Magnesium--essentials for anesthesiologists.


:Magnesium plays a fundamental role in many cellular functions, and thus there is increasing interest in its role in clinical medicine. Although numerous experimental studies indicate positive effects of magnesium in a variety of disease states, large clinical trials often give conflicting results. However, there is clear evidence for magnesium to benefit patients with eclampsia or torsades de pointes arrhythmias. In addition, magnesium seems to have antinociceptive and anesthetic as well as neuroprotective effects, yet well-designed large clinical trials are required to determine its actual efficacy in pain management or in the state of stroke or subarachnoid hemorrhage. The current review aims to provide an overview of current knowledge and available evidence with respect to physiologic aspects of magnesium and proposed indications and recommendations for its use in the clinical setting.






Herroeder S,Schönherr ME,De Hert SG,Hollmann MW




Has Abstract


2011-04-01 00:00:00












  • Enhancement by hyponatremia and hyperkalemia of ventricular conduction and rhythm disorders caused by bupivacaine.

    abstract::Intraventricular conduction disorders and reentrant arrhythmias in dogs can be produced by high plasma bupivacaine concentrations. The authors' aim was to determine if these conduction disturbances also occurred at moderate plasma bupivacaine concentrations (2.2-3.7 micrograms/ml) when in association with other factor...


    pub_type: 杂志文章


    authors: Timour Q,Freysz M,Mazze R,Couzon P,Bertix L,Faucon G

    更新日期:1990-06-01 00:00:00

  • Hemodynamic interactions of verapamil and isoflurane.

    abstract::The hemodynamic interactions of verapamil and isoflurane were studied in eight dogs. Left ventricular function was analyzed using a right heart bypass preparation to permit rigid hemodynamic control. Hemodynamic studies were performed at 0.7, 1.05, and 1.40% isoflurane before and during the maintenance of two stable l...


    pub_type: 杂志文章


    authors: Kates RA,Kaplan JA,Guyton RA,Dorsey L,Hug CC Jr,Hatcher CR

    更新日期:1983-08-01 00:00:00

  • Regional differences in left ventricular wall motion in the anesthetized dog.

    abstract::Data regarding left ventricular function suggest that the extent of shortening may differ between regions. This study was undertaken to determine the effects of negative inotropic drugs used during anesthesia on different areas of the left ventricle. Forty mongrel dogs were anesthetized and instrumented for measuremen...


    pub_type: 杂志文章


    authors: Diedericks J,Leone BJ,Foëx P

    更新日期:1989-01-01 00:00:00

  • Critical incidents associated with intraoperative exchanges of anesthesia personnel.

    abstract::It is a common practice for anesthesia to substitute for one another, especially for short breaks during long surgical procedures. The assets and liabilities of this practice of relief have not been examined previously. In the course of gathering 1,089 reports of preventable errors and failures associated with anesthe...


    pub_type: 杂志文章


    authors: Cooper JB,Long CD,Newbower RS,Philip JH

    更新日期:1982-06-01 00:00:00

  • Acute opioid tolerance: intraoperative remifentanil increases postoperative pain and morphine requirement.

    abstract:BACKGROUND:Rapid development of acute opioid tolerance is well established in animals and is more likely to occur with large doses of short-acting drugs. The authors therefore tested the hypothesis that intraoperative remifentanil administration results in acute opioid tolerance that is manifested by increased postoper...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Guignard B,Bossard AE,Coste C,Sessler DI,Lebrault C,Alfonsi P,Fletcher D,Chauvin M

    更新日期:2000-08-01 00:00:00

  • Effects of volatile anesthetics on acetylcholine-induced relaxation in the rabbit mesenteric resistance artery.

    abstract:BACKGROUND:Vascular endothelium plays an important role in the regulation of vascular tone. Volatile anesthetics have been shown to attenuate endothelium-mediated relaxation in conductance arteries, such as aorta. However, significant differences in volatile anesthetic pharmacology between these large vessels and the s...


    pub_type: 杂志文章


    authors: Akata T,Nakashima M,Kodama K,Boyle WA 3rd,Takahashi S

    更新日期:1995-01-01 00:00:00

  • Anesthesia for thoracoscopic laser ablation of bullous emphysema.

    abstract:BACKGROUND:We describe the anesthetic management for a new surgical procedure: laser ablation of emphysematous bullae via thoracoscope. Although thoracoscopy is not new, this is the first description of a series of patients with bilateral, chronic lung disease who underwent long periods of one-lung ventilation (OLV) du...


