The actions of halothane, ibuprofen and BW755C on hypoxic pulmonary vasoconstriction.

abstract：BACKGROUND:Hydroxyethyl starch (HES) is commonly used as plasma expander during surgery but may be nephrotoxic as seen in studies in patients with sepsis. The authors hypothesized that the possible nephrotoxicity of 6% HES 130/0.4 could be revealed by measurements of urinary excretion of neutrophil gelatinase-associate...

journal_title：Anesthesiology

authors： Kancir AS,Pleckaitiene L,Hansen TB,Ekeløf NP,Pedersen EB

更新日期：2014-11-01 00:00:00

abstract：:The anesthetic effects and interactions of midazolam and fentanyl were determined in terms of their reduction of enflurane MAC in dogs, and the effects of their specific antagonists were also investigated. Control enflurane MAC was determined by the tail clamp method in 18 mongrel dogs. Each animal then received an iv...

journal_title：Anesthesiology

authors： Schwieger IM,Hall RI,Szlam F,Hug CC Jr

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Optimal risk adjustment is a requisite precondition for monitoring quality of care and interpreting public reports of hospital outcomes. Current risk-adjustment measures have been criticized for including baseline variables that are difficult to obtain and inadequately adjusting for high-risk patients. The a...

journal_title：Anesthesiology

authors： Dalton JE,Kurz A,Turan A,Mascha EJ,Sessler DI,Saager L

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Previous studies integrated opioid benefit and harm into one single function-the utility function-to determine the drug toxicity (respiratory depression) in light of its wanted effect (analgesia). This study further refined the concept of the utility function using the respiratory and analgesic effects of th...

journal_title：Anesthesiology

authors： Roozekrans M,van der Schrier R,Aarts L,Sarton E,van Velzen M,Niesters M,Dahan A,Olofsen E

更新日期：2018-05-01 00:00:00

abstract：:Thirty-six halogenated Me Et ethers have been synthesized for evaluation as volatile anesthetics. Eleven of the ethers were too unstable to test, and, of the remaining 25, 13 had promising anesthetic properties in mice and are suitable for study in larger animals. Those ethers having one H with at least 2 halogens oth...

journal_title：Anesthesiology

authors： Terrell RC

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Pentobarbital decreases the gain of the baroreceptor reflex on the order of 50%, and this blunting is caused nearly entirely by decreasing cardioinhibitory parasympathetic activity. The most likely site of action of pentobarbital is the gamma-aminobutyric acid type A (GABA(A)) receptor. The authors tested wh...

journal_title：Anesthesiology

authors： Irnaten M,Walwyn WM,Wang J,Venkatesan P,Evans C,Chang KS,Andresen MC,Hales TG,Mendelowitz D

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:About one in four patients suffers from postoperative nausea and vomiting. Fortunately, risk scores have been developed to better manage this outcome in hospitalized patients, but there is currently no risk score for postdischarge nausea and vomiting (PDNV) in ambulatory surgical patients. METHODS:We conduc...

journal_title：Anesthesiology

authors： Apfel CC,Philip BK,Cakmakkaya OS,Shilling A,Shi YY,Leslie JB,Allard M,Turan A,Windle P,Odom-Forren J,Hooper VD,Radke OC,Ruiz J,Kovac A

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The mechanisms of ventilator-induced lung injury, an iatrogenic inflammatory condition induced by mechanical ventilation, are not completely understood. Toll-like receptor 4 (TLR4) signaling via the adaptor protein myeloid differentiation factor 88 (MyD88) is proinflammatory and plays a critical role in host...

journal_title：Anesthesiology

authors： Li H,Su X,Yan X,Wasserloos K,Chao W,Kaynar AM,Liu ZQ,Leikauf GD,Pitt BR,Zhang LM

更新日期：2010-09-01 00:00:00

abstract：:To examine the effects of cardiac surgery and cardiopulmonary bypass (CPB) on the lung, functional residual capacity (FRC) and lung-thorax compliance were measured at four stages during open heart surgery in 15 children. The patients were anesthetized with fentanyl/droperidol and N2O/O2, paralyzed, and ventilated with...

