type: 杂志文章


    authors: Knill RL,Moote CA,Skinner MI,Rose EA

    更新日期:1990-07-01 00:00:00

  • Propofol-induced Changes in α-β Sensorimotor Cortical Connectivity.

    abstract:BACKGROUND:Anesthetics are believed to alter functional connectivity across brain regions. However, network-level analyses of anesthesia, particularly in humans, are sparse. The authors hypothesized that propofol-induced loss of consciousness results in functional disconnection of human sensorimotor cortices underlying...


    pub_type: 杂志文章


    authors: Malekmohammadi M,AuYong N,Price CM,Tsolaki E,Hudson AE,Pouratian N

    更新日期:2018-02-01 00:00:00

  • Factor VII levels and international normalized ratios in the early phase of warfarin therapy.

    abstract:BACKGROUND:Factor VII is the most affected clotting factor during the early phase of warfarin therapy. An international normalized ratio (INR) of more than 1.4 is considered unsafe for epidural catheter placement or removal, according to the American Society of Regional Anesthesia and Pain Medicine. The authors tested ...


    pub_type: 杂志文章


    authors: Benzon HT,Avram MJ,Benzon HA,Kirby-Nolan M,Nader A

    更新日期:2010-02-01 00:00:00

  • Adaptive support ventilation: an appropriate mechanical ventilation strategy for acute respiratory distress syndrome?

    abstract:BACKGROUND:Adaptive support ventilation (ASV) allows the clinician to set a maximum plateau pressure (PP) and automatically adjusts tidal volume to keep PP below the set maximum. METHODS:ASV was compared to a fixed tidal volume of 6 ml/kg. ASV determined the respiratory rate and tidal volume based on its algorithms. M...


    pub_type: 杂志文章


    authors: Sulemanji D,Marchese A,Garbarini P,Wysocki M,Kacmarek RM

    更新日期:2009-10-01 00:00:00

  • Caudal epidural morphine for control of pain following open heart surgery in children.

    abstract::The safety and efficacy of epidural morphine injected into the caudal space for control of postoperative pain following open cardiac surgery in children was studied. Thirty-two children between the ages of 2-12 yr for whom early postoperative tracheal extubation was anticipated were randomly assigned to control and st...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rosen KR,Rosen DA

    更新日期:1989-03-01 00:00:00

  • Influence of mannitol and furosemide, alone and in combination, on brain water content after fluid percussion injury.

    abstract:BACKGROUND:Furosemide and mannitol are used to reduce intracranial pressure, but the impact of furosemide on edema of injured brain is unclear. The authors examined the effects of furosemide and mannitol, alone and in combination, on brain water content in brain-injured rats. METHODS:Anesthetized rats were subjected t...


    pub_type: 杂志文章


    authors: Todd MM,Cutkomp J,Brian JE

    更新日期:2006-12-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of rocuronium in patients with cirrhosis.

    abstract:BACKGROUND:Rocuronium, like other steroidal nondepolarizing muscle relaxants, may in part be eliminated by the liver. To determine the influence of liver disease on its neuromuscular blocking effect, we studied the pharmacokinetics and pharmacodynamics of rocuronium in patients with cirrhosis. METHODS:Eighteen patient...


    pub_type: 杂志文章


    authors: Khalil M,D'Honneur G,Duvaldestin P,Slavov V,De Hys C,Gomeni R

    更新日期:1994-06-01 00:00:00

  • Cardiovascular responses to the induction of mild hypothermia in the presence of epidural anesthesia.

    abstract:BACKGROUND:The combining of epidural anesthesia with general anesthesia impairs central and peripheral thermoregulatory control and therefore is often accompanied by unintended intraoperative hypothermia. However, little is known about the cardiovascular response to hypothermia during combined epidural and general anes...


    pub_type: 杂志文章


    authors: Yoshida M,Shibata K,Itoh H,Yamamoto K

    更新日期:2001-04-01 00:00:00

  • Efficacy of continuous insufflation of oxygen combined with active cardiac compression-decompression during out-of-hospital cardiorespiratory arrest.

