Blockade of the complement C5a receptor reduces incisional allodynia, edema, and cytokine expression.


BACKGROUND:Activation of the complement system is one component of the inflammatory response. Various components of the complement system participate in killing foreign organisms, recruiting immune cells, enhancing edema, and stimulating cytokine formation. Complement-mediated enhancement of the inflammation surrounding surgical incisions may increase pain. METHODS:In these studies, the authors used a murine hind paw incisional model to study the role of the complement C5a receptor in supporting incisional inflammation. At baseline and at various time points after incision, they measured the effects of a highly selective C5a receptor antagonist on nociceptive thresholds, edema formation, and cytokine production in the skin surrounding the incision. They also measured changes in C5a receptor expression near the incisions. RESULTS:The once-daily injection of the C5a receptor antagonist AcF-[OPdChaWR] reduced mechanical allodynia and edema in the incised hind paw. A multiplexed cytokine assay revealed that 8 of the 18 cytokines examined showed significant increases in skin tissue abundance after incision. Distinct time courses for the patterns of elevation were seen, though some degree of resolution occurred for all cytokines within 96 h. For 7 of these 8 cytokines, the C5a receptor antagonist reduced the enhancement of expression. In addition, the authors found that the C5a receptor messenger RNA level increased 15-fold in the skin surrounding the incisions within 24 h and then slowly declined. CONCLUSIONS:The tissue directly surrounding incisions in mouse hind paws undergoes large changes in the content of specific cytokines in addition to demonstrating edema and nociceptive sensitization. By blocking the receptor for one component of the complement system, C5a, all of these changes can be reduced. Complement receptor inhibitors may constitute a novel group of compounds useful in reducing the pain and swelling of surgical incisions.






Clark JD,Qiao Y,Li X,Shi X,Angst MS,Yeomans DC




Has Abstract


2006-06-01 00:00:00














  • Parental presence during induction of anesthesia: physiological effects on parents.

    abstract:BACKGROUND:The authors conducted a randomized controlled trial to determine whether parental presence during induction of anesthesia (PPIA) is associated with parental physiologic and behavioral manifestations of stress. METHODS:Children and their parents (N = 80) were randomly assigned to one of three groups: (1) PPI...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kain ZN,Caldwell-Andrews AA,Mayes LC,Wang SM,Krivutza DM,LoDolce ME

    更新日期:2003-01-01 00:00:00

  • Response to mivacurium in a patient compound heterozygous for a novel and a known silent mutation in the butyrylcholinesterase gene: genotyping by sequencing.

    abstract:BACKGROUND:Patients who are homozygous for the atypical mutation, compound heterozygous for atypical and silent mutations, or homozygous for silent mutations (SS) respond to mivacurium with extensively prolonged neuromuscular block. Although important, exact phenotyping of these patients is difficult. This article pres...


    pub_type: 杂志文章


    authors: Gätke MR,Ostergaard D,Bundgaard JR,Varin F,Viby-Mogensen J

    更新日期:2001-09-01 00:00:00

  • A focal cryogenic brain lesion does not reduce the minimum alveolar concentration for halothane in rats.

    abstract:BACKGROUND:A focal cortical cryogenic brain injury has been reported to reduce the brain pentobarbital concentrations needed to prevent movement in response to pain in rats. This occurred despite any apparent behavioral changes in the awake animals. To determine whether this was true with other anesthetics, the authors...


    pub_type: 杂志文章


    authors: Todd MM,Weeks JB,Warner DS

    更新日期:1993-07-01 00:00:00

  • Reaginic antibodies to drugs used in anesthesia.

    abstract::Twenty-four patients survived life-threatening clinical anaphylaxis due to anesthesia. In each case the diagnosis of anaphylaxis was confirmed and the responsible drug was found by intradermal testing. To determine whether the reactions were anaphylactic or anaphylactoid, serum from each patient was tested for reagini...


    pub_type: 杂志文章


    authors: Fisher MM

    更新日期:1980-04-01 00:00:00

  • Transcranial Doppler to Predict Neurologic Outcome after Mild to Moderate Traumatic Brain Injury.

