Prothrombin Complex Concentrate Is Effective in Treating the Anticoagulant Effects of Dabigatran in a Porcine Polytrauma Model.

abstract：:The safety and efficacy of epidural morphine injected into the caudal space for control of postoperative pain following open cardiac surgery in children was studied. Thirty-two children between the ages of 2-12 yr for whom early postoperative tracheal extubation was anticipated were randomly assigned to control and st...

journal_title：Anesthesiology

authors： Rosen KR,Rosen DA

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:Liver damage by ischemia and reperfusion injury is a risk factor for morbidity and mortality after liver surgery. Postoperative oxygen treatment is routinely applied in the postanesthesia and intensive care unit after liver surgery. The risks of aggravating the injury by increasing inspiratory oxygen from 21...

journal_title：Anesthesiology

authors： Zangl Q,Martignoni A,Jackson SH,Ohta A,Klaunberg B,Kaufmann I,Lukashev D,Ward JM,Sitkovsky M,Thiel M,Choukèr A

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Because the nuclear factor-κB (NF-κB) coupled pathway is believed to amplify inflammation prevailing in sepsis, the authors tested the hypotheses that the insertion-deletion polymorphism (-94ins/delATTG) (1) alters nuclear translocation of nuclear factor-κB and activator protein-1 (NF-κB1) in monocytes after...

journal_title：Anesthesiology

authors： Adamzik M,Schäfer S,Frey UH,Becker A,Kreuzer M,Winning S,Frede S,Steinmann J,Fandrey J,Zacharowski K,Siffert W,Peters J,Hartmann M

更新日期：2013-01-01 00:00:00

abstract：:Complications after major surgery are a leading cause of morbidity and mortality. The etiology of postoperative complications is complex, but poor cardiorespiratory reserve appears to be a key factor. There is increasing interest in the use of central and mixed venous oxygen saturation to guide therapeutic interventio...

journal_title：Anesthesiology

authors： Shepherd SJ,Pearse RM

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Early acquisition of critical competencies by novice anesthesiology residents is essential for patient safety, but traditional training methods may be insufficient. The purpose of this study was to determine the effectiveness of high-fidelity simulation training of novice residents in the initial management ...

journal_title：Anesthesiology

authors： Park CS,Rochlen LR,Yaghmour E,Higgins N,Bauchat JR,Wojciechowski KG,Sullivan JT,McCarthy RJ

更新日期：2010-01-01 00:00:00

abstract：:Hepatic drug-metabolizing enzymes and hepatic ultrastructure were studied in rats after two hours of anesthesia with 1 MAC halothane or diethyl ether. Twelve hours after cessation of either anesthetic smooth endoplasmic reticulum was increased in centrilobular but not in periportal hepatocytes. This change persisted a...

journal_title：Anesthesiology

authors： Ross WT Jr,Cardell RR Jr

更新日期：1978-05-01 00:00:00

abstract：BACKGROUND:Endothelium-derived hyperpolarizing factor is thought to be a cytochrome P450-derived arachidonic acid metabolite that hyperpolarizes vascular smooth muscle cells by opening Ca(2+)-activated K+ channels (K+Ca channels). In the rabbit carotid artery both volatile and intravenous anesthetics inhibit the acetyl...

journal_title：Anesthesiology

authors： Kessler P,Lischke V,Hecker M

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:A high proportion of patients having cardiac bypass surgery receive erythrocyte transfusions. Decisions about when to transfuse patients having surgery for coronary artery disease may impact on erythrocyte utilization and patient morbidity and mortality. There are no published data about the factors that inf...

journal_title：Anesthesiology

authors： Shehata N,Wilson K,Mazer CD,Tomlinson G,Streiner D,Hebert P,Naglie G

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Acute respiratory distress syndrome (ARDS) is a devastating condition with an estimated mortality exceeding 30%. There are data suggesting risk factors for ARDS development in high-risk populations, but few data are available in lower incidence populations. Using risk-matched analysis and a combination of cl...

journal_title：Anesthesiology

authors： Blum JM,Stentz MJ,Dechert R,Jewell E,Engoren M,Rosenberg AL,Park PK

更新日期：2013-01-01 00:00:00

abstract：:Pulmonary shunting (Qs/Qt) was measured in 16 anesthetized and paralyzed healthy beagle puppies during a control period when the end-expired CO2 concentration was 5 per cent and during alveolar hypoventilation, when the PaCO2 increased to 100 plus or minus 13 torr (mean plus or minus SE) and the ;Ha vecame 7.04 plus o...

