Dual exposure to sevoflurane improves anesthetic preconditioning in intact hearts.


BACKGROUND:Anesthetic preconditioning (APC) with sevoflurane reduces myocardial ischemia-reperfusion injury. The authors tested whether two brief exposures to sevoflurane would lead to a better preconditioning state than would a single longer exposure and whether dual exposure to a lower (L) concentration of sevoflurane would achieve an outcome similar to that associated with a single exposure to a higher (H) concentration. METHODS:Langendorff-prepared guinea pig hearts were exposed to 0.4 mM sevoflurane once for 15 min (H1-15; n = 8) or 0.4 mM (H2-5; n = 8) or 0.2 mM sevoflurane (L2-5; n = 8) twice for 5 min, with a 5-min washout period interspersed. Sevoflurane was then washed out for 20 min before 30 min of global no-flow ischemia and 120 min of reperfusion. Control hearts (n = 8) were not subjected to APC. Left ventricular pressure was measured isovolumetrically. Ventricular infarct size was determined by tetrazolium staining and cumulative planimetry. Values are expressed as mean +/- SD. RESULTS:The authors found a better functional return and a lesser percentage of infarction on reperfusion in H2-5 (28 +/- 9%) than in H1-15 (36 +/- 8%; P < 0.05), L2-5 (43 +/- 6%; P < 0.05), or control hearts (52 +/- 7%; P < 0.05). CONCLUSION:These results suggest that APC depends not only on the concentration but also on the protocol used for preconditioning. Similarly to ischemic preconditioning, repeated application of the volatile anesthetic seems to be more important than the duration of exposure in initiating the signaling sequence that elicits APC at clinically relevant concentrations. Therefore, repeated cycles of anesthetic exposure followed by volatile anesthetic-free periods may be beneficial for APC in the clinical setting.






Riess ML,Kevin LG,Camara AK,Heisner JS,Stowe DF




Has Abstract


2004-03-01 00:00:00












  • Deficit Accumulation and Phenotype Assessments of Frailty Both Poorly Predict Duration of Hospitalization and Serious Complications after Noncardiac Surgery.

    abstract:BACKGROUND:Frailty is associated with adverse postoperative outcomes, but it remains unclear which measure of frailty is best. This study compared two approaches: the Modified Frailty Index, which is a deficit accumulation model (number of accumulated deficits), and the Hopkins Frailty Score, which is a phenotype model...


    pub_type: 杂志文章


    authors: Sonny A,Kurz A,Skolaris LA,Boehm L,Reynolds A,Cummings KC 3rd,Makarova N,Yang D,Sessler DI

    更新日期:2020-01-01 00:00:00

  • Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice.

    abstract:BACKGROUND:The long-term use of opioids for analgesia carries significant risk for tolerance, addiction, and diversion. These adverse effects are largely mediated by μ-opioid receptors in the central nervous system. Based on the authors' previous observation that morphine and δ-opioid receptor agonists synergize in spi...


    pub_type: 杂志文章


    authors: Bruce DJ,Peterson CD,Kitto KF,Akgün E,Lazzaroni S,Portoghese PS,Fairbanks CA,Wilcox GL

    更新日期:2019-09-01 00:00:00

  • Thiopental requirements for induction of anesthesia in neonates and in infants one to six months of age.

    abstract::The authors determined the thiopental dose needed for satisfactory induction in ten neonates, 0-14 days of age, and 20 infants, 1-6 months of age. A single iv bolus of thiopental was given. Thirty seconds after injection the anesthesia mask was applied and the response was observed during the following 30 s while the ...


    pub_type: 杂志文章


    authors: Westrin P,Jonmarker C,Werner O

    更新日期:1989-09-01 00:00:00

  • Cardiac and regional hemodynamic interactions between halothane and nitric oxide synthase activity in dogs.