    abstract:BACKGROUND:To assess the performance of transcranial Doppler (TCD) in predicting neurologic worsening after mild to moderate traumatic brain injury. METHODS:The authors conducted a prospective observational study across 17 sites. TCD was performed upon admission in 356 patients (Glasgow Coma Score [GCS], 9 to 15) with...


    pub_type: 杂志文章,多中心研究


    authors: Bouzat P,Almeras L,Manhes P,Sanders L,Levrat A,David JS,Cinotti R,Chabanne R,Gloaguen A,Bobbia X,Thoret S,Oujamaa L,Bosson JL,Payen JF,Asehnoune K,Pes P,Lefrant JY,Mirek S,Albasini F,Scrimgeour C,Thouret JM,Char

    更新日期:2016-08-01 00:00:00

  • The American Society of Anesthesiologists Postoperative Visual Loss Registry: analysis of 93 spine surgery cases with postoperative visual loss.

    abstract:BACKGROUND:Postoperative visual loss after prone spine surgery is increasingly reported in association with ischemic optic neuropathy, but its etiology is unknown. METHODS:To describe the clinical characteristics of these patients, the authors analyzed a retrospectively collected series of 93 spine surgery cases volun...


    pub_type: 杂志文章


    authors: Lee LA,Roth S,Posner KL,Cheney FW,Caplan RA,Newman NJ,Domino KB

    更新日期:2006-10-01 00:00:00

  • Offset analgesia in neuropathic pain patients and effect of treatment with morphine and ketamine.

    abstract:BACKGROUND:Offset analgesia, in which a disproportionally large amount of analgesia becomes apparent upon a slight decrease in noxious heat stimulation, has not been described previously in patients with chronic pain. METHODS:Offset analgesia responses in 10 patients with neuropathic pain (in both legs) were compared ...


    pub_type: 杂志文章,随机对照试验


    authors: Niesters M,Hoitsma E,Sarton E,Aarts L,Dahan A

    更新日期:2011-11-01 00:00:00

  • Sonographic visualization and ultrasound-guided block of the third occipital nerve: prospective for a new method to diagnose C2-C3 zygapophysial joint pain.

    abstract:BACKGROUND:Chronic neck pain after whiplash injury is caused by cervical zygapophysial joints in 50% of patients. Diagnostic blocks of nerves supplying the joints are performed using fluoroscopy. The authors' hypothesis was that the third occipital nerve can be visualized and blocked with use of an ultrasound-guided te...


    pub_type: 杂志文章,随机对照试验


    authors: Eichenberger U,Greher M,Kapral S,Marhofer P,Wiest R,Remonda L,Bogduk N,Curatolo M

    更新日期:2006-02-01 00:00:00

  • Comparison of the effects of convulsant and depressant barbiturate stereoisomers on AMPA-type glutamate receptors.

    abstract:BACKGROUND:Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors mediate fast excitatory synaptic transmission in the central nervous system. Although barbiturates have been shown to suppress the AMPA receptor-mediated responses, it is unclear whether this effect contributes to the a...


    pub_type: 杂志文章


    authors: Kamiya Y,Andoh T,Furuya R,Hattori S,Watanabe I,Sasaki T,Ito H,Okumura F

    更新日期:1999-06-01 00:00:00

  • A randomized controlled trial of adaptive support ventilation mode to wean patients after fast-track cardiac valvular surgery.

    abstract:BACKGROUND:Adaptive support ventilation can speed weaning after coronary artery surgery compared with protocolized weaning using other modes. There are no data to support this mode of weaning after cardiac valvular surgery. Furthermore, control group weaning times have been long, suggesting that the results may reflect...


    pub_type: 杂志文章,随机对照试验


    authors: Zhu F,Gomersall CD,Ng SK,Underwood MJ,Lee A

    更新日期:2015-04-01 00:00:00

  • Common Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion Channels.

    abstract:BACKGROUND:Identifying functionally relevant anesthetic-binding sites in pentameric ligand-gated ion channels (pLGICs) is an important step toward understanding the molecular mechanisms underlying anesthetic action. The anesthetic propofol is known to inhibit cation-conducting pLGICs, including a prokaryotic pLGIC from...


