A brief regional ischemic-reperfusion enhances propofol-induced depression in left ventricular function of in situ rat hearts.


BACKGROUND:Propofol is short-acting intravenous general anesthetics that reduces cardiovascular hemodynamics. The effects of propofol on intrinsic myocardial contractility, however, remain debatable. The aim of the current study was to test the hypothesis that inhibitory effects of propofol on left ventricular (LV) contractility and mechanical work capability of in situ ejecting rat hearts are attenuated after a brief regional ischemia and reperfusion. METHODS:The authors obtained steady-state LV pressure-volume loops and intermittently obtained LV end-systolic pressure-volume relation and evaluated effects of propofol on LV function by end-systolic pressure (ESPmLVV), systolic pressure-volume area (PVAmLVV) at midrange LV volume (mLVV). RESULTS:Propofol (5.2 +/- 0.3 approximately 11.1 +/- 3.7 microg.ml) significantly decreased ESP0.08 to 78 +/- 12% approximately 64 +/- 13% of prepropofol and PVA0.08 to 76 +/- 13%approximately 63 +/- 16% of prepropofol in normal hearts, whereas propofol at a lower concentration (4.1 +/- 1.0 microg/ml) did not. Although brief ischemic-reperfusion per se did not affect LV function, propofol after that, even at a lower concentration (4.1 +/- 1.0 microg/ml), significantly decreased ESP0.08 to 70 +/- 27% of prepropofol and PVA0.08 to 68 +/- 33% of prepropofol. Pretreatment with a protein kinase C (PKC) inhibitor, bisindolylmaleimide reduced the propofol (4.1 +/- 1.0 microg/ml)-induced greater decreases in ESP0.08 and PVA0.08 after brief ischemic-reperfusion to 94 +/- 33% and 92 +/- 39% of prepropofol. In the propofol-infused hearts after brief ischemic-reperfusion, protein kinase C-epsilon translocation to the nucleus-myofibril fraction was found. CONCLUSION:In contrast to the study hypothesis, brief ischemic-reperfusion enhanced the inhibitory effects of propofol on LV systolic function; this enhancement is attributable to activation of protein kinase C.






Kuzumoto N,Kitagawa Y,Uemura K,Ueyama T,Yoshida K,Furuya H,Takaki M




Has Abstract


2004-10-01 00:00:00














  • Electroencephalogram approximate entropy correctly classifies the occurrence of burst suppression pattern as increasing anesthetic drug effect.

    abstract:BACKGROUND:Approximate entropy, a measure of signal complexity and regularity, quantifies electroencephalogram changes during anesthesia. With increasing doses of anesthetics, burst-suppression patterns occur. Because of the high-frequency bursts, spectrally based parameters such as median electroencephalogram frequenc...


    pub_type: 临床试验,杂志文章


    authors: Bruhn J,Röpcke H,Rehberg B,Bouillon T,Hoeft A

    更新日期:2000-10-01 00:00:00

  • Intrathecal opioids and lower urinary tract function: a urodynamic evaluation.

    abstract:BACKGROUND:Intrathecal administration of opioids may cause lower urinary tract dysfunction. In this study, the authors compared the effects of morphine and sufentanil administered intrathecally in a randomized double-blind fashion (two doses each) on lower urinary tract function in healthy male volunteers. METHODS:Uro...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kuipers PW,Kamphuis ET,van Venrooij GE,van Roy JP,Ionescu TI,Knape JT,Kalkman CJ

    更新日期:2004-06-01 00:00:00

  • Relationship between oxygen uptake and mixed venous oxygen saturation in the immediate postoperative period.

    abstract:BACKGROUND:During muscular exercise, a negative correlation has been demonstrated between the value of mixed venous oxygen saturation (SvO2) and the level of muscular work, expressed at each level as the ratio of oxygen uptake (VO2) to each subject's maximal oxygen uptake (VO2max). Because the immediate postoperative p...


