Enflurane causes a prolonged and reversible increase in the rate of CSF production in the dog.

abstract：BACKGROUND:Ketamine has been associated with a unique spectrum of subjective "psychedelic" effects in patients emerging from anesthesia. This study quantified these effects of ketamine and related them to steady-state plasma concentrations. METHODS:Ketamine or saline was administered in a single-blinded crossover prot...

journal_title：Anesthesiology

authors： Bowdle TA,Radant AD,Cowley DS,Kharasch ED,Strassman RJ,Roy-Byrne PP

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:It is not always possible to predict when tracheal intubation will be difficult or impossible. The authors wanted to determine whether indirect laryngoscopy could identify patients in whom intubation was difficult. METHODS:Indirect laryngoscopy was done in 2,504 patients. The Wilson risk sum score and the m...

journal_title：Anesthesiology

authors： Yamamoto K,Tsubokawa T,Shibata K,Ohmura S,Nitta S,Kobayashi T

更新日期：1997-02-01 00:00:00

abstract：:This study examined whether pain or stress can enhance the analgesic effects of spinally administered opiates. The experiments determined the effects of mechanically produced pain and of the stress of being restrained on the analgesic effects of 0.63 microgram of epidural sufentanil in rats using a tail-withdrawal pro...

journal_title：Anesthesiology

authors： Van den Hoogen RH,Bervoets K,Colpaert FC

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:Local anesthetics were suggested to have a potential for neurotoxicity in both clinical reports and laboratory experiments. Growing neurons have been shown to be susceptible to the toxic effects of local anesthetics in culture. These findings have generated the interest in factors that would rescue the neuro...

journal_title：Anesthesiology

authors： Radwan IA,Saito S,Goto F

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Chronic pain is associated with depression. In rodents, pain is often assessed by sensory hypersensitivity, which does not sufficiently measure affective responses. Low-dose ketamine has been used to treat both pain and depression, but it is not clear whether ketamine can relieve depression associated with c...

journal_title：Anesthesiology

authors： Wang J,Goffer Y,Xu D,Tukey DS,Shamir DB,Eberle SE,Zou AH,Blanck TJ,Ziff EB

更新日期：2011-10-01 00:00:00

abstract：:Inorganic fluoride (F-) production and renal function were assessed in six groups of Fischer 344 rats administered either methoxyflurane (MOF) or deuterated methoxyflurane (d4-MOF). One untreated and one phenobarbital (PB)-treated group were exposed for two hours to either air, 0.5 per cent (V/v) MOF, or 0.5 per cent ...

journal_title：Anesthesiology

authors： Baden JM,Rice SA,Mazze RI

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:Sevoflurane is a volatile general anesthetic that differs in chemical nature from the gaseous anesthetic nitrous oxide. In a controlled laboratory setting, the authors characterized the subjective, psychomotor, and analgesic effects of sevoflurane and nitrous oxide at two equal minimum alveolar subanesthetic...

journal_title：Anesthesiology

authors： Galinkin JL,Janiszewski D,Young CJ,Klafta JM,Klock PA,Coalson DW,Apfelbaum JL,Zacny JP

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Studies using transthoracic thermodilution have demonstrated increased extravascular lung water (EVLW) measurements attributed to progression of edema and flooding during sepsis and acute lung injury. The authors hypothesized that redistribution of pulmonary blood flow can cause increased apparent EVLW secon...

journal_title：Anesthesiology

authors： Easley RB,Mulreany DG,Lancaster CT,Custer JW,Fernandez-Bustamante A,Colantuoni E,Simon BA

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Recent trials indicate that rapacuronium's pharmacokinetic characteristics are influenced by both renal failure and cirrhosis but the time course of a single bolus dose of 1.5 mg/kg is affected minimally. The authors reassessed these pharmacokinetic findings and examined the time course of the same bolus dos...

journal_title：Anesthesiology

authors： Fisher DM,Dempsey GA,Atherton DP,Brown R,Abengochea A,Hunter JM

更新日期：2000-12-01 00:00:00

abstract：:A carcinogen bioassay of enflurane was performed in Swiss/ICR mice. Two groups of weanling mice, each of 125 males and 125 females, were exposed to eigher a maximum tolerated dose of enflurane, 3000 ppm (0.3 per cent v/v) or compressed air for 4 hs per day, 5 days per week. After 52 weeks exposure, 25 males and 25 fem...

