Redistribution of pulmonary blood flow impacts thermodilution-based extravascular lung water measurements in a model of acute lung injury.

abstract：BACKGROUND:Mice lacking calsequestrin-1 (CASQ1-null), a Ca-binding protein that modulates the activity of Ca release in the skeletal muscle, exhibit lethal hypermetabolic episodes that resemble malignant hyperthermia in humans when exposed to halothane or heat stress. METHODS:Because oxidative species may play a criti...

journal_title：Anesthesiology

authors： Michelucci A,Paolini C,Canato M,Wei-Lapierre L,Pietrangelo L,De Marco A,Reggiani C,Dirksen RT,Protasi F

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:The authors hypothesized that myoclonus after etomidate is dose-related, could be suppressed when small doses of etomidate were administered before induction, and is unassociated with seizure-like activity on electroencephalogram (EEG). METHODS:Three studies were performed. In the first study, 36 men were r...

journal_title：Anesthesiology

authors： Doenicke AW,Roizen MF,Kugler J,Kroll H,Foss J,Ostwald P

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Propofol is an alternative to thiopental as an intravenous induction agent for cesarean section. Because it has relaxant effects on vascular and other smooth muscles, the authors set out to determine whether propofol has any effect on pregnant human uterine smooth muscle in an isolated preparation. METHODS:...

journal_title：Anesthesiology

authors： Shin YK,Kim YD,Collea JV

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:In patients with acute respiratory distress syndrome (ARDS), the ventilatory approach is based on tidal volume (VT) of 10-15 ml/kg and positive end-expiratory pressure (PEEP). To avoid further pulmonary injury, decreasing VT and allowing PaCO2 to increase (permissive hypercapnia) has been suggested. Effects ...

journal_title：Anesthesiology

authors： Ranieri VM,Mascia L,Fiore T,Bruno F,Brienza A,Giuliani R

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Pneumocephalus occurs in a variety of clinical settings and has important anesthetic implications, particularly if N2O is used. One common cause of pneumocephalus is a craniotomy or craniectomy, and therefore, patients undergoing these neurosurgical procedures may be at increased risk for the development of ...

journal_title：Anesthesiology

authors： Reasoner DK,Todd MM,Scamman FL,Warner DS

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Adaptive support ventilation can speed weaning after coronary artery surgery compared with protocolized weaning using other modes. There are no data to support this mode of weaning after cardiac valvular surgery. Furthermore, control group weaning times have been long, suggesting that the results may reflect...

journal_title：Anesthesiology

authors： Zhu F,Gomersall CD,Ng SK,Underwood MJ,Lee A

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Intrathecal methylprednisolone acetate (MPA) has been used in patients with chronic pain syndromes. Its safety has been debated after reports of adverse events. No systematic preclinical evaluation of MPA has been reported. In the current study, the acute and long-term effects of intrathecal MPA on dog spina...

journal_title：Anesthesiology

authors： Rijsdijk M,van Wijck AJ,Kalkman CJ,Meulenhoff PC,Grafe MR,Steinauer J,Yaksh TL

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that desflurane and isoflurane produce similar hemodynamic actions. This investigation examined the cardiovascular effects of desflurane and isoflurane in the presence or absence of dexmedetomidine, a highly selective alpha 2-adrenergic agonist that may be clinically useful as a p...

journal_title：Anesthesiology

authors： Kersten J,Pagel PS,Tessmer JP,Roerig DL,Schmeling WT,Warltier DC

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Chloroprocaine has been associated with severe back pain after epidural anesthesia. Factors proposed to contribute to this problem are: 1) the preservative disodium ethylenediaminetetraacetic acid (EDTA), 2) large volumes of chloroprocaine, 3) low pH of chloroprocaine, and 4) local infiltration with chloropr...

journal_title：Anesthesiology

authors： Stevens RA,Urmey WF,Urquhart BL,Kao TC

更新日期：1993-03-01 00:00:00

abstract：:An important guideline for anesthesia in patients with ischemic heart disease is the effect on myocardial oxygen demand. Therefore, this investigation evaluated commonly used myocardial oxygen demand formulas for clinical application. The study was performed on patients undergoing coronary bypass surgery (n = 62). Mea...