    abstract:BACKGROUND:During experimental cardiac arrest, continuous insufflation of air or oxygen (CIO) through microcannulas inserted into the inner wall of a modified intubation tube and generating a permanent positive intrathoracic pressure, combined with external cardiac massage, has previously been shown to be as effective ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Saïssy JM,Boussignac G,Cheptel E,Rouvin B,Fontaine D,Bargues L,Levecque JP,Michel A,Brochard L

    更新日期:2000-06-01 00:00:00

  • Cardiopulmonary bypass induces neurologic and neurocognitive dysfunction in the rat.

    abstract:BACKGROUND:Neurocognitive dysfunction is a common complication of cardiac surgery using cardiopulmonary bypass (CPB). Elucidating injury mechanisms and developing neuroprotective strategies have been hampered by the lack of a suitable long-term recovery model of CPB. The purpose of this study was to investigate neurolo...


    pub_type: 杂志文章


    authors: Mackensen GB,Sato Y,Nellgård B,Pineda J,Newman MF,Warner DS,Grocott HP

    更新日期:2001-12-01 00:00:00

  • Learning curves for bag-and-mask ventilation and orotracheal intubation: an application of the cumulative sum method.

    abstract:BACKGROUND:In this study, the authors determined the success and failure rates for interns learning bag-and-mask ventilation and orotracheal intubation. Their goal was to determine the amount of experience needed to perform these procedures correctly. METHODS:The authors recorded 695 bag-and-mask ventilations and 679 ...


    pub_type: 杂志文章


    authors: Komatsu R,Kasuya Y,Yogo H,Sessler DI,Mascha E,Yang D,Ozaki M

    更新日期:2010-06-01 00:00:00

  • Intracarotid verapamil decreases both proximal and distal human cerebrovascular resistance.

    abstract:BACKGROUND:The authors determined the segmental effects of intracarotid verapamil in human subjects by using a novel method of measuring proximal and distal cerebrovascular resistance. Their hypothesis was that intracarotid verapamil, a calcium channel-blocking drug that augments cerebral blood flow and reverses arteri...


    pub_type: 杂志文章


    authors: Joshi S,Meyers PM,Pile-Spellman J,Wang M,Sahlein DH

    更新日期:2004-04-01 00:00:00

  • Postoperative nausea and vomiting. Its etiology, treatment, and prevention.

    abstract::In a recent editorial, Kapur described perioperative nausea and vomiting as "the big 'little problem' following ambulatory surgery."257 Although the actual morbidity associated with nausea is relatively low in health outpatients, it should not be considered an unavoidable part of the perioperative experience. The avai...


    pub_type: 杂志文章,评审


    authors: Watcha MF,White PF

    更新日期:1992-07-01 00:00:00

  • Isoflurane and an alpha 2-adrenoceptor agonist suppress nociceptive neurotransmission in neonatal rat spinal cord.

    abstract::Analgesia is an important component of general anesthesia. alpha 2-adrenoceptor agonists such as clonidine and dexmedetomidine are effective analgesics at the spinal level, and furthermore, they reduce the volatile anesthetic requirement. In order to probe a possible spinal-level contribution to general anesthetic-ind...


    pub_type: 杂志文章


    authors: Savola MK,Woodley SJ,Maze M,Kendig JJ

    更新日期:1991-09-01 00:00:00

  • Role of central and mixed venous oxygen saturation measurement in perioperative care.

    abstract::Complications after major surgery are a leading cause of morbidity and mortality. The etiology of postoperative complications is complex, but poor cardiorespiratory reserve appears to be a key factor. There is increasing interest in the use of central and mixed venous oxygen saturation to guide therapeutic interventio...


    pub_type: 杂志文章


    authors: Shepherd SJ,Pearse RM

    更新日期:2009-09-01 00:00:00

  • Relaxation before Debriefing during High-fidelity Simulation Improves Memory Retention of Residents at Three Months: A Prospective Randomized Controlled Study.

    abstract:BACKGROUND:High-fidelity simulation is known to improve participant learning and behavioral performance. Simulation scenarios generate stress that affects memory retention and may impact future performance. The authors hypothesized that more participants would recall three or more critical key messages at three months ...


