Abstract:
:An important guideline for anesthesia in patients with ischemic heart disease is the effect on myocardial oxygen demand. Therefore, this investigation evaluated commonly used myocardial oxygen demand formulas for clinical application. The study was performed on patients undergoing coronary bypass surgery (n = 62). Measurements of standard hemodynamics were obtained before and after induction of anesthesia, as well as during sternotomy and after surgery. Coronary blood flow was determined by the argon wash-in technique. In 15 patients, a left ventricular tip manometer was used to accurately assess the first derivative of left ventricular pressure time course. The following indices of left ventricular oxygen demand were calculated: 1) rate pressure product (RPP); 2) tension time index (TTI); 3) pressure work index (PWI) according to the methods of Rooke; and 4) additive parameter (Eg), according to the methods of Bretschneider. All hemodynamic indices of myocardial oxygen demand showed moderate correlation with myocardial oxygen uptake (MVO2) (RPP: r = 0.77; TTI: r = 0.79; PWI: r = 0.79; Eg: r = 0.71). On the average, PWI and Eg led to an underestimation of MVO2 in patients. The constants of the PWI and Eg formulas, which have been developed based on animal experiments, therefore are not directly applicable to clinical conditions. New constants have been derived for PWI by multiple linear regression analysis of the data in the current investigation.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Hoeft A,Sonntag H,Stephan H,Kettler Ddoi
10.1097/00000542-199107000-00009subject
Has Abstractpub_date
1991-07-01 00:00:00pages
49-56issue
1eissn
0003-3022issn
1528-1175journal_volume
75pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract:BACKGROUND:We evaluated whether spectral entropy (SpE) can measure the depth of hypnosis and the hypnotic drug effect in children during total intravenous anesthesia. METHODS:Sixty healthy children, aged 3-16 yr, were studied. Anesthesia was induced with an increasing target controlled infusion of propofol, and mainta...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3182410b5e
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:The Pediatric Craniofacial Collaborative Group established the Pediatric Craniofacial Surgery Perioperative Registry to elucidate practices and outcomes in children with craniosynostosis undergoing complex cranial vault reconstruction and inform quality improvement efforts. The aim of this study is to determ...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/ALN.0000000000001481
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Aqueous suspensions of the local anesthetic n-butyl-p-aminobenzoate (BAB), epidurally applied in terminal cancer patients, resulted in a sensory blockade, lasting up to several months. To investigate the mechanism of action on the cellular level, the effect of 100 microM BAB on Na+ action potentials and on N...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199506000-00018
更新日期:1995-06-01 00:00:00
abstract::Vastus lateralis muscle was excised from normal pigs and from pigs susceptible to malignant hyperthermia. Anesthesia consisted of diazepam, N2O:O2, and a lidocaine field block. In the susceptible (MHS) pigs, respiratory control in mitochondria of excised muscle was normal, while electron transport was accelerated. Glu...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:
更新日期:1975-03-01 00:00:00
abstract::We sought to determine the percent delivery by metered-dose inhaler (MDI) of a preparation of salbutamol (albuterol) to the distal end of either pediatric-size tracheal tubes or a narrow-gauge catheter. A bench model consisting of a swivel actuator; 3.0-6.0-mm ID tracheal tubes all 16 cm in length or a 19-G (standard ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199102000-00024
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND:Although hyper- and hypoglycemia induce neurophysiologic changes, there have been no reports on the effects of blood glucose changes on anesthetic requirements. This study examined the effects of hyper- and hypoglycemia on the minimum alveolar concentration (MAC) of halothane in rats. In addition, based on a...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199708000-00023
更新日期:1997-08-01 00:00:00
abstract::Controversy persists about the cardiac toxicity of bupivacaine if accidentally administered intravenously during regional anesthesia. Using awake, unanesthetized sheep, we evaluated the cardiac effects of low and high equivalent doses of lidocaine and bupivacaine given intravenously over 10 s. All animals convulsed wi...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198401000-00004
更新日期:1984-01-01 00:00:00
abstract::There has been a dramatic growth of scholarly articles in medical education in recent years. Evaluating medical education research requires specific orientation to issues related to format and content. Our goal is to review the quantitative aspects of research in medical education so that clinicians may understand the...
journal_title:Anesthesiology
pub_type: 杂志文章,评审
doi:10.1097/ALN.0000000000002727
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Although neuromuscular blocking agents do not cross the blood-brain barrier, they may penetrate the central nervous system under particular circumstances and eventually cause neurotoxic consequences. METHODS:The effects of neuromuscular blocking agents on excitatory and inhibitory transmission in area CA1 o...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199804000-00021
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:Identifying functionally relevant anesthetic-binding sites in pentameric ligand-gated ion channels (pLGICs) is an important step toward understanding the molecular mechanisms underlying anesthetic action. The anesthetic propofol is known to inhibit cation-conducting pLGICs, including a prokaryotic pLGIC from...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001005
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:The authors reviewed efficacy and safety data for ondansetron for preventing postoperative nausea and vomiting (PONV). METHODS:Systematically searched, randomized, controlled trials (obtained through MEDLINE, EMBASE, Biological Abstracts, manufacturer's database, manual searching of journals, and article ref...
