Abstract:
BACKGROUND:The myocardial negative inotropic effects of desflurane are less pronounced than those of other halogenated anesthetics, partly because of intramyocardial catecholamine store release. However, the effects of desflurane on aging myocardium are unknown, whereas aging is known to be associated with an attenuation of catecholamine responsiveness. METHODS:The effects of desflurane (1.9-9.3 vol%) were studied in left ventricular papillary muscle of adult and senescent rats (29 degrees C; 0.5 mm Ca; stimulation frequency 12 pulses/min). The inotropic effects were compared under low and high loads, using the maximum unloaded shortening velocity and maximum isometric active force, and without or with alpha- and beta-adrenoceptor blockade. RESULTS:Desflurane induced a moderate positive inotropic effect in adult rats but a negative inotropic effect in senescent rats. After alpha- and beta-adrenoceptor blockade, desflurane induced a comparable negative inotropic effect in adult and senescent rats. No lusitropic effect under low load was observed, whereas desflurane induced a slight but significant positive lusitropic effect under high load similar between the two groups of rats. This positive effect was abolished by adrenoceptor blockade. CONCLUSION:The authors' study suggests that desflurane does not induce significant intramyocardial catecholamine release in senescent myocardium, a result that should be integrated in the well-known alteration in the catecholamine response during aging.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Rozenberg S,Besse S,Amour J,Vivien B,Tavernier B,Riou Bdoi
10.1097/00000542-200611000-00017subject
Has Abstractpub_date
2006-11-01 00:00:00pages
961-7issue
5eissn
0003-3022issn
1528-1175pii
00000542-200611000-00017journal_volume
105pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract:BACKGROUND:Use of high-dose inhalational anesthesia during open fetal surgery may induce maternal-fetal hemodynamic instability and fetal myocardial depression. The authors' preliminary human retrospective study demonstrated less fetal bradycardia and left ventricular systolic dysfunction with lower dose desflurane sup...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e318283c954
更新日期:2013-04-01 00:00:00
abstract::Neurophysiologic studies indicate that local anesthetic-induced seizures are generated in subcortical brain structures. The authors utilized a quantitative autoradiographic technique to measure cerebral metabolism during lidocaine-induced seizure activity in rats anesthetized with nitrous oxide. Local cerebral metabol...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198101000-00007
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Preservation of gut integrity has become a therapeutic goal to obviate bacterial translocation in the critically ill. The authors examined whether olprinone, a phosphodiesterase III inhibitor, protected functional and structural integrity of gut mucosa against acute progressive hypoxia. METHODS:Thirty-two a...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200306000-00016
更新日期:2003-06-01 00:00:00
abstract::Pharmacokinetics and pharmacodynamics of propofol infusions during general anesthesia. By Audrey Shafer, Van A. Doze, Steven L. Shafer, and Paul F. White. Anesthesiology 1988; 69:348-56. Reprinted with permission.The pharmacokinetic and pharmacodynamic properties of propofol (Diprivan) were studied in 50 elective surg...
