The effect of isoflurane-induced hypotension on cerebral blood flow and cerebral metabolic rate for oxygen in humans.

abstract：:Twenty-four patients survived life-threatening clinical anaphylaxis due to anesthesia. In each case the diagnosis of anaphylaxis was confirmed and the responsible drug was found by intradermal testing. To determine whether the reactions were anaphylactic or anaphylactoid, serum from each patient was tested for reagini...

journal_title：Anesthesiology

authors： Fisher MM

更新日期：1980-04-01 00:00:00

abstract：:The authors had previously observed a deleterious cerebrovascular effect of prolonged hypothermia in primates and cats. In this study they examined the systemic as well as cerebral hemodynamic and metabolic effects of 24 hours of hypothermia in the dog. With decreases in temperature to 29 C, cardiac output (Q) and who...

journal_title：Anesthesiology

authors： Steen PA,Milde JH,Michenfelder JD

更新日期：1980-03-01 00:00:00

abstract：:Initial studies have suggested that oral transmucosal fentanyl citrate (OTFC) in a dose of 15-20 micrograms/kg may be a safe and effective preanesthetic medication in children and adults, but this has not been demonstrated in a randomized, double-blind fashion. The purpose of this study was to determine in a randomize...

journal_title：Anesthesiology

authors： Feld LH,Champeau MW,van Steennis CA,Scott JC

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:We examined the effects of different anesthetics on cerebral oxygenation and systemic hemodynamics in patients undergoing surgery in beach chair position (BCP). Jugular venous bulb oxygen saturation (SjvO2) and regional cerebral tissue oxygen saturation (SctO2) were determined while patients were placed from...

journal_title：Anesthesiology

authors： Jeong H,Jeong S,Lim HJ,Lee J,Yoo KY

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:The tuberomammillary histaminergic neurons are involved in the sedative component of anesthetic action. The nucleus basalis magnocellularis (NBM) in the basal forebrain receives dense excitatory innervation from the tuberomammillary nucleus and is recognized as an important site of sleep-wake regulation. Thi...

journal_title：Anesthesiology

authors： Luo T,Leung LS

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Rapid elimination of nitrous oxide from the lungs at the end of inhalational anesthesia dilutes alveolar oxygen, producing "diffusion hypoxia." A similar dilutional effect on accompanying volatile anesthetic agent has not been evaluated and may impact the speed of emergence. METHODS:Twenty patients undergoi...

journal_title：Anesthesiology

authors： Peyton PJ,Chao I,Weinberg L,Robinson GJ,Thompson BR

更新日期：2011-03-01 00:00:00

abstract：:Anesthesia and surgery are a risk for all, the healthy as well as the sick. While the prevention of adverse outcomes in healthy patients is paramount, enhancement of safety for critically ill patients is also essential, since they are more likely to suffer a SNO after a critical incident. Dangers originate from a vari...

journal_title：Anesthesiology

authors： Gaba DM,Maxwell M,DeAnda A

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:It has been known that skeletal muscles show atrophic changes after prolonged sedation or general anesthesia. Whether these effects are due to anesthesia itself or disuse during anesthesia has not been fully clarified. Autophagy dysregulation has been implicated in muscle-wasting conditions. This study teste...

journal_title：Anesthesiology

authors： Kashiwagi A,Hosokawa S,Maeyama Y,Ueki R,Kaneki M,Martyn JA,Yasuhara S

更新日期：2015-05-01 00:00:00

abstract：:Two groups of women, ASA physical status 1, undergoing surgery for primary breast cancer, were studied to assess the effect of alcohol intake on alfentanil pharmacodynamics. Patients in group 1 (n = 6) had an average daily consumption of 20-40 g alcohol. Patients in group 2 (n = 8) were life-long abstainers or drank o...

journal_title：Anesthesiology

authors： Lemmens HJ,Bovill JG,Hennis PJ,Gladines MP,Burm AG

更新日期：1989-11-01 00:00:00

abstract：:Thiopental-14C (30 mg and 10 muCi/kg) was injected intravenously into rats 36-48 hours following bilateral nephrectomy and one minute after pretreatment with sulfadimethoxine (30 mg/kg, iv). Control groups of normal and sham-operated animals were used. The distributions of radioactivity in plasma, brain, and heart 1, ...

