Halothane potentiates the antitumor activity of gamma-interferon and mimics calmodulin-blocking agents.


:This study reports effects of halothane on tumor cells in vitro. Cells from the human colon cancer cell line HT-29 were exposed to various concentrations of halothane for 8-72 h. The effect of this exposure on this colon cancer cell line, with and without coincubation with the biologic response modifier gamma-interferon (IFN-gamma), was studied. Using the tumor target cell survival (TTCS) assay, concentrations of halothane from 0.5 to 2% markedly augmented the antitumor activities of IFN-gamma against HT-29. The tumor cell cytostatic effects of IFN-gamma in the 0.75-6-unit/ml range were increased nearly 400% by concentrations of halothane as low as 1%. These results were confirmed in a separate cytolytic assay (Indium-111 release assay), which revealed that halothane concentrations in the 2-4% range markedly increased the cytolytic capacity of IFN-gamma at doses of IFN-gamma between 75 and 1,250 units/ml. The cytolytic activity of IFN-gamma was increased nearly 300% by doses of halothane as low as 1%. A nearly identical pattern of augmentation of IFN-gamma-induced antitumor activity was observed when the known calmodulin inhibitor trifluoperazine (TFP) was coincubated with IFN-gamma. At concentrations of 4-10 microM, the antitumor activity of IFN-gamma was increased nearly 400%. These observations suggest that the pattern of halothane potentiation of the antitumor activity of IFN-gamma is similar to that exhibited by known calmodulin inhibitors.






Rudnick S,Stevenson GW,Hall SC,Espinoza-Delgado I,Stevenson HC,Longo DL




Has Abstract


1991-01-01 00:00:00












  • A comparison of obstetric and nonobstetric anesthesia malpractice claims.

    abstract::Malpractice claims filed against anesthesiologists for care involving obstetric (OB) anesthesia (n = 190) were taken from the American Society of Anesthesiologists' Closed Claims Database and compared to claims not involving OB cases (n = 1351). The most common complications in the OB claims were (percentage of all OB...


    pub_type: 杂志文章


    authors: Chadwick HS,Posner K,Caplan RA,Ward RJ,Cheney FW

    更新日期:1991-02-01 00:00:00

  • Obesity in diabetic patients undergoing coronary artery bypass graft surgery is associated with increased postoperative morbidity.

    abstract:BACKGROUND:Despite the fact that obesity is a known risk factor for cardiovascular disease, many studies have failed to demonstrate that obesity is independently associated with an increased risk of cardiovascular morbidity and mortality in nondiabetic patients undergoing coronary artery bypass graft surgery. The autho...


    pub_type: 杂志文章


    authors: Pan W,Hindler K,Lee VV,Vaughn WK,Collard CD

    更新日期:2006-03-01 00:00:00

  • Development and feasibility of a scale to assess postoperative recovery: the post-operative quality recovery scale.

    abstract:BACKGROUND:Good postoperative recovery is increasingly recognized as an important outcome after surgery. The authors created a new Post-operative Quality Recovery Scale (PQRS) that tracks multiple domains of recovery from immediate to long-term time periods in patients of varying ages, languages, and cultures. METHODS...


    pub_type: 杂志文章


    authors: Royse CF,Newman S,Chung F,Stygall J,McKay RE,Boldt J,Servin FS,Hurtado I,Hannallah R,Yu B,Wilkinson DJ

    更新日期:2010-10-01 00:00:00

  • Local anesthetic properties of prenylamine.

    abstract:BACKGROUND:Local anesthetics that produce analgesia of long duration with minimal impairment of autonomic functions are highly desirable for pain management in the clinic. Prenylamine is a known calcium channel blocker, but its local anesthetic blocking effects on voltage-gated sodium channels have not been studied thu...


    pub_type: 杂志文章


    authors: Mujtaba MG,Gerner P,Wang GK

    更新日期:2001-11-01 00:00:00

  • Caudal epidural morphine for control of pain following open heart surgery in children.

    abstract::The safety and efficacy of epidural morphine injected into the caudal space for control of postoperative pain following open cardiac surgery in children was studied. Thirty-two children between the ages of 2-12 yr for whom early postoperative tracheal extubation was anticipated were randomly assigned to control and st...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rosen KR,Rosen DA

    更新日期:1989-03-01 00:00:00

  • Using process analysis to assess the impact of medical education on the delivery of pain services: a natural experiment.

    abstract:BACKGROUND:The medical, social, and economic effects of the teaching mission on delivery of care at an academic medical center (AMC) are not fully understood. When a free-standing private practice ambulatory clinic with no teaching mission was merged into an AMC, a natural experiment was created. The authors compared p...


