Abstract:
:Inorganic fluoride (F-) production and renal function were assessed in six groups of Fischer 344 rats administered either methoxyflurane (MOF) or deuterated methoxyflurane (d4-MOF). One untreated and one phenobarbital (PB)-treated group were exposed for two hours to either air, 0.5 per cent (V/v) MOF, or 0.5 per cent (v/v) d4-MOF. Serum and urinary F- and serum urea nitrogen and creatinine were measured. Urine volume and urinary F- excretion were only slightly greater among MOF than among d4-MOF exposed animals. Pretreatment with PB, however, greatly enhanced F- production in MOF-exposed animals leading to marked renal impairment but only slightly enhanced F- production in d4-MOF animals leading to mild renal impairment. Thus, only in PB-pretreated animals could a biologically significant difference in nephrotoxicity be demonstrated for MOF and d4-MOF.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Baden JM,Rice SA,Mazze RIdoi
10.1097/00000542-198203000-00009subject
Has Abstractpub_date
1982-03-01 00:00:00pages
203-6issue
3eissn
0003-3022issn
1528-1175journal_volume
56pub_type
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