    pub_type: 杂志文章,随机对照试验


    authors: Lilot M,Evain JN,Bauer C,Cejka JC,Faure A,Balança B,Vassal O,Payet C,Bui Xuan B,Duclos A,Lehot JJ,Rimmelé T

    更新日期:2018-03-01 00:00:00

  • Developmental effects of neonatal isoflurane and sevoflurane exposure in rats.

    abstract:BACKGROUND:The general anesthetics, isoflurane and sevoflurane, cause developmental abnormalities in neonatal animal models via incompletely understood mechanisms. Despite many common molecular targets, isoflurane and sevoflurane exhibit substantial differences in their actions. The authors sought to determine whether ...


    pub_type: 杂志文章


    authors: Seubert CN,Zhu W,Pavlinec C,Gravenstein N,Martynyuk AE

    更新日期:2013-08-01 00:00:00

  • Association between Neuraxial Labor Analgesia and Neonatal Morbidity after Operative Vaginal Delivery.

    abstract:BACKGROUND:Up to 84% of women who undergo operative vaginal delivery receive neuraxial analgesia. However, little is known about the association between neuraxial analgesia and neonatal morbidity in women who undergo operative vaginal delivery. The authors hypothesized that neuraxial analgesia is associated with a redu...


    pub_type: 杂志文章


    authors: Butwick AJ,Wong CA,Lee HC,Blumenfeld YJ,Guo N

    更新日期:2021-01-01 00:00:00

  • Dose-response and plasma concentration-response relationships of pancuronium in man.

    abstract::The dose-response and plasma concentration-response relationships for pancuronium in man were studied during its intravenous administration to eight patients at a rate of 1.62 microgram/kg/min. The (log) dose-response relationships resulted in a sigmoid curve that was linear in its central range. At 20, 50 and 80 per ...


    pub_type: 杂志文章


    authors: Shanks CA,Somogyi AA,Triggs EJ

    更新日期:1979-08-01 00:00:00

  • Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.

    abstract:BACKGROUND:Renal and hepatic toxicity of the fluorinated ether volatile anesthetics is caused by biotransformation to toxic metabolites. Metabolism also contributes significantly to the elimination pharmacokinetics of some volatile agents. Although innumerable studies have explored anesthetic metabolism in animals, the...


    pub_type: 杂志文章


    authors: Kharasch ED,Thummel KE

    更新日期:1993-10-01 00:00:00

  • The well-being model: a new drug interaction model for positive and negative effects.

    abstract:BACKGROUND:Drugs are routinely combined in anesthesia and pain management to obtain an enhancement of the desired effects. However, a parallel enhancement of the undesired effects might take place as well, resulting in a limited therapeutic usefulness. Therefore, when addressing the question of optimal drug combination...


    pub_type: 杂志文章


    authors: Zanderigo E,Sartori V,Sveticic G,Bouillon T,Schumacher P,Morari M,Curatolo M

    更新日期:2006-04-01 00:00:00

  • Impaired systolic thickening associated with halothane in the presence of a coronary stenosis is mediated by changes in hemodynamics.

    abstract::Myocardial ischemia results when halothane is administered to animals with severe coronary stenosis. This study was done to separate the effect of halothane, per se, on myocardial ischemia from indirect cardiovascular effects, primarily hypotension, that might cause ischemia by altering the oxygen supply-demand balanc...


    pub_type: 杂志文章


    authors: Buffington CW

    更新日期:1986-05-01 00:00:00

  • Ventilatory response to CO2 following intravenous and epidural lidocaine.

    abstract::The authors determined the effects of intravenous infusion and epidural administration of lidocaine on the control of ventilation in two groups of eight healthy unpremedicated subjects. In the intravenous group, an injection of 1.5 mg/kg lidocaine was followed by an infusion at a rate of 60 micrograms X kg-1 X min-1 f...


