Abstract:
BACKGROUND:Activation of the complement system is one component of the inflammatory response. Various components of the complement system participate in killing foreign organisms, recruiting immune cells, enhancing edema, and stimulating cytokine formation. Complement-mediated enhancement of the inflammation surrounding surgical incisions may increase pain. METHODS:In these studies, the authors used a murine hind paw incisional model to study the role of the complement C5a receptor in supporting incisional inflammation. At baseline and at various time points after incision, they measured the effects of a highly selective C5a receptor antagonist on nociceptive thresholds, edema formation, and cytokine production in the skin surrounding the incision. They also measured changes in C5a receptor expression near the incisions. RESULTS:The once-daily injection of the C5a receptor antagonist AcF-[OPdChaWR] reduced mechanical allodynia and edema in the incised hind paw. A multiplexed cytokine assay revealed that 8 of the 18 cytokines examined showed significant increases in skin tissue abundance after incision. Distinct time courses for the patterns of elevation were seen, though some degree of resolution occurred for all cytokines within 96 h. For 7 of these 8 cytokines, the C5a receptor antagonist reduced the enhancement of expression. In addition, the authors found that the C5a receptor messenger RNA level increased 15-fold in the skin surrounding the incisions within 24 h and then slowly declined. CONCLUSIONS:The tissue directly surrounding incisions in mouse hind paws undergoes large changes in the content of specific cytokines in addition to demonstrating edema and nociceptive sensitization. By blocking the receptor for one component of the complement system, C5a, all of these changes can be reduced. Complement receptor inhibitors may constitute a novel group of compounds useful in reducing the pain and swelling of surgical incisions.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Clark JD,Qiao Y,Li X,Shi X,Angst MS,Yeomans DCdoi
10.1097/00000542-200606000-00024subject
Has Abstractpub_date
2006-06-01 00:00:00pages
1274-82issue
6eissn
0003-3022issn
1528-1175pii
00000542-200606000-00024journal_volume
104pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract:INTRODUCTION:Spinal alpha2-adrenoceptor stimulation produces analgesia in neuropathic pain states, and this effect in animals is blocked by the inhibitors of brain-derived neurotrophic factor (BDNF) function. In rats, alpha2-adrenoceptor stimulation normally inhibits acetylcholine release, but it excites release after ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181de6d2c
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Crystalloid solutions are used to restore intravascular volume in septic patients, but each solution has limitations. The authors compared the effects of three crystalloid solutions on hemodynamics, organ function, microcirculation, and survival in a sepsis model. METHODS:Peritonitis was induced by injectio...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001273
更新日期:2016-10-01 00:00:00
abstract::Postoperative itching is an important problem in the postoperative care unit. Pruritus after surgery may be drug induced (including intrathecal opioids) or secondary to a preexisting systemic disease. Mechanisms of itching are complex and not completely understood. The purpose of this review is to highlight new discov...
journal_title:Anesthesiology
pub_type: 杂志文章,评审
doi:10.1097/00000542-200507000-00025
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively....
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002103
更新日期:2018-04-01 00:00:00
abstract::A constantly coupled bigeminal arrhythmia was induced in dogs anesthetized with thiopental-halothane by infusion of epinephrine (1 microgram.kg-1.min-1). The site of origin of the abnormal beat was localized to the interventricular septum by bipolar recordings from the left and right ventricular epicardium and two sit...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198208000-00006
更新日期:1982-08-01 00:00:00
abstract:BACKGROUND:The chemokine family has been revealed to be involved in the pathogenesis of neuropathic pain. In this study, the authors investigated the role of chemokine (C-C motif) ligand 3 and its receptors chemokine (C-C motif) receptor 1 and chemokine (C-C motif) receptor (CCR) 5 in neuropathic pain. METHODS:A spina...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000190
更新日期:2014-06-01 00:00:00
abstract::This study was designed to evaluate a new drug delivery system. The authors undertook to determine if microdroplets prepared by encapsulating volatile anesthetics with a membrane of lecithin could be used for local anesthesia. Local anesthesia was determined by monitoring the response of the rat to tail clamping and e...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198511000-00004
更新日期:1985-11-01 00:00:00
abstract::Neuromuscular blockers may affect cerebral blood flow (CBF) regulation in the newborn. We studied the effects of d-tubocurarine (0.1 mg.kg-1, n = 8), pancuronium (0.1 and 0.4 mg.kg-1, n = 6 and 7), and vecuronium (0.1 and 0.4 mg.kg-1, n = 6 and 7) on CBF measured over the same range of mean systemic blood pressure ([B...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199202000-00013
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:The relative contributions of intraoperative and postoperative hypotension to perioperative morbidity remain unclear. We determined the association between hypotension and a composite of 30-day myocardial infarction and death over three periods: (1) intraoperative, (2) remaining day of surgery, and (3) durin...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/ALN.0000000000001985
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Isoflurane induces cell apoptosis by an unknown mechanism. The authors hypothesized that isoflurane activates inositol 1,4,5-trisphosphate (IP3) receptors on the endoplasmic reticulum (ER) membrane, causing excessive calcium release, triggering apoptosis. METHODS:The authors determined isoflurane-induced cy...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/01.anes.0000299435.59242.0e
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Ketamine is a potent bronchodilator that, in clinically used concentrations, relaxes airway smooth muscle in part by a direct effect. This study explored the role of calcium concentration (Ca2+) in this relaxation. METHODS:Canine trachea smooth muscle strips were loaded with the fluorescent probe fura-2 and...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199705000-00014
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Interscalene nerve blockade remains one of the most commonly used anesthetic and analgesic approaches for shoulder surgery. The high incidence of hemidiaphragmatic paralysis associated with the block, however, precludes its use among patients with compromised pulmonary function. To address this issue, recent...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000002841
更新日期:2019-09-01 00:00:00
abstract::Administration of the oxidant lipid peroxide tertiary butyl hydroperoxide (t-bu-OOH) in the isolated rabbit lung leads to acute pulmonary vasoconstriction, which is caused by the synthesis of thromboxane. The inhalational anesthetics, halothane, nitrous oxide, and cyclopropane, markedly enhance t-bu-OOH-induced pulmon...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198905000-00012
更新日期:1989-05-01 00:00:00
abstract::Whereas opiate receptor agonists have resulted in spinal cord damage; opiate receptor antagonists have demonstrated protection against spinal cord injury. Because opioids are used in clinical anesthesia, the effect of an opiate antagonist was evaluated on neurologic outcome in a rat model of spinal cord injury occurri...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198909000-00019
更新日期:1989-09-01 00:00:00
abstract::Pharmacokinetics and pharmacodynamics of propofol infusions during general anesthesia. By Audrey Shafer, Van A. Doze, Steven L. Shafer, and Paul F. White. Anesthesiology 1988; 69:348-56. Reprinted with permission.The pharmacokinetic and pharmacodynamic properties of propofol (Diprivan) were studied in 50 elective surg...