    pub_type: 杂志文章


    authors: Barker SJ,Clarke C,Trivedi N,Hyatt J,Fynes M,Roessler P

    更新日期:1993-01-01 00:00:00

  • Bacterial reduction by cell salvage washing and leukocyte depletion filtration.

    abstract:BACKGROUND:Blood conservation techniques are being increasingly used because of the increased cost and lack of availability of allogeneic blood. Cell salvage offers great blood savings opportunities but is thought to be contraindicated in a number of areas (e.g., blood contaminated with bacteria). Several outcome studi...


    pub_type: 杂志文章


    authors: Waters JH,Tuohy MJ,Hobson DF,Procop G

    更新日期:2003-09-01 00:00:00

  • Ultra-long-duration local anesthesia produced by injection of lecithin-coated methoxyflurane microdroplets.

    abstract::This study was designed to evaluate a new drug delivery system. The authors undertook to determine if microdroplets prepared by encapsulating volatile anesthetics with a membrane of lecithin could be used for local anesthesia. Local anesthesia was determined by monitoring the response of the rat to tail clamping and e...


    pub_type: 杂志文章


    authors: Haynes DH,Kirkpatrick AF

    更新日期:1985-11-01 00:00:00

  • The well-being model: a new drug interaction model for positive and negative effects.

    abstract:BACKGROUND:Drugs are routinely combined in anesthesia and pain management to obtain an enhancement of the desired effects. However, a parallel enhancement of the undesired effects might take place as well, resulting in a limited therapeutic usefulness. Therefore, when addressing the question of optimal drug combination...


    pub_type: 杂志文章


    authors: Zanderigo E,Sartori V,Sveticic G,Bouillon T,Schumacher P,Morari M,Curatolo M

    更新日期:2006-04-01 00:00:00

  • Isoflurane and the pulmonary vascular pressure-flow relation at baseline and during sympathetic alpha- and beta-adrenoreceptor activation in chronically instrumented dogs.

    abstract:BACKGROUND:The extent to which isoflurane anesthesia alters systemic vascular regulation has received considerable attention. In contrast, the pulmonary vascular effects of isoflurane have not been elucidated. Our initial objective was to investigate the net effect of isoflurane on the baseline left pulmonary vascular ...


    pub_type: 杂志文章


    authors: Lennon PF,Murray PA

    更新日期:1995-03-01 00:00:00

  • Onset of maximum neuromuscular block following succinylcholine or vecuronium in four age groups.

    abstract:BACKGROUND:Increasing age appears to be associated with a slower onset of neuromuscular blockade, but such an effect has not been studied with the same doses of the same drugs across pediatric and adult age groups. METHODS:The authors measured the evoked compound action potential of the adductor pollicis muscle in res...


    pub_type: 杂志文章


    authors: Koscielniak-Nielsen ZJ,Bevan JC,Popovic V,Baxter MR,Donati F,Bevan DR

    更新日期:1993-08-01 00:00:00

  • Inhalation anesthetics inhibit the release of endothelium-derived hyperpolarizing factor in the rabbit carotid artery.

    abstract:BACKGROUND:Inhalation anesthetics may interfere with the synthesis or action of endothelium-derived vasoactive factors. We investigated the effects of desflurane, enflurane, halothane, isoflurane, and sevoflurane on the release of nitric oxide and endothelium-derived hyperpolarizing factor (EDHF) in the isolated endoth...


    pub_type: 杂志文章


    authors: Lischke V,Busse R,Hecker M

    更新日期:1995-09-01 00:00:00

  • Multiport epidural catheters: does the air test work?

    abstract:BACKGROUND:Multiport epidural catheters are popular; however, the reliability of the air test has not been evaluated with this catheter design. The authors determined the effectiveness of aspirating for blood and the air test in detecting intravascular multiorifice epidural catheters. METHODS:Three hundred women in la...


    pub_type: 临床试验,杂志文章


    authors: Leighton BL,Topkis WG,Gross JB,Arkoosh VA,Lee SH,Huffnagle HJ,Huffnagle SL

    更新日期:2000-06-01 00:00:00

  • Measuring Clinical Productivity of Anesthesiology Groups: Surgical Anesthesia at the Facility Level.

    abstract::Benchmarking and comparing group productivity is an essential activity of data-driven management. For clinical anesthesiology, accomplishing this task is a daunting effort if meaningful conclusions are to be made. For anesthesiology groups, productivity must be done at the facility level in order to reduce some of the...


