Inhibition of superoxide production and Ca2+ mobilization in human neutrophils by halothane, enflurane, and isoflurane.

abstract：:Five healthy, nonpregnant volunteers were studied before and after induction of lumbar epidural anesthesia to determine the cause of central hypothermia during epidural anesthesia. Cutaneous heat loss was measured from 10 area-weighted sites using thermal flux transducers. Oxygen consumption was measured and converted...

journal_title：Anesthesiology

authors： Hynson JM,Sessler DI,Glosten B,McGuire J

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Propofol may produce amnesia by affecting encoding. The hypothesis that propofol weakens encoding was tested by measuring regional cerebral blood flow during verbal encoding. METHODS:Seventeen volunteer participants (12 men; aged 30.4 +/- 6.5 yr) had regional cerebral blood flow measured using H2O positron ...

journal_title：Anesthesiology

authors： Veselis RA,Pryor KO,Reinsel RA,Mehta M,Pan H,Johnson R Jr

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Intrathecal sufentanil (ITS) is frequently used to provide analgesia during labor. Decreases in blood pressure and sensory changes in this circumstance suggest that ITS may have a local anesthetic effect and thus cause a sympathectomy. To determine whether ITS given to laboring women causes a sympathectomy, ...

journal_title：Anesthesiology

authors： Riley ET,Walker D,Hamilton CL,Cohen SE

更新日期：1997-10-01 00:00:00

abstract：:This study was performed to determine if direct arterial dilating actions of propofol contribute to the drug's hypotensive actions. The effects of propofol were compared with those of thiopental on isolated vascular ring preparations from rat thoracic aorta and pulmonary artery. Thoracic aortic ring responses were eva...

journal_title：Anesthesiology

authors： Park WK,Lynch C 3rd,Johns RA

更新日期：1992-11-01 00:00:00

abstract：:Critically ill patients must often breathe spontaneously through an endotracheal tube that acts as a fixed inspiratory and expiratory tubular airway resistor. Although this practice is common, its effect on the pattern of breathing is not known. The mean breathing patterns of seven normal, healthy male subjects and ei...

journal_title：Anesthesiology

authors： Weissman C,Askanazi J,Rosenbaum SH,Damask MC,Hyman AI,Kinney JM

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Because patients may be taking clonidine chronically or may be receiving it as a premedication before surgery, the authors investigated its effect on cerebral hemodynamics. METHODS:In nine volunteers, middle cerebral artery mean blood flow velocity (Vm) was measured using transcranial Doppler ultrasonograph...

journal_title：Anesthesiology

authors： Lee HW,Caldwell JE,Dodson B,Talke P,Howley J

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Volatile anesthetics inhibit presynaptic voltage-gated sodium channels to reduce neurotransmitter release, but their effects on excitatory neuron excitability by sodium current inhibition are unclear. The authors hypothesized that inhibition of transient and persistent neuronal sodium currents by the volatil...

journal_title：Anesthesiology

authors： Zhao W,Zhang M,Liu J,Liang P,Wang R,Hemmings HC,Zhou C

更新日期：2019-07-01 00:00:00

abstract：:To assess depth of anesthesia for intravenous anesthetics using clinical stimuli and observed responses, it is necessary to achieve constant serum concentrations of drug that result in constant biophase or central nervous system concentrations. The goal of this investigation was to use a computer-controlled infusion p...

journal_title：Anesthesiology

authors： Bührer M,Maitre PO,Hung OR,Ebling WF,Shafer SL,Stanski DR

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Macrophage recruitment into atherosclerotic plaques drives lesion progression, destabilization, and rupture. Chronic statin treatment reduces macrophage plaque content. Information on dynamics of macrophage recruitment would help assessing plaque vulnerability and guiding therapy. Techniques to image macroph...

journal_title：Anesthesiology

authors： Larmann J,Frenzel T,Schmitz M,Hahnenkamp A,Demmer P,Immenschuh S,Tietge UJ,Bremer C,Theilmeier G

更新日期：2013-07-01 00:00:00

abstract：:The effects of morphine, halothane, and their various combinations on the purposeful movement (PM) response and the heart rate (HR) increase caused by noxious stimulation were studied in 250 rat experiments. Doses that block the PM and HR responses for the single agent and for combinations were determined with a probi...

