Bupivacaine-induced cardiac arrhythmias in sheep.

abstract：BACKGROUND:The authors' objective was to assess the role of protein kinase C (PKC) and nitric oxide synthase (NOS) in mediating the effects of propofol on diabetic cardiomyocyte contractility, intracellular free Ca2+ concentration ([Ca2+]i), and myofilament Ca2+ sensitivity. METHODS:Freshly isolated ventricular myocyt...

journal_title：Anesthesiology

authors： Wickley PJ,Shiga T,Murray PA,Damron DS

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Halothane induces negative inotropic and lusitropic effects in myocardium. It has been suggested that halothane potentiates beta-adrenoceptor stimulation. However, its effects on the inotropic response to alpha-adrenoceptor stimulation and its effects on the lusitropic effects of alpha- and beta-adrenoceptor...

journal_title：Anesthesiology

authors： Hanouz JL,Riou B,Massias L,Lecarpentier Y,Coriat P

更新日期：1997-01-01 00:00:00

abstract：:Administration of the oxidant lipid peroxide tertiary butyl hydroperoxide (t-bu-OOH) in the isolated rabbit lung leads to acute pulmonary vasoconstriction, which is caused by the synthesis of thromboxane. The inhalational anesthetics, halothane, nitrous oxide, and cyclopropane, markedly enhance t-bu-OOH-induced pulmon...

journal_title：Anesthesiology

authors： McShane AJ,Crowley K,Shayevitz JR,Michael JR,Adkinson NF Jr,Traystman RJ,Gurtner GH

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Vasospasm of arterial grafts represents an unpredictable complication of coronary artery surgery and may compromise myocardial revascularization, and treatment is based on empirical therapy with nitroglycerin. Because of the potential for tolerance to nitroglycerin to occur, the authors studied different vas...

journal_title：Anesthesiology

authors： Huraux C,Makita T,Montes F,Szlam F,Levy JH

更新日期：1998-06-01 00:00:00

abstract：:We performed a prospective randomized controlled trial to assess the efficacy of a chlorhexidine dressing in reducing the microbial flora at the insertion site of epidural catheters. These catheters were used for acute pain management and were dressed either by a standardized method or with a CHX/urethane sponge compo...

journal_title：Anesthesiology

authors： Shapiro JM,Bond EL,Garman JK

更新日期：1990-10-01 00:00:00

abstract：:The authors determined whether they could predict accurately the solubility of anesthetics in aqueous solutions at 37 degrees C, knowing the osmolarity and the pH of the solution and the solute composition. The partition coefficients of the four volatile anesthetics, isoflurane, enflurane, halothane, and methoxyfluran...

journal_title：Anesthesiology

authors： Lerman J,Willis MM,Gregory GA,Eger EI 2nd

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND:In spinal anesthesia, often a large interindividual variability in analgesic response is observed after administration of a certain fixed dose of anesthetic to a patient population. To improve therapeutic outcome it is important to characterize the variability in response by means of a population model (e.g....

journal_title：Anesthesiology

authors： Schnider TW,Minto CF,Bruckert H,Mandema JW

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Propofol can be associated with delayed awakening after prolonged infusion. The aim of this study was to characterize the preclinical pharmacology of AZD-3043, a positive allosteric modulator of the γ-aminobutyric acid type A (GABA(A)) receptor containing a metabolically labile ester moiety. The authors post...

journal_title：Anesthesiology

authors： Egan TD,Obara S,Jenkins TE,Jaw-Tsai SS,Amagasu S,Cook DR,Steffensen SC,Beattie DT

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Tracheal intubation with conventional laryngoscopy requires many trials until beginners are sufficiently skilled in intubating patients safely. To facilitate intubation, the authors used retrograde light-guided laryngoscopy (RLGL) and compared its feasibility with conventional direct laryngoscopy (DL). METH...

journal_title：Anesthesiology

authors： Yang T,Hou J,Li J,Zhang X,Zhu X,Ni W,Mao Y,Deng X

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Epidural morphine yields postoperative pain relief and hemodynamic stability. However, the effects of epidural morphine on sympathetic tone are unclear. This study was designed to elucidate the effects of epidural morphine on cardiac (CSNA) and renal (RSNA) sympathetic nerve activity by direct measurement in...