    pub_type: 杂志文章,评审


    authors: Abouleish AE,Hudson ME,Whitten CW

    更新日期:2019-02-01 00:00:00

  • Low-dose propofol-induced amnesia is not due to a failure of encoding: left inferior prefrontal cortex is still active.

    abstract:BACKGROUND:Propofol may produce amnesia by affecting encoding. The hypothesis that propofol weakens encoding was tested by measuring regional cerebral blood flow during verbal encoding. METHODS:Seventeen volunteer participants (12 men; aged 30.4 +/- 6.5 yr) had regional cerebral blood flow measured using H2O positron ...


    pub_type: 杂志文章,随机对照试验


    authors: Veselis RA,Pryor KO,Reinsel RA,Mehta M,Pan H,Johnson R Jr

    更新日期:2008-08-01 00:00:00

  • Halothane and enflurane constrict canine mesenteric arteries by releasing Ca2+ from intracellular Ca2+ stores.

    abstract:BACKGROUND:Recent studies suggest that volatile anesthetics cause not only vasodilation but also vasoconstriction, depending on the experimental conditions. However, the mechanism of the constrictive effect of volatile anesthetics has not been clarified. The aim of this study was to evaluate the vasoconstrictor effects...


    pub_type: 杂志文章


    authors: Kakuyama M,Hatano Y,Nakamura K,Toda H,Terasako K,Nishiwada M,Mori K

    更新日期:1994-05-01 00:00:00

  • Influence of nitrous oxide anesthesia, B-vitamins, and MTHFR gene polymorphisms on perioperative cardiac events: the vitamins in nitrous oxide (VINO) randomized trial.

    abstract:BACKGROUND:Nitrous oxide causes an acute increase in plasma homocysteine that is more pronounced in patients with the methylenetetrahydrofolate reductase (MTHFR) C677T or A1298C gene variant. In this randomized controlled trial, the authors sought to determine whether patients carrying the MTHFR C677T or A1298C variant...


    pub_type: 杂志文章,随机对照试验


    authors: Nagele P,Brown F,Francis A,Scott MG,Gage BF,Miller JP,VINO Study Team.

    更新日期:2013-07-01 00:00:00

  • Isoflurane causes "flickering" of the acetylcholine receptor channel: observations using the patch clamp.

    abstract::The authors investigated the effects of a volatile anesthetic (isoflurane) on the functional properties of a well characterized membrane ion channel (the acetylcholine receptor channel), using the patch clamp electrophysiological method together with local microperfusion of isoflurane. They found that isoflurane cause...


    pub_type: 杂志文章


    authors: Brett RS,Dilger JP,Yland KF

    更新日期:1988-08-01 00:00:00

  • Effect of halothane anesthesia on glucose utilization and production in adolescents.

    abstract:BACKGROUND:It should be possible to avoid variations in plasma glucose concentration during anesthesia by adjusting glucose infusion rate to whole-body glucose uptake. To study this hypothesis, we measured glucose utilization and production, before and during halothane anesthesia. METHODS:After an overnight fast, six ...


    pub_type: 杂志文章


    authors: Sbaï D,Jouvet P,Soulier A,Pénicaud L,Merckx J,Bresson JL

    更新日期:1995-05-01 00:00:00

  • Barbiturate anesthetics inhibit thromboxane-, potassium-, but not angiotensin-induced pulmonary vasoconstriction.

    abstract::Administration of the oxidant lipid peroxide tertiary butyl hydroperoxide (t-bu-OOH) in the isolated rabbit lung leads to acute pulmonary vasoconstriction, which is caused by the synthesis of thromboxane. The inhalational anesthetics, halothane, nitrous oxide, and cyclopropane, markedly enhance t-bu-OOH-induced pulmon...


    pub_type: 杂志文章


    authors: McShane AJ,Crowley K,Shayevitz JR,Michael JR,Adkinson NF Jr,Traystman RJ,Gurtner GH

    更新日期:1989-05-01 00:00:00

  • Sensitization of spinal neurons by non-noxious stimuli in the awake but not anesthetized state.

    abstract:BACKGROUND:The observation that peripheral trauma causes enhanced spinal neuronal excitability has provided the scientific rationale for the concept of "pre-emptive analgesia." The premise has been that only noxious stimuli cause sensitization in sensory pathways, but this premise has not been tested in the conscious s...


    pub_type: 杂志文章


    authors: Herrero JF,Headley PM

    更新日期:1995-01-01 00:00:00

  • Contact-free infrared thermography for assessing effects during acupuncture: a randomized, single-blinded, placebo-controlled crossover clinical trial.