    pub_type: 杂志文章


    authors: Williams KA,Chambers CG,Dada M,Hough D,Aron R,Ulatowski JA

    更新日期:2012-04-01 00:00:00

  • A focal cryogenic brain lesion does not reduce the minimum alveolar concentration for halothane in rats.

    abstract:BACKGROUND:A focal cortical cryogenic brain injury has been reported to reduce the brain pentobarbital concentrations needed to prevent movement in response to pain in rats. This occurred despite any apparent behavioral changes in the awake animals. To determine whether this was true with other anesthetics, the authors...


    pub_type: 杂志文章


    authors: Todd MM,Weeks JB,Warner DS

    更新日期:1993-07-01 00:00:00

  • The effect of halothane on the steady-state levels of high-energy phosphates in the neonatal heart.

    abstract::The neonatal heart is especially vulnerable to cardiac depression caused by halothane. The cause of this sensitivity is uncertain. Isolated, perfused, isovolumic, contracting neonatal rabbit hearts were studied using 31P NMR to determine whether changes in concentrations of high energy phosphates (HEP) or intracellula...


    pub_type: 杂志文章


    authors: McAuliffe JJ,Hickey PR

    更新日期:1987-08-01 00:00:00

  • Role of the O-linked β-N-acetylglucosamine in the cardioprotection induced by isoflurane.

    abstract:BACKGROUND:Cardiac protection by volatile anesthetic-induced preconditioning and ischemic preconditioning have similar signaling pathways. Recently, it was reported that augmentation of protein modified with O-linked β-N-acetylglucosamine (O-GlcNAc) contributes to cardiac protection. This study investigated the role of...


    pub_type: 杂志文章


    authors: Hirose K,Tsutsumi YM,Tsutsumi R,Shono M,Katayama E,Kinoshita M,Tanaka K,Oshita S

    更新日期:2011-11-01 00:00:00

  • Thiopental pharmacokinetics under conditions of long-term infusion.

    abstract::Thiopental was used in long-term infusion (3-4.5 mg . kg-1 . h-1 during 4-8 days) to protect the brain from injury following trauma. Thiopental plasma concentrations were measured during infusion (48 patients) and after infusion (14 patients) to determine the kinetics of the drug in continuous infusion. All mean value...


    pub_type: 杂志文章


    authors: Turcant A,Delhumeau A,Premel-Cabic A,Granry JC,Cottineau C,Six P,Allain P

    更新日期:1985-07-01 00:00:00

  • Differential effects of halothane and isoflurane on contractile force and calcium transients in cardiac Purkinje fibers.

    abstract:BACKGROUND:Halothane and isoflurane have been shown to differentially effect mechanisms of contraction in working myocardial fibers. The aim of this study was to compare effects of halothane and isoflurane on contractile force (CF) and Ca2+ transients in canine cardiac Purkinje fiber preparations. METHODS:Fiber prepar...


    pub_type: 杂志文章


    authors: Stowe DF,Sprung J,Turner LA,Kampine JP,Bosnjak ZJ

    更新日期:1994-06-01 00:00:00

  • Thermal balance and tremor patterns during epidural anesthesia.

    abstract::Five healthy, nonpregnant volunteers were studied before and after induction of lumbar epidural anesthesia to determine the cause of central hypothermia during epidural anesthesia. Cutaneous heat loss was measured from 10 area-weighted sites using thermal flux transducers. Oxygen consumption was measured and converted...


    pub_type: 杂志文章


    authors: Hynson JM,Sessler DI,Glosten B,McGuire J

    更新日期:1991-04-01 00:00:00

  • Effect of edrophonium and neostigmine on the pharmacokinetics and neuromuscular effects of mivacurium.

    abstract:BACKGROUND:Previous studies demonstrated that both edrophonium and neostigmine affect mivacurium's pharmacokinetics, thereby potentially affecting its recovery profile. However, those studies were not clinically relevant because mivacurium was still infused after the antagonists were given. In the present study, the au...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Szenohradszky J,Fogarty D,Kirkegaard-Nielsen H,Brown R,Sharma ML,Fisher DM

    更新日期:2000-03-01 00:00:00

  • A clinical grading scale to predict malignant hyperthermia susceptibility.

    abstract:BACKGROUND:The diagnosis of an acute malignant hyperthermia reaction by clinical criteria can be difficult because of the nonspecific nature and variable incidence of many of the clinical signs and laboratory findings. Development of a standardized means for estimating the qualitative likelihood of malignant hypertherm...


    pub_type: 杂志文章


    authors: Larach MG,Localio AR,Allen GC,Denborough MA,Ellis FR,Gronert GA,Kaplan RF,Muldoon SM,Nelson TE,Ording H

    更新日期:1994-04-01 00:00:00

  • Effects of halothane and isoflurane on hyperexcitability of spinal dorsal horn neurons after incision in the rat.