    pub_type: 杂志文章


    authors: Kinde MN,Bu W,Chen Q,Xu Y,Eckenhoff RG,Tang P

    更新日期:2016-03-01 00:00:00

  • Propofol suppresses macrophage functions and modulates mitochondrial membrane potential and cellular adenosine triphosphate synthesis.

    abstract:BACKGROUND:Propofol is an intravenous anesthetic agent that may impair host defense system. The aim of this study was to evaluate the effects of propofol on macrophage functions and its possible mechanism. METHODS:Mouse macrophage-like Raw 264.7 cells were exposed to propofol, at 3, 30 (a clinically relevant concentra...


    pub_type: 杂志文章


    authors: Chen RM,Wu CH,Chang HC,Wu GJ,Lin YL,Sheu JR,Chen TL

    更新日期:2003-05-01 00:00:00

  • Extracellular histones play an inflammatory role in acid aspiration-induced acute respiratory distress syndrome.

    abstract:BACKGROUND:Systemic inflammation is a key feature in acid aspiration-induced acute respiratory distress syndrome (ARDS), but the factors that trigger inflammation are unclear. The authors hypothesize that extracellular histones, a newly identified inflammatory mediator, play important roles in the pathogenesis of ARDS....


    pub_type: 杂志文章


    authors: Zhang Y,Wen Z,Guan L,Jiang P,Gu T,Zhao J,Lv X,Wen T

    更新日期:2015-01-01 00:00:00

  • Cumulative duration of "triple low" state of low blood pressure, low bispectral index, and low minimum alveolar concentration of volatile anesthesia is not associated with increased mortality.

    abstract:BACKGROUND:Mortality after noncardiac surgery has been associated with the "triple low state," a combination of low mean arterial blood pressure (<75 mmHg), low bispectral index (<45), and low minimum alveolar concentration of volatile anesthesia (<0.70). The authors set out to determine whether duration of a triple lo...


    pub_type: 杂志文章


    authors: Kertai MD,White WD,Gan TJ

    更新日期:2014-07-01 00:00:00

  • Neuroprotective effects of riluzole and ketamine during transient spinal cord ischemia in the rabbit.

    abstract:BACKGROUND:Massive release of central excitatory neurotransmitters is an important initial step in ischemic neuronal injury, and modification of this process may provide neuroprotection. We studied the protective effects of the voltage-dependent sodium channel antagonist riluzole and the N-methyl-d-aspartate receptor a...


    pub_type: 杂志文章


    authors: Lips J,de Haan P,Bodewits P,Vanicky I,Dzoljic M,Jacobs MJ,Kalkman CJ

    更新日期:2000-11-01 00:00:00

  • Cardioprotective trafficking of caveolin to mitochondria is Gi-protein dependent.

    abstract:BACKGROUND:Caveolae are a nexus for protective signaling. Trafficking of caveolin to mitochondria is essential for adaptation to cellular stress though the trafficking mechanisms remain unknown. The authors hypothesized that G protein-coupled receptor/inhibitory G protein (Gi) activation leads to caveolin trafficking t...


    pub_type: 杂志文章


    authors: Wang J,Schilling JM,Niesman IR,Headrick JP,Finley JC,Kwan E,Patel PM,Head BP,Roth DM,Yue Y,Patel HH

    更新日期:2014-09-01 00:00:00

  • Dose-response relationship of intrathecal morphine for postcesarean analgesia.

    abstract:BACKGROUND:This series investigated the quality of analgesia and the incidence and severity of side effects of intrathecal morphine for post-cesarean analgesia administered over a dose range of 0.0-0.5 mg. METHODS:ONE hundred eight term parturients undergoing cesarean delivery at term and given spinal anesthesia were ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Palmer CM,Emerson S,Volgoropolous D,Alves D

    更新日期:1999-02-01 00:00:00

  • The local anesthetic n-butyl-p-aminobenzoate selectively affects inactivation of fast sodium currents in cultured rat sensory neurons.

