Pharmacokinetics, neuromuscular effects, and biodisposition of 3-desacetylvecuronium (Org 7268) in cats.

abstract：BACKGROUND:mu-Opioids administered spinally produce a potent, dose-dependent analgesic response in preclinical and clinical investigations. Side-effect profile of these compounds may be altered as a function of pharmacokinetics. The effects of intrathecal and intraperitoneal remifentanil, an esterase-metabolized mu opi...

journal_title：Anesthesiology

authors： Buerkle H,Yaksh TL

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Because the ultimate purpose of new medical knowledge is to achieve improved health outcomes, physicians need to possess and use this knowledge in their practice. The authors introduced enhanced education and individualized feedback to reduce postoperative nausea and vomiting (PONV). The primary objective wa...

journal_title：Anesthesiology

authors： Cohen MM,Rose DK,Yee DA

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Spinal nitric oxide (NO) is important for the analgesic actions of morphine and cholinergic agents. Its role in the analgesic effect of delta-opioid receptor agonists is not known. In the present study, the authors determined the role of spinal endogenous NO in the antinociceptive effect of intrathecal [D-Pe...

journal_title：Anesthesiology

authors： Chen SR,Pan HL

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Systemically administered local anesthetics and other sodium channel blockers produce analgesia in patients with hypersensitivity disorders. To assess whether these agents have a role in the treatment of visceral pain, the present study examined the effects of intravenous lidocaine on neuronal and reflex res...

journal_title：Anesthesiology

authors： Ness TJ

更新日期：2000-06-01 00:00:00

abstract：:Hepatic drug-metabolizing enzymes and hepatic ultrastructure were studied in rats after two hours of anesthesia with 1 MAC halothane or diethyl ether. Twelve hours after cessation of either anesthetic smooth endoplasmic reticulum was increased in centrilobular but not in periportal hepatocytes. This change persisted a...

journal_title：Anesthesiology

authors： Ross WT Jr,Cardell RR Jr

更新日期：1978-05-01 00:00:00

abstract：BACKGROUND:Glucose-insulin-potassium (GIK) administration during cardiac surgery inconsistently improves myocardial function, perhaps because hyperglycemia negates the beneficial effects of GIK. The hyperinsulinemic normoglycemic clamp (HNC) technique may better enhance the myocardial benefits of GIK. The authors exten...

journal_title：Anesthesiology

authors： Duncan AE,Kateby Kashy B,Sarwar S,Singh A,Stenina-Adognravi O,Christoffersen S,Alfirevic A,Sale S,Yang D,Thomas JD,Gillinov M,Sessler DI

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Ketamine is a potent bronchodilator that, in clinically used concentrations, relaxes airway smooth muscle in part by a direct effect. This study explored the role of calcium concentration (Ca2+) in this relaxation. METHODS:Canine trachea smooth muscle strips were loaded with the fluorescent probe fura-2 and...

journal_title：Anesthesiology

authors： Pabelick CM,Jones KA,Street K,Lorenz RR,Warner DO

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Dynorphin A in the spinal cord is considered to contribute to nociceptive stimuli. However, it has not yet been determined whether activation of the spinal dynorphinergic system under nociceptive stimuli plays a role in direct acceleration of the ascending nociceptive pathway. In this study, the authors inve...

journal_title：Anesthesiology

authors： Taketa Y,Niikura K,Kobayashi Y,Furuya M,Shimizu T,Narita M,Imai S,Kuzumaki N,Maitani Y,Yamazaki M,Inada E,Iseki M,Suzuki T,Narita M

更新日期：2010-02-01 00:00:00

abstract：:Recent reports have described resistance to pancuronium-induced neuromuscular blockade in patients chronically receiving anticonvulsants. This study examines the pharmacokinetics and pharmacodynamics of metocurine (MTC) in 12 patients undergoing craniotomy--six on chronic phenytoin therapy and six comparable controls....

journal_title：Anesthesiology

authors： Ornstein E,Matteo RS,Young WL,Diaz J

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:Impaired excitatory and inhibitory balance in the spinal dorsal horn has a crucial role in the pathophysiology of chronic pain. The authors addressed the therapeutic impact of increasing spinal glycine applied exogenously or via blockade of glycine transporter 1 using its selective inhibitors sarcosine and N...