    abstract:BACKGROUND:The aim of this study was to determine whether halothane and isoflurane used during and after surgical injury attenuate subsequent hyperexcitability of spinal dorsal horn (SDH) neurons by preventing development of central sensitization. METHODS:Activity of a wide-dynamic-range neuron of the SDH was isolated...


    pub_type: 杂志文章


    authors: Kawamata M,Narimatsu E,Kozuka Y,Takahashi T,Sugino S,Niiya T,Namiki A

    更新日期:2005-01-01 00:00:00

  • Positive end-expiratory pressure ventilation elicits increases in endogenously formed nitric oxide as detected in air exhaled by rabbits.

    abstract:BACKGROUND:Nitric oxide (NO) formed from L-arginine is exhaled by mammals and regulates pulmonary vascular tone. Little is known about how its formation is stimulated. METHODS:The concentration of NO in exhaled air was monitored by chemiluminescence in pentobarbital-anesthetized rabbits receiving mechanical ventilatio...


    pub_type: 杂志文章


    authors: Persson MG,Lönnqvist PA,Gustafsson LE

    更新日期:1995-04-01 00:00:00

  • Isoflurane and nociception: spinal alpha2A adrenoceptors mediate antinociception while supraspinal alpha1 adrenoceptors mediate pronociception.

    abstract:BACKGROUND:The authors recently established that the analgesic actions of the inhalation anesthetic nitrous oxide were mediated by noradrenergic bulbospinal neurons and spinal alpha2B adrenoceptors. They now determined whether noradrenergic brainstem nuclei and descending spinal pathways are responsible for the antinoc...


    pub_type: 杂志文章


    authors: Kingery WS,Agashe GS,Guo TZ,Sawamura S,Davies MF,Clark JD,Kobilka BK,Maze M

    更新日期:2002-02-01 00:00:00

  • Low reticulocyte hemoglobin content is associated with a higher blood transfusion rate in critically ill patients: a cohort study.

    abstract:BACKGROUND:Intensive care unit (ICU) patients often need blood transfusion, but no reliable predictors of transfusion requirements are available at ICU admission. The authors hypothesized that ICU patients with functional iron deficiency may be at higher risk for developing anemia, requiring blood transfusion. Their ob...


    pub_type: 杂志文章


    authors: Fernandez R,Tubau I,Masip J,Muñoz L,Roig I,Artigas A

    更新日期:2010-05-01 00:00:00

  • Effects of volatile anesthetics on acetylcholine-induced relaxation in the rabbit mesenteric resistance artery.

    abstract:BACKGROUND:Vascular endothelium plays an important role in the regulation of vascular tone. Volatile anesthetics have been shown to attenuate endothelium-mediated relaxation in conductance arteries, such as aorta. However, significant differences in volatile anesthetic pharmacology between these large vessels and the s...


    pub_type: 杂志文章


    authors: Akata T,Nakashima M,Kodama K,Boyle WA 3rd,Takahashi S

    更新日期:1995-01-01 00:00:00

  • Alterations in the functional connectivity of frontal lobe networks preceding emergence delirium in children.

    abstract:BACKGROUND:This study aimed to characterize the electroencephalogram in children who emerged with emergence delirium (ED) compared with children without ED using methods that involved the assessment of cortical functional connectivity. METHODS:Children aged 5 to 15 yr had multichannel electroencephalographic recording...


    pub_type: 杂志文章


    authors: Martin JC,Liley DT,Harvey AS,Kuhlmann L,Sleigh JW,Davidson AJ

    更新日期:2014-10-01 00:00:00

  • AZD-3043: a novel, metabolically labile sedative-hypnotic agent with rapid and predictable emergence from hypnosis.

    abstract:BACKGROUND:Propofol can be associated with delayed awakening after prolonged infusion. The aim of this study was to characterize the preclinical pharmacology of AZD-3043, a positive allosteric modulator of the γ-aminobutyric acid type A (GABA(A)) receptor containing a metabolically labile ester moiety. The authors post...


    pub_type: 杂志文章


    authors: Egan TD,Obara S,Jenkins TE,Jaw-Tsai SS,Amagasu S,Cook DR,Steffensen SC,Beattie DT

    更新日期:2012-06-01 00:00:00

  • Clinician-delivered intervention to facilitate tobacco quitline use by surgical patients.

    abstract:BACKGROUND:Telephone quitlines that provide counseling support are efficacious in helping cigarette smokers quit and have been widely disseminated; currently, they are underused. Surgery represents a teachable moment for smoking cessation, which can benefit surgical outcomes; however, few surgical patients receive smok...


    pub_type: 杂志文章,随机对照试验


    authors: Warner DO,Klesges RC,Dale LC,Offord KP,Schroeder DR,Shi Y,Vickers KS,Danielson DR