    abstract:BACKGROUND:Aqueous suspensions of the local anesthetic n-butyl-p-aminobenzoate (BAB), epidurally applied in terminal cancer patients, resulted in a sensory blockade, lasting up to several months. To investigate the mechanism of action on the cellular level, the effect of 100 microM BAB on Na+ action potentials and on N...


    pub_type: 杂志文章


    authors: Van den Berg RJ,Van Soest PF,Wang Z,Grouls RJ,Korsten HH

    更新日期:1995-06-01 00:00:00

  • Differentiating Drug-related and State-related Effects of Dexmedetomidine and Propofol on the Electroencephalogram.

    abstract:BACKGROUND:Differentiating drug-related changes and state-related changes on the electroencephalogram during anesthetic-induced unconsciousness has remained a challenge. To distinguish these, we designed a rigorous experimental protocol with two drugs known to have distinct molecular mechanisms of action. We hypothesiz...


    pub_type: 杂志文章,随机对照试验


    authors: Scheinin A,Kallionpää RE,Li D,Kallioinen M,Kaisti K,Långsjö J,Maksimow A,Vahlberg T,Valli K,Mashour GA,Revonsuo A,Scheinin H

    更新日期:2018-07-01 00:00:00

  • Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers.

    abstract:BACKGROUND:Propofol and alfentanil frequently are administered together for intravenous sedation. This study investigated pharmacokinetic and pharmacodynamic interactions between propofol and alfentanil, at sedative concentrations, with specific regard to effects on ventilation, analgesia, sedation, and nausea. METHOD...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pavlin DJ,Coda B,Shen DD,Tschanz J,Nguyen Q,Schaffer R,Donaldson G,Jacobson RC,Chapman CR

    更新日期:1996-01-01 00:00:00

  • A comparison of the cerebral protective effects of isoflurane and barbiturates during temporary focal ischemia in primates.

    abstract::Isoflurane has protective properties during experimental global brain ischemia or hypoxia. However, this has not been evaluated in the more common case of focal ischemia, e.g., as caused by middle cerebral artery occlusion (MCAO). The authors therefore compared the effects of isoflurane, thiopental, and N2O/fentanyl a...


    pub_type: 杂志文章


    authors: Nehls DG,Todd MM,Spetzler RF,Drummond JC,Thompson RA,Johnson PC

    更新日期:1987-04-01 00:00:00

  • The use of propofol, nitrous oxide, or isoflurane does not affect the reproductive success rate following gamete intrafallopian transfer (GIFT): a multicenter pilot trial/survey.

    abstract:BACKGROUND:Whether anesthetic agents administered during gamete intrafallopian transfer (GIFT) affect reproductive outcome is controversial. This multicenter pilot trial and survey had two purposes: to evaluate the effect of propofol, nitrous oxide, midazolam, and isoflurane on pregnancy outcome after GIFT, and to dete...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Beilin Y,Bodian CA,Mukherjee T,Andres LA,Vincent RD Jr,Hock DL,Sparks AE,Munson AK,Minnich ME,Steinkampf MP,Christman GM,McKay RS,Eisenkraft JB

    更新日期:1999-01-01 00:00:00

  • Reference Values for Noninvasive Blood Pressure in Children during Anesthesia: A Multicentered Retrospective Observational Cohort Study.

    abstract:BACKGROUND:Although noninvasive blood pressure (NIBP) monitoring during anesthesia is a standard of care, reference ranges for blood pressure in anesthetized children are not available. We developed sex- and age-specific reference ranges for NIBP in children during anesthesia and surgery. METHODS:In this retrospective...


    pub_type: 杂志文章,多中心研究


    authors: de Graaff JC,Pasma W,van Buuren S,Duijghuisen JJ,Nafiu OO,Kheterpal S,van Klei WA

    更新日期:2016-11-01 00:00:00

  • Inhibition of interferon stimulation of natural killer cell activity in mice anesthetized with halothane or isoflurane.

