Pharmacokinetics, neuromuscular effects, and biodisposition of 3-desacetylvecuronium (Org 7268) in cats.


:The pharmacokinetics, biodisposition, and neuromuscular blocking properties of 3-desacetylvecuronium were studied in 17 adult cats. Animals were divided into three groups: five cats with kidney failure induced by bilateral ligation of the renal pedicles, six cats with galactosamine-induced fulminant hepatitis, and six control cats. An intravenous bolus of 300 of 3-desacetylvecuronium was rapidly injected into the jugular vein. Arterial blood, urine, and bile samples were collected at regular intervals for 6 h in control cats and for 8 h in cats with kidney or liver failure. The liver was excised for analysis at the end of the experiment. In cats with renal failure, 3-desacetylvecuronium pharmacokinetic and pharmacodynamic variables did not differ from those in control cats. In cats with liver failure, plasma clearance was significantly less and mean residence time greater than in control cats (2.8 +/- 0.6 vs. 14.1 +/- 6.5 and 334 +/- 225 vs. 49 +/- 29 min, mean +/- SD, respectively). Volume of distribution at steady state in cats with liver failure and in control cats was not different. Also, in cats with liver failure, the duration of action and recovery index of 3-desacetylvecuronium was significantly greater than in control cats (168 +/- 62 vs. 82 +/- 32 min, and 39 +/- 19 vs. 10 +/- 4 min, respectively). Onset time of neuromuscular blockade was similar in all three groups. Total recovery of 3-desacetylvecuronium, for all three groups, in urine, bile, and liver was 90 +/- 11% (mean +/- SD). In control cats, 70 +/- 18% of 3-desacetylvecuronium was recovered in bile and liver and 19 +/- 14% in urine. No 3,17-bidesacetylvecuronium (a putative 3-desacetylvecuronium metabolite) was detected.(ABSTRACT TRUNCATED AT 250 WORDS)






Segredo V,Shin YS,Sharma ML,Gruenke LD,Caldwell JE,Khuenl-Brady KS,Agoston S,Miller RD




Has Abstract


1991-06-01 00:00:00












  • Noninvasive Tracking of Anesthesia Neurotoxicity in the Developing Rodent Brain.

    abstract:BACKGROUND:Potential deleterious effect of multiple anesthesia exposures on the developing brain remains a clinical concern. We hypothesized that multiple neonatal anesthesia exposures are more detrimental to brain maturation than an equivalent single exposure, with more pronounced long-term behavioral consequences. We...


    pub_type: 杂志文章


    authors: Makaryus R,Lee H,Robinson J,Enikolopov G,Benveniste H

    更新日期:2018-07-01 00:00:00

  • Glutamate release from the ovine fetal brain during maternal hemorrhage. A study using chronic in utero cerebral microdialysis.

    abstract:BACKGROUND:Glutamate has been implicated in the pathophysiology of neuronal injury associated with cerebral hypoxia-ischemia. A model using chronic in utero microdialysis was developed to sample the extracellular space of the fetal brain. Using this model, we tested the hypothesis that glutamate efflux from the parasag...


    pub_type: 杂志文章


    authors: Penning DH,Chestnut DH,Dexter F,Hrdy J,Poduska D,Atkins B

    更新日期:1995-02-01 00:00:00

  • Inhibition of interferon stimulation of natural killer cell activity in mice anesthetized with halothane or isoflurane.

    abstract:BACKGROUND:Basal cytotoxic activity of NK cells, a subtype of lymphocytes involved in the nonspecific immune response to viruses, tumors, and some bacteria, is altered in the postoperative period. The current study examines the effects of halothane and isoflurane on interferon-induced stimulation of NK cell cytotoxicit...


    pub_type: 杂志文章


    authors: Markovic SN,Knight PR,Murasko DM

    更新日期:1993-04-01 00:00:00

  • Uppermost blood levels of the right and left atria in the supine position: implication for measuring central venous pressure and pulmonary artery wedge pressure.