    更新日期:2011-04-01 00:00:00

  • Flammability of endotracheal tubes during Nd-YAG laser application in the airway.

    abstract::The effects of the neodymium-yttrium aluminum garnet (Nd-YAG) laser on several commonly used endotracheal tubes were examined. Six different types of tubes were tested for flammability. Three tubes were clear, transparent polyvinylchloride with black lettering on the surface. One was yellow-green silicone rubber with ...


    pub_type: 杂志文章


    authors: Geffin B,Shapshay SM,Bellack GS,Hobin K,Setzer SE

    更新日期:1986-11-01 00:00:00

  • Direct evidence for the ongoing brain activation by enhanced dynorphinergic system in the spinal cord under inflammatory noxious stimuli.

    abstract:BACKGROUND:Dynorphin A in the spinal cord is considered to contribute to nociceptive stimuli. However, it has not yet been determined whether activation of the spinal dynorphinergic system under nociceptive stimuli plays a role in direct acceleration of the ascending nociceptive pathway. In this study, the authors inve...


    pub_type: 杂志文章


    authors: Taketa Y,Niikura K,Kobayashi Y,Furuya M,Shimizu T,Narita M,Imai S,Kuzumaki N,Maitani Y,Yamazaki M,Inada E,Iseki M,Suzuki T,Narita M

    更新日期:2010-02-01 00:00:00

  • Pulsus alternans during general anesthesia with halothane: effects of permissive hypercapnia.

    abstract:BACKGROUND:Pulsus alternans is a classic type of abnormal pulse. It can be defined as a regular alternation of pulse amplitude in which runs of weak and strong beats follow each other alternatively without any change in cycle length. It may be a sign of severe decompensated congestive heart failure. The authors infrequ...


    pub_type: 杂志文章


    authors: Saghaei M,Mortazavian M

    更新日期:2000-07-01 00:00:00

  • Electrophysiologic characteristics of large neurons in dorsal root ganglia during development and after hind paw incision in the rat.

    abstract:BACKGROUND:Withdrawal thresholds in the paw are lower in younger animals, and incision further reduces these thresholds. The authors hypothesized that these differences result in part from changes in intrinsic electrophysiologic properties of large neurons. METHODS:Using isolated whole dorsal root ganglion, current cl...


    pub_type: 杂志文章


    authors: Ririe DG,Liu B,Clayton B,Tong C,Eisenach JC

    更新日期:2008-07-01 00:00:00

  • Pulmonary uptake of propofol in cats. Effect of fentanyl and halothane.

    abstract:BACKGROUND:Many drugs are removed by the lung. The pulmonary uptake of one drug can be inhibited when a second, highly accumulated drug is administered parenterally or as a chronic oral treatment. The effect of inhalational anesthetics on pulmonary drug uptake has not been extensively studied and may alter pharmacokine...


    pub_type: 杂志文章


    authors: Matot I,Neely CF,Katz RY,Neufeld GR

    更新日期:1993-06-01 00:00:00

  • Monitoring hepatic venous hemoglobin oxygen saturation in patients undergoing liver surgery.

    abstract::Hepatic venous oxygen saturation (ShvO2) was continuously monitored in 33 consecutive patients undergoing hepatic lobectomy. Fiberoptic pulmonary artery catheters were inserted into the hepatic vein (HV) and in the pulmonary artery through the right internal jugular vein before anesthetic induction. The success rate a...


    pub_type: 杂志文章


    authors: Kainuma M,Fujiwara Y,Kimura N,Shitaokoshi A,Nakashima K,Shimada Y

    更新日期:1991-01-01 00:00:00

  • Intracuff pressure and tracheal morbidity: influence of filling with saline during nitrous oxide anesthesia.

    abstract:BACKGROUND:Diffusion of nitrous oxide into the cuff of the endotracheal tube results in an increase in cuff pressure. Excessive endotracheal tube cuff pressure may impair tracheal mucosal perfusion and cause tracheal damage and sore throat. Filling the cuff of the endotracheal tube with saline instead of air prevents t...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Combes X,Schauvliege F,Peyrouset O,Motamed C,Kirov K,Dhonneur G,Duvaldestin P

    更新日期:2001-11-01 00:00:00

  • Absence of abundant binding sites for anesthetics in rabbit brain: an in vivo NMR study.

    abstract::Using magnetic resonance spectroscopy, the authors tested whether cerebral concentrations of inhaled anesthetics do not increase proportionately at inspired concentrations exceeding 3% 1) because anesthetics bind to and saturate specific sites in the brain or 2) because anesthetic-induced depression of ventilation lim...


    pub_type: 杂志文章


    authors: Lockhart SH,Cohen Y,Yasuda N,Kim F,Litt L,Eger EI 2nd,Chang LH,James T

    更新日期:1990-09-01 00:00:00