Pharmacokinetics, neuromuscular effects, and biodisposition of 3-desacetylvecuronium (Org 7268) in cats.


:The pharmacokinetics, biodisposition, and neuromuscular blocking properties of 3-desacetylvecuronium were studied in 17 adult cats. Animals were divided into three groups: five cats with kidney failure induced by bilateral ligation of the renal pedicles, six cats with galactosamine-induced fulminant hepatitis, and six control cats. An intravenous bolus of 300 of 3-desacetylvecuronium was rapidly injected into the jugular vein. Arterial blood, urine, and bile samples were collected at regular intervals for 6 h in control cats and for 8 h in cats with kidney or liver failure. The liver was excised for analysis at the end of the experiment. In cats with renal failure, 3-desacetylvecuronium pharmacokinetic and pharmacodynamic variables did not differ from those in control cats. In cats with liver failure, plasma clearance was significantly less and mean residence time greater than in control cats (2.8 +/- 0.6 vs. 14.1 +/- 6.5 and 334 +/- 225 vs. 49 +/- 29 min, mean +/- SD, respectively). Volume of distribution at steady state in cats with liver failure and in control cats was not different. Also, in cats with liver failure, the duration of action and recovery index of 3-desacetylvecuronium was significantly greater than in control cats (168 +/- 62 vs. 82 +/- 32 min, and 39 +/- 19 vs. 10 +/- 4 min, respectively). Onset time of neuromuscular blockade was similar in all three groups. Total recovery of 3-desacetylvecuronium, for all three groups, in urine, bile, and liver was 90 +/- 11% (mean +/- SD). In control cats, 70 +/- 18% of 3-desacetylvecuronium was recovered in bile and liver and 19 +/- 14% in urine. No 3,17-bidesacetylvecuronium (a putative 3-desacetylvecuronium metabolite) was detected.(ABSTRACT TRUNCATED AT 250 WORDS)






Segredo V,Shin YS,Sharma ML,Gruenke LD,Caldwell JE,Khuenl-Brady KS,Agoston S,Miller RD




Has Abstract


1991-06-01 00:00:00












  • Acute normovolemic hemodilution in the pig is associated with renal tissue edema, impaired renal microvascular oxygenation, and functional loss.

    abstract:BACKGROUND:The authors investigated the impact of acute normovolemic hemodilution (ANH) on intrarenal oxygenation and its functional short-term consequences in pigs. METHODS:Renal microvascular oxygenation (µPO2) was measured in cortex, outer and inner medulla via three implanted optical fibers by oxygen-dependent que...


    pub_type: 杂志文章


    authors: Konrad FM,Mik EG,Bodmer SI,Ates NB,Willems HF,Klingel K,de Geus HR,Stolker RJ,Johannes T

    更新日期:2013-08-01 00:00:00

  • Effects of blood glucose changes and physostigmine on anesthetic requirements of halothane in rats.

    abstract:BACKGROUND:Although hyper- and hypoglycemia induce neurophysiologic changes, there have been no reports on the effects of blood glucose changes on anesthetic requirements. This study examined the effects of hyper- and hypoglycemia on the minimum alveolar concentration (MAC) of halothane in rats. In addition, based on a...


    pub_type: 杂志文章


    authors: Ishizawa Y,Ohta S,Shimonaka H,Dohi S

    更新日期:1997-08-01 00:00:00

  • Isoflurane causes "flickering" of the acetylcholine receptor channel: observations using the patch clamp.

    abstract::The authors investigated the effects of a volatile anesthetic (isoflurane) on the functional properties of a well characterized membrane ion channel (the acetylcholine receptor channel), using the patch clamp electrophysiological method together with local microperfusion of isoflurane. They found that isoflurane cause...


    pub_type: 杂志文章


    authors: Brett RS,Dilger JP,Yland KF

    更新日期:1988-08-01 00:00:00

  • Modulation of platelet surface adhesion receptors during cardiopulmonary bypass.

    abstract::Alterations in platelet receptors critical to adhesion may play a role in the pathogenesis of the qualitative platelet defect associated with cardiopulmonary bypass. Using flow cytometry, we measured changes in the following platelet surface adhesive proteins: the von Willebrand factor receptor, glycoprotein Ib; the f...


    pub_type: 杂志文章


    authors: Rinder CS,Mathew JP,Rinder HM,Bonan J,Ault KA,Smith BR

    更新日期:1991-10-01 00:00:00

  • Sympathetic muscle nerve activity, peripheral blood flows, and baroreceptor reflexes in humans during propofol anesthesia and surgery.

    abstract:BACKGROUND:With percutaneous recordings of muscle nerve sympathetic activity (MSA), it is possible to study interactions between the autonomic nervous system and anesthetics. This study describes the effects of propofol infusion both before and during microlaryngoscopy. METHODS:Nine patients participated. MSA was reco...