journal_title：Anesthesiology

authors： Stone JG,Sullivan SF

更新日期：1975-04-01 00:00:00

abstract：BACKGROUND:Hydroxyethyl starch (HES) is commonly used as plasma expander during surgery but may be nephrotoxic as seen in studies in patients with sepsis. The authors hypothesized that the possible nephrotoxicity of 6% HES 130/0.4 could be revealed by measurements of urinary excretion of neutrophil gelatinase-associate...

journal_title：Anesthesiology

authors： Kancir AS,Pleckaitiene L,Hansen TB,Ekeløf NP,Pedersen EB

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:The surface membrane Ca(2+)-adenosine triphosphatase and Na(+)-Ca(2+) exchanger transport Ca(2+) out of the ventricular myocyte, competing for cytosolic Ca(2+) with the Ca(2+)-adenosine triphosphatase located in the sarcoplasmic reticulum. In this study the authors examined the effects of halothane, isoflura...

journal_title：Anesthesiology

authors： Hannon JD,Cody MJ

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Clonidine produces analgesia after spinal injection by activating alpha2-adrenergic receptors. Recently, clonidine has been demonstrated to increase spinal release of norepinephrine (NE) in vivo, in contrast to that anticipated by classic presynaptic autoinhibition. The purpose of the current study was to de...

journal_title：Anesthesiology

authors： Li X,Zhao Z,Pan HL,Eisenach JC,Paqueron X

更新日期：2000-07-01 00:00:00

abstract：:Liver surgery is often accompanied by hepatic hypoperfusion and hypoxia, and it is controversial whether catecholamines increase hepatic blood flow and oxygen supply. The effects of 3 micrograms.kg-1.min-1 dobutamine on hepatic circulation and oxygen balance were examined in patients anesthetized with enflurane, nitro...

journal_title：Anesthesiology

authors： Kainuma M,Kimura N,Nonami T,Kurokawa T,Ito T,Nakashima K,Shimada Y

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Factor VII is the most affected clotting factor during the early phase of warfarin therapy. An international normalized ratio (INR) of more than 1.4 is considered unsafe for epidural catheter placement or removal, according to the American Society of Regional Anesthesia and Pain Medicine. The authors tested ...

journal_title：Anesthesiology

authors： Benzon HT,Avram MJ,Benzon HA,Kirby-Nolan M,Nader A

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:A combination of opioid and nonopioid analgesic drugs may improve the quality of postoperative analgesia as well as reduce opioid requirements and their associated side effects. Studies have shown synergism between gabapentin and morphine in animal and human experiments and in the treatment of incisional pai...

journal_title：Anesthesiology

authors： Turan A,Karamanlioğlu B,Memiş D,Hamamcioglu MK,Tükenmez B,Pamukçu Z,Kurt I

更新日期：2004-04-01 00:00:00

abstract：:The inhibitory effects of three inhalation anesthetics, i.e., halothane, enflurane, and isoflurane, on superoxide production and the intracellular mobilization of calcium in human neutrophils were studied. The superoxide production induced by N-formyl-methionyl-leucyl-phenylalanine (FMLP) was inhibited by the anesthet...

journal_title：Anesthesiology

authors： Nakagawara M,Takeshige K,Takamatsu J,Takahashi S,Yoshitake J,Minakami S

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Available treatments for neuropathic pain have modest efficacy and significant adverse effects, including abuse potential. Because oxidative stress is a key mechanistic node for neuropathic pain, the authors focused on the master regulator of the antioxidant response-nuclear factor erythroid 2-related factor...

journal_title：Anesthesiology

authors： Li J,Ma J,Lacagnina MJ,Lorca S,Odem MA,Walters ET,Kavelaars A,Grace PM

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Awake tracheal intubation may evoke reflex bronchoconstriction in asthmatics. Whether this effect is altered by the choice of the local anesthetic used or by pretreatment with a beta2-adrenoceptor agonist is unknown. Therefore, we assessed the effect of awake fiberoptic intubation after lidocaine or dyclonin...

journal_title：Anesthesiology

authors： Groeben H,Schlicht M,Stieglitz S,Pavlakovic G,Peters J

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Although noninvasive blood pressure (NIBP) monitoring during anesthesia is a standard of care, reference ranges for blood pressure in anesthetized children are not available. We developed sex- and age-specific reference ranges for NIBP in children during anesthesia and surgery. METHODS:In this retrospective...