journal_title：Anesthesiology

authors： Ghoneim MM,Pandya HB,Kelley SE,Fischer LJ,Corry RJ

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND:Factors determining renal function at organ recovery in deceased kidney donors are not well established. METHODS:The authors studied the prevalence and risk factors associated with elevated prerecovery creatinine and calculated glomerular filtration rate in 458 deceased organ donors identified through the C...

journal_title：Anesthesiology

authors： Blasi-Ibanez A,Hirose R,Feiner J,Freise C,Stock PG,Roberts JP,Niemann CU

更新日期：2009-02-01 00:00:00

abstract：:Reversal of the usual relationship between aortic and radial artery pressure can occur in patients following cardiopulmonary bypass. Radial systolic (and often radial mean) pressures were lower, relative to aortic pressure, after cardiopulmonary bypass than before bypass in all 18 patients studied. The systolic pressu...

journal_title：Anesthesiology

authors： Stern DH,Gerson JI,Allen FB,Parker FB

更新日期：1985-05-01 00:00:00

abstract：:To determine whether anesthesiologists, because of prolonged exposure to halothane or other inhalational anesthetics, might have higher death rates from all causes, from cancer, and from hepatic or renal disease than other physicians, the mortality rates of male and female members of the American Society of Anesthesio...

journal_title：Anesthesiology

authors： Lew EA

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND:Thermoregulatory vasoconstriction minimizes further core hypothermia during anesthesia. Elderly patients become more hypothermic during surgery than do younger patients, and take longer to rewarm postoperatively. These data indicate that perianesthetic thermoregulatory responses may be especially impaired in...

journal_title：Anesthesiology

authors： Kurz A,Plattner O,Sessler DI,Huemer G,Redl G,Lackner F

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Perfluorocarbon (PFC) liquids are known to improve gas exchange and pulmonary function in various models of acute respiratory failure. Vaporization has been recently reported as a new method of delivering PFC to the lung. Our aim was to study the effect of PFC vapor on the ventilation/perfusion (VA/Q) matchi...

journal_title：Anesthesiology

authors： Hübler M,Souders JE,Shade ED,Polissar NL,Schimmel C,Hlastala MP

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Inhalational anesthetics inhibit the nitric oxide-guanylyl cyclase signaling pathway, but the site of this inhibition is not yet clear. This study was designed to test the hypothesis that receptor activation or downstream signaling events leading to nitric oxide synthase activation are important sites for th...

journal_title：Anesthesiology

authors： Zuo Z,Tichotsky A,Johns RA

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:The value of exercise electrocardiography in the prediction of perioperative cardiac risk has yet to be defined. This study was performed to determine the predictive value of exercise electrocardiography as compared with clinical parameters and resting electrocardiography. METHODS:A total of 204 patients at...

journal_title：Anesthesiology

authors： Gauss A,Röhm HJ,Schäuffelen A,Vogel T,Mohl U,Straehle A,Meierhenrich R,Georgieff M,Steinbach G,Schütz W

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Anesthetic drugs administered to immature animals may cause neurohistopathologic changes and alterations in behavior. The authors studied association between anesthetic exposure before age 4 yr and the development of reading, written language, and math learning disabilities (LD). METHODS:This was a populati...

journal_title：Anesthesiology

authors： Wilder RT,Flick RP,Sprung J,Katusic SK,Barbaresi WJ,Mickelson C,Gleich SJ,Schroeder DR,Weaver AL,Warner DO

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Postoperative visual loss after prone spine surgery is increasingly reported in association with ischemic optic neuropathy, but its etiology is unknown. METHODS:To describe the clinical characteristics of these patients, the authors analyzed a retrospectively collected series of 93 spine surgery cases volun...

journal_title：Anesthesiology

authors： Lee LA,Roth S,Posner KL,Cheney FW,Caplan RA,Newman NJ,Domino KB

更新日期：2006-10-01 00:00:00

abstract：:Five healthy, nonpregnant volunteers were studied before and after induction of lumbar epidural anesthesia to determine the cause of central hypothermia during epidural anesthesia. Cutaneous heat loss was measured from 10 area-weighted sites using thermal flux transducers. Oxygen consumption was measured and converted...