    abstract:BACKGROUND:Basal cytotoxic activity of NK cells, a subtype of lymphocytes involved in the nonspecific immune response to viruses, tumors, and some bacteria, is altered in the postoperative period. The current study examines the effects of halothane and isoflurane on interferon-induced stimulation of NK cell cytotoxicit...


    pub_type: 杂志文章


    authors: Markovic SN,Knight PR,Murasko DM

    更新日期:1993-04-01 00:00:00

  • Effects of morphine and midazolam on pharyngeal function, airway protection, and coordination of breathing and swallowing in healthy adults.

    abstract:BACKGROUND:Drugs used for sedation in anesthesia and intensive care may cause pharyngeal dysfunction and increased risk for aspiration. In this study, the authors investigate the impact of sedative doses of morphine and midazolam on pharyngeal function during swallowing and coordination of breathing and swallowing. ME...


    pub_type: 杂志文章


    authors: Hårdemark Cedborg AI,Sundman E,Bodén K,Hedström HW,Kuylenstierna R,Ekberg O,Eriksson LI

    更新日期:2015-06-01 00:00:00

  • Isoflurane postconditioning protects against reperfusion injury by preventing mitochondrial permeability transition by an endothelial nitric oxide synthase-dependent mechanism.

    abstract:BACKGROUND:The role of endothelial nitric oxide synthase (eNOS) in isoflurane postconditioning (IsoPC)-elicited cardioprotection is poorly understood. The authors addressed this issue using eNOS mice. METHODS:In vivo or Langendorff-perfused mouse hearts underwent 30 min of ischemia followed by 2 h of reperfusion in th...


    pub_type: 杂志文章


    authors: Ge ZD,Pravdic D,Bienengraeber M,Pratt PF Jr,Auchampach JA,Gross GJ,Kersten JR,Warltier DC

    更新日期:2010-01-01 00:00:00

  • Cardiovascular responses to the induction of mild hypothermia in the presence of epidural anesthesia.

    abstract:BACKGROUND:The combining of epidural anesthesia with general anesthesia impairs central and peripheral thermoregulatory control and therefore is often accompanied by unintended intraoperative hypothermia. However, little is known about the cardiovascular response to hypothermia during combined epidural and general anes...


    pub_type: 杂志文章


    authors: Yoshida M,Shibata K,Itoh H,Yamamoto K

    更新日期:2001-04-01 00:00:00

  • Effect of spinal morphine after long-term potentiation of wide dynamic range neurones in the rat.

    abstract:BACKGROUND:Studies have shown that long-term increase in the excitability of single wide dynamic range neurones in the spinal dorsal horn of rats may be induced after tetanic stimulation to the sciatic nerve. This sensory event is possibly an in vivo counterpart of long-term potentiation, described in the brain. This s...


    pub_type: 杂志文章


    authors: Rygh LJ,Green M,Athauda N,Tjølsen A,Dickenson AH

    更新日期:2000-01-01 00:00:00

  • Propofol decreases myofilament Ca2+ sensitivity via a protein kinase C-, nitric oxide synthase-dependent pathway in diabetic cardiomyocytes.

    abstract:BACKGROUND:The authors' objective was to assess the role of protein kinase C (PKC) and nitric oxide synthase (NOS) in mediating the effects of propofol on diabetic cardiomyocyte contractility, intracellular free Ca2+ concentration ([Ca2+]i), and myofilament Ca2+ sensitivity. METHODS:Freshly isolated ventricular myocyt...


    pub_type: 杂志文章


    authors: Wickley PJ,Shiga T,Murray PA,Damron DS

    更新日期:2006-05-01 00:00:00

  • Toxicity and distribution of lidocaine in nonasphyxiated and asphyxiated baboon fetuses.

    abstract::The dosage and blood concentration of lidocaine required to produce central nervous and cardiovascular system toxicity in both nonasphyxiated and asphyxiated fetuses were determined in ten pregnant baboons with fetuses of average gestation of 158 days (term, 185 days). Lidocaine was infused into the fetal jugular vein...


    pub_type: 杂志文章


    authors: Morishima HO,Covino BG

    更新日期:1981-03-01 00:00:00