journal_title：Anesthesiology

authors： Baden JM,Egbert B,Mazze RI

更新日期：1982-01-01 00:00:00

abstract：:The serum and urinary concentrations of fluorinated metabolites of isoflurane after inhalation of three different concentrations of isoflurane were studied in 18 ASA physical status 1 or 2 patients, scheduled for orthopedic or otolaryngeal surgery. Isoflurane was administered for 60 min during fentanyl-nitrous oxide-o...

journal_title：Anesthesiology

authors： Davidkova T,Kikuchi H,Fujii K,Mukaida K,Sato N,Kawachi S,Morio M

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND:There is an increasing interest in the use of dexmedetomidine for anesthesia and sedation. Here, we used the mouse organotypic hippocampal slice culture to investigate whether dexmedetomidine exhibits postconditioning properties against oxygen and glucose deprivation (OGD). The role of the focal adhesion and...

journal_title：Anesthesiology

authors： Dahmani S,Rouelle D,Gressens P,Mantz J

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Because the ultimate purpose of new medical knowledge is to achieve improved health outcomes, physicians need to possess and use this knowledge in their practice. The authors introduced enhanced education and individualized feedback to reduce postoperative nausea and vomiting (PONV). The primary objective wa...

journal_title：Anesthesiology

authors： Cohen MM,Rose DK,Yee DA

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Acute kidney injury is a common complication after cardiac surgery, leading to increased morbidity and mortality. One suggested cause for acute kidney injury is extracorporeal circulation-induced ischemia-reperfusion injury. In animal studies, cyclosporine has been shown to reduce ischemia-reperfusion injury...

journal_title：Anesthesiology

authors： Ederoth P,Dardashti A,Grins E,Brondén B,Metzsch C,Erdling A,Nozohoor S,Mokhtari A,Hansson MJ,Elmér E,Algotsson L,Jovinge S,Bjursten H

更新日期：2018-04-01 00:00:00

abstract：:To determine the effects of cardiopulmonary bypass (CPB) and hypothermia on the neuromuscular blockade produced by pancuronium, this relaxant was infused intravenously into 10 anesthetized patients to produce and maintain 90% depression of the twitch tension of the adductor pollicis muscle following supramaximal ulnar...

journal_title：Anesthesiology

authors： d'Hollander AA,Duvaldestin P,Henzel D,Nevelsteen M,Bomblet JP

更新日期：1983-06-01 00:00:00

abstract：:Patients with mitral valve disease can develop pulmonary artery hypertension that persists after mitral valve replacement. In 1987, nitric oxide (NO) was reported to be an important factor accounting for the biologic activity of endothelium-derived relaxing factor. Inhaled NO was subsequently reported to be a selectiv...

journal_title：Anesthesiology

authors： Girard C,Lehot JJ,Pannetier JC,Filley S,Ffrench P,Estanove S

更新日期：1992-11-01 00:00:00

abstract：:The authors determined the thiopental dose needed for satisfactory induction in ten neonates, 0-14 days of age, and 20 infants, 1-6 months of age. A single iv bolus of thiopental was given. Thirty seconds after injection the anesthesia mask was applied and the response was observed during the following 30 s while the ...

journal_title：Anesthesiology

authors： Westrin P,Jonmarker C,Werner O

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:It has been reported that opioid antinociceptive effects are enhanced in animal models of inflammation, but it remains unclear whether this sensitization to morphine is related to predominant central or peripheral increased effects. METHODS:The authors compared the behavioral effects of intraplantar and int...

journal_title：Anesthesiology

authors： Perrot S,Guilbaud G,Kayser V

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Obstetrics carries high medical liability risk. Maternal death and newborn death/brain damage were the most common complications in obstetric anesthesia malpractice claims before 1990. As the liability profile may have changed over the past two decades, the authors reviewed recent obstetric claims in the Ame...

journal_title：Anesthesiology

authors： Davies JM,Posner KL,Lee LA,Cheney FW,Domino KB

更新日期：2009-01-01 00:00:00

abstract：:Neurophysiologic and local cerebral metabolic mapping techniques indicate that seizures associated with lidocaine toxicity originate in subcortical brain structures. Normally local cerebral blood flow (l-CBF) is quantitatively coupled to local cerebral metabolic rate for glucose (l-CMRg). In the present study the resp...

journal_title：Anesthesiology

authors： Tommasino C,Maekawa T,Shapiro HM

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:Suboptimal tissue perfusion and oxygenation during surgery may be responsible for postoperative nausea and vomiting in some patients. This trial tested the hypothesis that muscular tissue oxygen saturation-guided intraoperative care reduces postoperative nausea and vomiting. METHODS:This multicenter, pragma...

journal_title：Anesthesiology

authors： Li G,Tian DD,Wang X,Feng X,Zhang W,Bao J,Wang DX,Ai YQ,Liu Y,Zhang M,Xu M,Mu DL,Zhao X,Dai F,Yang JJ,Che X,Yanez D,Guo X,Meng L,iMODIPONV Research Group.

