Differential behavioral effects of peripheral and systemic morphine and naloxone in a rat model of repeated acute inflammation.

abstract：BACKGROUND:Studies using transthoracic thermodilution have demonstrated increased extravascular lung water (EVLW) measurements attributed to progression of edema and flooding during sepsis and acute lung injury. The authors hypothesized that redistribution of pulmonary blood flow can cause increased apparent EVLW secon...

journal_title：Anesthesiology

authors： Easley RB,Mulreany DG,Lancaster CT,Custer JW,Fernandez-Bustamante A,Colantuoni E,Simon BA

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Neuroligin-1 (NL1) forms a complex with the presynaptic neurexin-1β (Nrx1b), regulating clustering of N-methyl-D-aspartate receptors with postsynaptic density-95 (PSD-95) to underlie learning-/memory-associated plasticity. Pain-related spinal neuroplasticity shares several common features with learning-/memo...

journal_title：Anesthesiology

authors： Lin TB,Lai CY,Hsieh MC,Jiang JL,Cheng JK,Chau YP,Ruan T,Chen GD,Peng HY

更新日期：2015-10-01 00:00:00

abstract：:A carcinogen bioassay of enflurane was performed in Swiss/ICR mice. Two groups of weanling mice, each of 125 males and 125 females, were exposed to eigher a maximum tolerated dose of enflurane, 3000 ppm (0.3 per cent v/v) or compressed air for 4 hs per day, 5 days per week. After 52 weeks exposure, 25 males and 25 fem...

journal_title：Anesthesiology

authors： Baden JM,Egbert B,Mazze RI

更新日期：1982-01-01 00:00:00

abstract：:The use of venovenous extracorporeal membrane oxygenation is increasing worldwide. These patients often require noncardiac surgery. In the perioperative period, preoperative assessment, patient transport, choice of anesthetic type, drug dosing, patient monitoring, and intraoperative and postoperative management of com...

journal_title：Anesthesiology

authors： Fierro MA,Daneshmand MA,Bartz RR

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Oral clonidine may influence plasma glucose and lipid homeostasis by modulating endocrinologic responses to surgical stress. The effect of oral clonidine premedication on plasma glucose and lipid homeostasis associated with exogenous glucose infusion were investigated in children undergoing minor surgery. M...

journal_title：Anesthesiology

authors： Nishina K,Mikawa K,Maekawa N,Shiga M,Obara H

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:One-lung ventilation (OLV) results in alveolar proinflammatory effects, whereas their extent may depend on administration of anesthetic drugs. The current study evaluates the effects of different volatile anesthetics compared with an intravenous anesthetic and the relationship between pulmonary and systemic ...

journal_title：Anesthesiology

authors： Schilling T,Kozian A,Senturk M,Huth C,Reinhold A,Hedenstierna G,Hachenberg T

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Conflicting opinions are present in the literature regarding the origin of the negative inotropic effect of propofol on the myocardium. This study aims to resolve these discrepancies by investigating the inotropic effects of propofol the L-type calcium channels and the sodium-calcium exchanger (NCX). METHOD...

journal_title：Anesthesiology

authors： de Ruijter W,Stienen GJ,van Klarenbosch J,de Lange JJ

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Phenotyping malignant hyperthermia (MH) by contracture testing has a low but quantifiable degree of inaccuracy, measured by its sensitivity and specificity. Quantifying the limitations inherent in diagnostic testing for MH can help resolve issues in clinical practice, such as the interpretation of a negative...

journal_title：Anesthesiology

authors： Loke JC,MacLennan DH

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Indirect evidence supports a role of spinal cholinergic neurons in tonically reducing response to noxious mechanical stimulation and in effecting analgesia from alpha2-adrenergic agonists. This study directly assessed the role of cholinergic neurons in regulating the level of mechanical allodynia and in part...

journal_title：Anesthesiology

authors： Paqueron X,Li X,Bantel C,Tobin JR,Voytko ML,Eisenach JC

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Hypotension induced by sodium nitroprusside can minimize intraoperative blood loss. The release of endogenous catecholamines can influence adrenoceptors of platelets and thus might change the ability of platelets to aggregate. METHODS:Forty patients undergoing nasal septum, tympanoplastic, or sphenoid sinus...

journal_title：Anesthesiology

authors： Dietrich GV,Heesen M,Boldt J,Hempelmann G

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:In this open, randomized study, the pharmacokinetics, clinical efficacy, and safety of a 48-h continuous interscalene infusion of 2 mg/ml ropivacaine for postoperative pain relief were investigated in patients undergoing open major shoulder surgery. METHODS:An initial interscalene block with 30 ml ropivacai...