journal_title：Anesthesiology

authors： Mori T,Nishikawa K,Terai T,Yukioka H,Asada A

更新日期：1998-06-01 00:00:00

abstract：:To determine the correlation between the partial pressures of anesthetics in venous and arterial blood (Pv and Pa), and to assess whether this correlation was better than that between the partial pressure of anesthetic in alveolar gas (PA) and Pa, isoflurane (n = 4) or halothane (n = 4) was administered to eight patie...

journal_title：Anesthesiology

authors： Carpenter RL,Eger EI 2nd

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Transfusion-related acute lung injury incidence remains the leading cause of posttransfusion mortality. The etiology may be related to leukocyte antibodies or biologically active compounds in transfused plasma, injuring susceptible recipient's lungs. The authors have hypothesized that transfusion could have ...

journal_title：Anesthesiology

authors： Feiner JR,Gropper MA,Toy P,Lieberman J,Twiford J,Weiskopf RB

更新日期：2015-07-01 00:00:00

abstract：:The cerebral and systemic hemodynamic and metabolic effects of hypotension induced with desflurane were examined in 11 dogs. During a steady-state baseline period under 1 MAC desflurane (7.2%), the following were measured or derived: arterial, pulmonary artery, and pulmonary artery occlusion pressures; arterial, mixed...

journal_title：Anesthesiology

authors： Milde LN,Milde JH

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:The mechanism by which barbiturates protect neurons against ischemia is unclear, particularly when they are given after ischemia or reperfusion begins. Because an excess release of excitatory neurotransmitters causes postsynaptic membrane depolarization, which triggers neuronal damage in ischemia, the effect...

journal_title：Anesthesiology

authors： Amakawa K,Adachi N,Liu K,Ikemune K,Fujitani T,Arai T

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Hemodilution (HD) with oxyhemoglobin colloid (oxyHb) provides a greater arterial oxygen content (CaO2) than HD with conventional colloids; however, oxygen delivery (DO2) is essentially the same, because, in contrast to conventional HD, cardiac output (CO) is not augmented. This study seeks to elucidate the m...

journal_title：Anesthesiology

authors： Rooney MW,Hirsch LJ,Mathru M

更新日期：1993-07-01 00:00:00

abstract：:Making good decisions in the era of Big Data requires a sophisticated approach to causality. We are acutely aware that association ≠ causation, yet untangling the two remains one of our greatest challenges. This realization has stimulated a Causal Revolution in epidemiology, and the lessons learned are highly relevant...

journal_title：Anesthesiology

authors： Gaskell AL,Sleigh JW

更新日期：2020-05-01 00:00:00

abstract：:Pharmacokinetics and pharmacodynamics of propofol infusions during general anesthesia. By Audrey Shafer, Van A. Doze, Steven L. Shafer, and Paul F. White. Anesthesiology 1988; 69:348-56. Reprinted with permission.The pharmacokinetic and pharmacodynamic properties of propofol (Diprivan) were studied in 50 elective surg...

journal_title：Anesthesiology

authors： White PF

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:The main disadvantage of the posterior approach to the block of the sciatic nerve in the popliteal fossa (popliteal block [PB]) is the need to place the patient in the prone position. In this study, the authors examined the clinical utility of a recently described lateral approach to PB that is performed wit...

journal_title：Anesthesiology

authors： Hadzić A,Vloka JD

更新日期：1998-06-01 00:00:00

abstract：:Critically ill patients requiring mechanical ventilation are particularly susceptible to malnutrition. A knowledge of the energy requirements of these patients is essential in designing nutritional regimens. This study examines 45 resting energy-expenditure measurements performed in a group (n = 40) of postoperative, ...

journal_title：Anesthesiology

authors： Weissman C,Kemper M,Askanazi J,Hyman AI,Kinney JM

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:Postoperative nausea and vomiting (PONV) is still common, especially among female patients. Our hypothesis is that coinduction with clonidine reduces the incidence of PONV in adult patients undergoing breast cancer surgery. METHODS:Sixty-eight women premedicated with midazolam were randomly allocated to coi...

journal_title：Anesthesiology

authors： Oddby-Muhrbeck E,Eksborg S,Bergendahl HT,Muhrbeck O,Lönnqvist PA

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the relationship of four postanesthesia care unit (PACU) cardiovascular events to long-term outcomes (unplanned critical care admission or mortality) and to evaluate the contribution of anesthetic management compared with other perioperative factors in predicting th...

