Effects of propofol and thiopental in isolated rat aorta and pulmonary artery.


:This study was performed to determine if direct arterial dilating actions of propofol contribute to the drug's hypotensive actions. The effects of propofol were compared with those of thiopental on isolated vascular ring preparations from rat thoracic aorta and pulmonary artery. Thoracic aortic ring responses were evaluated in the presence and absence of endothelium, indomethacin, and N omega-nitro-L-arginine methyl ester (LNAME; a specific inhibitor of endothelium-derived relaxing factor-nitric oxide [EDRF/NO] synthase). Pulmonary artery responses were investigated with intact endothelium. After the induction of active isometric force by a predetermined EC50 dose of phenylephrine for each ring, effects of propofol (30, 100, 300 microM) and thiopental (10, 30, 100 microM) were examined. Propofol caused significant vasodilation in endothelium-intact, endothelium-denuded, and LNAME-treated aortic rings. In the endothelium-intact aortic and pulmonary artery rings, the initial vasodilation due to 30 and 100 microM propofol showed gradual and partial recovery over 15 min; 300 microM propofol caused sustained vasodilation. Endothelium-denuded rings and LNAME-pretreated endothelium-intact rings showed constant and sustained vasodilation with all propofol concentrations. Propofol also caused marked vasodilation in pulmonary arteries. In contrast, thiopental had no vasodilating effect in aortic or pulmonary artery preparations. In control experiments, propofol vehicle (Intralipid) also had no effect on vascular rings. Indomethacin pretreatment induced a dose-dependent vasoconstriction by thiopental in endothelium-intact rings and decreased the vasodilation due to propofol.(ABSTRACT TRUNCATED AT 250 WORDS)






Park WK,Lynch C 3rd,Johns RA




Has Abstract


1992-11-01 00:00:00












  • Blockade of the complement C5a receptor reduces incisional allodynia, edema, and cytokine expression.

    abstract:BACKGROUND:Activation of the complement system is one component of the inflammatory response. Various components of the complement system participate in killing foreign organisms, recruiting immune cells, enhancing edema, and stimulating cytokine formation. Complement-mediated enhancement of the inflammation surroundin...


    pub_type: 杂志文章


    authors: Clark JD,Qiao Y,Li X,Shi X,Angst MS,Yeomans DC

    更新日期:2006-06-01 00:00:00

  • Effects of volatile anesthetics on store-operated Ca(2+) influx in airway smooth muscle.

    abstract:BACKGROUND:In airway smooth muscle (ASM), volatile anesthetics deplete sarcoplasmic reticulum (SR) Ca(2+) stores by increasing Ca(2+) "leak." Accordingly, SR replenishment becomes dependent on Ca(2+) influx. Depletion of SR Ca(2+) stores triggers Ca(2+) influx via specific plasma membrane channels, store-operated Ca(2+...


    pub_type: 杂志文章


    authors: Pabelick CM,Ay B,Prakash YS,Sieck GC

    更新日期:2004-08-01 00:00:00

  • Direct evidence for the ongoing brain activation by enhanced dynorphinergic system in the spinal cord under inflammatory noxious stimuli.

    abstract:BACKGROUND:Dynorphin A in the spinal cord is considered to contribute to nociceptive stimuli. However, it has not yet been determined whether activation of the spinal dynorphinergic system under nociceptive stimuli plays a role in direct acceleration of the ascending nociceptive pathway. In this study, the authors inve...


    pub_type: 杂志文章


    authors: Taketa Y,Niikura K,Kobayashi Y,Furuya M,Shimizu T,Narita M,Imai S,Kuzumaki N,Maitani Y,Yamazaki M,Inada E,Iseki M,Suzuki T,Narita M

    更新日期:2010-02-01 00:00:00

  • Improved postoperative outcomes associated with preoperative statin therapy.

    abstract::Statin therapy is well established for prevention of cardiovascular disease. Statins may also reduce postoperative mortality and morbidity via a pleiotropic (non-lipid-lowering) effect. The authors conducted a meta-analysis to determine the influence of statin treatment on adverse postoperative outcomes in patients un...