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Epidural morphine has proven analgesic efficacy in the postoperative period and is widely used. This study evaluated the efficacy of extended-release epidural morphine (EREM; DepoDur; Endo Pharmaceuticals Inc., Chadds Ford, PA; SkyePharma, Inc., San Diego, CA) in providing pain relief for 48 h after surgery....

journal_title：Anesthesiology

authors： Viscusi ER,Martin G,Hartrick CT,Singla N,Manvelian G,EREM Study Group.

更新日期：2005-05-01 00:00:00

abstract：:The effect of temperature (37 degrees C, 28 degrees C, and 18 degrees C), 160 mg/kg lidocaine, and 40 mg/kg thiopental on the efflux of cellular potassium in the cerebral cortex during complete global ischemia was examined. Cerebral ischemia was induced in dogs on cardiopulmonary bypass circulation by stopping the pum...

journal_title：Anesthesiology

authors： Astrup J,Skovsted P,Gjerris F,Sørensen HR

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND:Cardiac surgery requiring cardiopulmonary bypass is associated with platelet activation. Because platelets are increasingly recognized as important effectors of ischemia and end-organ inflammatory injury, the authors explored whether postoperative nadir platelet counts are associated with acute kidney injury...

journal_title：Anesthesiology

authors： Kertai MD,Zhou S,Karhausen JA,Cooter M,Jooste E,Li YJ,White WD,Aronson S,Podgoreanu MV,Gaca J,Welsby IJ,Levy JH,Stafford-Smith M,Mathew JP,Fontes ML

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Cardiac surgery requiring the use of cardiopulmonary bypass is frequently complicated by coagulopathic bleeding that, largely due to the shortcomings of conventional coagulation tests, is difficult to manage. This study evaluated a novel transfusion algorithm that uses point-of-care coagulation testing. MET...

journal_title：Anesthesiology

authors： Karkouti K,McCluskey SA,Callum J,Freedman J,Selby R,Timoumi T,Roy D,Rao V

更新日期：2015-03-01 00:00:00

abstract：:Ropivacaine is an amide local anesthetic structurally related to, but appearing less cardiotoxic, than bupivacaine. The authors' investigation was designed in a randomized, double-blind fashion to compare the clinical effectiveness of ropivacaine and bupivacaine in patients undergoing lower-extremity surgery. Forty-fi...

journal_title：Anesthesiology

authors： Brown DL,Carpenter RL,Thompson GE

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:Transient receptor potential vanilloid 1 channels integrate nociceptive stimuli and are predominantly expressed by unmyelinated C-fiber nociceptors, but not low-threshold mechanoreceptive sensory or motor fibers. A recent report showed that the transient receptor potential vanilloid 1 channel agonist capsaic...

journal_title：Anesthesiology

authors： Gerner P,Binshtok AM,Wang CF,Hevelone ND,Bean BP,Woolf CJ,Wang GK

更新日期：2008-11-01 00:00:00

abstract：:The anesthetic requirements for sevoflurane, isoflurane, and halothane were determined in mongrel dogs. The MACs (minimum alveolar concentration) of sevoflurane, isoflurane, and halothane were 2.36 +/- 0.46% (n = 18), 1.39 +/- 0.25% (n = 10), and 0.89 +/- 0.20% (n = 12), respectively (mean +/- SD). In agreement with s...

journal_title：Anesthesiology

authors： Kazama T,Ikeda K

更新日期：1988-03-01 00:00:00

abstract：:Deliberate hypotension was induced with isoflurane (mean inspired concentration 2.3 +/- 1.0%) in 12 patients undergoing craniotomy for clipping of cerebral aneurysms. Global cerebral blood flow (CBF) was measured before, during, and after hypotension. Arterio-venous O2 content difference was measured concomitantly, an...

journal_title：Anesthesiology

authors： Newman B,Gelb AW,Lam AM

更新日期：1986-03-01 00:00:00

abstract：:There is controversy about whether N2O increases cerebral blood flow and cortical oxygen consumption (CMRO2) in rats. Cortical and subcortical blood flow and CMRO2 were measured in awake, unrestrained rats while awake and during 70% N2O administration using radioactive microspheres. In the awake state, cortical and su...

journal_title：Anesthesiology

authors： Baughman VL,Hoffman WE,Miletich DJ,Albrecht RF

更新日期：1990-08-01 00:00:00