journal_title:Anesthesiology
pub_type: 古典文章,评论,杂志文章
doi:10.1097/ALN.0b013e31818ddba8
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Cardiac surgery requiring the use of cardiopulmonary bypass is frequently complicated by coagulopathic bleeding that, largely due to the shortcomings of conventional coagulation tests, is difficult to manage. This study evaluated a novel transfusion algorithm that uses point-of-care coagulation testing. MET...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000556
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Compared to other perioperative complications, failure to rescue (i.e., death after suffering a complication) is highest after perioperative myocardial infarction (a myocardial infarction that occurs intraoperatively or within 30 days after surgery). The purpose of this study was to identify patient and surg...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/ALN.0000000000003330
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:The long-lasting high-affinity opioid buprenorphine has complex pharmacology, including ceiling effects with respect to analgesia and respiratory depression. Plasma concentrations of the major buprenorphine metabolites norbuprenorphine, buprenorphine-3-glucuronide, and norbuprenorphine-3-glucuronide approxim...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e318238fea0
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:This study was design to assess clinical agitation, electroencephalogram (EEG) and autonomic cardiovascular activity changes in children during induction of anesthesia with sevoflurane compared with halothane using noninvasive recording of EEG, heart rate, and finger blood pressure. METHODS:Children aged 2-...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199912000-00010
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:A recent model of acute incisional pain has been characterized that strongly parallels the postoperative period in patients experiencing evoked pain. In that setting, abundant literature has revealed antihypersensitive effects produced by intrathecally administered alpha2-adrenergic receptor agonists, such a...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200512000-00022
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Intraspinally administered alpha 2-adrenergic agonists may relieve pain in sympathetically maintained pain (SMP) syndromes, such as reflex sympathetically dystrophy (RSD), by spinal, peripheral, and central nervous system actions. This study examined analgesic efficacy and side effects of epidurally administ...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to compare the effects of goal-directed colloid fluid therapy with goal-directed crystalloid and restricted crystalloid fluid therapy on healthy and perianastomotic colon tissue in a pig model of colon anastomosis surgery. METHODS:Pigs (n = 27, 9 per group) were anesthetized and me...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e31819841f6
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Although hyper- and hypoglycemia induce neurophysiologic changes, there have been no reports on the effects of blood glucose changes on anesthetic requirements. This study examined the effects of hyper- and hypoglycemia on the minimum alveolar concentration (MAC) of halothane in rats. In addition, based on a...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199708000-00023
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Oral clonidine may influence plasma glucose and lipid homeostasis by modulating endocrinologic responses to surgical stress. The effect of oral clonidine premedication on plasma glucose and lipid homeostasis associated with exogenous glucose infusion were investigated in children undergoing minor surgery. M...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199804000-00011
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:Percutaneous cricothyroidotomy is a lifesaving procedure for airway obstruction in trauma victims who need airway establishment and cannot be intubated or in whom intubation has failed. METHODS:The purpose of this study was to examine whether there is a training effect using Seldinger technique emergency cr...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200501000-00005
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Ketamine is a commonly used anesthetic, but the mechanistic basis for its clinically relevant actions remains to be determined. The authors previously showed that HCN1 channels are inhibited by ketamine and demonstrated that global HCN1 knockout mice are twofold less sensitive to hypnotic actions of ketamine...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e318287b7c8
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Nonsteroidal antiinflammatory drugs are commonly used to treat postoperative and chronic pain. Animal studies suggest that these drugs act, in part, by blocking prostaglandin production in the spinal cord. The authors tested intrathecal ketorolac in patients with chronic or postoperative pain. METHODS:After...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/ALN.0b013e3181d94dc0
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Up to 84% of women who undergo operative vaginal delivery receive neuraxial analgesia. However, little is known about the association between neuraxial analgesia and neonatal morbidity in women who undergo operative vaginal delivery. The authors hypothesized that neuraxial analgesia is associated with a redu...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000003589
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Hydroxyethyl starch (HES) 130/0.4 may impair blood coagulation less than other HES solutions and, thus, may be used at larger doses without increasing the risk of postoperative bleeding. This study tested the hypothesis that volume replacement with 6% HES 130/0.4 at a dose of up to 50 ml/kg does not increase...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200307000-00010
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:The Pediatric Craniofacial Collaborative Group established the Pediatric Craniofacial Surgery Perioperative Registry to elucidate practices and outcomes in children with craniosynostosis undergoing complex cranial vault reconstruction and inform quality improvement efforts. The aim of this study is to determ...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/ALN.0000000000001481
更新日期:2017-02-01 00:00:00