    pub_type: 杂志文章


    authors: Labaille T,Clergue F,Samii K,Ecoffey C,Berdeaux A

    更新日期:1985-08-01 00:00:00

  • Cervical spinal cord, root, and bony spine injuries: a closed claims analysis.

    abstract:BACKGROUND:The aim of this study was to characterize cervical cord, root, and bony spine claims in the American Society of Anesthesiologists Closed Claims database to formulate hypotheses regarding mechanisms of injury. METHODS:All general anesthesia claims (1970-2007) in the Closed Claims database were searched to id...


    pub_type: 杂志文章


    authors: Hindman BJ,Palecek JP,Posner KL,Traynelis VC,Lee LA,Sawin PD,Tredway TL,Todd MM,Domino KB

    更新日期:2011-04-01 00:00:00

  • Alcohol consumption alters the pharmacodynamics of alfentanil.

    abstract::Two groups of women, ASA physical status 1, undergoing surgery for primary breast cancer, were studied to assess the effect of alcohol intake on alfentanil pharmacodynamics. Patients in group 1 (n = 6) had an average daily consumption of 20-40 g alcohol. Patients in group 2 (n = 8) were life-long abstainers or drank o...


    pub_type: 杂志文章


    authors: Lemmens HJ,Bovill JG,Hennis PJ,Gladines MP,Burm AG

    更新日期:1989-11-01 00:00:00

  • Influence of epinephrine as an adjuvant to epidural morphine.

    abstract::The effects of epinephrine 1/200,000 as an adjuvant to epidural morphine were investigated in three healthy male volunteers, during 26-h observation sessions. Peak blood concentrations of morphine were 44 +/- 12.9 ng/ml after plain morphine and 13.7 +/- 6.7 ng/ml after epinephrine-morphine. Cutaneous hypalgesia was mo...


    pub_type: 杂志文章


    authors: Bromage PR,Camporesi EM,Durant PA,Nielsen CH

    更新日期:1983-03-01 00:00:00

  • Nitrogen analyzer adaptation for use in the presence of halogenated anesthetics.

    abstract::Interposition of activated carbon between a nitrogen analyzer needle valve and gas mixtures containing halothane, methoxyflurane, enflurane, or isoflurane eliminated the interfering effects of these agents, but added sampling delays. Placement of a carbon-filled Swinney adaptor in the sampling line between the needle ...


    pub_type: 杂志文章


    authors: Gilmour IJ,Holland R,Craig DB

    更新日期:1975-12-01 00:00:00

  • Sodium channel in human malignant hyperthermia.

    abstract:BACKGROUND:The abundance of a specific sodium channel subunit (SkM2) appeared to be altered in vitro in cell cultures from persons susceptible to malignant hyperthermia. This study sought to determine whether these findings are artifacts of cell culture or whether they may be relevant to malignant hyperthermia. METHOD...


    pub_type: 杂志文章


    authors: Fletcher JE,Wieland SJ,Karan SM,Beech J,Rosenberg H

    更新日期:1997-05-01 00:00:00

  • Perioperative Management of the Adult Patient on Venovenous Extracorporeal Membrane Oxygenation Requiring Noncardiac Surgery.

    abstract::The use of venovenous extracorporeal membrane oxygenation is increasing worldwide. These patients often require noncardiac surgery. In the perioperative period, preoperative assessment, patient transport, choice of anesthetic type, drug dosing, patient monitoring, and intraoperative and postoperative management of com...


    pub_type: 杂志文章,评审


    authors: Fierro MA,Daneshmand MA,Bartz RR

    更新日期:2018-01-01 00:00:00

  • Forebrain HCN1 channels contribute to hypnotic actions of ketamine.

    abstract:BACKGROUND:Ketamine is a commonly used anesthetic, but the mechanistic basis for its clinically relevant actions remains to be determined. The authors previously showed that HCN1 channels are inhibited by ketamine and demonstrated that global HCN1 knockout mice are twofold less sensitive to hypnotic actions of ketamine...


    pub_type: 杂志文章


    authors: Zhou C,Douglas JE,Kumar NN,Shu S,Bayliss DA,Chen X

    更新日期:2013-04-01 00:00:00