journal_title：Anesthesiology

authors： Kissin I,Kerr CR,Smith LR

更新日期：1984-06-01 00:00:00

abstract：:The effect of neuromuscular blockade with vecuronium on the hemodynamic responses to a noxious stimulus was investigated in male Sprague-Dawley rats. The rats were anesthetized with either halothane (group 1, n = 10), or isoflurane (group 2, n = 10). The maximum values for heart rate and mean arterial pressure during ...

journal_title：Anesthesiology

authors： Gibbs NM,Larach DR,Schuler HG

更新日期：1989-08-01 00:00:00

abstract：:Anesthesia and surgery are a risk for all, the healthy as well as the sick. While the prevention of adverse outcomes in healthy patients is paramount, enhancement of safety for critically ill patients is also essential, since they are more likely to suffer a SNO after a critical incident. Dangers originate from a vari...

journal_title：Anesthesiology

authors： Gaba DM,Maxwell M,DeAnda A

更新日期：1987-05-01 00:00:00

abstract：:Administration of the oxidant lipid peroxide tertiary butyl hydroperoxide (t-bu-OOH) in the isolated rabbit lung leads to acute pulmonary vasoconstriction, which is caused by the synthesis of thromboxane. The inhalational anesthetics, halothane, nitrous oxide, and cyclopropane, markedly enhance t-bu-OOH-induced pulmon...

journal_title：Anesthesiology

authors： McShane AJ,Crowley K,Shayevitz JR,Michael JR,Adkinson NF Jr,Traystman RJ,Gurtner GH

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Acute lung injury (ALI) is a serious postoperative complication with limited treatment options. A preoperative risk-prediction model would assist clinicians and scientists interested in ALI. The objective of this investigation was to develop a surgical lung injury prediction (SLIP) model to predict risk of p...

journal_title：Anesthesiology

authors： Kor DJ,Warner DO,Alsara A,Fernández-Pérez ER,Malinchoc M,Kashyap R,Li G,Gajic O

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Whether intraoperative use of hydroxyethyl starch impairs kidney function remains unknown. The authors thus tested the primary hypothesis that Hextend promotes renal injury in surgical patients. Secondarily, the authors evaluated the dose-outcome relationship, in-hospital and 90-day mortality, and whether th...

journal_title：Anesthesiology

authors： Kashy BK,Podolyak A,Makarova N,Dalton JE,Sessler DI,Kurz A

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Reversal of residual neuromuscular blockade by acetylcholinesterase inhibitors (e.g., neostigmine) improves respiratory function. However, neostigmine may also impair muscle strength. We hypothesized that neostigmine administered after recovery of the train-of-four (TOF) ratio impairs upper airway integrity ...

journal_title：Anesthesiology

authors： Herbstreit F,Zigrahn D,Ochterbeck C,Peters J,Eikermann M

更新日期：2010-12-01 00:00:00

abstract：UNLABELLED:BACKGROUND. Injection of local anesthetic into cerebrospinal fluid (CSF) produces anesthesia of unpredictable extent and duration. Although many factors have been identified that affect the extent of spinal anesthesia, correlations are relatively poor and the extent of spread remains unpredictable. This stud...

journal_title：Anesthesiology

authors： Carpenter RL,Hogan QH,Liu SS,Crane B,Moore J

更新日期：1998-07-01 00:00:00

abstract：:We performed a prospective randomized controlled trial to assess the efficacy of a chlorhexidine dressing in reducing the microbial flora at the insertion site of epidural catheters. These catheters were used for acute pain management and were dressed either by a standardized method or with a CHX/urethane sponge compo...

journal_title：Anesthesiology

authors： Shapiro JM,Bond EL,Garman JK

更新日期：1990-10-01 00:00:00

abstract：:Cardiac arrest causes a rapid loss of cerebral adenosine triphosphate [corrected] (ATP) and a decrease in cerebral intracellular pH (pHi). Depending on the efficacy of cardiopulmonary resuscitation (CPR), cerebral blood flow levels (CBF) ranging from near zero to near normal have been reported experimentally. Using 31...

journal_title：Anesthesiology

authors： Eleff SM,Schleien CL,Koehler RC,Shaffner DH,Tsitlik J,Halperin HR,Rogers MC,Traystman RJ

更新日期：1992-01-01 00:00:00

abstract：:Some previous reports indicate that the excitability of the brain may be increased for days following enflurane anesthesia. The authors investigated this possibility in cats by determining whether or not pentylenetetrazol- (Metrazol) or lidocaine-seizure thresholds decreased after repeated enflurane exposure. The lido...

