Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve.


BACKGROUND:Transient receptor potential vanilloid 1 channels integrate nociceptive stimuli and are predominantly expressed by unmyelinated C-fiber nociceptors, but not low-threshold mechanoreceptive sensory or motor fibers. A recent report showed that the transient receptor potential vanilloid 1 channel agonist capsaicin allows a hydrophilic quaternary ammonium derivative of lidocaine, QX-314, to selectively block C fibers without motor block. The authors tested whether a similar differential block would be produced using amphipathic N-methyl amitriptyline, amitriptyline, bupivacaine, or lidocaine, either alone or together with 0.05% capsaicin, in a rat sciatic nerve block model. METHODS:Rats (n = 8/group) were anesthetized with sevoflurane, and 0.2 ml of drug was injected either alone or with capsaicin (simultaneously or 10 min later) next to the sciatic nerve in the sciatic notch. Motor function was assessed by the extensor postural thrust. Nociception was evaluated by the nocifensive withdrawal reflex and vocalization evoked by pinch of a skin fold over the lateral metatarsus (cutaneous pain) with a serrated forceps. RESULTS:N-Methyl amitriptyline, amitriptyline, bupivacaine, or lidocaine, followed by injection of capsaicin 10 min later, each elicited a predominantly nociceptive-specific blockade. In comparison, simultaneous application of each local anesthetic with capsaicin did not elicit a clinically significant differential block, with the exception of N-methyl amitriptyline. CONCLUSIONS:Both tertiary amine local anesthetics and their quaternary ammonium derivatives can elicit a predominantly sensory/nociceptor selective block when followed by injection of capsaicin. The combined application of transient receptor potential vanilloid 1 channel agonists and various local anesthetics or their quaternary ammonium derivatives is an appealing strategy to achieve a long-lasting differential block in regional analgesia.






Gerner P,Binshtok AM,Wang CF,Hevelone ND,Bean BP,Woolf CJ,Wang GK




Has Abstract


2008-11-01 00:00:00














  • Effect of flumazenil on ventilatory drive during sedation with midazolam and alfentanil.

    abstract:BACKGROUND:Patients who receive a combination of a benzodiazepine and an opioid for conscious sedation are at risk for developing respiratory depression. While flumazenil effectively antagonizes the respiratory depression associated with a benzodiazepine alone, its efficacy in the presence of both a benzodiazepine and ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gross JB,Blouin RT,Zandsberg S,Conard PF,Häussler J

    更新日期:1996-10-01 00:00:00

  • Association of ethnicity with the minimum alveolar concentration of sevoflurane.

    abstract:BACKGROUND:Selective breeding produces animal strains with varying anesthetic sensitivity. It thus seems unlikely that various human ethnicities have identical anesthetic requirements. Therefore, the authors tested the hypothesis that the minimum alveolar concentration of sevoflurane differs significantly as a function...


    pub_type: 杂志文章,随机对照试验


    authors: Ezri T,Sessler D,Weisenberg M,Muzikant G,Protianov M,Mascha E,Evron S

    更新日期:2007-07-01 00:00:00

  • In vivo fluorescence-mediated tomography imaging demonstrates atorvastatin-mediated reduction of lesion macrophages in ApoE-/- mice.

    abstract:BACKGROUND:Macrophage recruitment into atherosclerotic plaques drives lesion progression, destabilization, and rupture. Chronic statin treatment reduces macrophage plaque content. Information on dynamics of macrophage recruitment would help assessing plaque vulnerability and guiding therapy. Techniques to image macroph...


    pub_type: 杂志文章


    authors: Larmann J,Frenzel T,Schmitz M,Hahnenkamp A,Demmer P,Immenschuh S,Tietge UJ,Bremer C,Theilmeier G

    更新日期:2013-07-01 00:00:00

  • Lateral position decreases collapsibility of the passive pharynx in patients with obstructive sleep apnea.

    abstract:BACKGROUND:Reduction of nocturnal obstructive events during lateral position in patients with obstructive sleep apnea was previously reported. However, little information is available regarding mechanisms of the improvement and the precise pharyngeal site influenced by the lateral position. The authors tested the hypot...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Isono S,Tanaka A,Nishino T

    更新日期:2002-10-01 00:00:00

  • A departmental policy addressing chemical substance abuse.

    abstract::Substance abuse is a major socioeconomic problem. However, the ready availability of potent narcotic and sedative drugs probably constitutes a unique risk for anesthesiologists. Until recently, few anesthesia departments were prepared to recognize or safely manage afflicted colleagues. Because we felt it important to ...


    pub_type: 杂志文章


    authors: Lecky JH,Aukburg SJ,Conahan TJ 3rd,Geer RT,Ominsky AJ,Gross J,Muravchick S,Wollman H