    pub_type: 杂志文章,meta分析,评审


    authors: Hindler K,Shaw AD,Samuels J,Fulton S,Collard CD,Riedel B

    更新日期:2006-12-01 00:00:00

  • Malignant hyperthermia.

    abstract::In MH, skeletal muscle acutely and unexpectedly increases its oxygen consumption and lactate production, resulting in greater heat production, respiratory and metabolic acidosis, muscle ridigity, sympathetic stimulation, and increased cellular permeability. The best-accepted theory is that MH is due to an inability to...


    pub_type: 杂志文章,评审


    authors: Gronert GA

    更新日期:1980-11-01 00:00:00

  • Preserved memory function during bispectral index-guided anesthesia with sevoflurane for major orthopedic surgery.

    abstract:BACKGROUND:Memory function under anesthesia is undesired but may arise from light hypnosis as well as stress-enhanced learning during surgery. The bispectral index (BIS, Aspect Medical Systems, Norwood, MA) is a monitor of hypnotic state that can help to avoid light hypnosis (i.e., BIS above 60). This study tested the ...


    pub_type: 杂志文章,随机对照试验


    authors: Kerssens C,Gaither JR,Sebel PS

    更新日期:2009-09-01 00:00:00

  • Vaporized perfluorocarbon improves oxygenation and pulmonary function in an ovine model of acute respiratory distress syndrome.

    abstract:BACKGROUND:Perfluorocarbon liquids are being used experimentally and in clinical trials for the treatment of acute lung injury. Their resemblance to inhaled anesthetic agents suggests the possibility of application by vaporization. The authors' aim was to develop the technical means for perfluorocarbon vaporization and...


    pub_type: 杂志文章


    authors: Bleyl JU,Ragaller M,Tschö U,Regner M,Kanzow M,Hübler M,Rasche S,Albrecht M

    更新日期:1999-08-01 00:00:00

  • Platelet Counts, Acute Kidney Injury, and Mortality after Coronary Artery Bypass Grafting Surgery.

    abstract:BACKGROUND:Cardiac surgery requiring cardiopulmonary bypass is associated with platelet activation. Because platelets are increasingly recognized as important effectors of ischemia and end-organ inflammatory injury, the authors explored whether postoperative nadir platelet counts are associated with acute kidney injury...


    pub_type: 杂志文章


    authors: Kertai MD,Zhou S,Karhausen JA,Cooter M,Jooste E,Li YJ,White WD,Aronson S,Podgoreanu MV,Gaca J,Welsby IJ,Levy JH,Stafford-Smith M,Mathew JP,Fontes ML

    更新日期:2016-02-01 00:00:00

  • Factors affecting perioperative transfusion decisions in patients with coronary artery disease undergoing coronary artery bypass surgery.

    abstract:BACKGROUND:A high proportion of patients having cardiac bypass surgery receive erythrocyte transfusions. Decisions about when to transfuse patients having surgery for coronary artery disease may impact on erythrocyte utilization and patient morbidity and mortality. There are no published data about the factors that inf...


    pub_type: 杂志文章


    authors: Shehata N,Wilson K,Mazer CD,Tomlinson G,Streiner D,Hebert P,Naglie G

    更新日期:2006-07-01 00:00:00

  • Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function.

    abstract:BACKGROUND:Etomidate is a sedative hypnotic that is often used in critically ill patients because it provides superior hemodynamic stability. However, it also binds with high affinity to 11beta-hydroxylase, potently suppressing the synthesis of steroids by the adrenal gland that are necessary for survival. The authors ...


    pub_type: 杂志文章


    authors: Cotten JF,Forman SA,Laha JK,Cuny GD,Husain SS,Miller KW,Nguyen HH,Kelly EW,Stewart D,Liu A,Raines DE

    更新日期:2010-03-01 00:00:00

  • Isoflurane anesthesia and circadian temperature cycles in humans.