journal_title：Anesthesiology

authors： Hoeft A,Sonntag H,Stephan H,Kettler D

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Intraspinally administered alpha 2-adrenergic agonists may relieve pain in sympathetically maintained pain (SMP) syndromes, such as reflex sympathetically dystrophy (RSD), by spinal, peripheral, and central nervous system actions. This study examined analgesic efficacy and side effects of epidurally administ...

journal_title：Anesthesiology

authors： Rauck RL,Eisenach JC,Jackson K,Young LD,Southern J

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Chronic pain models are commonly defined as either nerve-injury or inflammation models, but recent work suggests inflammatory processes are important in nerve injury-induced pain. METHODS:In the rat spinal nerve ligation model, the authors examined effects of systemic corticosteroid triamcinolone acetonide ...

journal_title：Anesthesiology

authors： Li H,Xie W,Strong JA,Zhang JM

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Systemically administered local anesthetics and other sodium channel blockers produce analgesia in patients with hypersensitivity disorders. To assess whether these agents have a role in the treatment of visceral pain, the present study examined the effects of intravenous lidocaine on neuronal and reflex res...

journal_title：Anesthesiology

authors： Ness TJ

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Ethical conduct in human research in anesthesia includes approval by an institutional review board (IRB) or ethics committee and informed consent. Evidence of these is sometimes lacking in journal publications. METHODS:The authors reviewed all publications involving human subjects in six leading anesthesia ...

journal_title：Anesthesiology

authors： Myles PS,Tan N

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:To assess changing patterns of injury and liability associated with central venous or pulmonary artery catheters, the authors analyzed closed malpractice claims for central catheter injuries in the American Society of Anesthesiologists Closed Claims database. METHODS:All claims for which a central catheter ...

journal_title：Anesthesiology

authors： Domino KB,Bowdle TA,Posner KL,Spitellie PH,Lee LA,Cheney FW

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Patient blood management combines the use of several transfusion alternatives. Integrated use of erythropoietin, cell saver, and/or postoperative drain reinfusion devices on allogeneic erythrocyte use was evaluated using a restrictive transfusion threshold. METHODS:In a factorial design, adult elective hip-...

journal_title：Anesthesiology

authors： So-Osman C,Nelissen RG,Koopman-van Gemert AW,Kluyver E,Pöll RG,Onstenk R,Van Hilten JA,Jansen-Werkhoven TM,van den Hout WB,Brand R,Brand A

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Whether anesthetic agents administered during gamete intrafallopian transfer (GIFT) affect reproductive outcome is controversial. This multicenter pilot trial and survey had two purposes: to evaluate the effect of propofol, nitrous oxide, midazolam, and isoflurane on pregnancy outcome after GIFT, and to dete...

journal_title：Anesthesiology

authors： Beilin Y,Bodian CA,Mukherjee T,Andres LA,Vincent RD Jr,Hock DL,Sparks AE,Munson AK,Minnich ME,Steinkampf MP,Christman GM,McKay RS,Eisenkraft JB

更新日期：1999-01-01 00:00:00

abstract：:The effect of temperature (37 degrees C, 28 degrees C, and 18 degrees C), 160 mg/kg lidocaine, and 40 mg/kg thiopental on the efflux of cellular potassium in the cerebral cortex during complete global ischemia was examined. Cerebral ischemia was induced in dogs on cardiopulmonary bypass circulation by stopping the pum...

journal_title：Anesthesiology

authors： Astrup J,Skovsted P,Gjerris F,Sørensen HR

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND:Glutamate has been implicated in the pathophysiology of neuronal injury associated with cerebral hypoxia-ischemia. A model using chronic in utero microdialysis was developed to sample the extracellular space of the fetal brain. Using this model, we tested the hypothesis that glutamate efflux from the parasag...

journal_title：Anesthesiology

authors： Penning DH,Chestnut DH,Dexter F,Hrdy J,Poduska D,Atkins B

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Mechanical ventilation (MV) is a life-saving intervention in patients with acute respiratory failure. However, prolonged MV results in ventilator-induced diaphragm dysfunction (VIDD), a condition characterized by both diaphragm fiber atrophy and contractile dysfunction. Previous work has shown that calpain, ...