journal_title：Anesthesiology

authors： Rose DK,Cohen MM,DeBoer DP

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Anesthesia during the synaptogenic period induces dendritic spine formation, which may affect neurodevelopment. The authors, therefore, evaluated whether changes in synaptic transmission after dendritic spine formation induced by sevoflurane were associated with long-term behavioral changes. The effects of s...

journal_title：Anesthesiology

authors： Chung W,Ryu MJ,Heo JY,Lee S,Yoon S,Park H,Park S,Kim Y,Kim YH,Yoon SH,Shin YS,Lee WH,Ju X,Kweon GR,Ko Y

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Sevoflurane is a volatile general anesthetic that differs in chemical nature from the gaseous anesthetic nitrous oxide. In a controlled laboratory setting, the authors characterized the subjective, psychomotor, and analgesic effects of sevoflurane and nitrous oxide at two equal minimum alveolar subanesthetic...

journal_title：Anesthesiology

authors： Galinkin JL,Janiszewski D,Young CJ,Klafta JM,Klock PA,Coalson DW,Apfelbaum JL,Zacny JP

更新日期：1997-11-01 00:00:00

abstract：:Sevoflurane was submitted to phase-1 studies in man following extensive testing in animal species during maintenance, was administered with oxygen to produce one hour of anesthesia in six healthy adult male volunteers. Respiratory and cardiovascular functions, the electroencephalogram, arterial blood gases, blood sevo...

journal_title：Anesthesiology

authors： Holaday DA,Smith FR

更新日期：1981-02-01 00:00:00

abstract：:ECG changes suggestive of myocardial ischemia are common during cesarean delivery under regional anesthesia. To determine the time course, duration, and significance of these ECG changes, we monitored 111 parturients with continuous ambulatory ECG (Holter) during and after cesarean delivery. Twenty-two parturients und...

journal_title：Anesthesiology

authors： Mathew JP,Fleisher LA,Rinehouse JA,Sevarino FB,Sinatra RS,Nelson AH,Prokop EK,Rosenbaum SH

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Postoperative nausea and vomiting continue to be a significant problem for pediatric ambulatory surgery patients. Although ondansetron has been demonstrated to be effective in the prophylactic treatment of postoperative nausea and vomiting (surrogate end point) no one has demonstrated a benefit of antiemetic...

journal_title：Anesthesiology

authors： Davis PJ,McGowan FX Jr,Landsman I,Maloney K,Hoffmann P

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Ketamine is often administered to patients in whom hemodynamic instability is suspected. This study was designed to investigate the effect and possible site of action of ketamine on baroreflex response in rats. The site focused upon was the N-methyl-D-aspartate (NMDA) receptor of the nucleus tractus solitari...

journal_title：Anesthesiology

authors： Ogawa A,Uemura M,Kataoka Y,Ol K,Inokuchi T

更新日期：1993-01-01 00:00:00

abstract：:Decreased urinary output (Vu ml/min) after institution of PEEP is attributed to a variety of mechanisms including decreased cardiac output and renal blood flow (RBF), activation of neurohormonal reflexes, increased catecholamines, plasma renin activity (PRA), and antidiuretic hormone (ADH) release. To evaluate these f...

journal_title：Anesthesiology

authors： Payen DM,Farge D,Beloucif S,Leviel F,De La Coussaye JE,Carli P,Wirquin V

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:The hanging drop technique is used for identifying the cervical epidural space, using its negative pressure. However, it is doubtful whether the epidural space intrinsically exhibits a negative pressure. We designed this study to test the hypothesis that the cervical epidural pressure (CEP) is significantly ...

journal_title：Anesthesiology

authors： Moon JY,Lee PB,Nahm FS,Kim YC,Choi JB

更新日期：2010-09-01 00:00:00

abstract：:Thiopental-14C (30 mg and 10 muCi/kg) was injected intravenously into rats 36-48 hours following bilateral nephrectomy and one minute after pretreatment with sulfadimethoxine (30 mg/kg, iv). Control groups of normal and sham-operated animals were used. The distributions of radioactivity in plasma, brain, and heart 1, ...

journal_title：Anesthesiology

authors： Ghoneim MM,Pandya HB,Kelley SE,Fischer LJ,Corry RJ

更新日期：1976-12-01 00:00:00