    abstract::Cognitive performance in postsurgical patients may be impaired by disturbances of normal circadian rhythm analogous to those produced by rapid transmeridian travel ("jet lag"). We therefore tested the hypothesis that isoflurane anesthesia alone produces a phase-delay in the human circadian temperature rhythm. We monit...


    pub_type: 杂志文章


    authors: Sessler DI,Lee KA,McGuire J

    更新日期:1991-12-01 00:00:00

  • The sheath of the brachial plexus: fact or fiction?

    abstract:BACKGROUND:The concept of the axillary "sheath" has been a central tenet of brachial plexus regional anesthesia for many years. Recent investigations have cast doubt on its nature and existence. This study further examines the issue. METHODS:Computerized axial tomographic dye studies were performed using continuous ca...


    pub_type: 杂志文章


    authors: Cornish PB,Leaper C

    更新日期:2006-09-01 00:00:00

  • Low-dose propofol-induced amnesia is not due to a failure of encoding: left inferior prefrontal cortex is still active.

    abstract:BACKGROUND:Propofol may produce amnesia by affecting encoding. The hypothesis that propofol weakens encoding was tested by measuring regional cerebral blood flow during verbal encoding. METHODS:Seventeen volunteer participants (12 men; aged 30.4 +/- 6.5 yr) had regional cerebral blood flow measured using H2O positron ...


    pub_type: 杂志文章,随机对照试验


    authors: Veselis RA,Pryor KO,Reinsel RA,Mehta M,Pan H,Johnson R Jr

    更新日期:2008-08-01 00:00:00

  • Effect of antiemetic therapy on recovery and hospital discharge time. A double-blind assessment of ondansetron, droperidol, and placebo in pediatric patients undergoing ambulatory surgery.

    abstract:BACKGROUND:Postoperative nausea and vomiting continue to be a significant problem for pediatric ambulatory surgery patients. Although ondansetron has been demonstrated to be effective in the prophylactic treatment of postoperative nausea and vomiting (surrogate end point) no one has demonstrated a benefit of antiemetic...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Davis PJ,McGowan FX Jr,Landsman I,Maloney K,Hoffmann P

    更新日期:1995-11-01 00:00:00

  • Interaction of isoflurane with the dopamine transporter.

    abstract:BACKGROUND:Isoflurane administration is known to increase extracellular dopamine (DA) concentration. Because the dopamine transporter (DAT) is a key regulator of DA, it is likely affected by isoflurane. This study investigates the hypothesis that isoflurane inhibits DA reuptake by causing DAT to be trafficked into the ...


    pub_type: 杂志文章


    authors: Votaw J,Byas-Smith M,Hua J,Voll R,Martarello L,Levey AI,Bowman FD,Goodman M

    更新日期:2003-02-01 00:00:00

  • Ineffectiveness of burst suppression therapy in mitigating perioperative cerebrovascular dysfunction. Multicenter Study of Perioperative Ischemia (McSPI) Research Group.

    abstract:BACKGROUND:Cerebral injury is among the most common and disabling complications of open heart surgery. Attempts to provide neuroprotection have yielded conflicting results. We assessed the potential of propofol-induced burst suppression during open heart surgery to provide cerebral protection as determined by postopera...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Roach GW,Newman MF,Murkin JM,Martzke J,Ruskin A,Li J,Guo A,Wisniewski A,Mangano DT

    更新日期:1999-05-01 00:00:00

  • Functional magnetic resonance imaging studies of pain: an investigation of signal decay during and across sessions.

    abstract:BACKGROUND:Several investigations into brain activation caused by pain have suggested that the multiple painful stimulations used in typical block designs may cause attenuation over time of the signal within activated areas. The effect this may have on pain investigations using multiple tasks has not been investigated....


    pub_type: 杂志文章


    authors: Ibinson JW,Small RH,Algaze A,Roberts CJ,Clark DL,Schmalbrock P

    更新日期:2004-10-01 00:00:00

  • Isoflurane pretreatment inhibits cytokine-induced cell death in cultured rat smooth muscle cells and human endothelial cells.

