Proliferation of smooth endoplasmic reticulum and induction of microsomal drug-metabolizing enzymes after ether or halothane.

abstract：BACKGROUND:While electroconvulsive therapy is widely regarded as a lifesaving and safe procedure, evidence regarding its effects on myocardial cell injury is sparse. The objective of this investigation was to determine the incidence and magnitude of new cardiac troponin elevation after electroconvulsive therapy using a...

journal_title：Anesthesiology

authors： Duma A,Pal S,Johnston J,Helwani MA,Bhat A,Gill B,Rosenkvist J,Cartmill C,Brown F,Miller JP,Scott MG,Sanchez-Conde F,Jarvis M,Farber NB,Zorumski CF,Conway C,Nagele P

更新日期：2017-04-01 00:00:00

abstract：:Volatile anesthetics inhibit phagocytic cell function, yet little is known about their effects on target tissues or on the target tissue response to stimulated phagocytes. Experiments were performed to determine how exposure to halothane and isoflurane changes rat pulmonary artery endothelial cell (RPAEC) viability in...

journal_title：Anesthesiology

authors： Shayevitz JR,Varani J,Ward PA,Knight PR

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Serious complications related to regional anesthesia have previously been described primarily in case reports and retrospective surveys. The authors prospectively evaluated a multicenter series of regional anesthetics, using preplanned criteria to measure the incidence and characteristics of associated serio...

journal_title：Anesthesiology

authors： Auroy Y,Narchi P,Messiah A,Litt L,Rouvier B,Samii K

更新日期：1997-09-01 00:00:00

abstract：:Groups of rats were exposed to air or 80 per cent nitrous oxide for 30 min or 18 h, following which the brainstem opiate receptor density and the apparent affinity of these receptors to the radiolabeled agonist, 3H-dihydromorphine, were assayed, Thirty-minute exposure to nitrous oxide did not change opiate receptor ch...

journal_title：Anesthesiology

authors： Ngai SH,Finck AD

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND:The incidence of awareness has been reported to be higher in children than in adults. Accurately assessing awareness in children is difficult, and the lack of a specific measure of awareness makes it difficult to determine exactly how many and why children are aware. The aim of this study was to determine th...

journal_title：Anesthesiology

authors： Davidson AJ,Sheppard SJ,Engwerda AL,Wong A,Phelan L,Ironfield CM,Stargatt R

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Anesthesia during the synaptogenic period induces dendritic spine formation, which may affect neurodevelopment. The authors, therefore, evaluated whether changes in synaptic transmission after dendritic spine formation induced by sevoflurane were associated with long-term behavioral changes. The effects of s...

journal_title：Anesthesiology

authors： Chung W,Ryu MJ,Heo JY,Lee S,Yoon S,Park H,Park S,Kim Y,Kim YH,Yoon SH,Shin YS,Lee WH,Ju X,Kweon GR,Ko Y

更新日期：2017-02-01 00:00:00

abstract：:Premedication with diazepam, hydroxyzine or secobarbital significantly increased ketamine-induced sleep time (137 +/- 3.5 min, 135 +/- 9.2 min, 128 +/- 4.7 min) over that of unpremedicated controls (98.5 +/- 4.4 min) in man. The corresponding mean plasma half-lives (t1/2) of ketamine were longer in patients premedicat...

journal_title：Anesthesiology

authors： Lo JN,Cumming JF

更新日期：1975-09-01 00:00:00

abstract：BACKGROUND:Awareness during anesthesia is foremost assessed with postoperative interviews, which may underestimate its incidence. On-line monitors such as the Bispectral Index and patient response to verbal command are not necessarily commonly used. This study investigated response to command during deep sedation (Bisp...

journal_title：Anesthesiology

authors： Kerssens C,Klein J,Bonke B

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Studies have shown that long-term increase in the excitability of single wide dynamic range neurones in the spinal dorsal horn of rats may be induced after tetanic stimulation to the sciatic nerve. This sensory event is possibly an in vivo counterpart of long-term potentiation, described in the brain. This s...

journal_title：Anesthesiology

authors： Rygh LJ,Green M,Athauda N,Tjølsen A,Dickenson AH

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:In an effort to measure and improve the quality of perioperative care, the Surgical Care Improvement Project (SCIP) was introduced in 2003. The SCIP guidelines are evidence-based process measures designed to reduce preventable morbidity, but it remains to be determined whether SCIP-measure compliance is asso...