journal_title：Anesthesiology

authors： Ekatodramis G,Borgeat A,Huledal G,Jeppsson L,Westman L,Sjövall J

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Whether anesthetic agents administered during gamete intrafallopian transfer (GIFT) affect reproductive outcome is controversial. This multicenter pilot trial and survey had two purposes: to evaluate the effect of propofol, nitrous oxide, midazolam, and isoflurane on pregnancy outcome after GIFT, and to dete...

journal_title：Anesthesiology

authors： Beilin Y,Bodian CA,Mukherjee T,Andres LA,Vincent RD Jr,Hock DL,Sparks AE,Munson AK,Minnich ME,Steinkampf MP,Christman GM,McKay RS,Eisenkraft JB

更新日期：1999-01-01 00:00:00

abstract：:Five healthy, nonpregnant volunteers were studied before and after induction of lumbar epidural anesthesia to determine the cause of central hypothermia during epidural anesthesia. Cutaneous heat loss was measured from 10 area-weighted sites using thermal flux transducers. Oxygen consumption was measured and converted...

journal_title：Anesthesiology

authors： Hynson JM,Sessler DI,Glosten B,McGuire J

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Neurally adjusted ventilatory assist (NAVA) is a new mode of mechanical ventilation that delivers ventilatory assist in proportion to the electrical activity of the diaphragm. This study aimed to compare the ventilatory and gas exchange effects between NAVA and pressure support ventilation (PSV) during the w...

journal_title：Anesthesiology

authors： Coisel Y,Chanques G,Jung B,Constantin JM,Capdevila X,Matecki S,Grasso S,Jaber S

更新日期：2010-10-01 00:00:00

abstract：:The effect of halothane on the pressor responses to hypoxia (3% O2, 5% CO2, balance N2) and to Angiotensin II (Ang II) (0.2 microgram) has been compared in an in vitro perfused and ventilated rat lung preparation in the presence and absence of agents known to block the lipoxygenase (BW755C) and/or the cyclooxygenase (...

journal_title：Anesthesiology

authors： Marshall C,Kim SD,Marshall BE

更新日期：1987-04-01 00:00:00

abstract：:To determine the percentage of anesthetic metabolized and to assess the role of metabolism in the total elimination of inhaled anesthetics, the authors administered isoflurane, enflurane, halothane, and methoxyflurane simultaneously, for 2 h, to nine healthy patients. Total anesthetic uptake during the 2 h of washin a...

journal_title：Anesthesiology

authors： Carpenter RL,Eger EI 2nd,Johnson BH,Unadkat JD,Sheiner LB

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:Clinical concentrations of volatile anesthetics significantly influence contractile response to the sympathetic neurotransmitter norepinephrine although its precise mechanisms remain unclarified. In this study, we investigated its possible alterations in diabetes, as well as its underlying mechanisms. METHO...

journal_title：Anesthesiology

authors： Yoshino J,Akata T,Shirozu K,Izumi K,Hoka S

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Investigators in the authors' laboratory previously established the critical participation of the cerulospinal noradrenergic pathway in muscular rigidity elicited by fentanyl. The identification of colocalization of glutamate with tyrosine hydroxylase in most locus ceruleus neurons suggests a role for cerulo...

journal_title：Anesthesiology

authors： Fu MJ,Tsen LY,Lee TY,Lui PW,Chan SH

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:The authors hypothesized that myoclonus after etomidate is dose-related, could be suppressed when small doses of etomidate were administered before induction, and is unassociated with seizure-like activity on electroencephalogram (EEG). METHODS:Three studies were performed. In the first study, 36 men were r...

journal_title：Anesthesiology

authors： Doenicke AW,Roizen MF,Kugler J,Kroll H,Foss J,Ostwald P

更新日期：1999-01-01 00:00:00

abstract：:Recent reports have described resistance to pancuronium-induced neuromuscular blockade in patients chronically receiving anticonvulsants. This study examines the pharmacokinetics and pharmacodynamics of metocurine (MTC) in 12 patients undergoing craniotomy--six on chronic phenytoin therapy and six comparable controls....

