Effects of neuromuscular blocking agents on excitatory transmission and gamma-aminobutyric acidA-mediated inhibition in the rat hippocampal slice.

abstract：:Isoflurane has a lesser ability than halothane to induce contracture in malignant hyperthermia (MH) muscle in vitro. This does not necessarily imply that isoflurane is not as potent an MH trigger as halothane in vivo. A hypothesis was tested that in vitro treatment with Bay K 8644, an activator of both the dihydropyri...

journal_title：Anesthesiology

authors： Adnet PJ,Krivosic-Horber RM,Adamantidis MM,Haudecoeur G,Reyford H,Imbenotte M

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Breastfeeding is an important public health concern. High cumulative doses of epidural fentanyl administered for labor analgesia have been reported to be associated with early termination of breastfeeding. We tested the hypothesis that breastfeeding success is adversely influenced by the cumulative epidural ...

journal_title：Anesthesiology

authors： Lee AI,McCarthy RJ,Toledo P,Jones MJ,White N,Wong CA

更新日期：2017-10-01 00:00:00

abstract：AIMS:Helium protects myocardium by inducing preconditioning in animals. We investigated whether human endothelium is preconditioned by helium inhalation in vivo. METHODS AND RESULTS:Forearm ischemia-reperfusion (I/R) in healthy volunteers (each group n = 10) was performed by inflating a blood pressure cuff for 20 min....

journal_title：Anesthesiology

authors： Smit KF,Oei GT,Brevoord D,Stroes ES,Nieuwland R,Schlack WS,Hollmann MW,Weber NC,Preckel B

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Ketamine has been associated with a unique spectrum of subjective "psychedelic" effects in patients emerging from anesthesia. This study quantified these effects of ketamine and related them to steady-state plasma concentrations. METHODS:Ketamine or saline was administered in a single-blinded crossover prot...

journal_title：Anesthesiology

authors： Bowdle TA,Radant AD,Cowley DS,Kharasch ED,Strassman RJ,Roy-Byrne PP

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Whether the fetus can experience pain remains controversial. During the last half of pregnancy, the neuroanatomic connections for nociception are in place, and the human fetus mounts sizable stress responses to physical insults. Analgesia has been recommended for intrauterine procedures or late termination, ...

journal_title：Anesthesiology

authors： Fisk NM,Gitau R,Teixeira JM,Giannakoulopoulos X,Cameron AD,Glover VA

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:The effects of triiodothyronine (T3) on systemic hemodynamics, myocardial contractility (preload recruitable stroke work slope; Mw), and left ventricular (LV) isovolumic relaxation (time constant; tau) were examined before and after the development of pacing-induced cardiomyopathy in conscious dogs. METHODS...

journal_title：Anesthesiology

authors： Jamall IN,Pagel PS,Hettrick DA,Lowe D,Kersten JR,Tessmer JP,Warltier DC

更新日期：1997-07-01 00:00:00

abstract：:A carcinogen bioassay of enflurane was performed in Swiss/ICR mice. Two groups of weanling mice, each of 125 males and 125 females, were exposed to eigher a maximum tolerated dose of enflurane, 3000 ppm (0.3 per cent v/v) or compressed air for 4 hs per day, 5 days per week. After 52 weeks exposure, 25 males and 25 fem...

journal_title：Anesthesiology

authors： Baden JM,Egbert B,Mazze RI

更新日期：1982-01-01 00:00:00

abstract：:The dose-response and plasma concentration-response relationships for pancuronium in man were studied during its intravenous administration to eight patients at a rate of 1.62 microgram/kg/min. The (log) dose-response relationships resulted in a sigmoid curve that was linear in its central range. At 20, 50 and 80 per ...

journal_title：Anesthesiology

authors： Shanks CA,Somogyi AA,Triggs EJ

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Obstetrics carries high medical liability risk. Maternal death and newborn death/brain damage were the most common complications in obstetric anesthesia malpractice claims before 1990. As the liability profile may have changed over the past two decades, the authors reviewed recent obstetric claims in the Ame...

journal_title：Anesthesiology

authors： Davies JM,Posner KL,Lee LA,Cheney FW,Domino KB

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Recent evidence implicates nitric oxide (*NO) in the pathogenesis of preeclampsia. The authors tested the hypothesis that administration of low-dose endotoxin to pregnant rats mimics the signs of preeclampsia in humans and that *NO and *NO-derived species play a role in that animal model. METHODS:Endotoxin ...