journal_title:Anesthesiology
pub_type: 杂志文章,meta分析
doi:10.1097/00000542-199712000-00004
更新日期:1997-12-01 00:00:00
abstract::The teratogenic potential of subanesthetic and anesthetic exposure to halothane was studied in Swiss/ICR mice. Two treatment regimens were employed: daily exposure of males and females for nine weeks prior to conception and on days 1 through 17 of pregnancy; and exposure of females only on days 6 through 15 of pregnan...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197912000-00010
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:Combined spinal-epidural anesthesia is a technique growing in popularity. However, there have been no attempts to investigate the risk of epidural drug reaching the subarachnoid space in high concentration by passing through the meningeal hole left by the spinal needle. This study begins to address this ques...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199404000-00019
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:Prone ventilation redistributes lung inflation along the gravitational axis; however, localized, nongravitational effects of body position are less well characterized. The authors hypothesize that positional inflation improvements follow both gravitational and nongravitational distributions. This study is a ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000003509
更新日期:2020-11-01 00:00:00
abstract::Despite evidence from animal experiments to the contrary, nitrous oxide (N2O) reportedly does not induce myocardial ischemia when used as an adjunct to fentanyl anesthesia in patients with coronary artery disease who have well-preserved left ventricular (LV) function. However, the incidence of ischemia with N2O admini...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198910000-00008
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:Exposure of rhesus macaque fetuses for 24 h or neonates for 9 h to ketamine anesthesia causes neuroapoptosis in the developing brain. The current study clarifies the minimum exposure required for and the extent and spatial distribution of ketamine-induced neuroapoptosis in rhesus fetuses and neonates. METHO...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e318242b2cd
更新日期:2012-02-01 00:00:00
abstract::The safety and efficacy of epidural morphine injected into the caudal space for control of postoperative pain following open cardiac surgery in children was studied. Thirty-two children between the ages of 2-12 yr for whom early postoperative tracheal extubation was anticipated were randomly assigned to control and st...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-198903000-00009
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:Moxonidine, a novel imidazoline-alpha2-adrenergic receptor-selective analgesic, was recently identified as antinociceptive but has yet to be evaluated in neuropathic pain models. alpha2-adrenergic receptor-selective analgesics, and high-efficacy opioids, effectively inhibit neuropathic pain behaviors in rode...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200009000-00026
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:Multiport epidural catheters are popular; however, the reliability of the air test has not been evaluated with this catheter design. The authors determined the effectiveness of aspirating for blood and the air test in detecting intravascular multiorifice epidural catheters. METHODS:Three hundred women in la...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1097/00000542-200006000-00018
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:In pediatric patients, obstruction of the upper airway is a common problem during general anesthesia. Chin lift is a commonly used technique to improve upper airway patency. However, little is known about the mechanism underlying this technique. METHODS:The authors studied the effect of the chin lift maneuv...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199906000-00018
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Inhaled nitric oxide (NO), a selective vasodilator, improves oxygenation in many patients with adult respiratory distress syndrome (ARDS). Vasoconstrictors may also improve oxygenation, possibly by enhancing hypoxic pulmonary vasoconstriction. This study compared the effects of phenylephrine, NO, and their c...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199707000-00004
更新日期:1997-07-01 00:00:00
abstract::Administration of the oxidant lipid peroxide tertiary butyl hydroperoxide (t-bu-OOH) in the isolated rabbit lung leads to acute pulmonary vasoconstriction, which is caused by the synthesis of thromboxane. The inhalational anesthetics, halothane, nitrous oxide, and cyclopropane, markedly enhance t-bu-OOH-induced pulmon...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198905000-00012
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Labor pain derives primarily from stimulation of afferents innervating the uterine cervix and lower uterine segment. The authors have previously shown that the excitability of these afferents is regulated by sex hormones and test in this study whether pregnancy also alters their excitability. METHODS:After ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e31817302e0
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Neosaxitoxin (NeoSTX) is a site-1 sodium channel blocker that produces prolonged local anesthesia in animals and humans. Under a Food and Drug Administration-approved phase 1 Investigational New Drug trial, the authors evaluated safety and efficacy of NeoSTX alone and combined with 0.2% bupivacaine (Bup) wit...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000000831
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Active sodium transport is the primary mechanism that drives alveolar fluid clearance. In the current study, the effects of exposure to halothane and isoflurane on alveolar fluid clearance in rats were evaluated. METHODS:Rats were exposed to either halothane (0.4% for 6 h or 2% for 2 h) or isoflurane (0.6% ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199803000-00027
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Compared to other perioperative complications, failure to rescue (i.e., death after suffering a complication) is highest after perioperative myocardial infarction (a myocardial infarction that occurs intraoperatively or within 30 days after surgery). The purpose of this study was to identify patient and surg...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/ALN.0000000000003330
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Diphenhydramine is used as an antipruritic and antiemetic in patients receiving opioids. Whether it might exacerbate opioid-induced ventilatory depression has not been determined. METHODS:The ventilatory response to carbon dioxide during hyperoxia and the ventilatory response to hypoxia during hypercapnia (...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199809000-00013
更新日期:1998-09-01 00:00:00
abstract:INTRODUCTION:Spinal alpha2-adrenoceptor stimulation produces analgesia in neuropathic pain states, and this effect in animals is blocked by the inhibitors of brain-derived neurotrophic factor (BDNF) function. In rats, alpha2-adrenoceptor stimulation normally inhibits acetylcholine release, but it excites release after ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181de6d2c
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Sepsis and septic shock are severe inflammatory conditions related to high morbidity and mortality. We performed a systematic review with meta-analysis of randomized trials to assess whether extracorporeal blood purification reduces mortality in this setting. METHODS:Electronic databases were searched for p...
journal_title:Anesthesiology
pub_type: 杂志文章,meta分析
doi:10.1097/ALN.0000000000002820
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Anesthetics inhibit airway smooth muscle contraction in part by a direct effect on the smooth muscle cell. This study tested the hypothesis that the anesthetics halothane and hexanol, which both relax airway smooth muscle in vitro, inhibit acetylcholine-promoted nucleotide exchange at the alpha subunit of th...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200407000-00019
更新日期:2004-07-01 00:00:00