journal_title：Anesthesiology

authors： Tanabe M,Takasu K,Yamaguchi S,Kodama D,Ono H

更新日期：2008-05-01 00:00:00

abstract：:To determine if a relationship exists between perioperative myocardial ischemia (ST segment depression greater than or equal to 0.1 mV) and postoperative myocardial infarction (PMI), nonparticipating observers recorded all ECG, hemodynamic, and other events between arrival of patients in the operating room and onset o...

journal_title：Anesthesiology

authors： Slogoff S,Keats AS

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:A decrease in radial artery blood pressure relative to central arterial blood pressure is commonly associated with the rewarming phase of cardiopulmonary bypass. Decreased hand vascular resistance has been suggested as a possible mechanism. Although decreased blood viscosity due to hemodilution may contribut...

journal_title：Anesthesiology

authors： Hynson JM,Sessler DI,Moayeri A,Katz JA

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Recent studies have revealed that N2O exerts its antinociceptive effect by inducing opioid peptide release in the brain stem, thereby activating the descending noradrenergic inhibitory neurons, which modulate pain processing in the spinal cord. However, the precise neuronal pathways that mediate these events...

journal_title：Anesthesiology

authors： Ohashi Y,Guo T,Orii R,Maze M,Fujinaga M

更新日期：2003-10-01 00:00:00

abstract：:Characteristics of nocturnal sleep were investigated in six patients after anesthesia and cholecystectomy and in another six after anesthesia and gastroplasty. All night polysomnographic recordings were obtained while each patient slept in a private surgical ward room through two nights before and five or six nights a...

journal_title：Anesthesiology

authors： Knill RL,Moote CA,Skinner MI,Rose EA

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Animal models of ventilator-associated pneumonia (VAP) in primates, sheep, and pigs differ in the underlying pulmonary injury, etiology, bacterial inoculation methods, and time to onset. The most common ovine and porcine models do not reproduce the primary pathogenic mechanism of the disease, through the asp...

journal_title：Anesthesiology

authors： Li Bassi G,Rigol M,Marti JD,Saucedo L,Ranzani OT,Roca I,Cabanas M,Muñoz L,Giunta V,Luque N,Rinaudo M,Esperatti M,Fernandez-Barat L,Ferrer M,Vila J,Ramirez J,Torres A

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Despite improvements in neonatal heart surgery, neurologic complications continue to occur from low-flow cardiopulmonary bypass (LF-CPB) and deep hypothermic circulatory arrest (DHCA). Desflurane confers neuroprotection against ischemia at normothermia and for DHCA. This study compared neurologic outcome of ...

journal_title：Anesthesiology

authors： Loepke AW,Priestley MA,Schultz SE,McCann J,Golden J,Kurth CD

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Acute pancreatitis has been linked to intestinal barrier dysfunction and systemic inflammatory response with high mortality. Thoracic epidural analgesia improves intestinal perfusion. The authors hypothesized that thoracic epidural analgesia influences microcirculation injury, inflammatory response, and outc...

journal_title：Anesthesiology

authors： Freise H,Lauer S,Anthonsen S,Hlouschek V,Minin E,Fischer LG,Lerch MM,Van Aken HK,Sielenkämper AW

更新日期：2006-08-01 00:00:00

abstract：:Some previous reports indicate that the excitability of the brain may be increased for days following enflurane anesthesia. The authors investigated this possibility in cats by determining whether or not pentylenetetrazol- (Metrazol) or lidocaine-seizure thresholds decreased after repeated enflurane exposure. The lido...

journal_title：Anesthesiology

authors： Heavner JE,Amory DW

更新日期：1981-05-01 00:00:00

abstract：:Despite evidence from animal experiments to the contrary, nitrous oxide (N2O) reportedly does not induce myocardial ischemia when used as an adjunct to fentanyl anesthesia in patients with coronary artery disease who have well-preserved left ventricular (LV) function. However, the incidence of ischemia with N2O admini...

journal_title：Anesthesiology

authors： Mitchell MM,Prakash O,Rulf EN,van Daele ME,Cahalan MK,Roelandt JR

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:It is well established that neuronal nicotinic acetylcholine receptors (nAChRs) are sensitive to inhalational anesthetics. The authors previously reported that halothane potently blocked alpha4beta2-type nAChRs of rat cortical neurons. However, the effect of isoflurane, which is widely used clinically, on nA...

journal_title：Anesthesiology

authors： Yamashita M,Mori T,Nagata K,Yeh JZ,Narahashi T

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Liver damage by ischemia and reperfusion injury is a risk factor for morbidity and mortality after liver surgery. Postoperative oxygen treatment is routinely applied in the postanesthesia and intensive care unit after liver surgery. The risks of aggravating the injury by increasing inspiratory oxygen from 21...