    abstract:BACKGROUND:To eliminate the influence of hydrostatic pressure, proper transducer positions for central venous pressure and pulmonary artery wedge pressure are at the uppermost blood levels of right atrium (RA) and left atrium (LA). This study was performed to investigate accurate reference levels of central venous pres...


    pub_type: 杂志文章


    authors: Seo JH,Jung CW,Bahk JH

    更新日期:2007-08-01 00:00:00

  • Effects of halothane, propofol, and thiopental on peripheral airway reactivity.

    abstract:BACKGROUND:General anesthetics modify airway responsiveness by several mechanisms, including direct effects on airway smooth muscle and reductions in neural reflex activity. Halothane has been shown to reduce responsiveness through both of these mechanisms. The airway effects of barbiturates are controversial, and the ...


    pub_type: 杂志文章


    authors: Mehr EH,Lindeman KS

    更新日期:1993-08-01 00:00:00

  • Improved resuscitation after cardiac arrest in rats expressing the baculovirus caspase inhibitor protein p35 in central neurons.

    abstract:BACKGROUND:Global cerebral ischemia is associated with delayed neuronal death. Given the role of caspases in apoptosis, caspase inhibitors may provide neuronal protection after cardiac arrest. To this end, the authors generated a transgenic rat line expressing baculovirus p35, a broad-spectrum caspase inhibitor, in cen...


    pub_type: 杂志文章


    authors: Vogel P,Putten Hv,Popp E,Krumnikl JJ,Teschendorf P,Galmbacher R,Kisielow M,Wiessner C,Schmitz A,Tomaselli KJ,Schmitz B,Martin E,Böttiger BW

    更新日期:2003-07-01 00:00:00

  • Acquisition of critical intraoperative event management skills in novice anesthesiology residents by using high-fidelity simulation-based training.

    abstract:BACKGROUND:Early acquisition of critical competencies by novice anesthesiology residents is essential for patient safety, but traditional training methods may be insufficient. The purpose of this study was to determine the effectiveness of high-fidelity simulation training of novice residents in the initial management ...


    pub_type: 杂志文章,随机对照试验


    authors: Park CS,Rochlen LR,Yaghmour E,Higgins N,Bauchat JR,Wojciechowski KG,Sullivan JT,McCarthy RJ

    更新日期:2010-01-01 00:00:00

  • Prolonged d-tubocurarine infusion and/or immobilization cause upregulation of acetylcholine receptors and hyperkalemia to succinylcholine in rats.

    abstract:BACKGROUND:Hyperkalemic cardiac arrest after the administration of succinylcholine (SCh) to critically ill intensive care patients has been attributed to changes in the acetylcholine receptors (AChRs) at the muscle membrane. The current study attempts to characterize the contributory roles of chronic administration of ...


    pub_type: 杂志文章


    authors: Yanez P,Martyn JA

    更新日期:1996-02-01 00:00:00

  • Echocardiographic Doppler assessment of pulmonary capillary wedge pressure in surgical patients with postoperative circulatory shock and acute lung injury.

    abstract:BACKGROUND:In cardiac patients, pulmonary capillary wedge pressure (PCWP) is estimated using color M-mode Doppler study of left ventricular filling and Doppler tissue imaging. The goal of this study was to assess whether echocardiography accurately estimates PCWP in critically ill patients. METHODS:Sixty ventilated pa...


    pub_type: 杂志文章


    authors: Bouhemad B,Nicolas-Robin A,Benois A,Lemaire S,Goarin JP,Rouby JJ

    更新日期:2003-05-01 00:00:00

  • Volatile organic compounds during inflammation and sepsis in rats: a potential breath test using ion-mobility spectrometry.

    abstract:BACKGROUND:Multicapillary column ion-mobility spectrometry (MCC-IMS) may identify volatile components in exhaled gas. The authors therefore used MCC-IMS to evaluate exhaled gas in a rat model of sepsis, inflammation, and hemorrhagic shock. METHODS:Male Sprague-Dawley rats were anesthetized and ventilated via tracheost...