journal_title:Anesthesiology
pub_type: 古典文章,评论,杂志文章
doi:10.1097/ALN.0b013e31818ddba8
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Ventilator-associated pneumonia (VAP) requires early diagnosis and adequate antibiotic therapy. The aim of this prospective postmortem study was to assess the accuracy of direct examination and quantification of intracellular organisms (ICO) for the diagnosis of VAP. METHODS:Total and differential cell coun...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199708000-00013
更新日期:1997-08-01 00:00:00
abstract::The formation of acute edema in the tracheobronchial mucosa following local instillation of hydrochloric acid or gastric juice was studied in rats. Protein extravasation using the Evans blue technique was measured and used to indicate edema formation. A pH dependent Evans blue extravasation was observed whereby pH 2 p...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198803000-00005
更新日期:1988-03-01 00:00:00
abstract::To determine whether neuronal firing is affected by anesthetics, the behavior of neurons in the mesencephalic reticular formation in response to repetitive somatosensory stimulation at 2/sec was studied during wakefulness and during nitrous oxide, halothane, and thiopental anesthesia in the cat. With clinical doses of...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197710000-00005
更新日期:1977-10-01 00:00:00
abstract:BACKGROUND:The results of sevoflurane biotransformation (fluoromethyl-1,1,1,3,3,3,-hexafluoro-2-propyl ether) to inorganic fluoride have been examined. However, these investigations have lacked a simplified assay for determining the primary organic metabolite, hexafluoroisopropanol. Previous attempts have involved exte...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199401000-00027
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Cardiac surgery requiring cardiopulmonary bypass is associated with platelet activation. Because platelets are increasingly recognized as important effectors of ischemia and end-organ inflammatory injury, the authors explored whether postoperative nadir platelet counts are associated with acute kidney injury...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000959
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:To characterize the impact of lung volume changes in the lung function impairment after the surgical repair of congenital heart diseases, combined measurements of functional residual capacity, lung clearance index, and respiratory mechanics were performed in children with hypoperfused lungs (tetralogy of Fal...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181a32887
更新日期:2009-06-01 00:00:00
abstract::The effect of hypocapnia on autoregulation of cerebral blood flow (CBF) and the lower limit of autoregulation (LLA) was determined in dogs anesthetized with nitrous oxide (66%) and halothane (0.2%, end-expired concentration). CBF and cerebral vascular resistance (CVR) were determined during both normocapnia and hypoca...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198902000-00018
更新日期:1989-02-01 00:00:00
abstract::To determine the minimum alveolar concentration (MAC) and hemodynamic responses to halothane, isoflurane, and sevoflurane in newborn swine, 36 fasting swine 4-10 days of age were anesthetized with one of the three volatile anesthetics in 100% oxygen. MAC was determined for each swine. Carotid artery and internal jugul...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199010000-00018
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND:In airway smooth muscle (ASM), volatile anesthetics deplete sarcoplasmic reticulum (SR) Ca(2+) stores by increasing Ca(2+) "leak." Accordingly, SR replenishment becomes dependent on Ca(2+) influx. Depletion of SR Ca(2+) stores triggers Ca(2+) influx via specific plasma membrane channels, store-operated Ca(2+...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200408000-00018
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:There is an increasing interest in the use of dexmedetomidine for anesthesia and sedation. Here, we used the mouse organotypic hippocampal slice culture to investigate whether dexmedetomidine exhibits postconditioning properties against oxygen and glucose deprivation (OGD). The role of the focal adhesion and...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181ca6982
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Endothelium-derived hyperpolarizing factor is thought to be a cytochrome P450-derived arachidonic acid metabolite that hyperpolarizes vascular smooth muscle cells by opening Ca(2+)-activated K+ channels (K+Ca channels). In the rabbit carotid artery both volatile and intravenous anesthetics inhibit the acetyl...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199606000-00025
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:Pneumocephalus occurs in a variety of clinical settings and has important anesthetic implications, particularly if N2O is used. One common cause of pneumocephalus is a craniotomy or craniectomy, and therefore, patients undergoing these neurosurgical procedures may be at increased risk for the development of ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199405000-00009
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:The authors compare three techniques for insertion of the ProSeal laryngeal mask airway. METHODS:Two hundred forty healthy patients aged 18-80 yr were randomly allocated for ProSeal laryngeal mask airway insertion using the digital, introducer tool (IT), or gum elastic bougie (GEB)-guided techniques. The di...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200401000-00008