journal_title：Anesthesiology

authors： Jonmarker C,Larsson A,Werner O

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:The mechanisms of amino-amide local anesthetic agent-induced vasoconstriction remain unclear. The current study was designed to examine the roles of the protein kinase C (PKC), Rho kinase, and p44/42 mitogen-activated protein kinase (p44/42 MAPK) signaling pathways in calcium (Ca2+)-sensitization mechanisms ...

journal_title：Anesthesiology

authors： Yu J,Tokinaga Y,Kuriyama T,Uematsu N,Mizumoto K,Hatano Y

更新日期：2005-09-01 00:00:00

abstract：:The sensitivity of the masseter, one of the muscles of the upper airway, to pancuronium was measured in ten adults undergoing elective surgery and compared with that of the adductor pollicis. During thiopental-nitrous oxide-enflurane (end-tidal concentration less than 0.25%) anesthesia, supramaximal nerve stimulation ...

journal_title：Anesthesiology

authors： Smith CE,Donati F,Bevan DR

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Although transesophageal echocardiography allows continuous intraoperative cardiac monitoring, the technique has been limited by the lack of a method for realtime, quantitative assessment of cardiac chamber size and systolic function. Automated border detection (ABD), based on an analysis of integrated backs...

journal_title：Anesthesiology

authors： Perrino AC Jr,Luther MA,O'Connor TZ,Cohen IS

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:Sweating, vasoconstriction, and shivering have been observed during general anesthesia. Among these, vasoconstriction is especially important because-once triggered-it minimizes further hypothermia. Surprisingly, the core-temperature plateau associated with vasoconstriction appears to preserve core temperatu...

journal_title：Anesthesiology

authors： Plattner O,Semsroth M,Sessler DI,Papousek A,Klasen C,Wagner O

更新日期：1997-04-01 00:00:00

abstract：:Although suppression of thermoregulatory mechanisms by anesthetics is generally assumed, the extent to which thermoregulation is active during general anesthesia is not known. The only thermoregulatory responses available to anesthetized, hypothermic patients are vasoconstriction and non-shivering thermogenesis. To te...

journal_title：Anesthesiology

authors： Sessler DI,Olofsson CI,Rubinstein EH,Beebe JJ

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:Lamotrigine inhibits glutamate release through the preferential blockade of voltage-dependent Na+ channels. In contrast, morphine reduces release of excitatory amino acids through the activation of opioid receptors and also inhibits tetrodotoxin-resistant Na+ channels on peripheral afferent neurons. The curr...

journal_title：Anesthesiology

authors： Argüelles CF,Torres-López JE,Granados-Soto V

更新日期：2002-04-01 00:00:00

abstract：:The authors studied the influence of locally administered isoflurane anesthesia on the pulmonary vascular response to regional alveolar hypoxia (hypoxic pulmonary vasoconstriction [HPV]) over a range of cardiac outputs (COs) in seven mechanically ventilated, closed-chest dogs. The right lung was ventilated with 100% O...

journal_title：Anesthesiology

authors： Domino KB,Borowec L,Alexander CM,Williams JJ,Chen L,Marshall C,Marshall BE

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:Succinylcholine causes immediate and severe arterial hypotension in swine with the malignant hyperthermia phenotype. The underlying mechanisms are unknown. METHODS:Malignant hyperthermia-susceptible (MHS; n = 10) and normal swine (n = 5) were anesthetized with thiopental. The following were monitored: elect...

journal_title：Anesthesiology

authors： Sigg DC,Iaizzo PA

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Systemic magnesium has been used to minimize postoperative pain with conflicting results by clinical studies. It remains unknown whether the administration of perioperative systemic magnesium can minimize postoperative pain. The objective of the current investigation was to evaluate the effect of systemic ma...

journal_title：Anesthesiology

authors： De Oliveira GS Jr,Castro-Alves LJ,Khan JH,McCarthy RJ

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The results of sevoflurane biotransformation (fluoromethyl-1,1,1,3,3,3,-hexafluoro-2-propyl ether) to inorganic fluoride have been examined. However, these investigations have lacked a simplified assay for determining the primary organic metabolite, hexafluoroisopropanol. Previous attempts have involved exte...

journal_title：Anesthesiology

authors： Morgan SE,Frink EJ,Gandolfi AJ

更新日期：1994-01-01 00:00:00

abstract：:The blood flow in the sciatic nerve of the rabbit was estimated from the wash out of intraneurally injected 133Xe. To avoid diffusion of the tracer into the surrounding muscular tissue, the nerve was covered by a gas-tight plastic film. Using this technique, the basal blood flow in the sciatic nerve was estimated to 3...