    abstract:BACKGROUND:In vitro, halothane appears to affect the role played by nitric oxide in the regulation of vascular tone and cardiac function. In vivo, the results of the interactions between halothane and the nitric oxide pathway remain controversial. The authors investigated the effects of halothane on the cardiac and reg...


    pub_type: 杂志文章


    authors: Chelly JE,Doursout MF,Lechevalier T,Liang YY,Chelly F,Hartley C,Kilbourn RG

    更新日期:1996-07-01 00:00:00

  • Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active.

    abstract:BACKGROUND:The long-lasting high-affinity opioid buprenorphine has complex pharmacology, including ceiling effects with respect to analgesia and respiratory depression. Plasma concentrations of the major buprenorphine metabolites norbuprenorphine, buprenorphine-3-glucuronide, and norbuprenorphine-3-glucuronide approxim...


    pub_type: 杂志文章


    authors: Brown SM,Holtzman M,Kim T,Kharasch ED

    更新日期:2011-12-01 00:00:00

  • Only carbon dioxide absorbents free of both NaOH and KOH do not generate compound A during in vitro closed-system sevoflurane: evaluation of five absorbents.

    abstract:BACKGROUND:Insufficient data exist on the production of compound A during closed-system sevoflurane administration with newer carbon dioxide absorbents. METHODS:A modified PhysioFlex apparatus (Dräger, Lübeck, Germany) was connected to an artificial test lung (inflow at the top of the bellow approximately/= 160 ml/min...


    pub_type: 杂志文章


    authors: Versichelen LF,Bouche MP,Rolly G,Van Bocxlaer JF,Struys MM,De Leenheer AP,Mortier EP

    更新日期:2001-09-01 00:00:00

  • Electrocardiographic exercise stress testing for cardiac risk assessment in patients undergoing noncardiac surgery.

    abstract:BACKGROUND:The value of exercise electrocardiography in the prediction of perioperative cardiac risk has yet to be defined. This study was performed to determine the predictive value of exercise electrocardiography as compared with clinical parameters and resting electrocardiography. METHODS:A total of 204 patients at...


    pub_type: 杂志文章


    authors: Gauss A,Röhm HJ,Schäuffelen A,Vogel T,Mohl U,Straehle A,Meierhenrich R,Georgieff M,Steinbach G,Schütz W

    更新日期:2001-01-01 00:00:00

  • Effects of halothane, propofol, and thiopental on peripheral airway reactivity.

    abstract:BACKGROUND:General anesthetics modify airway responsiveness by several mechanisms, including direct effects on airway smooth muscle and reductions in neural reflex activity. Halothane has been shown to reduce responsiveness through both of these mechanisms. The airway effects of barbiturates are controversial, and the ...


    pub_type: 杂志文章


    authors: Mehr EH,Lindeman KS

    更新日期:1993-08-01 00:00:00

  • Antinociceptive interaction between opioids and medetomidine: systemic additivity and spinal synergy.

    abstract::The antinociceptive interaction on the tail flick (TF) and hot plate (HP) tests between opioid analgesics and medetomidine after intravenous (iv) or intrathecal administration were examined by isobolographic analysis. Male Sprague-Dawley rats received fixed ratios of medetomidine to morphine, fentanyl, and meperidine ...


    pub_type: 杂志文章


    authors: Ossipov MH,Harris S,Lloyd P,Messineo E,Lin BS,Bagley J

    更新日期:1990-12-01 00:00:00

  • Drug actions at mammalian motor nerve endings: the suppression of neostigmine-induced fasciculations by vecuronium and isoflurane.

    abstract::The occurrence of fasciculations following administration of agents is a well-known pharmacologic phenomenon. Using the cat soleus nerve-muscle preparation, intravenous neostigmine doses between 20-200 micrograms/kg evoked fasciculations in a dose-related manner. The data demonstrate that the fasciculations were the r...