    pub_type: 杂志文章


    authors: Fink T,Wolf A,Maurer F,Albrecht FW,Heim N,Wolf B,Hauschild AC,Bödeker B,Baumbach JI,Volk T,Sessler DI,Kreuer S

    更新日期:2015-01-01 00:00:00

  • Halothane and isoflurane increase pulmonary artery endothelial cell sensitivity to oxidant-mediated injury.

    abstract::Volatile anesthetics inhibit phagocytic cell function, yet little is known about their effects on target tissues or on the target tissue response to stimulated phagocytes. Experiments were performed to determine how exposure to halothane and isoflurane changes rat pulmonary artery endothelial cell (RPAEC) viability in...


    pub_type: 杂志文章


    authors: Shayevitz JR,Varani J,Ward PA,Knight PR

    更新日期:1991-06-01 00:00:00

  • Epidural catheter reconnection. Safe and unsafe practice.

    abstract:BACKGROUND:An in vitro model of epidural catheter contamination was used to determine if disconnected catheters can be safely reconnected. METHODS:Epidural catheters were filled with brain-heart infusion (BHI) broth or preservative-free saline containing 5 micrograms/ml fentanyl. Escherichia coli, Pseudomonas aerugino...


    pub_type: 杂志文章


    authors: Langevin PB,Gravenstein N,Langevin SO,Gulig PA

    更新日期:1996-10-01 00:00:00

  • Factor VII levels and international normalized ratios in the early phase of warfarin therapy.

    abstract:BACKGROUND:Factor VII is the most affected clotting factor during the early phase of warfarin therapy. An international normalized ratio (INR) of more than 1.4 is considered unsafe for epidural catheter placement or removal, according to the American Society of Regional Anesthesia and Pain Medicine. The authors tested ...


    pub_type: 杂志文章


    authors: Benzon HT,Avram MJ,Benzon HA,Kirby-Nolan M,Nader A

    更新日期:2010-02-01 00:00:00

  • Redistribution of microcirculatory blood flow within the intestinal wall during sepsis and general anesthesia.

    abstract:BACKGROUND:Hypoperfusion of the intestinal mucosa remains an important clinical problem during sepsis. Impairment of the autoregulation of microcirculatory blood flow in the intestinal tract has been suggested to play an important role in the development of multiple organ failure during sepsis and surgery. The authors ...


    pub_type: 杂志文章


    authors: Hiltebrand LB,Krejci V,tenHoevel ME,Banic A,Sigurdsson GH

    更新日期:2003-03-01 00:00:00

  • Transcutaneous cardiac pacing during thoracic surgery. Feasibility and hemodynamic evaluation by transesophageal echocardiography.

    abstract:BACKGROUND:Occasionally, emergency perioperative pacing is necessary. Transcutaneous cardiac pacing is noninvasive, safe, and readily available. Its feasibility and hemodynamic effects during thoracic surgery and one-lung ventilation have not been established. METHODS:Twenty anesthetized patients (aged 25-70 yr) witho...


    pub_type: 临床试验,杂志文章


    authors: Amar D,Gross JN,Burt M,Schwinger ME,Rusch VW,Reinsel RA

    更新日期:1993-10-01 00:00:00

  • Increasing isoflurane from 0.9 to 1.1 minimum alveolar concentration minimally affects dorsal horn cell responses to noxious stimulation.

    abstract:BACKGROUND:The spinal cord appears to be the site at which isoflurane suppresses movement that occurs in response to a noxious stimulus. In an attempt to localize its site of suppressant action, the authors determined the effect of isoflurane on dorsal horn neuronal responses to supramaximal noxious stimulation at end-...


    pub_type: 杂志文章


    authors: Antognini JF,Carstens E

    更新日期:1999-01-01 00:00:00

  • Measuring Clinical Productivity of Anesthesiology Groups: Surgical Anesthesia at the Facility Level.