journal_title：Anesthesiology

authors： Selander D,Månsson LG,Karlsson L,Svanvik J

更新日期：1985-01-01 00:00:00

abstract：UNLABELLED:BACKGROUND. Injection of local anesthetic into cerebrospinal fluid (CSF) produces anesthesia of unpredictable extent and duration. Although many factors have been identified that affect the extent of spinal anesthesia, correlations are relatively poor and the extent of spread remains unpredictable. This stud...

journal_title：Anesthesiology

authors： Carpenter RL,Hogan QH,Liu SS,Crane B,Moore J

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Some patients develop recrudescence after a malignant hyperthermia (MH) reaction, but it is not clear which patients are at risk. The authors analyzed clinical variables associated with recrudescence after a clinical MH episode. METHODS:Data were obtained from Adverse Metabolic Reaction to Anesthesia report...

journal_title：Anesthesiology

authors： Burkman JM,Posner KL,Domino KB

更新日期：2007-05-01 00:00:00

abstract：:A potentially serious complication of long-term epidural catheterization in cancer patients is infection. The early signs of infection were studied in 350 patients in whom long-term epidural catheters were inserted. Three areas of the catheter track were found to be involved; exit site and superficial catheter track i...

journal_title：Anesthesiology

authors： Du Pen SL,Peterson DG,Williams A,Bogosian AJ

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Recent advances have indicated a complex interplay between the autonomic nervous system and the innate immune system. Targeting neural networks for the treatment of sepsis is being developed as a therapeutic strategy. Because electroacupuncture at select acupoints can modulate activities of the autonomic ner...

journal_title：Anesthesiology

authors： Song JG,Li HH,Cao YF,Lv X,Zhang P,Li YS,Zheng YJ,Li Q,Yin PH,Song SL,Wang HY,Wang XR

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:It has been known that skeletal muscles show atrophic changes after prolonged sedation or general anesthesia. Whether these effects are due to anesthesia itself or disuse during anesthesia has not been fully clarified. Autophagy dysregulation has been implicated in muscle-wasting conditions. This study teste...

journal_title：Anesthesiology

authors： Kashiwagi A,Hosokawa S,Maeyama Y,Ueki R,Kaneki M,Martyn JA,Yasuhara S

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:The pharmacokinetics of epidurally administered drugs has been the subject of many studies, yet drug concentration in the epidural space has never been measured. This study was undertaken to characterize the epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidurally administered opioids on the ...

journal_title：Anesthesiology

authors： Bernards CM,Shen DD,Sterling ES,Adkins JE,Risler L,Phillips B,Ummenhofer W

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:The authors' purpose of this study was to elucidate the mechanisms of direct effects of halothane on the contractile proteins and Ca2+ release from the sarcoplasmic reticulum Ca2+ stores using isolated skinned strips (sarcolemma permealized with saponin) from rabbit pulmonary arteries. METHODS:The sarcoplas...

journal_title：Anesthesiology

authors： Su JY,Tang LJ

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Due to economic pressures and improvements in perioperative care, outpatient surgical procedures have become commonplace. However, risk factors for outpatient surgical morbidity and mortality remain unclear. There are no multicenter clinical data guiding patient selection for outpatient surgery. The authors ...

journal_title：Anesthesiology

authors： Mathis MR,Naughton NN,Shanks AM,Freundlich RE,Pannucci CJ,Chu Y,Haus J,Morris M,Kheterpal S

更新日期：2013-12-01 00:00:00

abstract：:Ketamine is used clinically as a racemic mixture of optical isomers that differ in their analgesic properties and psychomimetic effects. Administered individually, or together as the racemate, ketamine enantiomers differ in their hepatic clearance and duration of anesthetic effect. S(+) ketamine exhibits a greater cle...

journal_title：Anesthesiology

authors： Kharasch ED,Labroo R

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Ethical conduct in human research in anesthesia includes approval by an institutional review board (IRB) or ethics committee and informed consent. Evidence of these is sometimes lacking in journal publications. METHODS:The authors reviewed all publications involving human subjects in six leading anesthesia ...

journal_title：Anesthesiology

authors： Myles PS,Tan N

更新日期：2003-11-01 00:00:00