Effect of diltiazem on midazolam and alfentanil disposition in patients undergoing coronary artery bypass grafting.

abstract：BACKGROUND:Synergistic antinociception of opioids and local anesthetics has been established in bolus injections but not in long-term use. The somatic and visceral antinociceptive effects of intrathecally infused morphine or lidocaine were characterized, and the nature of the interaction of those agents in rats was eva...

journal_title：Anesthesiology

authors： Saito Y,Kaneko M,Kirihara Y,Sakura S,Kosaka Y

更新日期：1998-12-01 00:00:00

abstract：:ECG changes suggestive of myocardial ischemia are common during cesarean delivery under regional anesthesia. To determine the time course, duration, and significance of these ECG changes, we monitored 111 parturients with continuous ambulatory ECG (Holter) during and after cesarean delivery. Twenty-two parturients und...

journal_title：Anesthesiology

authors： Mathew JP,Fleisher LA,Rinehouse JA,Sevarino FB,Sinatra RS,Nelson AH,Prokop EK,Rosenbaum SH

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:We previously described the use of the nematode Caenorabditis elegans as a genetic model for studying the mechanism of action of volatile anesthetics. All previous strains of C. elegans with altered responses to anesthetics have been identified by screening the response to halothane. The current study was de...

journal_title：Anesthesiology

authors： Morgan PG,Sedensky MM

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Ketamine has been associated with a unique spectrum of subjective "psychedelic" effects in patients emerging from anesthesia. This study quantified these effects of ketamine and related them to steady-state plasma concentrations. METHODS:Ketamine or saline was administered in a single-blinded crossover prot...

journal_title：Anesthesiology

authors： Bowdle TA,Radant AD,Cowley DS,Kharasch ED,Strassman RJ,Roy-Byrne PP

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:In vitro studies have shown that isoflurane, enflurane, and halothane inhibit the hypoxic pulmonary vasoconstriction (HPV) with essentially the same potency. The aim of this study is to compare the effects of sevoflurane and isoflurane on HPV in constant-flow perfused rabbit lungs. METHODS:Constant-flow per...

journal_title：Anesthesiology

authors： Ishibe Y,Gui X,Uno H,Shiokawa Y,Umeda T,Suekane K

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Mutations in the ryanodine type 1 receptor (RyR1) are causative for malignant hyperthermia. Studies in human B lymphocytes have shown that measurement of RyR1-mediated intracellular Ca(2+) (Ca(2+)(i)) release can differentiate between normal and malignant hyperthermia-susceptible individuals. The authors hav...

journal_title：Anesthesiology

authors： McKinney LC,Butler T,Mullen SP,Klein MG

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Medical errors exact an inordinate toll on healthcare costs. One of the most publicized and analyzed type of medical error is wrong-site surgery. Yet, despite the burgeoning number of procedures performed, no literature exists on wrong-site pain management injections. The purpose of this study was to estimat...

journal_title：Anesthesiology

authors： Cohen SP,Hayek SM,Datta S,Bajwa ZH,Larkin TM,Griffith S,Hobelmann G,Christo PJ,White R

更新日期：2010-03-01 00:00:00

abstract：:Using a randomized double-blind protocol, the authors prospectively compared three nondepolarizing muscle relaxants with respect to their influence on hemodynamics and on the electrocardiogram. Thirty-three patients undergoing elective coronary artery bypass grafting (CABG) with high-dose (100 micrograms/kg) fentanyl ...

journal_title：Anesthesiology

authors： Thomson IR,Putnins CL

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND:Intravascular volume replacement is often required in the presence of increased pulmonary capillary leakage, for example in patients with volutrauma with major hemorrhage. In the present study, the effects of Ringer's acetate (RA), gelatin-polysuccinate (GEL), and a modern hydroxyethyl starch (HES, 6% 130/0....

journal_title：Anesthesiology

authors： Silva PL,Güldner A,Uhlig C,Carvalho N,Beda A,Rentzsch I,Kasper M,Wiedemann B,Spieth PM,Koch T,Capelozzi VL,Pelosi P,Rocco PR,de Abreu MG

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Intravenously administered anesthetics directly inhibit airway smooth muscle contraction. Because many anesthetic agents affect membrane ion channel function and sustained contraction of airway smooth muscle requires the influx of Ca2+ through voltage-dependent Ca2+ channels, it was hypothesized that intrave...