journal_title：Anesthesiology

authors： Sakawi Y,Tarpey M,Chen YF,Calhoun DA,Connor MG,Chestnut DH,Parks DA

更新日期：2000-12-01 00:00:00

abstract：:Arteriolar diameters and tissue oxygen tensions were measured in the cremaster muscles of 68 hemorrhaged rats which were anesthetized with either intramuscular ketamine, 125 mg/kg, plus 30 mg/kg supplements as needed, or enflurane, 2.2% inspired. Animals breathed room air, or room air plus enflurane, throughout the ex...

journal_title：Anesthesiology

authors： Longnecker DE,Ross DC,Silver IA

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND:Positive end expiratory pressure (PEEP) is an important component of therapy in patients with acute lung injury or acute respiratory distress syndrome. The independent effect of PEEP on mortality is currently unknown. METHODS:A systematic review and meta-analysis of randomized controlled clinical trials com...

journal_title：Anesthesiology

authors： Phoenix SI,Paravastu S,Columb M,Vincent JL,Nirmalan M

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:The pharmacokinetics and pharmacodynamics of succinylcholine were studied simultaneously in anesthetized patients to understand why the drug has a rapid onset and short duration of action. A quantitative model describing the concentration-effect relation of succinylcholine was proposed. The correlation betwe...

journal_title：Anesthesiology

authors： Roy JJ,Donati F,Boismenu D,Varin F

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Vasospasm of arterial grafts represents an unpredictable complication of coronary artery surgery and may compromise myocardial revascularization, and treatment is based on empirical therapy with nitroglycerin. Because of the potential for tolerance to nitroglycerin to occur, the authors studied different vas...

journal_title：Anesthesiology

authors： Huraux C,Makita T,Montes F,Szlam F,Levy JH

更新日期：1998-06-01 00:00:00

abstract：:The aim of the study was to establish whether there exists a relationship between blood methadone concentration and analgesic response and the intrasubject and intersubject variability in this relationship. Sixteen general surgical (upper abdominal) and orthopedic (spinal fusion) patients were administered methadone (...

journal_title：Anesthesiology

authors： Gourlay GK,Willis RJ,Wilson PR

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:Repetitive C-fiber stimulation induces a state of facilitated processing of sensory information in the dorsal horn, while chronic nerve compression gives rise to a hyperalgesic state, characterized by spontaneous neuronal activity generated by voltage-sensitive sodium channels, as well as spinal facilitation...

journal_title：Anesthesiology

authors： Abram SE,Yaksh TL

更新日期：1994-02-01 00:00:00

abstract：:Arterial and peripheral venous plasma levels of bupivacaine were determined in 30 patients following epidural anesthesia using 150 and 225 mg, as well as following intercostal nerve block with 400 mg. Arterial levels were consistently higher than levels in simultaneously sampled venous blood, and the highest levels oc...

journal_title：Anesthesiology

authors： Moore DC,Mather LE,Bridenbaugh PO,Bridenbaugh LD,Balfour RI,Lysons DF,Horton WG

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND:Transcranial motor-evoked potentials (TcMEPs) monitor spinal cord motor tract integrity. Using a swine model, the authors studied the effects of vasodilatory hypotension, hemorrhage, and various resuscitation efforts on TcMEP responses. METHODS:Twelve pigs were anesthetized with constant infusions of propof...

journal_title：Anesthesiology

authors： Lieberman JA,Feiner J,Lyon R,Rollins MD

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Because tactile evaluation is the most common form of clinical neuromuscular monitoring, this study examines the relative efficacy of antagonizing residual block at different levels of recovery of the tactile train-of-four (TOF) response. METHODS:Anesthesia was induced in 64 adults with 2-5 microg/kg fentan...

journal_title：Anesthesiology

authors： Kirkegaard H,Heier T,Caldwell JE

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Despite decreasing cardiac events, perioperative beta-blockade also increases perioperative stroke and mortality. Major bleeding and/or hypotension are independently associated with these outcomes. To investigate the hypothesis that beta-blockade limits the cardiac reserve to compensate for acute surgical an...