    pub_type: 杂志文章


    authors: Baker T,Stanec A

    更新日期:1987-12-01 00:00:00

  • Sevoflurane Exposure during the Critical Period Affects Synaptic Transmission and Mitochondrial Respiration but Not Long-term Behavior in Mice.

    abstract:BACKGROUND:Anesthesia during the synaptogenic period induces dendritic spine formation, which may affect neurodevelopment. The authors, therefore, evaluated whether changes in synaptic transmission after dendritic spine formation induced by sevoflurane were associated with long-term behavioral changes. The effects of s...


    pub_type: 杂志文章


    authors: Chung W,Ryu MJ,Heo JY,Lee S,Yoon S,Park H,Park S,Kim Y,Kim YH,Yoon SH,Shin YS,Lee WH,Ju X,Kweon GR,Ko Y

    更新日期:2017-02-01 00:00:00

  • Effect of hydroxyethyl starch on postoperative kidney function in patients having noncardiac surgery.

    abstract:BACKGROUND:Whether intraoperative use of hydroxyethyl starch impairs kidney function remains unknown. The authors thus tested the primary hypothesis that Hextend promotes renal injury in surgical patients. Secondarily, the authors evaluated the dose-outcome relationship, in-hospital and 90-day mortality, and whether th...


    pub_type: 杂志文章


    authors: Kashy BK,Podolyak A,Makarova N,Dalton JE,Sessler DI,Kurz A

    更新日期:2014-10-01 00:00:00

  • Maximum tolerated dose of nalmefene in patients receiving epidural fentanyl and dilute bupivacaine for postoperative analgesia.

    abstract:BACKGROUND:This study investigated the ability of the modified continual reassessment method (MCRM) to determine the maximum tolerated dose of the opioid antagonist nalmefene, which does not reverse analgesia in an acceptable number of postoperative patients receiving epidural fentanyl in 0.075% bupivacaine. METHODS:I...


    pub_type: 临床试验,杂志文章


    authors: Dougherty TB,Porche VH,Thall PF

    更新日期:2000-04-01 00:00:00

  • Compliance with Surgical Care Improvement Project for Body Temperature Management (SCIP Inf-10) Is Associated with Improved Clinical Outcomes.

    abstract:BACKGROUND:In an effort to measure and improve the quality of perioperative care, the Surgical Care Improvement Project (SCIP) was introduced in 2003. The SCIP guidelines are evidence-based process measures designed to reduce preventable morbidity, but it remains to be determined whether SCIP-measure compliance is asso...


    pub_type: 杂志文章


    authors: Scott AV,Stonemetz JL,Wasey JO,Johnson DJ,Rivers RJ,Koch CG,Frank SM

    更新日期:2015-07-01 00:00:00

  • Povidone iodine and skin disinfection before initiation of epidural anesthesia.

    abstract:BACKGROUND:Povidone iodine (PI) solution is used commonly for skin disinfection before epidural and spinal anesthesia. Although there have been reports indicating the presence of microbial contaminants in PI solution, none have evaluated the prevalence of PI contamination. The aims of this study were to assess the freq...


    pub_type: 杂志文章


    authors: Birnbach DJ,Stein DJ,Murray O,Thys DM,Sordillo EM

    更新日期:1998-03-01 00:00:00

  • Astrocytes Protect against Isoflurane Neurotoxicity by Buffering pro-brain-derived Neurotrophic Factor.

    abstract:BACKGROUND:Isoflurane induces cell death in neurons undergoing synaptogenesis via increased production of pro-brain-derived neurotrophic factor (proBDNF) and activation of postsynaptic p75 neurotrophin receptor (p75). Astrocytes express p75, but their role in neuronal p75-mediated cell death remains unclear. The author...


    pub_type: 杂志文章


    authors: Stary CM,Sun X,Giffard RG

    更新日期:2015-10-01 00:00:00

  • Fibromyalgia survey criteria are associated with increased postoperative opioid consumption in women undergoing hysterectomy.