    abstract::Benchmarking and comparing group productivity is an essential activity of data-driven management. For clinical anesthesiology, accomplishing this task is a daunting effort if meaningful conclusions are to be made. For anesthesiology groups, productivity must be done at the facility level in order to reduce some of the...


    pub_type: 杂志文章,评审


    authors: Abouleish AE,Hudson ME,Whitten CW

    更新日期:2019-02-01 00:00:00

  • Effect of sevoflurane on hypoxic pulmonary vasoconstriction in the perfused rabbit lung.

    abstract:BACKGROUND:In vitro studies have shown that isoflurane, enflurane, and halothane inhibit the hypoxic pulmonary vasoconstriction (HPV) with essentially the same potency. The aim of this study is to compare the effects of sevoflurane and isoflurane on HPV in constant-flow perfused rabbit lungs. METHODS:Constant-flow per...


    pub_type: 杂志文章


    authors: Ishibe Y,Gui X,Uno H,Shiokawa Y,Umeda T,Suekane K

    更新日期:1993-12-01 00:00:00

  • Neostigmine/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure.

    abstract:BACKGROUND:Reversal of residual neuromuscular blockade by acetylcholinesterase inhibitors (e.g., neostigmine) improves respiratory function. However, neostigmine may also impair muscle strength. We hypothesized that neostigmine administered after recovery of the train-of-four (TOF) ratio impairs upper airway integrity ...


    pub_type: 杂志文章


    authors: Herbstreit F,Zigrahn D,Ochterbeck C,Peters J,Eikermann M

    更新日期:2010-12-01 00:00:00

  • Autologous platelet-rich plasma does not reduce transfusion of homologous blood products in patients undergoing repeat valvular surgery.

    abstract:BACKGROUND:Patients undergoing cardiac surgery employing cardiopulmonary bypass frequently require transfusion of homologous blood products and, therefore, are exposed to the risk of transfusions. Autologous platelet-rich plasma administration may reduce homologous transfusion and attendant risks. METHODS:In a blinded...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ereth MH,Oliver WC Jr,Beynen FM,Mullany CJ,Orszulak TA,Santrach PJ,Ilstrup DM,Weaver AL,Williamson KR

    更新日期:1993-09-01 00:00:00

  • Inhibition of [3H]isradipine binding to L-type calcium channels by the optical isomers of isoflurane. Lack of stereospecificity.

    abstract:BACKGROUND:The dose-dependent myocardial depression of volatile general anesthetics such as isoflurane has been linked to blockade of L-type Ca2+ channels. The effects of (+)- and (-)-isoflurane on the inhibition of [3H]isradipine binding to L-type Ca2+ channels in membranes prepared from mouse heart were examined. In ...


    pub_type: 杂志文章


    authors: Moody EJ,Harris B,Hoehner P,Skolnick P

    更新日期:1994-07-01 00:00:00

  • Shannon entropy applied to the measurement of the electroencephalographic effects of desflurane.

    abstract:BACKGROUND:The Shannon entropy is a standard measure for the order state of sequences. It quantifies the degree of skew of the distribution of values. Increasing hypnotic drug concentrations increase electroencephalographic amplitude. The probability density function of the amplitude values broadens and flattens, there...


    pub_type: 临床试验,杂志文章


    authors: Bruhn J,Lehmann LE,Röpcke H,Bouillon TW,Hoeft A

    更新日期:2001-07-01 00:00:00

  • Brain bioenergetics during cardiopulmonary resuscitation in dogs.

    abstract::Cardiac arrest causes a rapid loss of cerebral adenosine triphosphate [corrected] (ATP) and a decrease in cerebral intracellular pH (pHi). Depending on the efficacy of cardiopulmonary resuscitation (CPR), cerebral blood flow levels (CBF) ranging from near zero to near normal have been reported experimentally. Using 31...


    pub_type: 杂志文章


    authors: Eleff SM,Schleien CL,Koehler RC,Shaffner DH,Tsitlik J,Halperin HR,Rogers MC,Traystman RJ