journal_title：Anesthesiology

authors： Smuder AJ,Nelson WB,Hudson MB,Kavazis AN,Powers SK

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury and often leads to multiorgan dysfunction and systemic inflammation. Volatile anesthetics have potent antiinflammatory effects. We aimed to determine whether the representative volatile anesthetic isoflurane protects against acut...

journal_title：Anesthesiology

authors： Kim M,Park SW,Kim M,D'Agati VD,Lee HT

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:This series investigated the quality of analgesia and the incidence and severity of side effects of intrathecal morphine for post-cesarean analgesia administered over a dose range of 0.0-0.5 mg. METHODS:ONE hundred eight term parturients undergoing cesarean delivery at term and given spinal anesthesia were ...

journal_title：Anesthesiology

authors： Palmer CM,Emerson S,Volgoropolous D,Alves D

更新日期：1999-02-01 00:00:00

abstract：:To assess depth of anesthesia for intravenous anesthetics using clinical stimuli and observed responses, it is necessary to achieve constant serum concentrations of drug that result in constant biophase or central nervous system concentrations. The goal of this investigation was to use a computer-controlled infusion p...

journal_title：Anesthesiology

authors： Bührer M,Maitre PO,Hung OR,Ebling WF,Shafer SL,Stanski DR

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:The linearity of cisatracurium elimination and its concentration-effect relation were determined as part of a traditional rich data study with three dose levels in patients receiving balanced anesthesia. METHODS:Forty-eight adults with American Society of Anesthesiologists status I-II were randomized to rec...

journal_title：Anesthesiology

authors： Bergeron L,Bevan DR,Berrill A,Kahwaji R,Varin F

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Prone ventilation redistributes lung inflation along the gravitational axis; however, localized, nongravitational effects of body position are less well characterized. The authors hypothesize that positional inflation improvements follow both gravitational and nongravitational distributions. This study is a ...

journal_title：Anesthesiology

authors： Xin Y,Cereda M,Hamedani H,Martin KT,Tustison NJ,Pourfathi M,Kadlecek S,Siddiqui S,Amzajerdian F,Connell M,Abate N,Kajanaku A,Duncan I,Gee JC,Rizi RR

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Combining a hypnotic and an analgesic to produce sedation, analgesia, and surgical immobility required for clinical anesthesia is more common than administration of a volatile anesthetic alone. The aim of this study was to apply response surface methods to characterize the interactions between remifentanil a...

journal_title：Anesthesiology

authors： Manyam SC,Gupta DK,Johnson KB,White JL,Pace NL,Westenskow DR,Egan TD

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Frailty is associated with adverse postoperative outcomes, but it remains unclear which measure of frailty is best. This study compared two approaches: the Modified Frailty Index, which is a deficit accumulation model (number of accumulated deficits), and the Hopkins Frailty Score, which is a phenotype model...

journal_title：Anesthesiology

authors： Sonny A,Kurz A,Skolaris LA,Boehm L,Reynolds A,Cummings KC 3rd,Makarova N,Yang D,Sessler DI

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Sugammadex (Org 25969) forms a complex with steroidal neuromuscular blocking agents, thereby reversing neuromuscular block. This study investigated the dose-response relation, safety, and pharmacokinetics of sugammadex to reverse rocuronium-induced block. METHODS:Twenty-seven male surgical patients aged 18-...

journal_title：Anesthesiology

authors： Sorgenfrei IF,Norrild K,Larsen PB,Stensballe J,Ostergaard D,Prins ME,Viby-Mogensen J

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Reduced spinal excitability contributes to the suppression of movement responses to noxious stimuli during the anesthetic state. This study examines and compares presynaptic and postsynaptic effects of two anesthetics in the human spinal cord. METHODS:The authors tested two parameters during the administrat...

journal_title：Anesthesiology

authors： Baars JH,Benzke M,von Dincklage F,Reiche J,Schlattmann P,Rehberg B

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:The Bispectral Index (BIS) and the Patient State Index (PSI) quantify depth of anesthesia by analyzing the electroencephalogram. The authors examined the response of BIS and PSI to sevoflurane anesthesia. METHODS:In 22 patients, sevoflurane anesthesia was induced by inhalation with a tight-fitting facemask ...

journal_title：Anesthesiology

authors： Soehle M,Ellerkmann RK,Grube M,Kuech M,Wirz S,Hoeft A,Bruhn J

更新日期：2008-11-01 00:00:00