journal_title：Anesthesiology

authors： Scott AV,Stonemetz JL,Wasey JO,Johnson DJ,Rivers RJ,Koch CG,Frank SM

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Renal and hepatic toxicity of the fluorinated ether volatile anesthetics is caused by biotransformation to toxic metabolites. Metabolism also contributes significantly to the elimination pharmacokinetics of some volatile agents. Although innumerable studies have explored anesthetic metabolism in animals, the...

journal_title：Anesthesiology

authors： Kharasch ED,Thummel KE

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Remifentanil anesthesia enhances postoperative pain in animals and humans. The authors evaluated the impact of the dose (microg x kg(-1) x min(-1)) and duration of remifentanil infusion, and the effects of a second surgery on postoperative pain sensitization. METHODS:Mice received different doses of remifen...

journal_title：Anesthesiology

authors： Cabañero D,Campillo A,Célérier E,Romero A,Puig MM

更新日期：2009-12-01 00:00:00

abstract：:Eighty-six patients undergoing coronary artery bypass graft (n = 63) or intracardiac (n = 23) surgery were randomly assigned with respect to the target value for PaCO2 during cardiopulmonary bypass. In 44 patients the target PaCO2 was 40 mmHg, measured at the standard electrode temperature of 37 degrees C, while in 42...

journal_title：Anesthesiology

authors： Bashein G,Townes BD,Nessly ML,Bledsoe SW,Hornbein TF,Davis KB,Goldstein DE,Coppel DB

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Differentiating drug-related changes and state-related changes on the electroencephalogram during anesthetic-induced unconsciousness has remained a challenge. To distinguish these, we designed a rigorous experimental protocol with two drugs known to have distinct molecular mechanisms of action. We hypothesiz...

journal_title：Anesthesiology

authors： Scheinin A,Kallionpää RE,Li D,Kallioinen M,Kaisti K,Långsjö J,Maksimow A,Vahlberg T,Valli K,Mashour GA,Revonsuo A,Scheinin H

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Establishment of early oral nutrition after surgery is associated with a decrease in morbidity and mortality. The following studies were undertaken to determine how surgery influences food-reinforced behavior in rats and to determine the relevance of afferent input from the incision site on this behavior. M...

journal_title：Anesthesiology

authors： Martin TJ,Kahn WR,Eisenach JC

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Mechanical ventilation is crucial for patients with respiratory failure. The mechanical takeover of diaphragm function leads to diaphragm dysfunction and atrophy (ventilator-induced diaphragmatic dysfunction), with an increase in oxidative stress as a major contributor. In most patients, a sedative regimen h...

journal_title：Anesthesiology

authors： Bruells CS,Maes K,Rossaint R,Thomas D,Cielen N,Bergs I,Bleilevens C,Weis J,Gayan-Ramirez G

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Pulmonary function is impaired during pneumoperitoneum mainly as a result of atelectasis formation. We studied the effects of 10 cm H2O of positive end-expiratory pressure (PEEP) and PEEP followed by a recruitment maneuver (PEEP+RM) on end-expiratory lung volume (EELV), oxygenation and respiratory mechanics ...

journal_title：Anesthesiology

authors： Futier E,Constantin JM,Pelosi P,Chanques G,Kwiatkoskwi F,Jaber S,Bazin JE

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Transcranial motor-evoked potentials (TcMEPs) monitor spinal cord motor tract integrity. Using a swine model, the authors studied the effects of vasodilatory hypotension, hemorrhage, and various resuscitation efforts on TcMEP responses. METHODS:Twelve pigs were anesthetized with constant infusions of propof...

journal_title：Anesthesiology

authors： Lieberman JA,Feiner J,Lyon R,Rollins MD

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Optimal analgesia for total knee arthroplasty remains challenging. Many modalities have been used, including peripheral nerve block, periarticular infiltration, and epidural analgesia. However, the relative efficacy of various modalities remains unknown. The authors aimed to quantify and rank order the effic...

journal_title：Anesthesiology

authors： Terkawi AS,Mavridis D,Sessler DI,Nunemaker MS,Doais KS,Terkawi RS,Terkawi YS,Petropoulou M,Nemergut EC

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Victims of organophosphate intoxication with cholinergic crisis may have need for sedation and anesthesia, but little is known about how anesthetics work in these patients. Recent studies suggest that cholinergic stimulation impairs gamma-aminobutyric acid type A (GABAA) receptor function. Because GABAA rece...