更新日期:2004-01-01 00:00:00
abstract::Distribution and elimination of lidocaine and mepivacaine were studies in 114 subjects after obstetric epidural anesthesia, Epinephrine significantly lowered the concentrations of lidocaine in the mothers' circulations by about 33 per cent, and the concentrations of mepivacaine by about 22 per cent. It also significan...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197506000-00014
更新日期:1975-06-01 00:00:00
abstract::The need for accurate clinical diagnosis and appropriate intervention requires that a modern blood-gas laboratory have the means to correct for significant discrepancies between patient temperature and the temperature at which in vitro blood samples are analyzed. Recent advances in mini- and microcomputer technology p...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198109000-00022
更新日期:1981-09-01 00:00:00
abstract::In order to elucidate the possible mechanism(s) by which opiates may affect cerebral and spinal circulation, and cerebral metabolism, cerebral blood flow (CBF) and spinal cord blood flow (SCBF) were measured simultaneously following intravenous or subarachnoid administration of morphine in dogs lightly anesthetized wi...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:Medical errors exact an inordinate toll on healthcare costs. One of the most publicized and analyzed type of medical error is wrong-site surgery. Yet, despite the burgeoning number of procedures performed, no literature exists on wrong-site pain management injections. The purpose of this study was to estimat...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/ALN.0b013e3181cf892d
更新日期:2010-03-01 00:00:00
abstract::Chronic muscle disuse decreases the sensitivity of skeletal muscle to nondepolarizing relaxants, such as metocurine (MTC). In this study, the authors determined whether chronic conditioning would produce the opposite effect and increase the sensitivity of skeletal muscle to MTC. Five dogs were exercised by daily runni...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198906000-00015
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Potential deleterious effect of multiple anesthesia exposures on the developing brain remains a clinical concern. We hypothesized that multiple neonatal anesthesia exposures are more detrimental to brain maturation than an equivalent single exposure, with more pronounced long-term behavioral consequences. We...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002229
更新日期:2018-07-01 00:00:00
abstract::It is a common practice for anesthesia to substitute for one another, especially for short breaks during long surgical procedures. The assets and liabilities of this practice of relief have not been examined previously. In the course of gathering 1,089 reports of preventable errors and failures associated with anesthe...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198206000-00010
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:Both esophagectomy and pulmonary resection are associated with postoperative cardiac complications, partly because of autonomic perturbations involving the heart. This study was undertaken to determine whether heart rate variability (HRV), employed as an index of cardiac autonomic function, changes in patien...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199605000-00008
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:Propofol can be associated with delayed awakening after prolonged infusion. The aim of this study was to characterize the preclinical pharmacology of AZD-3043, a positive allosteric modulator of the γ-aminobutyric acid type A (GABA(A)) receptor containing a metabolically labile ester moiety. The authors post...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e31825685a6
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Septic shock is associated with vasopressin deficiency and a hypersensitivity to its exogenous administration. The goal of the current study was to determine whether short-term vasopressin infusion in patients experiencing severe septic shock has a vasopressor sparing effect while maintaining hemodynamic sta...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200203000-00011
更新日期:2002-03-01 00:00:00
abstract::Clonidine, an alpha 2-adrenergic agonist, can potentiate opioid-induced analgesia. In a double-blind placebo-controlled study in human volunteers, we sought to determine whether clonidine also potentiates opioid-induced respiratory depression. Hypercapnic ventilatory responses (minute ventilation, mean inspiratory flo...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1097/00000542-199206000-00005
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:Clonidine, an alpha 2-adrenoceptor agonist, has been shown to be effective as a preanesthetic medication in adults. The current study was designed to investigate the efficacy of two doses of oral clonidine as a premedicant preceding oral atropine in children. METHODS:In a prospective, randomized, double-bli...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199311000-00009
更新日期:1993-11-01 00:00:00
abstract::To determine whether anesthesiologists can manually detect significant changes in pulmonary compliance in neonates using an "educated hand," the authors tested whether clinicians could detect clamping of an endotracheal tube connecting a neonatal lung model to one of three anesthesia breathing circuits. The test lungs...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199110000-00022
更新日期:1991-10-01 00:00:00