    pub_type: 临床试验,杂志文章


    authors: Sellgren J,Ejnell H,Elam M,Pontén J,Wallin BG

    更新日期:1994-03-01 00:00:00

  • Dual exposure to sevoflurane improves anesthetic preconditioning in intact hearts.

    abstract:BACKGROUND:Anesthetic preconditioning (APC) with sevoflurane reduces myocardial ischemia-reperfusion injury. The authors tested whether two brief exposures to sevoflurane would lead to a better preconditioning state than would a single longer exposure and whether dual exposure to a lower (L) concentration of sevofluran...


    pub_type: 杂志文章


    authors: Riess ML,Kevin LG,Camara AK,Heisner JS,Stowe DF

    更新日期:2004-03-01 00:00:00

  • Etomidate and thiopental inhibit the release of endothelium-derived hyperpolarizing factor in the human renal artery.

    abstract:BACKGROUND:Endothelium-derived hyperpolarizing factor is thought to be a cytochrome P450-derived arachidonic acid metabolite that hyperpolarizes vascular smooth muscle cells by opening Ca(2+)-activated K+ channels (K+Ca channels). In the rabbit carotid artery both volatile and intravenous anesthetics inhibit the acetyl...


    pub_type: 杂志文章


    authors: Kessler P,Lischke V,Hecker M

    更新日期:1996-06-01 00:00:00

  • Incidence and root cause analysis of wrong-site pain management procedures: a multicenter study.

    abstract:BACKGROUND:Medical errors exact an inordinate toll on healthcare costs. One of the most publicized and analyzed type of medical error is wrong-site surgery. Yet, despite the burgeoning number of procedures performed, no literature exists on wrong-site pain management injections. The purpose of this study was to estimat...


    pub_type: 杂志文章,多中心研究


    authors: Cohen SP,Hayek SM,Datta S,Bajwa ZH,Larkin TM,Griffith S,Hobelmann G,Christo PJ,White R

    更新日期:2010-03-01 00:00:00

  • Hemodynamic predictors of myocardial ischemia during halothane anesthesia for coronary-artery revascularization.

    abstract::The authors undertook a prospective study of 30 patients undergoing halothane anesthesia for coronary-artery revascularization to ascertain which clinically monitored hemodynamic variables--or combination of variables--associated with myocardial oxygen supply and demand best predict myocardial ischemia. Simultaneous r...


    pub_type: 杂志文章


    authors: Lieberman RW,Orkin FK,Jobes DR,Schwartz AJ

    更新日期:1983-07-01 00:00:00

  • Intrathecal sufentanil for labor analgesia does not cause a sympathectomy.

    abstract:BACKGROUND:Intrathecal sufentanil (ITS) is frequently used to provide analgesia during labor. Decreases in blood pressure and sensory changes in this circumstance suggest that ITS may have a local anesthetic effect and thus cause a sympathectomy. To determine whether ITS given to laboring women causes a sympathectomy, ...


    pub_type: 杂志文章


    authors: Riley ET,Walker D,Hamilton CL,Cohen SE

    更新日期:1997-10-01 00:00:00

  • Growth cone collapsing effect of lidocaine on DRG neurons is partially reversed by several neurotrophic factors.

    abstract:BACKGROUND:Local anesthetics were suggested to have a potential for neurotoxicity in both clinical reports and laboratory experiments. Growing neurons have been shown to be susceptible to the toxic effects of local anesthetics in culture. These findings have generated the interest in factors that would rescue the neuro...


    pub_type: 杂志文章


    authors: Radwan IA,Saito S,Goto F

    更新日期:2002-09-01 00:00:00

  • The well-being model: a new drug interaction model for positive and negative effects.

    abstract:BACKGROUND:Drugs are routinely combined in anesthesia and pain management to obtain an enhancement of the desired effects. However, a parallel enhancement of the undesired effects might take place as well, resulting in a limited therapeutic usefulness. Therefore, when addressing the question of optimal drug combination...


    pub_type: 杂志文章


    authors: Zanderigo E,Sartori V,Sveticic G,Bouillon T,Schumacher P,Morari M,Curatolo M

    更新日期:2006-04-01 00:00:00

  • Anesthetic-induced improvement of the inflammatory response to one-lung ventilation.

    abstract:BACKGROUND:Although one-lung ventilation (OLV) has become an established procedure during thoracic surgery, sparse data exist about inflammatory alterations in the deflated, reventilated lung. The aim of this study was to prospectively investigate the effect of OLV on the pulmonary inflammatory response and to assess p...