journal_title：Anesthesiology

authors： Ornstein E,Matteo RS,Young WL,Diaz J

更新日期：1985-09-01 00:00:00

abstract：:The hepatic effects of repeated anesthesia of phenobarbital-induced Fischer 344 rats with 1% halothane/14% oxygen were investigated, after anesthetics were administered at either 1-day or 5-day intervals. Urinary excretion of fluoride, a product of reductive halothane metabolism, was increased in the 24-h period follo...

journal_title：Anesthesiology

authors： Plummer JL,Hall PD,Jenner MA,Cousins MJ

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND:Ten-eleven translocation methylcytosine dioxygenase converts 5-methylcytosine in DNA to 5-hydroxymethylcytosine, which plays an important role in gene transcription. Although 5-hydroxymethylcytosine is enriched in mammalian neurons, its regulatory function in nociceptive information processing is unknown. M...

journal_title：Anesthesiology

authors： Pan Z,Xue ZY,Li GF,Sun ML,Zhang M,Hao LY,Tang QQ,Zhu LJ,Cao JL

更新日期：2017-07-01 00:00:00

abstract：:The effects of vasopressor therapy on intracranial pressure (ICP) during hypotension were evaluated in 45 adult cats anesthetized with pentobarbital and hyperventilated via an endotracheal tube with nitrous oxide, 70 per cent, and oxygen, 30 per cent, to maintain Paco2 25 plus or minus 5 torr. Hypotension was induced ...

journal_title：Anesthesiology

authors： Stullken EH Jr,Sokoll MD

更新日期：1975-04-01 00:00:00

abstract：BACKGROUND:Although considerable evidence indicates neuronal Ca channels play significant roles in pain perception, their possible importance in hypersensitization after acute inflammation has not been investigated. METHODS:Using carrageenan for inducing hypersensitization, the authors investigated the analgesic effec...

journal_title：Anesthesiology

authors： Yokoyama K,Kurihara T,Makita K,Tanabe T

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Vascular endothelium plays an important role in the regulation of vascular tone. Volatile anesthetics have been shown to attenuate endothelium-mediated relaxation in conductance arteries, such as aorta. However, significant differences in volatile anesthetic pharmacology between these large vessels and the s...

journal_title：Anesthesiology

authors： Akata T,Nakashima M,Kodama K,Boyle WA 3rd,Takahashi S

更新日期：1995-01-01 00:00:00

abstract：:Neurophysiologic studies indicate that local anesthetic-induced seizures are generated in subcortical brain structures. The authors utilized a quantitative autoradiographic technique to measure cerebral metabolism during lidocaine-induced seizure activity in rats anesthetized with nitrous oxide. Local cerebral metabol...

journal_title：Anesthesiology

authors： Ingvar M,Shapiro HM

更新日期：1981-01-01 00:00:00

abstract：:Anesthetic induction with propofol commonly results in hypotension. This study explored potential mechanisms contributing to hypotension by recording cardiovascular responses including sympathetic neural activity from patients during induction of anesthesia with propofol (2.5 mg.kg-1 plus 200 micrograms.kg-1.min-1) or...

journal_title：Anesthesiology

authors： Ebert TJ,Muzi M,Berens R,Goff D,Kampine JP

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:The authors used the American Society of Anesthesiologists Closed Claims Project database to determine changes in the proportion of claims for death or permanent brain damage over a 26-yr period and to identify factors associated with the observed changes. METHODS:The Closed Claims Project is a structured e...

journal_title：Anesthesiology

authors： Cheney FW,Posner KL,Lee LA,Caplan RA,Domino KB

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:The authors compared the intubation success rate of straight reinforced tracheal tubes emerging from the Airtraq laryngoscope (Prodol Meditec S.A., Vizcaya, Spain) with standard preformed polyvinyl chloride tracheal tubes in anesthetized patients. METHODS:The authors randomly allocated 347 adult patients to...

journal_title：Anesthesiology

authors： Dimitriou VK,Zogogiannis ID,Douma AK,Pentilas ND,Liotiri DG,Wachtel MS,Karakitsos D

更新日期：2009-12-01 00:00:00

abstract：:The authors investigated the value of high-dose thiopental (TH) therapy after 16-min complete global brain ischemia (GBI) in three groups of pigtailed monkeys, using a neck cuff model of GBI with 96 h intensive care postischemia (PI). Control group (n18): Normotension was restored within 2 min PI; paralysis/controlled...

journal_title：Anesthesiology

authors： Gisvold SE,Safar P,Hendrickx HH,Rao G,Moossy J,Alexander H

更新日期：1984-02-01 00:00:00