    更新日期:1986-10-01 00:00:00

  • Regional gas exchange and cellular metabolic activity in ventilator-induced lung injury.

    abstract:BACKGROUND:Alveolar overdistension and repetitive derecruitment-recruitment contribute to ventilator-induced lung injury (VILI). The authors investigated (1) whether inflammatory cell activation due to VILI was assessable by positron emission tomography and (2) whether cell activation due to dynamic overdistension alon...


    pub_type: 杂志文章


    authors: Musch G,Venegas JG,Bellani G,Winkler T,Schroeder T,Petersen B,Harris RS,Melo MF

    更新日期:2007-04-01 00:00:00

  • I653 and isoflurane produce similar dose-related changes in the electroencephalogram of pigs.

    abstract::I653 is a new volatile anesthetic structurally similar to enflurane and isoflurane. Since enflurane can induce convulsions, whereas isoflurane progressively depresses cortical electrical activity, the authors believed it important to assess the effect of I653 on the EEG (in both the "time" and "frequency" domain). The...


    pub_type: 杂志文章


    authors: Rampil IJ,Weiskopf RB,Brown JG,Eger EI 2nd,Johnson BH,Holmes MA,Donegan JH

    更新日期:1988-09-01 00:00:00

  • An obligatory role for spinal cholinergic neurons in the antiallodynic effects of clonidine after peripheral nerve injury.

    abstract:BACKGROUND:Indirect evidence supports a role of spinal cholinergic neurons in tonically reducing response to noxious mechanical stimulation and in effecting analgesia from alpha2-adrenergic agonists. This study directly assessed the role of cholinergic neurons in regulating the level of mechanical allodynia and in part...


    pub_type: 杂志文章


    authors: Paqueron X,Li X,Bantel C,Tobin JR,Voytko ML,Eisenach JC

    更新日期:2001-06-01 00:00:00

  • Monitoring hepatic venous hemoglobin oxygen saturation in patients undergoing liver surgery.

    abstract::Hepatic venous oxygen saturation (ShvO2) was continuously monitored in 33 consecutive patients undergoing hepatic lobectomy. Fiberoptic pulmonary artery catheters were inserted into the hepatic vein (HV) and in the pulmonary artery through the right internal jugular vein before anesthetic induction. The success rate a...


    pub_type: 杂志文章


    authors: Kainuma M,Fujiwara Y,Kimura N,Shitaokoshi A,Nakashima K,Shimada Y

    更新日期:1991-01-01 00:00:00

  • Anterior shift of the dominant EEG rhytham during anesthesia in the Java monkey: correlation with anesthetic potency.

    abstract::EEG amplitude dominance in awake man is posterior. During EEG monitoring in patients, the authors observed the abrupt appearance of anterior amplitude dominance during induction of anesthesia with halothane, enflurane, or thiopental. This EEG change is coincident with loss of eyelid reflex and loss of ability to respo...


    pub_type: 杂志文章


    authors: Tinker JH,Sharbrough FW,Michenfelder JD

    更新日期:1977-04-01 00:00:00

  • Malignant hyperthermia.

    abstract::In MH, skeletal muscle acutely and unexpectedly increases its oxygen consumption and lactate production, resulting in greater heat production, respiratory and metabolic acidosis, muscle ridigity, sympathetic stimulation, and increased cellular permeability. The best-accepted theory is that MH is due to an inability to...


    pub_type: 杂志文章,评审


    authors: Gronert GA

    更新日期:1980-11-01 00:00:00

  • A randomized controlled trial of adaptive support ventilation mode to wean patients after fast-track cardiac valvular surgery.

    abstract:BACKGROUND:Adaptive support ventilation can speed weaning after coronary artery surgery compared with protocolized weaning using other modes. There are no data to support this mode of weaning after cardiac valvular surgery. Furthermore, control group weaning times have been long, suggesting that the results may reflect...


    pub_type: 杂志文章,随机对照试验


    authors: Zhu F,Gomersall CD,Ng SK,Underwood MJ,Lee A

    更新日期:2015-04-01 00:00:00

  • Dose-response relationship of intrathecal morphine for postcesarean analgesia.

    abstract:BACKGROUND:This series investigated the quality of analgesia and the incidence and severity of side effects of intrathecal morphine for post-cesarean analgesia administered over a dose range of 0.0-0.5 mg. METHODS:ONE hundred eight term parturients undergoing cesarean delivery at term and given spinal anesthesia were ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Palmer CM,Emerson S,Volgoropolous D,Alves D

    更新日期:1999-02-01 00:00:00

  • A 1966 Anesthetic Administered by Robert D. Dripps, M.D., Demonstrated His Experimental Style of Clinical Care.