    pub_type: 杂志文章,随机对照试验


    authors: De Conno E,Steurer MP,Wittlinger M,Zalunardo MP,Weder W,Schneiter D,Schimmer RC,Klaghofer R,Neff TA,Schmid ER,Spahn DR,Z'graggen BR,Urner M,Beck-Schimmer B

    更新日期:2009-06-01 00:00:00

  • The corrugator supercilii, not the orbicularis oculi, reflects rocuronium neuromuscular blockade at the laryngeal adductor muscles.

    abstract:BACKGROUND:Some studies suggest that the orbicularis oculi is resistant to neuromuscular blocking drugs and behaves like laryngeal muscles. Others report little or no difference between the orbicularis oculi and the adductor pollicis. These discrepancies could be related to the exact site of recording. The purpose of t...


    pub_type: 临床试验,杂志文章


    authors: Plaud B,Debaene B,Donati F

    更新日期:2001-07-01 00:00:00

  • Transcranial Doppler to Predict Neurologic Outcome after Mild to Moderate Traumatic Brain Injury.

    abstract:BACKGROUND:To assess the performance of transcranial Doppler (TCD) in predicting neurologic worsening after mild to moderate traumatic brain injury. METHODS:The authors conducted a prospective observational study across 17 sites. TCD was performed upon admission in 356 patients (Glasgow Coma Score [GCS], 9 to 15) with...


    pub_type: 杂志文章,多中心研究


    authors: Bouzat P,Almeras L,Manhes P,Sanders L,Levrat A,David JS,Cinotti R,Chabanne R,Gloaguen A,Bobbia X,Thoret S,Oujamaa L,Bosson JL,Payen JF,Asehnoune K,Pes P,Lefrant JY,Mirek S,Albasini F,Scrimgeour C,Thouret JM,Char

    更新日期:2016-08-01 00:00:00

  • Epidural clonidine treatment for refractory reflex sympathetic dystrophy.

    abstract:BACKGROUND:Intraspinally administered alpha 2-adrenergic agonists may relieve pain in sympathetically maintained pain (SMP) syndromes, such as reflex sympathetically dystrophy (RSD), by spinal, peripheral, and central nervous system actions. This study examined analgesic efficacy and side effects of epidurally administ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rauck RL,Eisenach JC,Jackson K,Young LD,Southern J

    更新日期:1993-12-01 00:00:00

  • Improved resuscitation after cardiac arrest in rats expressing the baculovirus caspase inhibitor protein p35 in central neurons.

    abstract:BACKGROUND:Global cerebral ischemia is associated with delayed neuronal death. Given the role of caspases in apoptosis, caspase inhibitors may provide neuronal protection after cardiac arrest. To this end, the authors generated a transgenic rat line expressing baculovirus p35, a broad-spectrum caspase inhibitor, in cen...


    pub_type: 杂志文章


    authors: Vogel P,Putten Hv,Popp E,Krumnikl JJ,Teschendorf P,Galmbacher R,Kisielow M,Wiessner C,Schmitz A,Tomaselli KJ,Schmitz B,Martin E,Böttiger BW

    更新日期:2003-07-01 00:00:00

  • Intranasal nicotine for postoperative pain treatment.

    abstract:BACKGROUND:Despite pharmacological treatment, 70-80% of patients report moderate to severe pain after surgery. Because nicotine has been reported to have analgesic properties in animal and human volunteer studies, the authors assessed the analgesic efficacy of a single 3 mg dose of nicotine nasal spray administered bef...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Flood P,Daniel D

    更新日期:2004-12-01 00:00:00

  • Development and validation of a risk quantification index for 30-day postoperative mortality and morbidity in noncardiac surgical patients.

    abstract:BACKGROUND:Optimal risk adjustment is a requisite precondition for monitoring quality of care and interpreting public reports of hospital outcomes. Current risk-adjustment measures have been criticized for including baseline variables that are difficult to obtain and inadequately adjusting for high-risk patients. The a...


    pub_type: 杂志文章,随机对照试验


    authors: Dalton JE,Kurz A,Turan A,Mascha EJ,Sessler DI,Saager L

    更新日期:2011-06-01 00:00:00

  • Prognostic significance of blood lactate and lactate clearance in trauma patients.

    abstract:BACKGROUND:Lactate has been shown to be a prognostic biomarker in trauma. Although lactate clearance has already been proposed as an intermediate endpoint in randomized trials, its precise role in trauma patients remains to be determined. METHODS:Blood lactate levels and lactate clearance (LC) were calculated at admis...


    pub_type: 杂志文章


    authors: Régnier MA,Raux M,Le Manach Y,Asencio Y,Gaillard J,Devilliers C,Langeron O,Riou B