    abstract:BACKGROUND:The current study was designed to test the hypothesis that the fibromyalgia survey criteria would be directly associated with increased opioid consumption after hysterectomy even when accounting for other factors previously described as being predictive for acute postoperative pain. METHODS:Two hundred eigh...


    pub_type: 杂志文章


    authors: Janda AM,As-Sanie S,Rajala B,Tsodikov A,Moser SE,Clauw DJ,Brummett CM

    更新日期:2015-05-01 00:00:00

  • A comparison of the effects of halothane and tetrodotoxin on the regional repolarization characteristics of canine Purkinje fibers.

    abstract::The effects of halothane, tetrodotoxin (TTX), veratridine (VTD), and alterations of extracellular calcium ion concentration [Ca++]0) on regional differences of canine Purkinje fiber action potential duration (APD50 and APD90) were investigated in vitro at a paced rate of 75 beats per min. Under control conditions (n =...


    pub_type: 杂志文章


    authors: Turner LA,Marijic J,Kampine JP,Bosnjak ZJ

    更新日期:1990-12-01 00:00:00

  • Higher frequency ventilation attenuates lung injury during high-frequency oscillatory ventilation in sheep models of acute respiratory distress syndrome.

    abstract:BACKGROUND:High-frequency oscillatory ventilation (HFOV) at higher frequencies minimizes the tidal volume. However, whether increased frequencies during HFOV can reduce ventilator-induced lung injury remains unknown. METHODS:After the induction of acute respiratory distress syndrome in the model by repeated lavages, 2...


    pub_type: 杂志文章


    authors: Liu S,Yi Y,Wang M,Chen Q,Huang Y,Liu L,Xie J,Zhou D,Qiu H

    更新日期:2013-08-01 00:00:00

  • Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat.

    abstract:BACKGROUND:Chronic postsurgical pain, a significant public health problem, occurs in 10 to 50% of patients undergoing major surgery. Acute pain induces endogenous analgesia termed conditioned pain modulation (CPM), and the strength of CPM preoperatively predicts the likelihood of chronic postsurgical pain. The relation...


    pub_type: 杂志文章


    authors: Peters CM,Hayashida K,Suto T,Houle TT,Aschenbrenner CA,Martin TJ,Eisenach JC

    更新日期:2015-04-01 00:00:00

  • Influence of mannitol and furosemide, alone and in combination, on brain water content after fluid percussion injury.

    abstract:BACKGROUND:Furosemide and mannitol are used to reduce intracranial pressure, but the impact of furosemide on edema of injured brain is unclear. The authors examined the effects of furosemide and mannitol, alone and in combination, on brain water content in brain-injured rats. METHODS:Anesthetized rats were subjected t...


    pub_type: 杂志文章


    authors: Todd MM,Cutkomp J,Brian JE

    更新日期:2006-12-01 00:00:00

  • Porcine malignant hyperthermia: effects of halothane on mitochondrial respiration and calcium accumulation.

    abstract::Vastus lateralis muscle was excised from normal pigs and from pigs susceptible to malignant hyperthermia. Anesthesia consisted of diazepam, N2O:O2, and a lidocaine field block. In the susceptible (MHS) pigs, respiratory control in mitochondria of excised muscle was normal, while electron transport was accelerated. Glu...


    pub_type: 杂志文章


    authors: Britt BA,Endrenyi L,Cadman DL,Fan HM,Fung HY

    更新日期:1975-03-01 00:00:00

  • Density detection in dependent left lung region using transesophageal echocardiography.

    abstract:BACKGROUND:Densities in dependent lung regions worsen oxygenation in patients with acute respiratory distress syndrome. Identification of these densities requires examination using computed tomography (CT). In this study, the authors evaluated the use of transesophageal echocardiography (TEE) to estimate densities in t...