    abstract::Robert D. Dripps, M.D. (1911 to 1973), helped found academic anesthesiology. Newly reviewed teaching slides from the University of Pennsylvania (Philadelphia, Pennsylvania) contain six anesthesia records from 1965 to 1967 that involved Dripps. They illustrate the clinical philosophy he taught-to consider administratio...


    pub_type: 传,历史文章,杂志文章


    authors: Johnstone RE,Fleisher LA

    更新日期:2016-06-01 00:00:00

  • Myocardial hypercarbic acidosis reduces cardiac resuscitability.

    abstract:BACKGROUND:The severity of spontaneous myocardial hypercarbic acidosis during cardiac arrest previously has been predictive of the likelihood of restoring spontaneous circulation. The present study investigated whether hypercarbia itself impairs cardiac resuscitation. Since coronary perfusion pressure is the overriding...


    pub_type: 杂志文章


    authors: Maldonado FA,Weil MH,Tang W,Bisera J,Gazmuri RJ,Johnson B,D'Alessio A

    更新日期:1993-02-01 00:00:00

  • Direct assessments of the antioxidant effects of propofol medium chain triglyceride/long chain triglyceride on the brain of stroke-prone spontaneously hypertensive rats using electron spin resonance spectroscopy.

    abstract:BACKGROUND:Antioxidant anesthetics such as propofol (2,6-diisopropylphenol) directly inhibit lipid peroxidation via the generation of reactive oxygen species. Currently, there are no other studies regarding the direct effects of propofol medium chain triglyceride/long chain triglyceride (MCT/LCT) on reactive oxygen spe...


    pub_type: 杂志文章


    authors: Kobayashi K,Yoshino F,Takahashi SS,Todoki K,Maehata Y,Komatsu T,Yoshida K,Lee MC

    更新日期:2008-09-01 00:00:00

  • Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice.

    abstract:BACKGROUND:The long-term use of opioids for analgesia carries significant risk for tolerance, addiction, and diversion. These adverse effects are largely mediated by μ-opioid receptors in the central nervous system. Based on the authors' previous observation that morphine and δ-opioid receptor agonists synergize in spi...


    pub_type: 杂志文章


    authors: Bruce DJ,Peterson CD,Kitto KF,Akgün E,Lazzaroni S,Portoghese PS,Fairbanks CA,Wilcox GL

    更新日期:2019-09-01 00:00:00

  • Ventilator-associated pneumonia leading to acute lung injury after trauma: importance of Haemophilus influenzae.

    abstract:BACKGROUND:Ventilator-associated pneumonia is a clear risk factor for acute lung injury which has been poorly described in trauma patients. This prospective study was undertaken to estimate the incidence of such ventilator-associated pneumonia leading to acute lung injury, the risk factors, and the associated morbidity...


    pub_type: 杂志文章


    authors: Stéphan F,Mabrouk N,Decailliot F,Delclaux C,Legrand P

    更新日期:2006-02-01 00:00:00

  • Involvement of cerulospinal glutamatergic neurotransmission in fentanyl-induced muscular rigidity in the rat.

    abstract:BACKGROUND:Investigators in the authors' laboratory previously established the critical participation of the cerulospinal noradrenergic pathway in muscular rigidity elicited by fentanyl. The identification of colocalization of glutamate with tyrosine hydroxylase in most locus ceruleus neurons suggests a role for cerulo...


    pub_type: 杂志文章


    authors: Fu MJ,Tsen LY,Lee TY,Lui PW,Chan SH

    更新日期:1997-12-01 00:00:00

  • Development and validation of a score for prediction of postoperative respiratory complications.

    abstract:BACKGROUND:Postoperative respiratory failure is associated with increased morbidity and mortality, as well as high costs of hospital care. METHODS:Using electronic anesthesia records, billing data, and chart review, the authors developed and validated a score predicting reintubation in the hospital after primary extub...


    pub_type: 杂志文章


    authors: Brueckmann B,Villa-Uribe JL,Bateman BT,Grosse-Sundrup M,Hess DR,Schlett CL,Eikermann M

    更新日期:2013-06-01 00:00:00

  • Moxonidine, a selective imidazoline-alpha2 -adrenergic receptor agonist, produces spinal synergistic antihyperalgesia with morphine in nerve-injured mice.

    abstract:BACKGROUND:Moxonidine, a novel imidazoline-alpha2-adrenergic receptor-selective analgesic, was recently identified as antinociceptive but has yet to be evaluated in neuropathic pain models. alpha2-adrenergic receptor-selective analgesics, and high-efficacy opioids, effectively inhibit neuropathic pain behaviors in rode...


    pub_type: 杂志文章


    authors: Fairbanks CA,Nguyen HO,Grocholski BM,Wilcox GL

    更新日期:2000-09-01 00:00:00

  • Bacterial reduction by cell salvage washing and leukocyte depletion filtration.