    更新日期:1992-01-01 00:00:00

  • Gestational differences in lidocaine toxicity in the fetal lamb.

    abstract::Effects of lidocaine on arterial pressure, heart rate and electrocortical activity were studied in nine fetal lambs at 0.77 to 0.92 gestation (116 to 138 days of gestation; term in sheep is 150 days). Lidocaine was administered into a fetal femoral vein either as a continuous infusion or as a bolus injection. Epilepti...


    pub_type: 杂志文章


    authors: Teramo K,Benowitz N,Heymann MA,Rudolph AM

    更新日期:1976-02-01 00:00:00

  • Reaginic antibodies to drugs used in anesthesia.

    abstract::Twenty-four patients survived life-threatening clinical anaphylaxis due to anesthesia. In each case the diagnosis of anaphylaxis was confirmed and the responsible drug was found by intradermal testing. To determine whether the reactions were anaphylactic or anaphylactoid, serum from each patient was tested for reagini...


    pub_type: 杂志文章


    authors: Fisher MM

    更新日期:1980-04-01 00:00:00

  • Neurologic evaluation of infant and adult rats before and after sciatic nerve blockade.

    abstract:BACKGROUND:Only limited data exist comparing differences in sensory function and responses to neural blockade in infant and adult rats. Therefore, the authors sought (1) to compare baseline thermal, proprioceptive, and postural responses in infant, adolescent, and adult rats; and (2) to compare the effects of sciatic n...


    pub_type: 杂志文章


    authors: Hu D,Hu R,Berde CB

    更新日期:1997-04-01 00:00:00

  • The pharmacodynamics and pharmacokinetics of vecuronium in patients anesthetized with isoflurane with normal renal function or with renal failure.

    abstract::The duration of action and the pharmacokinetics of vecuronium were compared in patients with and without renal function. Twenty patients were studied: 12 with renal failure who were to receive kidney transplants from cadaveric donors, and eight with normal renal function. After oral premedication with diazepam, 10 mg,...


    pub_type: 杂志文章


    authors: Lynam DP,Cronnelly R,Castagnoli KP,Canfell PC,Caldwell J,Arden J,Miller RD

    更新日期:1988-08-01 00:00:00

  • Adsorption characteristics of volatile anesthetics on activated carbons and performance of carbon canisters.

    abstract::The adsorption characteristics, such as the adsorption capacity, the nature of the mass transfer zone, and heats of adsorption, are important for evaluating the performances of carbon canisters for removal of waste anesthetic vapors. The adsorption capacities and the natures of the mass transfer zones were measured fo...


    pub_type: 杂志文章


    authors: Kim BM,Sircar S

    更新日期:1977-03-01 00:00:00

  • Amitriptyline for prolonged cutaneous analgesia in the rat.

    abstract:BACKGROUND:Amitriptyline has been reported to be a more potent local anesthetic than bupivacaine. In keeping with the objective of identifying drugs for prolonged cutaneous analgesia, the authors compared the cutaneous analgesic effectiveness of amitriptyline and bupivacaine in rats. METHODS:Rats were subcutaneously i...


    pub_type: 杂志文章


    authors: Khan MA,Gerner P,Kuo Wang G

    更新日期:2002-01-01 00:00:00

  • Performance of noninvasive partial CO2 rebreathing cardiac output and continuous thermodilution cardiac output in patients undergoing aortic reconstruction surgery.

    abstract:BACKGROUND:In the partial CO(2) rebreathing method, monitored changes in CO(2) elimination and end-tidal CO(2) in response to a brief rebreathing period are used to estimate cardiac output. However, dynamic changes in CO(2) production during ischemia and reperfusion may affect the accuracy of these estimates. This stud...


    pub_type: 临床试验,杂志文章


    authors: Kotake Y,Moriyama K,Innami Y,Shimizu H,Ueda T,Morisaki H,Takeda J

    更新日期:2003-08-01 00:00:00