journal_title：Anesthesiology

authors： Grasshoff C,Drexler B,Hentschke H,Thiermann H,Antkowiak B

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Traditional strategies for myofascial pain relief provide transient, incomplete, variable, or unpredictable outcomes. Botulinum toxin is itself an analgesic but can also cause sustained muscular relaxation, thereby possibly affording even greater relief than traditional therapies. METHODS:The study goal was...

journal_title：Anesthesiology

authors： Ferrante FM,Bearn L,Rothrock R,King L

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:The spinal cord appears to be the site at which isoflurane suppresses movement that occurs in response to a noxious stimulus. In an attempt to localize its site of suppressant action, the authors determined the effect of isoflurane on dorsal horn neuronal responses to supramaximal noxious stimulation at end-...

journal_title：Anesthesiology

authors： Antognini JF,Carstens E

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:The authors hypothesized that myoclonus after etomidate is dose-related, could be suppressed when small doses of etomidate were administered before induction, and is unassociated with seizure-like activity on electroencephalogram (EEG). METHODS:Three studies were performed. In the first study, 36 men were r...

journal_title：Anesthesiology

authors： Doenicke AW,Roizen MF,Kugler J,Kroll H,Foss J,Ostwald P

更新日期：1999-01-01 00:00:00

abstract：:Halothane-induced lipid peroxidation was studied in microsomes from phenobarbital-pretreated male rats at defined steady state oxygen partial pressures (PO2). At PO2 less than 10 mmHg on addition of halothane to NADPH-reduced microsomes, significant increases in malondialdehyde (MDA) formation, oxygen uptake, and conj...

journal_title：Anesthesiology

authors： de Groot H,Noll T

更新日期：1985-01-01 00:00:00

abstract：:Ropivacaine is an amide local anesthetic structurally related to, but appearing less cardiotoxic, than bupivacaine. The authors' investigation was designed in a randomized, double-blind fashion to compare the clinical effectiveness of ropivacaine and bupivacaine in patients undergoing lower-extremity surgery. Forty-fi...

journal_title：Anesthesiology

authors： Brown DL,Carpenter RL,Thompson GE

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:The dose-response relation for spinal ropivacaine is undetermined, and there are few data available for obstetric patients. METHODS:In a prospective, randomized, double-blind investigation, the authors studied 72 patients undergoing elective cesarean delivery. An epidural catheter was placed at the L2-L3 ve...

journal_title：Anesthesiology

authors： Khaw KS,Ngan Kee WD,Wong EL,Liu JY,Chung R

更新日期：2001-12-01 00:00:00

abstract：:To evaluate the effect of aging on the distribution, metabolism, and neuromuscular junction sensitivity to pancuronium and vecuronium, the authors determined the pharmacokinetics and pharmacodynamics of these drugs in 12 healthy elderly subjects (70-84 yr) and 12 young adults (30-57 yr) during halothane-nitrous oxide ...

journal_title：Anesthesiology

authors： Rupp SM,Castagnoli KP,Fisher DM,Miller RD

更新日期：1987-07-01 00:00:00

abstract：:The authors undertook a prospective study of 30 patients undergoing halothane anesthesia for coronary-artery revascularization to ascertain which clinically monitored hemodynamic variables--or combination of variables--associated with myocardial oxygen supply and demand best predict myocardial ischemia. Simultaneous r...

journal_title：Anesthesiology

authors： Lieberman RW,Orkin FK,Jobes DR,Schwartz AJ

更新日期：1983-07-01 00:00:00

abstract：:Chloroprocaine, 0.5 per cent, with physiologic saline solution, has a specific gravity of 1.007 and a osmolarity of 283 mOsm/l, which increase to a specific gravity of 1.025 and an osmolarity of 542 mOsm/l when chloroprocaine is prepared in dextrose, 5 per cent. Chloroprocaine, 2.7 per cent, shows similar increases in...

journal_title：Anesthesiology

authors： Park YR,Eastwood DW

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND:Animal models of ventilator-associated pneumonia (VAP) in primates, sheep, and pigs differ in the underlying pulmonary injury, etiology, bacterial inoculation methods, and time to onset. The most common ovine and porcine models do not reproduce the primary pathogenic mechanism of the disease, through the asp...

journal_title：Anesthesiology

authors： Li Bassi G,Rigol M,Marti JD,Saucedo L,Ranzani OT,Roca I,Cabanas M,Muñoz L,Giunta V,Luque N,Rinaudo M,Esperatti M,Fernandez-Barat L,Ferrer M,Vila J,Ramirez J,Torres A

更新日期：2014-05-01 00:00:00