    abstract:BACKGROUND:Blood conservation techniques are being increasingly used because of the increased cost and lack of availability of allogeneic blood. Cell salvage offers great blood savings opportunities but is thought to be contraindicated in a number of areas (e.g., blood contaminated with bacteria). Several outcome studi...


    pub_type: 杂志文章


    authors: Waters JH,Tuohy MJ,Hobson DF,Procop G

    更新日期:2003-09-01 00:00:00

  • Cerebrovascular and cerebral metabolic effects of N2O in unrestrained rats.

    abstract::There is controversy about whether N2O increases cerebral blood flow and cortical oxygen consumption (CMRO2) in rats. Cortical and subcortical blood flow and CMRO2 were measured in awake, unrestrained rats while awake and during 70% N2O administration using radioactive microspheres. In the awake state, cortical and su...


    pub_type: 杂志文章


    authors: Baughman VL,Hoffman WE,Miletich DJ,Albrecht RF

    更新日期:1990-08-01 00:00:00

  • Diagnosis of ventilator-associated pneumonia: an evaluation of direct examination and presence of intracellular organisms.

    abstract:BACKGROUND:Ventilator-associated pneumonia (VAP) requires early diagnosis and adequate antibiotic therapy. The aim of this prospective postmortem study was to assess the accuracy of direct examination and quantification of intracellular organisms (ICO) for the diagnosis of VAP. METHODS:Total and differential cell coun...


    pub_type: 杂志文章


    authors: Papazian L,Autillo-Touati A,Thomas P,Bregeon F,Garbe L,Saux P,Seite R,Gouin F

    更新日期:1997-08-01 00:00:00

  • Intracranial pressure during hypotension and subsequent vasopressor therapy in anesthetized cats.

    abstract::The effects of vasopressor therapy on intracranial pressure (ICP) during hypotension were evaluated in 45 adult cats anesthetized with pentobarbital and hyperventilated via an endotracheal tube with nitrous oxide, 70 per cent, and oxygen, 30 per cent, to maintain Paco2 25 plus or minus 5 torr. Hypotension was induced ...


    pub_type: 杂志文章


    authors: Stullken EH Jr,Sokoll MD

    更新日期:1975-04-01 00:00:00

  • Effect of diltiazem on midazolam and alfentanil disposition in patients undergoing coronary artery bypass grafting.

    abstract:BACKGROUND:Midazolam and alfentanil are desirable anesthetic adjuncts for cardiac anesthesia. They are metabolized by cytochrome P450 3A (CYP3A) enzymes. These isozymes are inhibited by concurrent medications, including the calcium channel antagonist diltiazem, which may have an effect on recovery from anesthesia. MET...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ahonen J,Olkkola KT,Salmenperä M,Hynynen M,Neuvonen PJ

    更新日期:1996-12-01 00:00:00

  • Prolonged exposure to nitrous oxide decreased opiate receptor density in rat brainstem.

    abstract::Groups of rats were exposed to air or 80 per cent nitrous oxide for 30 min or 18 h, following which the brainstem opiate receptor density and the apparent affinity of these receptors to the radiolabeled agonist, 3H-dihydromorphine, were assayed, Thirty-minute exposure to nitrous oxide did not change opiate receptor ch...


    pub_type: 杂志文章


    authors: Ngai SH,Finck AD

    更新日期:1982-07-01 00:00:00

  • Postoperative hyperoxia (60%) worsens hepatic injury in mice.

    abstract:BACKGROUND:Liver damage by ischemia and reperfusion injury is a risk factor for morbidity and mortality after liver surgery. Postoperative oxygen treatment is routinely applied in the postanesthesia and intensive care unit after liver surgery. The risks of aggravating the injury by increasing inspiratory oxygen from 21...


    pub_type: 杂志文章


    authors: Zangl Q,Martignoni A,Jackson SH,Ohta A,Klaunberg B,Kaufmann I,Lukashev D,Ward JM,Sitkovsky M,Thiel M,Choukèr A

    更新日期:2014-12-01 00:00:00

  • Role of central and mixed venous oxygen saturation measurement in perioperative care.

    abstract::Complications after major surgery are a leading cause of morbidity and mortality. The etiology of postoperative complications is complex, but poor cardiorespiratory reserve appears to be a key factor. There is increasing interest in the use of central and mixed venous oxygen saturation to guide therapeutic interventio...


    pub_type: 杂志文章


    authors: Shepherd SJ,Pearse RM

    更新日期:2009-09-01 00:00:00

  • Offset analgesia in neuropathic pain patients and effect of treatment with morphine and ketamine.

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    pub_type: 杂志文章,随机对照试验


    authors: Niesters M,Hoitsma E,Sarton E,Aarts L,Dahan A

    更新日期:2011-11-01 00:00:00