journal_title：Anesthesiology

authors： Beattie WS,Wijeysundera DN,Karkouti K,McCluskey S,Tait G,Mitsakakis N,Hare GM

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:While electroconvulsive therapy is widely regarded as a lifesaving and safe procedure, evidence regarding its effects on myocardial cell injury is sparse. The objective of this investigation was to determine the incidence and magnitude of new cardiac troponin elevation after electroconvulsive therapy using a...

journal_title：Anesthesiology

authors： Duma A,Pal S,Johnston J,Helwani MA,Bhat A,Gill B,Rosenkvist J,Cartmill C,Brown F,Miller JP,Scott MG,Sanchez-Conde F,Jarvis M,Farber NB,Zorumski CF,Conway C,Nagele P

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:mu-Opioids administered spinally produce a potent, dose-dependent analgesic response in preclinical and clinical investigations. Side-effect profile of these compounds may be altered as a function of pharmacokinetics. The effects of intrathecal and intraperitoneal remifentanil, an esterase-metabolized mu opi...

journal_title：Anesthesiology

authors： Buerkle H,Yaksh TL

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:The lightwand may be useful as an alternative for tracheal intubation during a rapid-sequence induction of anesthesia in the presence of a full stomach. This study was undertaken to assess the effect of application of cricoid pressure on the success of lightwand intubation. METHODS:Sixty adult female patien...

journal_title：Anesthesiology

authors： Hodgson RE,Gopalan PD,Burrows RC,Zuma K

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Malignant hyperthermia is associated with mutations within the gene encoding the skeletal muscle ryanodine receptor, the calcium channel that releases Ca from sarcoplasmic reticulum stores triggering muscle contraction, and other metabolic activities. More than 200 variants have been identified in the ryanod...

journal_title：Anesthesiology

authors： Sato K,Pollock N,Stowell KM

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Volatile anesthetics inhibit presynaptic voltage-gated sodium channels to reduce neurotransmitter release, but their effects on excitatory neuron excitability by sodium current inhibition are unclear. The authors hypothesized that inhibition of transient and persistent neuronal sodium currents by the volatil...

journal_title：Anesthesiology

authors： Zhao W,Zhang M,Liu J,Liang P,Wang R,Hemmings HC,Zhou C

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Emergence delirium has been investigated in several clinical trials. However, no reliable and valid rating scale exists to measure this phenomenon in children. Therefore, the authors developed and evaluated the Pediatric Anesthesia Emergence Delirium (PAED) scale to measure emergence delirium in children. M...

journal_title：Anesthesiology

authors： Sikich N,Lerman J

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") can mediate acute toxic effects such as muscle rigidity, metabolic acidosis, and hyperthermia. Because of close clinical similarities, an association between MDMA intoxication and malignant hyperthermia (MH) was suggested. The aim of this study was to inves...

journal_title：Anesthesiology

authors： Fiege M,Wappler F,Weisshorn R,Gerbershagen MU,Menge M,Schulte Am Esch J

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:The probability of recovering consciousness in acute brain-injured patients depends on central nervous system damage and complications acquired during their stay in the intensive care unit. The objective of this study was to establish a relation between the Bispectral Index (BIS) and other variables derived ...

journal_title：Anesthesiology

authors： Fàbregas N,Gambús PL,Valero R,Carrero EJ,Salvador L,Zavala E,Ferrer E

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Neurally adjusted ventilatory assist (NAVA) is a new mode of mechanical ventilation that delivers ventilatory assist in proportion to the electrical activity of the diaphragm. This study aimed to compare the ventilatory and gas exchange effects between NAVA and pressure support ventilation (PSV) during the w...

journal_title：Anesthesiology

authors： Coisel Y,Chanques G,Jung B,Constantin JM,Capdevila X,Matecki S,Grasso S,Jaber S

更新日期：2010-10-01 00:00:00

abstract：:The anesthetic requirements for sevoflurane, isoflurane, and halothane were determined in mongrel dogs. The MACs (minimum alveolar concentration) of sevoflurane, isoflurane, and halothane were 2.36 +/- 0.46% (n = 18), 1.39 +/- 0.25% (n = 10), and 0.89 +/- 0.20% (n = 12), respectively (mean +/- SD). In agreement with s...

journal_title：Anesthesiology

authors： Kazama T,Ikeda K

更新日期：1988-03-01 00:00:00