journal_title：Anesthesiology

authors： Zangl Q,Martignoni A,Jackson SH,Ohta A,Klaunberg B,Kaufmann I,Lukashev D,Ward JM,Sitkovsky M,Thiel M,Choukèr A

更新日期：2014-12-01 00:00:00

abstract：:To determine whether neuronal firing is affected by anesthetics, the behavior of neurons in the mesencephalic reticular formation in response to repetitive somatosensory stimulation at 2/sec was studied during wakefulness and during nitrous oxide, halothane, and thiopental anesthesia in the cat. With clinical doses of...

journal_title：Anesthesiology

authors： Shimoji K,Matsuki M,Shimizu H,Maruyama Y,Aida S

更新日期：1977-10-01 00:00:00

abstract：:The effects of halothane (0.75% and 1.5%) and isoflurane (2.6%) on macroscopic Ca2+ and K+ channel currents (ICa and IK, respectively) were investigated in voltage-clamped vascular muscle cells from the canine coronary artery. Single coronary arterial cells were dialyzed with K+ glutamate solution and superfused with ...

journal_title：Anesthesiology

authors： Buljubasic N,Rusch NJ,Marijic J,Kampine JP,Bosnjak ZJ

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Sevoflurane administered to neonatal rats induces neurobehavioral abnormalities and epigenetic reprogramming of their germ cells; the latter can pass adverse effects of sevoflurane to future offspring. As germ cells are susceptible to reprogramming by environmental factors across the lifespan, the authors hy...

journal_title：Anesthesiology

authors： Ju LS,Yang JJ,Xu N,Li J,Morey TE,Gravenstein N,Seubert CN,Setlow B,Martynyuk AE

更新日期：2019-11-01 00:00:00

abstract：:Magnesium plays a fundamental role in many cellular functions, and thus there is increasing interest in its role in clinical medicine. Although numerous experimental studies indicate positive effects of magnesium in a variety of disease states, large clinical trials often give conflicting results. However, there is cl...

journal_title：Anesthesiology

authors： Herroeder S,Schönherr ME,De Hert SG,Hollmann MW

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:The study evaluated the efficacy of recombinant human antithrombin (rhAT) for restoring heparin responsiveness in heparin resistant patients undergoing cardiac surgery. METHODS:This was a multicenter, randomized, double-blind, placebo-controlled study in heparin-resistant patients undergoing cardiac surgery...

journal_title：Anesthesiology

authors： Avidan MS,Levy JH,Scholz J,Delphin E,Rosseel PM,Howie MB,Gratz I,Bush CR,Skubas N,Aldea GS,Licina M,Bonfiglio LJ,Kajdasz DK,Ott E,Despotis GJ

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:A primary source of calcium (Ca2+) necessary for excitation contraction in vascular smooth muscle (VSM) is influx via voltage-dependent Ca2+ channels. Thus, force generation in VSM is coupled closely to resting transmembrane potential, which itself is primarily a function of potassium conductance. Previously...

journal_title：Anesthesiology

authors： Kokita N,Stekiel TA,Yamazaki M,Bosnjak ZJ,Kampine JP,Stekiel WJ

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Combining a hypnotic and an analgesic to produce sedation, analgesia, and surgical immobility required for clinical anesthesia is more common than administration of a volatile anesthetic alone. The aim of this study was to apply response surface methods to characterize the interactions between remifentanil a...

journal_title：Anesthesiology

authors： Manyam SC,Gupta DK,Johnson KB,White JL,Pace NL,Westenskow DR,Egan TD

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Acute renal dysfunction (ARD) and subsequent acute renal failure after cardiac surgery are associated with high mortality and morbidity. Early therapeutic or preventive intervention is hampered by the lack of an early biomarker for acute renal injury. Recent studies showed that urinary neutrophil gelatinase-...

journal_title：Anesthesiology

authors： Wagener G,Jan M,Kim M,Mori K,Barasch JM,Sladen RN,Lee HT

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Emergence delirium has been investigated in several clinical trials. However, no reliable and valid rating scale exists to measure this phenomenon in children. Therefore, the authors developed and evaluated the Pediatric Anesthesia Emergence Delirium (PAED) scale to measure emergence delirium in children. M...

journal_title：Anesthesiology

authors： Sikich N,Lerman J

更新日期：2004-05-01 00:00:00