    abstract:BACKGROUND:Anesthetics are protective during ischemic-reperfusion injury and associated inflammation; therefore, the authors hypothesized that anesthetic pretreatment may provide protection in culture from cytokine-induced cell death. METHODS:Rat vascular smooth muscle (VSM) cell and human umbilical vascular endotheli...


    pub_type: 杂志文章


    authors: de Klaver MJ,Manning L,Palmer LA,Rich GF

    更新日期:2002-07-01 00:00:00

  • Administration of nitrous oxide to pediatric patients provides analgesia for venous cannulation.

    abstract::To determine whether administration of nitrous oxide, 50% and 70%, could provide analgesia and anxiolysis during venous cannulation in pediatric patients, 165 ASA Physical Status 1 patients scheduled for elective surgery were studied. Children, 3 weeks to 18 yr of age, were randomly assigned either to receive nitrous ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Henderson JM,Spence DG,Komocar LM,Bonn GE,Stenstrom RJ

    更新日期:1990-02-01 00:00:00

  • Metabolism of ketamine stereoisomers by human liver microsomes.

    abstract::Ketamine is used clinically as a racemic mixture of optical isomers that differ in their analgesic properties and psychomimetic effects. Administered individually, or together as the racemate, ketamine enantiomers differ in their hepatic clearance and duration of anesthetic effect. S(+) ketamine exhibits a greater cle...


    pub_type: 杂志文章


    authors: Kharasch ED,Labroo R

    更新日期:1992-12-01 00:00:00

  • Period-dependent Associations between Hypotension during and for Four Days after Noncardiac Surgery and a Composite of Myocardial Infarction and Death: A Substudy of the POISE-2 Trial.

    abstract:BACKGROUND:The relative contributions of intraoperative and postoperative hypotension to perioperative morbidity remain unclear. We determined the association between hypotension and a composite of 30-day myocardial infarction and death over three periods: (1) intraoperative, (2) remaining day of surgery, and (3) durin...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Sessler DI,Meyhoff CS,Zimmerman NM,Mao G,Leslie K,Vásquez SM,Balaji P,Alvarez-Garcia J,Cavalcanti AB,Parlow JL,Rahate PV,Seeberger MD,Gossetti B,Walker SA,Premchand RK,Dahl RM,Duceppe E,Rodseth R,Botto F,Devereaux P

    更新日期:2018-02-01 00:00:00

  • Clinical Effectiveness of Intravenous Exenatide Infusion in Perioperative Glycemic Control after Coronary Artery Bypass Graft Surgery: A Phase II/III Randomized Trial.

    abstract:BACKGROUND:We aimed to assess the clinical effectiveness of intravenous exenatide compared to insulin in perioperative blood glucose control in coronary artery bypass grafting surgery patients. METHODS:Patients more than 18 yr old admitted for elective coronary artery bypass grafting were included in a phase II/III no...


    pub_type: 杂志文章,随机对照试验


    authors: Besch G,Perrotti A,Mauny F,Puyraveau M,Baltres M,Flicoteaux G,Salomon du Mont L,Barrucand B,Samain E,Chocron S,Pili-Floury S

    更新日期:2017-11-01 00:00:00

  • Flammability of endotracheal tubes during Nd-YAG laser application in the airway.

    abstract::The effects of the neodymium-yttrium aluminum garnet (Nd-YAG) laser on several commonly used endotracheal tubes were examined. Six different types of tubes were tested for flammability. Three tubes were clear, transparent polyvinylchloride with black lettering on the surface. One was yellow-green silicone rubber with ...


    pub_type: 杂志文章


    authors: Geffin B,Shapshay SM,Bellack GS,Hobin K,Setzer SE

    更新日期:1986-11-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of rocuronium in patients with cirrhosis.

    abstract:BACKGROUND:Rocuronium, like other steroidal nondepolarizing muscle relaxants, may in part be eliminated by the liver. To determine the influence of liver disease on its neuromuscular blocking effect, we studied the pharmacokinetics and pharmacodynamics of rocuronium in patients with cirrhosis. METHODS:Eighteen patient...


