Abstract:
:To determine whether anesthesiologists, because of prolonged exposure to halothane or other inhalational anesthetics, might have higher death rates from all causes, from cancer, and from hepatic or renal disease than other physicians, the mortality rates of male and female members of the American Society of Anesthesiologists (ASA) for the period 1954 to 1976 were examined. Records of all physicians on ASA membership lists in 1954, 1959, 1967 and 1976 were obtained. All members, including life members, retired members and those who had stopped paying dues, were traced. Of the 637 deaths between 1954 and 1976 in male anesthesiologists, death certificates were obtained for 610. Mortality from all causes in those members who were accredited prior to 1960 was 84% of the expected death rate of all physicians. Among male members of record in 1967, it was 93% of the expected rate. There was no suggestion of an increased rate of cancer or hepatic or renal disease. There was a high suicide rate in members less than 55 years old. The overall mortality rate for the relatively small group (n = 66) of female anesthesiologists was 75 to 85% of that expected for all female physicians.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Lew EAdoi
10.1097/00000542-197909000-00003subject
Has Abstractpub_date
1979-09-01 00:00:00pages
195-9issue
3eissn
0003-3022issn
1528-1175journal_volume
51pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract:BACKGROUND:Anesthetic potency is assessed by determination of the anesthetic concentration that prevents gross, purposeful movement in response to noxious stimulation. It is unclear whether anesthetics cause a progressive decrease in the number and force of limb movements evoked by noxious stimulation, or a step decrea...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199910000-00027
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:The current study used recombinant herpes simplex virus type I to increase expression of µ-opiate receptors and the opioid ligand preproenkephalin in peripheral nerve fibers in a mouse model of neuropathic pain. It was predicted that viral vector delivery of a combination of genes encoding the µ-opioid recep...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002063
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Nonsteroidal antiinflammatory drugs are commonly used to treat postoperative and chronic pain. Animal studies suggest that these drugs act, in part, by blocking prostaglandin production in the spinal cord. The authors tested intrathecal ketorolac in patients with chronic or postoperative pain. METHODS:After...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/ALN.0b013e3181d94dc0
更新日期:2010-05-01 00:00:00
abstract::Pain perception to minor physical stimuli has been hypothesized to be related to subsequent pain ratings after surgery. The objective of this systematic review was to evaluate the correlation between preoperative pain sensitivity and postoperative pain intensity. After a literature search of MEDLINE, EMBASE, and meeti...
journal_title:Anesthesiology
pub_type: 杂志文章,评审
doi:10.1097/ALN.0b013e3181f85ed2
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Glucocorticoids have been reported to aggravate ischemic brain damage. Because changes in the activities of various neuronal systems are closely related to the outcome of ischemic damage, the authors evaluated the effects of dexamethasone on the monoaminergic systems and ischemic neuronal damage. METHODS:Th...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199902000-00028
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Renal and hepatic toxicity of the fluorinated ether volatile anesthetics is caused by biotransformation to toxic metabolites. Metabolism also contributes significantly to the elimination pharmacokinetics of some volatile agents. Although innumerable studies have explored anesthetic metabolism in animals, the...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199310000-00023
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Anesthesia personnel are at risk for occupational infection with bloodborne pathogens from contaminated percutaneous injuries (CPIs). Additional information is needed to formulate methods to reduce risk. METHODS:The authors analyzed CPIs collected during a 2-yr period at 11 hospitals, assessed CPI underrepo...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00000542-199812000-00013
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:Due to potential neurologic sequelae, the risk:benefit ratio of thoracic epidural analgesia is controversial. Surprisingly, however, few available data address neurologic complications. The incidence of neurologic complications occurring after thoracic epidural catheterization was studied in patients schedul...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199701000-00009
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:The tube of the intubating laryngeal mask (ILM) is more rigid than the standard laryngeal mask airway (LMA), and the authors have tested the hypothesis that pharyngeal mucosal pressures, airway sealing pressures, and fiberoptic position are different when the two devices are compared. METHODS:Twenty anesthe...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199904000-00012
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND:Recent studies suggest that volatile anesthetics cause not only vasodilation but also vasoconstriction, depending on the experimental conditions. However, the mechanism of the constrictive effect of volatile anesthetics has not been clarified. The aim of this study was to evaluate the vasoconstrictor effects...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199405000-00021
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Awareness during anesthesia is foremost assessed with postoperative interviews, which may underestimate its incidence. On-line monitors such as the Bispectral Index and patient response to verbal command are not necessarily commonly used. This study investigated response to command during deep sedation (Bisp...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200309000-00011
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:The design of an endotracheal tube has been shown to influence the passage of the tube through the glottis during fiberoptic intubation. Difficulty in passing the endotracheal tube can occur if the aryepiglottic folds obstruct the passage of the bevel. The relevant aspects of endotracheal tube design include...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200105000-00007
更新日期:2001-05-01 00:00:00
abstract::The antinociceptive interaction on the tail flick (TF) and hot plate (HP) tests between opioid analgesics and medetomidine after intravenous (iv) or intrathecal administration were examined by isobolographic analysis. Male Sprague-Dawley rats received fixed ratios of medetomidine to morphine, fentanyl, and meperidine ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199012000-00022
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine whether either regional anesthesia (RA) or general anesthesia (GA) provided the best analgesia with the fewest adverse effects up to 2 weeks after ambulatory hand surgery. METHODS:Patients undergoing ambulatory hand surgery were randomly assigned to RA (axillary br...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200408000-00028
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Deep hypothermia has been associated with an increased incidence of postoperative neurologic dysfunction after cardiac surgery in children. Recent studies suggest an excitotoxic mechanism involving overstimulation of glutamate receptors. Extracellular glutamate uptake occurs primarily by astrocytes. Astrocyt...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199912000-00030
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:In acute lung injury positive end-expiratory pressure (PEEP) and recruitment maneuver are proposed to optimize arterial oxygenation. The aim of the study was to evaluate the impact of such a strategy on lung histological inflammation and hyperinflation in pigs with acid aspiration-induced lung injury. METHO...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e31827542aa
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Repetitive C-fiber stimulation induces a state of facilitated processing of sensory information in the dorsal horn, while chronic nerve compression gives rise to a hyperalgesic state, characterized by spontaneous neuronal activity generated by voltage-sensitive sodium channels, as well as spinal facilitation...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
abstract:AIMS:Helium protects myocardium by inducing preconditioning in animals. We investigated whether human endothelium is preconditioned by helium inhalation in vivo. METHODS AND RESULTS:Forearm ischemia-reperfusion (I/R) in healthy volunteers (each group n = 10) was performed by inflating a blood pressure cuff for 20 min....