journal_title：Anesthesiology

authors： Hynson JM,Sessler DI,Glosten B,McGuire J

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Cerebrospinal fluid (CSF) outflow to intra- and extracranial subarachnoid spaces caused by arterial inflow to the brain predominantly compensates systolic increases in cerebral blood volume. Phase-contrast magnetic resonance imaging is a new tool for noninvasive assessment of CSF displacement by measuring CS...

journal_title：Anesthesiology

authors： Kolbitsch C,Schocke M,Lorenz IH,Kremser C,Zschiegner F,Pfeiffer KP,Felber S,Aichner F,Hörmann C,Benzer A

更新日期：1999-06-01 00:00:00

abstract：:The effects of diazepam on cerebral blood flow (CBF) and cerebral oxygen uptake (CMRO2) was studied using a 133xenon modification of the Kety-Schmidt (1948) technique in paralyzed, artifically ventilated rats with and without simultaneous administration of 70 per cent nitrous oxide. Diazepam was given iv in doses that...

journal_title：Anesthesiology

authors： Carlsson C,Hgerdal M,Kaasik AE,Siesjö BK

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND:Recent evidence indicates that vascular adenosine triphosphate-sensitive potassium (K(ATP)) channels in vascular smooth muscle cells are critical in the regulation of vascular tonus under both physiologic and pathophysiologic conditions. Studies of the interaction of volatile anesthetics with vascular K(ATP)...

journal_title：Anesthesiology

authors： Tanaka K,Kawano T,Nakamura A,Nazari H,Kawahito S,Oshita S,Takahashi A,Nakaya Y

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:The anticonvulsant gabapentin, proven effective for neuropathic pain in two large, placebo-controlled clinical trials, is widely used for treatment of chronic pain. Preclinical studies have demonstrated analgesic and antiallodynic effects in models involving neuronal sensitization and nerve injury, without a...

journal_title：Anesthesiology

authors： Dirks J,Petersen KL,Rowbotham MC,Dahl JB

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Oral gabapentin is approved as an anticonvulsant medication and to treat postherpetic neuralgia. Its nonopioid properties and presumed spinal site of analgesic action made the study on intrathecal gabapentin attractive to establish the minimum effective dose for a later, pivotal trial. METHODS:The authors e...

journal_title：Anesthesiology

authors： Rauck R,Coffey RJ,Schultz DM,Wallace MS,Webster LR,McCarville SE,Grigsby EJ,Page LM

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Moxonidine, a novel imidazoline-alpha2-adrenergic receptor-selective analgesic, was recently identified as antinociceptive but has yet to be evaluated in neuropathic pain models. alpha2-adrenergic receptor-selective analgesics, and high-efficacy opioids, effectively inhibit neuropathic pain behaviors in rode...

journal_title：Anesthesiology

authors： Fairbanks CA,Nguyen HO,Grocholski BM,Wilcox GL

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Systemically administered local anesthetics and other sodium channel blockers produce analgesia in patients with hypersensitivity disorders. To assess whether these agents have a role in the treatment of visceral pain, the present study examined the effects of intravenous lidocaine on neuronal and reflex res...

journal_title：Anesthesiology

authors： Ness TJ

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Uptake of a second gas of a delivered gas mixture decreases the amount of carrier gas and potent inhaled anesthetic leaving the circle system through the pop-off valve. The authors hypothesized that the vaporizer settings required to maintain constant end-expired sevoflurane concentration (Etsevo) during min...

journal_title：Anesthesiology

authors： Hendrickx JF,Coddens J,Callebaut F,Artico H,Deloof T,Demeyer I,De Wolf AM

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Combining a hypnotic and an analgesic to produce sedation, analgesia, and surgical immobility required for clinical anesthesia is more common than administration of a volatile anesthetic alone. The aim of this study was to apply response surface methods to characterize the interactions between remifentanil a...

journal_title：Anesthesiology

authors： Manyam SC,Gupta DK,Johnson KB,White JL,Pace NL,Westenskow DR,Egan TD

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Studies have shown that long-term increase in the excitability of single wide dynamic range neurones in the spinal dorsal horn of rats may be induced after tetanic stimulation to the sciatic nerve. This sensory event is possibly an in vivo counterpart of long-term potentiation, described in the brain. This s...

journal_title：Anesthesiology

authors： Rygh LJ,Green M,Athauda N,Tjølsen A,Dickenson AH

更新日期：2000-01-01 00:00:00