Abstract:
:Arterial and peripheral venous plasma levels of bupivacaine were determined in 30 patients following epidural anesthesia using 150 and 225 mg, as well as following intercostal nerve block with 400 mg. Arterial levels were consistently higher than levels in simultaneously sampled venous blood, and the highest levels occurred with bilateral intercostal nerve block. No evidence of systemic toxicity was observed. The results suggest that bupivacaine may have a wider margin of safety in man than is now stated.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Moore DC,Mather LE,Bridenbaugh PO,Bridenbaugh LD,Balfour RI,Lysons DF,Horton WGdoi
10.1097/00000542-197607000-00008subject
Has Abstractpub_date
1976-07-01 00:00:00pages
39-45issue
1eissn
0003-3022issn
1528-1175journal_volume
45pub_type
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