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3182751300
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Perioperative beta-blockade has been shown to improve long-term cardiac outcome in noncardiac surgical patients. A possible mechanism for the reduced risk of perioperative myocardial infarction is the attenuation of the excitotoxic effects of catecholamine surges by beta-blockade. It was hypothesized that be...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199912000-00020
更新日期:1999-12-01 00:00:00
abstract::Anesthetic exposure is usually necessary but rarely sufficient to the conduct of therapy. Consequently, there is a natural abhorrence of any worsening of a patient's condition secondary to the administration of anesthesia, which offers the patient no direct benefit. Highly safe anesthesia is a necessary precondition...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197812000-00002
更新日期:1978-12-01 00:00:00
abstract::The dosage and blood concentration of lidocaine required to produce central nervous and cardiovascular system toxicity in both nonasphyxiated and asphyxiated fetuses were determined in ten pregnant baboons with fetuses of average gestation of 158 days (term, 185 days). Lidocaine was infused into the fetal jugular vein...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198103000-00002
更新日期:1981-03-01 00:00:00
abstract:BACKGROUND:Septic shock is associated with vasopressin deficiency and a hypersensitivity to its exogenous administration. The goal of the current study was to determine whether short-term vasopressin infusion in patients experiencing severe septic shock has a vasopressor sparing effect while maintaining hemodynamic sta...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200203000-00011
更新日期:2002-03-01 00:00:00
abstract:UNLABELLED:BACKGROUND. Injection of local anesthetic into cerebrospinal fluid (CSF) produces anesthesia of unpredictable extent and duration. Although many factors have been identified that affect the extent of spinal anesthesia, correlations are relatively poor and the extent of spread remains unpredictable. This stud...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199807000-00007
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Sevoflurane is commonly used for cervical cancer surgery, but its effect on cervical cancer cell biology remains unclear. This mechanistic study explores how sevoflurane affects the proliferation and metastatic potential of immortalized cervical cancer cell lines. METHODS:Cultured cervical cancer Caski and ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000003129
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers improve cognitive function. The authors therefore tested the primary hypothesis that preoperative use of angiotensin inhibitors is associated with less delirium in critical care patients. Post hoc, the association between postoperativ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000003329
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Only limited data exist comparing differences in sensory function and responses to neural blockade in infant and adult rats. Therefore, the authors sought (1) to compare baseline thermal, proprioceptive, and postural responses in infant, adolescent, and adult rats; and (2) to compare the effects of sciatic n...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199704000-00026
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:Inhaled nitric oxide (NO), a selective vasodilator, improves oxygenation in many patients with adult respiratory distress syndrome (ARDS). Vasoconstrictors may also improve oxygenation, possibly by enhancing hypoxic pulmonary vasoconstriction. This study compared the effects of phenylephrine, NO, and their c...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199707000-00004
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Excitatory amino acid receptors are important for both sensory and motor function in the spinal cord. We studied the effects of intrathecal LY293558, a competitive non-N-methyl-D-aspartate excitatory amino acid receptor antagonist, on motor and sensory function in rats to determine whether drugs blocking the...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200207000-00025
更新日期:2002-07-01 00:00:00
abstract::To determine whether anesthesiologists can manually detect significant changes in pulmonary compliance in neonates using an "educated hand," the authors tested whether clinicians could detect clamping of an endotracheal tube connecting a neonatal lung model to one of three anesthesia breathing circuits. The test lungs...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199110000-00022
更新日期:1991-10-01 00:00:00
abstract::The pharmacokinetics, biodisposition, and neuromuscular blocking properties of 3-desacetylvecuronium were studied in 17 adult cats. Animals were divided into three groups: five cats with kidney failure induced by bilateral ligation of the renal pedicles, six cats with galactosamine-induced fulminant hepatitis, and six...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199106000-00013
更新日期:1991-06-01 00:00:00