    abstract:BACKGROUND:Although evidence of its effects is tentative, acupuncture has long been used in the treatment of multiple maladies. So far, it has not been possible to discriminate the effects of the venue from specific results of needling itself, thus physicians merely depend on patients' statements. The authors investiga...


    pub_type: 杂志文章,随机对照试验


    authors: Agarwal-Kozlowski K,Lange AC,Beck H

    更新日期:2009-09-01 00:00:00

  • Cysteine reversal of the novel neuromuscular blocking drug CW002 in dogs: pharmacodynamics, acute cardiovascular effects, and preliminary toxicology.

    abstract:BACKGROUND:CW002 is a neuromuscular blocking drug that is inactivated by endogenous L-cysteine. This study determined the exogenous L-cysteine dose-response relationship for CW002 reversal along with acute cardiovascular effects and organ toxicity in dogs. METHODS:Six dogs were each studied four times during isofluran...


    pub_type: 杂志文章


    authors: Sunaga H,Malhotra JK,Yoon E,Savarese JJ,Heerdt PM

    更新日期:2010-04-01 00:00:00

  • Alpha(2A) adrenoceptors contribute to feedback inhibition of capsaicin-induced hyperalgesia.

    abstract:BACKGROUND:Studies on receptor knockout mice have so far shown that of the three alpha2-adrenoceptor subtypes, the alpha(2A) adrenoceptor has a major role in mediating the powerful central analgesia induced by synthetic alpha2-adrenoceptor agonists. However, because a knockout of the gene for the alpha(2A) adrenoceptor...


    pub_type: 杂志文章


    authors: Mansikka H,Lähdesmäki J,Scheinin M,Pertovaara A

    更新日期:2004-07-01 00:00:00

  • Volatile anesthetics enhance flash-induced gamma oscillations in rat visual cortex.

    abstract:BACKGROUND:The authors sought to understand neural correlates of anesthetic-induced unconsciousness. Cortical gamma oscillations have been associated with neural processes supporting conscious perception, but the effect of general anesthesia on these oscillations is controversial. In this study, the authors examined th...


    pub_type: 杂志文章


    authors: Imas OA,Ropella KM,Ward BD,Wood JD,Hudetz AG

    更新日期:2005-05-01 00:00:00

  • Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.

    abstract:BACKGROUND:Renal and hepatic toxicity of the fluorinated ether volatile anesthetics is caused by biotransformation to toxic metabolites. Metabolism also contributes significantly to the elimination pharmacokinetics of some volatile agents. Although innumerable studies have explored anesthetic metabolism in animals, the...


    pub_type: 杂志文章


    authors: Kharasch ED,Thummel KE

    更新日期:1993-10-01 00:00:00

  • Involvement of adenosine in the antiinflammatory action of ketamine.

    abstract:BACKGROUND:Ketamine is an anesthetic drug. Subanesthetic doses of ketamine have been shown to reduce interleukin-6 concentrations after surgery and to reduce mortality and the production of tumor necrosis factor alpha and interleukin 6 in septic animals. Similarly, adenosine was shown to reduce tumor necrosis factor al...


    pub_type: 杂志文章


    authors: Mazar J,Rogachev B,Shaked G,Ziv NY,Czeiger D,Chaimovitz C,Zlotnik M,Mukmenev I,Byk G,Douvdevani A

    更新日期:2005-06-01 00:00:00

  • Effects of halothane and isoflurane on ventilation and occlusion pressure.

    abstract:BACKGROUND:Isoflurane has been said to be more ventilatory depressant than halothane. However, data for comparing the respiratory effects of halothane and isoflurane in humans are insufficient at this time. The aim of this study was to extend our understanding of the nature of the central, as opposed to peripheral, ven...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Canet J,Sanchis J,Zegrí A,Llorente C,Navajas D,Casan P

    更新日期:1994-09-01 00:00:00

  • Electroacupuncture improves survival in rats with lethal endotoxemia via the autonomic nervous system.

    abstract:BACKGROUND:Recent advances have indicated a complex interplay between the autonomic nervous system and the innate immune system. Targeting neural networks for the treatment of sepsis is being developed as a therapeutic strategy. Because electroacupuncture at select acupoints can modulate activities of the autonomic ner...


    pub_type: 杂志文章


    authors: Song JG,Li HH,Cao YF,Lv X,Zhang P,Li YS,Zheng YJ,Li Q,Yin PH,Song SL,Wang HY,Wang XR

    更新日期:2012-02-01 00:00:00