journal_title：Anesthesiology

authors： de Graaff JC,Pasma W,van Buuren S,Duijghuisen JJ,Nafiu OO,Kheterpal S,van Klei WA

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:In spinal anesthesia, often a large interindividual variability in analgesic response is observed after administration of a certain fixed dose of anesthetic to a patient population. To improve therapeutic outcome it is important to characterize the variability in response by means of a population model (e.g....

journal_title：Anesthesiology

authors： Schnider TW,Minto CF,Bruckert H,Mandema JW

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Lamotrigine inhibits glutamate release through the preferential blockade of voltage-dependent Na+ channels. In contrast, morphine reduces release of excitatory amino acids through the activation of opioid receptors and also inhibits tetrodotoxin-resistant Na+ channels on peripheral afferent neurons. The curr...

journal_title：Anesthesiology

authors： Argüelles CF,Torres-López JE,Granados-Soto V

更新日期：2002-04-01 00:00:00

abstract：:Malpractice claims filed against anesthesiologists for care involving obstetric (OB) anesthesia (n = 190) were taken from the American Society of Anesthesiologists' Closed Claims Database and compared to claims not involving OB cases (n = 1351). The most common complications in the OB claims were (percentage of all OB...

journal_title：Anesthesiology

authors： Chadwick HS,Posner K,Caplan RA,Ward RJ,Cheney FW

更新日期：1991-02-01 00:00:00

abstract：:This study examined whether pain or stress can enhance the analgesic effects of spinally administered opiates. The experiments determined the effects of mechanically produced pain and of the stress of being restrained on the analgesic effects of 0.63 microgram of epidural sufentanil in rats using a tail-withdrawal pro...

journal_title：Anesthesiology

authors： Van den Hoogen RH,Bervoets K,Colpaert FC

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:This propensity score-matched cohort study evaluates the effect of anesthetic technique on a 30-day mortality after total hip or knee arthroplasty. METHODS:All patients who had hip or knee arthroplasty between January 1, 2003, and December 31, 2014, were evaluated. The principal exposure was spinal versus g...

journal_title：Anesthesiology

authors： Perlas A,Chan VW,Beattie S

更新日期：2016-10-01 00:00:00

abstract：:The metabolism of alfentanil was studied in three healthy subjects after a 1-h infusion of 2.5 mg alfentanil-3H. One of the subjects was a poor hydroxylator of debrisoquine. Pharmacokinetic parameters were similar in the three subjects and were in the same range as those reported for volunteers. The majority of the ad...

journal_title：Anesthesiology

authors： Meuldermans W,Van Peer A,Hendrickx J,Woestenborghs R,Lauwers W,Heykants J,Vanden Bussche G,Van Craeyvelt H,Van der Aa P

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND:Ethical conduct in human research in anesthesia includes approval by an institutional review board (IRB) or ethics committee and informed consent. Evidence of these is sometimes lacking in journal publications. METHODS:The authors reviewed all publications involving human subjects in six leading anesthesia ...

journal_title：Anesthesiology

authors： Myles PS,Tan N

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Anesthetic potency is assessed by determination of the anesthetic concentration that prevents gross, purposeful movement in response to noxious stimulation. It is unclear whether anesthetics cause a progressive decrease in the number and force of limb movements evoked by noxious stimulation, or a step decrea...

journal_title：Anesthesiology

authors： Antognini JF,Wang XW,Carstens E

更新日期：1999-10-01 00:00:00

abstract：:Measurement of serum fentanyl and alfentanil concentrations by radioimmunoassay (RIA) may result in significant errors and high variability when the technique described in the available fentanyl and alfentanil RIA kits is used. The authors found a 29-94% overestimation of measured fentanyl and alfentanil serum levels ...

journal_title：Anesthesiology

authors： Schüttler J,White PF

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Volatile anesthetics (VAs) have been found to induce a delayed protective response called preconditioning to subsequent hypoxic/ischemic injury. VA preconditioning has been primarily studied in canine and rodent heart. A more genetically tractable model of VA preconditioning would be extremely useful. Here, ...

journal_title：Anesthesiology

authors： Jia B,Crowder CM

更新日期：2008-03-01 00:00:00