journal_title：Anesthesiology

authors： Yamakage M,Hirshman CA,Croxton TL

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Plasminogen activator inhibitor 1 (PAI-1) attenuates the conversion of plasminogen to plasmin. Polymorphisms of the PAI-1 gene are associated with varying PAI-1 levels and risk of prothrombotic events in nonsurgical patients. The purpose of this study, a secondary analysis of a clinical trial, was to investi...

journal_title：Anesthesiology

authors： Iribarren JL,Jimenez JJ,Hernández D,Brouard M,Riverol D,Lorente L,de La Llana R,Nassar I,Perez R,Martinez R,Mora ML

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:The goal of this study was to identify interventions that anesthesiologists can make to decrease total costs of a postanesthesia care unit (PACU). METHODS:Data were collected retrospectively from patients who underwent ambulatory surgery at our tertiary care center. RESULTS:Supplies and medications account...

journal_title：Anesthesiology

authors： Dexter F,Tinker JH

更新日期：1995-01-01 00:00:00

abstract：:Controversy persists about the cardiac toxicity of bupivacaine if accidentally administered intravenously during regional anesthesia. Using awake, unanesthetized sheep, we evaluated the cardiac effects of low and high equivalent doses of lidocaine and bupivacaine given intravenously over 10 s. All animals convulsed wi...

journal_title：Anesthesiology

authors： Kotelko DM,Shnider SM,Dailey PA,Brizgys RV,Levinson G,Shapiro WA,Koike M,Rosen MA

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Few data support an association between blood pressure variability and clinical outcomes during cardiac surgery. We tested the hypothesis that intraoperative systolic blood pressure variability outside a targeted blood pressure range predicts 30-day mortality in patients undergoing cardiac surgery. METHODS:...

journal_title：Anesthesiology

authors： Aronson S,Stafford-Smith M,Phillips-Bute B,Shaw A,Gaca J,Newman M,Cardiothoracic Anesthesiology Research Endeavors.

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:The mechanism of the protective actions of volatile anesthetics in ischemic myocardium has not been clearly elucidated. The role of myocardial adenosine triphosphate-regulated potassium (KATP) channels in isoflurane-induced enhancement of recovery of regional contractile function after multiple brief occlusi...

journal_title：Anesthesiology

authors： Kersten JR,Schmeling TJ,Hettrick DA,Pagel PS,Gross GJ,Warltier DC

更新日期：1996-10-01 00:00:00

abstract：:Ropivacaine is an amide local anesthetic structurally related to, but appearing less cardiotoxic, than bupivacaine. The authors' investigation was designed in a randomized, double-blind fashion to compare the clinical effectiveness of ropivacaine and bupivacaine in patients undergoing lower-extremity surgery. Forty-fi...

journal_title：Anesthesiology

authors： Brown DL,Carpenter RL,Thompson GE

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:Neuropathic pain is a condition resulting from injury to the peripheral and/or central nervous system. Despite extensive research over the last several decades, neuropathic pain remains difficult to manage. METHODS:The authors conducted a randomized, placebo-controlled, double-blinded, and crossover clinica...

journal_title：Anesthesiology

authors： Ahmed SU,Zhang Y,Chen L,Cohen A,St Hillary K,Vo T,Houghton M,Mao J

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:The analgesic efficacy and side effect profile of intravenous parecoxib, a novel cyclooxygenase type-2 (COX-2) inhibitor, was assessed in a double-blinded, placebo-controlled study involving patients undergoing major gynecologic surgical procedures. METHODS:After Institutional Review Board approval, 60 cons...

journal_title：Anesthesiology

authors： Tang J,Li S,White PF,Chen X,Wender RH,Quon R,Sloninsky A,Naruse R,Kariger R,Webb T,Norel E

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:The current study was designed to investigate the influence of pretreatment with the oxygen radical scavengers polyethylene glycol superoxide dismutase and catalase (SODCAT) on altered opioid-induced pial artery dilation after fluid percussion brain injury (FPI) in the newborn pig. It has been observed previ...

journal_title：Anesthesiology

authors： Thorogood MC,Armstead WM

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:The aim of this study was to generate a score based on preoperative characteristics and predictive of the individual probability of allogeneic erythrocyte transfusion in patients undergoing elective thoracolumbar spine surgery. METHODS:Two hundred thirty consecutive patients were retrospectively included ov...