journal_title：Anesthesiology

authors： Heavner JE,Amory DW

更新日期：1981-05-01 00:00:00

abstract：BACKGROUND:Ca is the dominant second messenger in primary sensory neurons. In addition, disrupted Ca signaling is a prominent feature in pain models involving peripheral nerve injury. Standard cytoplasmic Ca recording techniques use high K or field stimulation and dissociated neurons. To compare findings in intact dors...

journal_title：Anesthesiology

authors： Gemes G,Rigaud M,Koopmeiners AS,Poroli MJ,Zoga V,Hogan QH

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Excessive bleeding often occurs during pediatric scoliosis surgery and is attributed to numerous factors, including accelerated fibrinolysis. The authors hypothesized that administration of tranexamic acid would reduce bleeding and transfusion requirements during scoliosis surgery. METHODS:Forty-four patien...

journal_title：Anesthesiology

authors： Sethna NF,Zurakowski D,Brustowicz RM,Bacsik J,Sullivan LJ,Shapiro F

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Chronic use of μ-opioid receptor agonists paradoxically causes both hyperalgesia and the loss of analgesic efficacy. Opioid treatment increases presynaptic N-methyl-D-aspartate receptor activity to potentiate nociceptive input to spinal dorsal horn neurons. However, the mechanism responsible for this opioid-...

journal_title：Anesthesiology

authors： Deng M,Chen SR,Chen H,Pan HL

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:A recent model of acute incisional pain has been characterized that strongly parallels the postoperative period in patients experiencing evoked pain. In that setting, abundant literature has revealed antihypersensitive effects produced by intrathecally administered alpha2-adrenergic receptor agonists, such a...

journal_title：Anesthesiology

authors： Duflo F,Boselli E,Ryvlin P,Chassard D

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Hyperkalemic cardiac arrest after the administration of succinylcholine (SCh) to critically ill intensive care patients has been attributed to changes in the acetylcholine receptors (AChRs) at the muscle membrane. The current study attempts to characterize the contributory roles of chronic administration of ...

journal_title：Anesthesiology

authors： Yanez P,Martyn JA

更新日期：1996-02-01 00:00:00

abstract：:Ropivacaine is an amide local anesthetic structurally related to, but appearing less cardiotoxic, than bupivacaine. The authors' investigation was designed in a randomized, double-blind fashion to compare the clinical effectiveness of ropivacaine and bupivacaine in patients undergoing lower-extremity surgery. Forty-fi...

journal_title：Anesthesiology

authors： Brown DL,Carpenter RL,Thompson GE

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:Protamine causes multiple adverse reactions. Heparinase I, a specific enzyme that inactivates heparin, is a possible alternative to protamine. In this study, the authors examined the efficacy of heparinase I to reverse heparin-induced anticoagulation in vitro and compared heparinase I to protamine as an anta...

journal_title：Anesthesiology

authors： Michelsen LG,Kikura M,Levy JH,Lee MK,Lee KC,Zimmermann JJ,Szlam F

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Intrathecal administration of opioids may cause lower urinary tract dysfunction. In this study, the authors compared the effects of morphine and sufentanil administered intrathecally in a randomized double-blind fashion (two doses each) on lower urinary tract function in healthy male volunteers. METHODS:Uro...

journal_title：Anesthesiology

authors： Kuipers PW,Kamphuis ET,van Venrooij GE,van Roy JP,Ionescu TI,Knape JT,Kalkman CJ

更新日期：2004-06-01 00:00:00

abstract：:The effect of liposome encapsulation on the analgesia produced by intrathecally administered alfentanil was examined in the rat. In rats prepared with chronic intrathecal catheters, alfentanil in doses of 1-50 micrograms was administered intrathecally in either saline or in multilamellar liposomes (dipalmitoylphosphat...

journal_title：Anesthesiology

authors： Bernards CM,Luger TJ,Malmberg AB,Hill HF,Yaksh TL

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Anesthetic potency is assessed by determination of the anesthetic concentration that prevents gross, purposeful movement in response to noxious stimulation. It is unclear whether anesthetics cause a progressive decrease in the number and force of limb movements evoked by noxious stimulation, or a step decrea...

journal_title：Anesthesiology

authors： Antognini JF,Wang XW,Carstens E

更新日期：1999-10-01 00:00:00