Abstract:
:Using the technique of ventriculocisternal perfusion, resistance to reabsorption of cerebrospinal fluid (Ra) was calculated from determinations of the rate of reabsorption of cerebrospinal fluid (Va) at differing cerebrospinal fluid pressures in dogs. Ra was examined during prolonged anesthesia (5.0-6.0 h) with enflurane (2.2%, end expired) or isoflurane (1.4%, end expired). Compared with previously reported normal values for Ra in dogs (220-224 cmH2O . ml-1 . min), enflurane increased Ra to 274 +/- 4 cmH2O . ml-1 . min (mean +/- SEM), and isoflurane decreased Ra to 104 +/- 1 cmH2O . ml-1 . min. The alterations of cerebrospinal fluid (CSF) dynamics caused by enflurane, namely increase of both Ra and the rate of production of cerebrospinal fluid (Vf), may contribute to the sustained increase of intracranial pressure observed during prolonged anesthesia with enflurane. In contrast, the different alterations of CSF dynamics caused by isoflurane, namely decrease of Ra with no change in Vf, may explain, in part, why minimal increase of intracranial pressure is observed during prolonged anesthesia with isoflurane. Because decreased Ra improves spatial compensation by cerebrospinal fluid volume for increased intracranial pressure, isoflurane may offer an advantage over enflurane in patients at risk because of increased intracranial pressure.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Artru AAdoi
10.1097/00000542-198411000-00009subject
Has Abstractpub_date
1984-11-01 00:00:00pages
529-33issue
5eissn
0003-3022issn
1528-1175journal_volume
61pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract:BACKGROUND:The health-related effects of the operating room environment are unclear. The authors compared mortality risks of anesthesiologists to those of internal medicine physicians between 1979 and 1995. METHODS:The Physician Master File database, a listing of all US physicians, was used to identify anesthesiologis...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200010000-00008
更新日期:2000-10-01 00:00:00
abstract::Anesthesiologist-reviewers examined 1,175 anesthetic-related closed malpractice claims from 17 professional liability insurance companies. The claims were filed between 1974 and 1988. The reviewers were asked to determine if the negative outcome was preventable by proper use of additional monitoring devices available ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198910000-00010
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:The distribution and elimination of 0.9% saline given by intravenous infusion has not been compared between the conscious state and during inhalational anesthesia. METHODS:Six adult sheep received an intravenous infusion of 25 ml/kg of 0.9% saline over 20 min in the conscious state and also during isofluran...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200202000-00033
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:This propensity score-matched cohort study evaluates the effect of anesthetic technique on a 30-day mortality after total hip or knee arthroplasty. METHODS:All patients who had hip or knee arthroplasty between January 1, 2003, and December 31, 2014, were evaluated. The principal exposure was spinal versus g...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001248
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:During emergence from anesthesia, breathing 100% oxygen is frequently used to provide a safety margin toward hypoxemia in case an airway problem occurs. Oxygen breathing has been shown to cause pulmonary gas exchange disorders in healthy individuals. This study investigates how oxygen breathing during emerge...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000000161
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Several beneficial effects of local anesthetics (LAs) were shown to be due to inhibition of G protein-coupled receptor signaling. Differences in exposure time might explain discrepancies in concentrations of LAs required to achieve these protective effects in vivo and in vitro (approximately 100-fold higher)...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200404000-00015
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Tight perioperative control of blood glucose improves the outcome of diabetic patients undergoing cardiac surgery. Because stress response and cardiopulmonary bypass can induce profound hyperglycemia, intraoperative glycemic control may become difficult. The authors undertook a prospective cohort study to de...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200510000-00006
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:An initial pilot study of 300 sub-Tenon local anesthetic blocks (STBs) for intraocular surgery established the effectiveness and patient acceptability of the technique. Following this, a decision was made in 1995 to change from sharp needle techniques to STB for all eye surgeries performed during local anest...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1097/00000542-200304000-00025
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Postoperative respiratory failure is associated with increased morbidity and mortality, as well as high costs of hospital care. METHODS:Using electronic anesthesia records, billing data, and chart review, the authors developed and validated a score predicting reintubation in the hospital after primary extub...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e318293065c
更新日期:2013-06-01 00:00:00
abstract::The authors evaluated the systemic and cerebral hemodynamic and metabolic effects of 1 h of hypotension to a mean arterial pressure of either 50 mmHg or 40 mmHg induced by intravenous adenosine or ATP in dogs maintained on 70% nitrous oxide and 0.1% halothane. Following the hypotensive period, brain biopsy specimens w...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198504000-00010
更新日期:1985-04-01 00:00:00
abstract:BACKGROUND:Anesthetic preconditioning (APC) is a clinically important phenomenon in which volatile anesthetics (VAs) protect tissues such as heart against ischemic injury. The mechanism of APC is thought to involve K channels encoded by the Slo gene family, and the authors showed previously that slo-2 is required for A...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001046
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Intraspinally administered alpha 2-adrenergic agonists may relieve pain in sympathetically maintained pain (SMP) syndromes, such as reflex sympathetically dystrophy (RSD), by spinal, peripheral, and central nervous system actions. This study examined analgesic efficacy and side effects of epidurally administ...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Investigators in the authors' laboratory previously established the critical participation of the cerulospinal noradrenergic pathway in muscular rigidity elicited by fentanyl. The identification of colocalization of glutamate with tyrosine hydroxylase in most locus ceruleus neurons suggests a role for cerulo...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199712000-00024