    pub_type: 杂志文章


    authors: Khalil M,D'Honneur G,Duvaldestin P,Slavov V,De Hys C,Gomeni R

    更新日期:1994-06-01 00:00:00

  • Effects of halothane on sarcoplasmic reticulum calcium release channels in porcine airway smooth muscle cells.

    abstract:BACKGROUND:Volatile anesthetics relax airway smooth muscle (ASM) by altering intracellular Ca2+ concentration ([Ca2+]i). The authors hypothesized that relaxation is produced by decreasing sarcoplasmic reticulum Ca2+ content via increased Ca2+ "leak" through both inositol trisphosphate (IP3) and ryanodine receptor chann...


    pub_type: 杂志文章


    authors: Pabelick CM,Prakash YS,Kannan MS,Warner DO,Sieck GC

    更新日期:2001-07-01 00:00:00

  • Bicitra (sodium citrate) and metoclopramide in outpatient anesthesia for prophylaxis against aspiration pneumonitis.

    abstract::To evaluate the effect of Bicitra (Willen Drug Company, Baltimore, Maryland), a commercial preparation of sodium citrate and metoclopramide, on gastric contents 150 elective outpatients allocated into six groups with 25 patients in each group were studied. Patients in Group 1 served as controls. Patients in Groups 2, ...


    pub_type: 杂志文章


    authors: Manchikanti L,Grow JB,Colliver JA,Hadley CH,Hohlbein LJ

    更新日期:1985-10-01 00:00:00

  • Isoflurane and an alpha 2-adrenoceptor agonist suppress nociceptive neurotransmission in neonatal rat spinal cord.

    abstract::Analgesia is an important component of general anesthesia. alpha 2-adrenoceptor agonists such as clonidine and dexmedetomidine are effective analgesics at the spinal level, and furthermore, they reduce the volatile anesthetic requirement. In order to probe a possible spinal-level contribution to general anesthetic-ind...


    pub_type: 杂志文章


    authors: Savola MK,Woodley SJ,Maze M,Kendig JJ

    更新日期:1991-09-01 00:00:00

  • Quantitative Research Methods in Medical Education.

    abstract::There has been a dramatic growth of scholarly articles in medical education in recent years. Evaluating medical education research requires specific orientation to issues related to format and content. Our goal is to review the quantitative aspects of research in medical education so that clinicians may understand the...


    pub_type: 杂志文章,评审


    authors: Ratelle JT,Sawatsky AP,Beckman TJ

    更新日期:2019-07-01 00:00:00

  • Transcranial Doppler to Predict Neurologic Outcome after Mild to Moderate Traumatic Brain Injury.

    abstract:BACKGROUND:To assess the performance of transcranial Doppler (TCD) in predicting neurologic worsening after mild to moderate traumatic brain injury. METHODS:The authors conducted a prospective observational study across 17 sites. TCD was performed upon admission in 356 patients (Glasgow Coma Score [GCS], 9 to 15) with...


    pub_type: 杂志文章,多中心研究


    authors: Bouzat P,Almeras L,Manhes P,Sanders L,Levrat A,David JS,Cinotti R,Chabanne R,Gloaguen A,Bobbia X,Thoret S,Oujamaa L,Bosson JL,Payen JF,Asehnoune K,Pes P,Lefrant JY,Mirek S,Albasini F,Scrimgeour C,Thouret JM,Char

    更新日期:2016-08-01 00:00:00

  • Proliferation of smooth endoplasmic reticulum and induction of microsomal drug-metabolizing enzymes after ether or halothane.

    abstract::Hepatic drug-metabolizing enzymes and hepatic ultrastructure were studied in rats after two hours of anesthesia with 1 MAC halothane or diethyl ether. Twelve hours after cessation of either anesthetic smooth endoplasmic reticulum was increased in centrilobular but not in periportal hepatocytes. This change persisted a...


    pub_type: 杂志文章


    authors: Ross WT Jr,Cardell RR Jr

    更新日期:1978-05-01 00:00:00