journal_title：Anesthesiology

authors： Lenoir B,Merckx P,Paugam-Burtz C,Dauzac C,Agostini MM,Guigui P,Mantz J

更新日期：2009-05-01 00:00:00

abstract：:The authors investigated the value of high-dose thiopental (TH) therapy after 16-min complete global brain ischemia (GBI) in three groups of pigtailed monkeys, using a neck cuff model of GBI with 96 h intensive care postischemia (PI). Control group (n18): Normotension was restored within 2 min PI; paralysis/controlled...

journal_title：Anesthesiology

authors： Gisvold SE,Safar P,Hendrickx HH,Rao G,Moossy J,Alexander H

更新日期：1984-02-01 00:00:00

abstract：BACKGROUND:It is not always possible to predict when tracheal intubation will be difficult or impossible. The authors wanted to determine whether indirect laryngoscopy could identify patients in whom intubation was difficult. METHODS:Indirect laryngoscopy was done in 2,504 patients. The Wilson risk sum score and the m...

journal_title：Anesthesiology

authors： Yamamoto K,Tsubokawa T,Shibata K,Ohmura S,Nitta S,Kobayashi T

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Age is a known risk factor for postoperative complications, but the genetic factors that account for variability in age at presentation for surgery have not been characterized. Because thrombosis is a critical process in the development of coronary syndromes, the authors hypothesized that patients bearing th...

journal_title：Anesthesiology

authors： Donahue BS,Byrne DW,Gailani D,George AL Jr

更新日期：2003-12-01 00:00:00

abstract：:Various animal models have been used for studies of bupivacaine cardiovascular toxicity. These studies are difficult to relate to the clinical situation, since the disposition of bupivacaine in the various species is unknown. The serum protein binding of bupivacaine, therefore, was determined in human, sheep, monkey, ...

journal_title：Anesthesiology

authors： Coyle DE,Denson DD,Thompson GA,Myers JA,Arthur GR,Bridenbaugh PO

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:Postoperative nausea and vomiting (PONV) is a commonly observed adverse effect of general anesthesia. Recently, ondansetron, a new serotonin3 (5-hydroxytryptamine3) receptor antagonist was shown to be effective in the prophylaxis and prevention of chemotherapy-induced nausea and vomiting in children and adul...

journal_title：Anesthesiology

authors： Ummenhofer W,Frei FJ,Urwyler A,Kern C,Drewe J

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:The mechanisms of amino-amide local anesthetic agent-induced vasoconstriction remain unclear. The current study was designed to examine the roles of the protein kinase C (PKC), Rho kinase, and p44/42 mitogen-activated protein kinase (p44/42 MAPK) signaling pathways in calcium (Ca2+)-sensitization mechanisms ...

journal_title：Anesthesiology

authors： Yu J,Tokinaga Y,Kuriyama T,Uematsu N,Mizumoto K,Hatano Y

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:The authors used the American Society of Anesthesiologists Closed Claims Project database to determine changes in the proportion of claims for death or permanent brain damage over a 26-yr period and to identify factors associated with the observed changes. METHODS:The Closed Claims Project is a structured e...

journal_title：Anesthesiology

authors： Cheney FW,Posner KL,Lee LA,Caplan RA,Domino KB

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Occasionally, emergency perioperative pacing is necessary. Transcutaneous cardiac pacing is noninvasive, safe, and readily available. Its feasibility and hemodynamic effects during thoracic surgery and one-lung ventilation have not been established. METHODS:Twenty anesthetized patients (aged 25-70 yr) witho...

journal_title：Anesthesiology

authors： Amar D,Gross JN,Burt M,Schwinger ME,Rusch VW,Reinsel RA

更新日期：1993-10-01 00:00:00

abstract：:Assessment of competency in traditional graduate medical education has been based on observation of clinical care and classroom teaching. In anesthesiology, this has been relatively easy because of the high volume of care provided by residents under the direct observation of faculty in the operating room. With the mov...

journal_title：Anesthesiology

authors： Tetzlaff JE

更新日期：2007-04-01 00:00:00

abstract：WHAT WE ALREADY KNOW ABOUT THIS TOPIC:Acute respiratory distress syndrome is defined according to clinical criteria, but lack of precise characterization may contribute to negative trials and impede personalized care. Polymorphisms of aquaporin-5, a key mediator of inflammation, may impact outcome. WHAT THIS ARTICLE T...

journal_title：Anesthesiology

authors： Rahmel T,Rump K,Peters J,Adamzik M

更新日期：2019-03-01 00:00:00