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Cerebral injury is among the most common and disabling complications of open heart surgery. Attempts to provide neuroprotection have yielded conflicting results. We assessed the potential of propofol-induced burst suppression during open heart surgery to provide cerebral protection as determined by postopera...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00000542-199905000-00006
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:alpha 2 Agonists are powerful analgesics after spinal delivery. The current work characterizes the dose-dependent antinociception and effects upon respiratory function of dexmedetomidine after intrathecal, epidural, intravenous, and intracisternal delivery in chronically prepared dogs. METHODS:Dogs were pre...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199405000-00015
更新日期:1994-05-01 00:00:00
abstract::The slow positive (P2) wave of the evoked electrospinogram was recorded from the dorsal epidural space in man. The waveform characteristics of the P2 wave were similar to those of the dorsal cord positive wave (P wave), which is believed to be caused by the primary afferent depolarization (PAD) and to be related to pr...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197510000-00003
更新日期:1975-10-01 00:00:00
abstract:BACKGROUND:Combined spinal-epidural anesthesia is a technique growing in popularity. However, there have been no attempts to investigate the risk of epidural drug reaching the subarachnoid space in high concentration by passing through the meningeal hole left by the spinal needle. This study begins to address this ques...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199404000-00019
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:Neuroligin-1 (NL1) forms a complex with the presynaptic neurexin-1β (Nrx1b), regulating clustering of N-methyl-D-aspartate receptors with postsynaptic density-95 (PSD-95) to underlie learning-/memory-associated plasticity. Pain-related spinal neuroplasticity shares several common features with learning-/memo...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000809
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:The authors reviewed efficacy and safety data for ondansetron for preventing postoperative nausea and vomiting (PONV). METHODS:Systematically searched, randomized, controlled trials (obtained through MEDLINE, EMBASE, Biological Abstracts, manufacturer's database, manual searching of journals, and article ref...
journal_title:Anesthesiology
pub_type: 杂志文章,meta分析
doi:10.1097/00000542-199712000-00004
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:The authors hypothesized that myoclonus after etomidate is dose-related, could be suppressed when small doses of etomidate were administered before induction, and is unassociated with seizure-like activity on electroencephalogram (EEG). METHODS:Three studies were performed. In the first study, 36 men were r...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199901000-00017
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Lactate has been shown to be a prognostic biomarker in trauma. Although lactate clearance has already been proposed as an intermediate endpoint in randomized trials, its precise role in trauma patients remains to be determined. METHODS:Blood lactate levels and lactate clearance (LC) were calculated at admis...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e318273349d
更新日期:2012-12-01 00:00:00
abstract::Postoperative adrenocortical function was compared in 23 out-patients receiving either thiopental, 4 mg/kg, for induction and a thiopental infusion, 0.26 mg . kg-1 . min-1, in combination with nitrous oxide 70% for maintenance of anesthesia (control); etomidate, 0.4 mg/kg, for induction followed by an etomidate infusi...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198412000-00003
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:Mice lacking calsequestrin-1 (CASQ1-null), a Ca-binding protein that modulates the activity of Ca release in the skeletal muscle, exhibit lethal hypermetabolic episodes that resemble malignant hyperthermia in humans when exposed to halothane or heat stress. METHODS:Because oxidative species may play a criti...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000748
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:The pharmacokinetics of epidurally administered drugs has been the subject of many studies, yet drug concentration in the epidural space has never been measured. This study was undertaken to characterize the epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidurally administered opioids on the ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200308000-00029
更新日期:2003-08-01 00:00:00
abstract::Halothane-induced lipid peroxidation was studied in microsomes from phenobarbital-pretreated male rats at defined steady state oxygen partial pressures (PO2). At PO2 less than 10 mmHg on addition of halothane to NADPH-reduced microsomes, significant increases in malondialdehyde (MDA) formation, oxygen uptake, and conj...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198501000-00009
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively....
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002103
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The spinal delivery of the cholinesterase inhibitor neostigmine yields analgesia in rats and augments the analgesic effects of alpha 2 agonists in sheep. To assess its activity in humans, preclinical toxicology studies to define its safety were required in two species. METHODS:Rats with chronic intrathecal ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199502000-00012
更新日期:1995-02-01 00:00:00
abstract::The occurrence of fasciculations following administration of agents is a well-known pharmacologic phenomenon. Using the cat soleus nerve-muscle preparation, intravenous neostigmine doses between 20-200 micrograms/kg evoked fasciculations in a dose-related manner. The data demonstrate that the fasciculations were the r...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198712000-00011
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:QX-314 produces nociceptive blockade, facilitated by permeation through transient receptor potential vanilloid-1 (TRPV1) channels. TRPV1 channel can be activated by noxious heat and sensitized by volatile anesthetics. The authors hypothesized that emulsified isoflurane (EI) could enhance thermal TRPV1 channe...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000236
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Densities in dependent lung regions worsen oxygenation in patients with acute respiratory distress syndrome. Identification of these densities requires examination using computed tomography (CT). In this study, the authors evaluated the use of transesophageal echocardiography (TEE) to estimate densities in t...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200105000-00017
更新日期:2001-05-01 00:00:00