    pub_type: 杂志文章


    authors: Tsubo T,Sakai I,Suzuki A,Okawa H,Ishihara H,Matsuki A

    更新日期:2001-05-01 00:00:00

  • Epidural Labor Analgesia-Fentanyl Dose and Breastfeeding Success: A Randomized Clinical Trial.

    abstract:BACKGROUND:Breastfeeding is an important public health concern. High cumulative doses of epidural fentanyl administered for labor analgesia have been reported to be associated with early termination of breastfeeding. We tested the hypothesis that breastfeeding success is adversely influenced by the cumulative epidural ...


    pub_type: 杂志文章,随机对照试验


    authors: Lee AI,McCarthy RJ,Toledo P,Jones MJ,White N,Wong CA

    更新日期:2017-10-01 00:00:00

  • Factors associated with postoperative exacerbation of sleep-disordered breathing.

    abstract:INTRODUCTION:The knowledge on the mechanism of the postoperative exacerbation of sleep-disordered breathing may direct the perioperative management of patients with obstructive sleep apnea. The objective of this study is to investigate the factors associated with postoperative severity of sleep-disordered breathing. M...


    pub_type: 杂志文章


    authors: Chung F,Liao P,Elsaid H,Shapiro CM,Kang W

    更新日期:2014-02-01 00:00:00

  • Olprinone, a phosphodiesterase III inhibitor, reduces gut mucosal injury and portal endotoxin level during acute hypoxia in rabbits.

    abstract:BACKGROUND:Preservation of gut integrity has become a therapeutic goal to obviate bacterial translocation in the critically ill. The authors examined whether olprinone, a phosphodiesterase III inhibitor, protected functional and structural integrity of gut mucosa against acute progressive hypoxia. METHODS:Thirty-two a...


    pub_type: 杂志文章


    authors: Satoh T,Morisaki H,Ai K,Kosugi S,Yamamoto M,Serita R,Kotake Y,Takeda J

    更新日期:2003-06-01 00:00:00

  • Exercise produces sensitivity to metocurine.

    abstract::Chronic muscle disuse decreases the sensitivity of skeletal muscle to nondepolarizing relaxants, such as metocurine (MTC). In this study, the authors determined whether chronic conditioning would produce the opposite effect and increase the sensitivity of skeletal muscle to MTC. Five dogs were exercised by daily runni...


    pub_type: 杂志文章


    authors: Gronert GA,White DA,Shafer SL,Matteo RS

    更新日期:1989-06-01 00:00:00

  • Mortality experience among anesthesiologists, 1954-1976.

    abstract::To determine whether anesthesiologists, because of prolonged exposure to halothane or other inhalational anesthetics, might have higher death rates from all causes, from cancer, and from hepatic or renal disease than other physicians, the mortality rates of male and female members of the American Society of Anesthesio...


    pub_type: 杂志文章


    authors: Lew EA

    更新日期:1979-09-01 00:00:00

  • Inhibition of the ubiquitin-proteasome pathway does not protect against ventilator-induced accelerated proteolysis or atrophy in the diaphragm.

    abstract:BACKGROUND:Mechanical ventilation (MV) is a life-saving intervention in patients with acute respiratory failure. However, prolonged MV results in ventilator-induced diaphragm dysfunction (VIDD), a condition characterized by both diaphragm fiber atrophy and contractile dysfunction. Previous work has shown that calpain, ...


    pub_type: 杂志文章


    authors: Smuder AJ,Nelson WB,Hudson MB,Kavazis AN,Powers SK

    更新日期:2014-07-01 00:00:00

  • Neurologic changes during awakening from anesthesia.

    abstract::Transient hyperreflexia, the Babinski reflex, and other transient neurologic signs may follow anesthesia in healthy persons. The authors describe the appearance and durations of these signs and relate them to anesthetic agent, time following cessation of anesthesia, and state of arousal. Twenty-nine neurologically nor...


    pub_type: 杂志文章


    authors: Rosenberg H,Clofine R,Bialik O

    更新日期:1981-02-01 00:00:00