    更新日期:2012-12-01 00:00:00

  • Impaired systolic thickening associated with halothane in the presence of a coronary stenosis is mediated by changes in hemodynamics.

    abstract::Myocardial ischemia results when halothane is administered to animals with severe coronary stenosis. This study was done to separate the effect of halothane, per se, on myocardial ischemia from indirect cardiovascular effects, primarily hypotension, that might cause ischemia by altering the oxygen supply-demand balanc...


    pub_type: 杂志文章


    authors: Buffington CW

    更新日期:1986-05-01 00:00:00

  • Hyperinsulinemic Normoglycemia Does Not Meaningfully Improve Myocardial Performance during Cardiac Surgery: A Randomized Trial.

    abstract:BACKGROUND:Glucose-insulin-potassium (GIK) administration during cardiac surgery inconsistently improves myocardial function, perhaps because hyperglycemia negates the beneficial effects of GIK. The hyperinsulinemic normoglycemic clamp (HNC) technique may better enhance the myocardial benefits of GIK. The authors exten...


    pub_type: 杂志文章,随机对照试验


    authors: Duncan AE,Kateby Kashy B,Sarwar S,Singh A,Stenina-Adognravi O,Christoffersen S,Alfirevic A,Sale S,Yang D,Thomas JD,Gillinov M,Sessler DI

    更新日期:2015-08-01 00:00:00

  • Concentration-effect relation of succinylcholine chloride during propofol anesthesia.

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    pub_type: 杂志文章


    authors: Roy JJ,Donati F,Boismenu D,Varin F

    更新日期:2002-11-01 00:00:00

  • No involvement of antidiuretic hormone in acute antidiuresis during PEEP ventilation in humans.

    abstract::Decreased urinary output (Vu ml/min) after institution of PEEP is attributed to a variety of mechanisms including decreased cardiac output and renal blood flow (RBF), activation of neurohormonal reflexes, increased catecholamines, plasma renin activity (PRA), and antidiuretic hormone (ADH) release. To evaluate these f...


    pub_type: 杂志文章


    authors: Payen DM,Farge D,Beloucif S,Leviel F,De La Coussaye JE,Carli P,Wirquin V

    更新日期:1987-01-01 00:00:00

  • Pulmonary vascular effects of isoflurane anesthesia after left lung autotransplantation in chronically instrumented dogs.

    abstract:BACKGROUND:Single lung transplantation has become a viable therapy for treatment of end-stage pulmonary disease. We previously observed that left lung autotransplantation (LLA) results in a chronic increase in pulmonary vascular resistance and enhanced pulmonary vascular reactivity to sympathetic alpha adrenoreceptor a...


    pub_type: 杂志文章


    authors: Lennon PF,Murray PA

    更新日期:1996-09-01 00:00:00

  • A comparative evaluation of the effects of multiple vasodilators on human internal mammary artery.

    abstract:BACKGROUND:Vasospasm of arterial grafts represents an unpredictable complication of coronary artery surgery and may compromise myocardial revascularization, and treatment is based on empirical therapy with nitroglycerin. Because of the potential for tolerance to nitroglycerin to occur, the authors studied different vas...


    pub_type: 杂志文章


    authors: Huraux C,Makita T,Montes F,Szlam F,Levy JH

    更新日期:1998-06-01 00:00:00

  • Calcium concentration-dependent mechanisms through which ketamine relaxes canine airway smooth muscle.

    abstract:BACKGROUND:Ketamine is a potent bronchodilator that, in clinically used concentrations, relaxes airway smooth muscle in part by a direct effect. This study explored the role of calcium concentration (Ca2+) in this relaxation. METHODS:Canine trachea smooth muscle strips were loaded with the fluorescent probe fura-2 and...


    pub_type: 杂志文章


    authors: Pabelick CM,Jones KA,Street K,Lorenz RR,Warner DO

    更新日期:1997-05-01 00:00:00

  • Volume kinetic analysis of the distribution of 0.9% saline in conscious versus isoflurane-anesthetized sheep.

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    pub_type: 杂志文章


    authors: Brauer KI,Svensén C,Hahn RG,Traber LD,Prough DS

    更新日期:2002-02-01 00:00:00

  • Cervical epidural pressure measurement: comparison in the prone and sitting positions.

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    pub_type: 杂志文章,随机对照试验


    authors: Moon JY,Lee PB,Nahm FS,Kim YC,Choi JB

    更新日期:2010-09-01 00:00:00

  • Cerebral cortex activation during experimentally induced ventilator fighting in normal humans receiving noninvasive mechanical ventilation.

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    pub_type: 杂志文章


    authors: Raux M,Ray P,Prella M,Duguet A,Demoule A,Similowski T

    更新日期:2007-11-01 00:00:00