    pub_type: 杂志文章


    authors: Viale JP,Annat G,Lehot JJ,Quard S,Quintin L,Parlow J,Durand PG,Zabot JM,Villard J,Estanove S

    更新日期:1994-02-01 00:00:00

  • Flammability of endotracheal tubes during Nd-YAG laser application in the airway.

    abstract::The effects of the neodymium-yttrium aluminum garnet (Nd-YAG) laser on several commonly used endotracheal tubes were examined. Six different types of tubes were tested for flammability. Three tubes were clear, transparent polyvinylchloride with black lettering on the surface. One was yellow-green silicone rubber with ...


    pub_type: 杂志文章


    authors: Geffin B,Shapshay SM,Bellack GS,Hobin K,Setzer SE

    更新日期:1986-11-01 00:00:00

  • Interaction between sedative premedicants and ketamine in man in isolated perfused rat livers.

    abstract::Premedication with diazepam, hydroxyzine or secobarbital significantly increased ketamine-induced sleep time (137 +/- 3.5 min, 135 +/- 9.2 min, 128 +/- 4.7 min) over that of unpremedicated controls (98.5 +/- 4.4 min) in man. The corresponding mean plasma half-lives (t1/2) of ketamine were longer in patients premedicat...


    pub_type: 杂志文章


    authors: Lo JN,Cumming JF

    更新日期:1975-09-01 00:00:00

  • Cerebral extracellular glucose and lactate concentrations during and after moderate hypoxia in glucose- and saline-infused rats.

    abstract::To assess the effect of a glucose infusion on brain extracellular fluid (ECF) during systemic hypoxia, changes in glucose and lactate concentrations in cerebral ECF during and after moderate hypoxic hypoxia were measured in adult, conscious, unrestrained rats, with a microdialysis probe in the posterior hippocampus. T...


    pub_type: 杂志文章


    authors: Harada M,Okuda C,Sawa T,Murakami T

    更新日期:1992-10-01 00:00:00

  • Hyperinsulinemic Normoglycemia Does Not Meaningfully Improve Myocardial Performance during Cardiac Surgery: A Randomized Trial.

    abstract:BACKGROUND:Glucose-insulin-potassium (GIK) administration during cardiac surgery inconsistently improves myocardial function, perhaps because hyperglycemia negates the beneficial effects of GIK. The hyperinsulinemic normoglycemic clamp (HNC) technique may better enhance the myocardial benefits of GIK. The authors exten...


    pub_type: 杂志文章,随机对照试验


    authors: Duncan AE,Kateby Kashy B,Sarwar S,Singh A,Stenina-Adognravi O,Christoffersen S,Alfirevic A,Sale S,Yang D,Thomas JD,Gillinov M,Sessler DI

    更新日期:2015-08-01 00:00:00

  • Mechanism of antagonism by physostigmine of acute flunitrazepam intoxication.

    abstract::The effect of physostigmine on the loss of consciousness and respiratory depression induced in rabbits by flunitrazepam, 1 mg/kg, was studied to demonstrate whether the restoration of consciousness and respiration rate results from an increase in central cholinergic activity or from an interference by physostigmine wi...


    pub_type: 杂志文章


    authors: Vatashsky E,Beilin B,Razin M,Weinstock M

    更新日期:1986-02-01 00:00:00

  • Population pharmacodynamic modeling and covariate detection for central neural blockade.

    abstract:BACKGROUND:In spinal anesthesia, often a large interindividual variability in analgesic response is observed after administration of a certain fixed dose of anesthetic to a patient population. To improve therapeutic outcome it is important to characterize the variability in response by means of a population model (e.g....


    pub_type: 杂志文章


    authors: Schnider TW,Minto CF,Bruckert H,Mandema JW

    更新日期:1996-09-01 00:00:00

  • Influence of epinephrine as an adjuvant to epidural morphine.

    abstract::The effects of epinephrine 1/200,000 as an adjuvant to epidural morphine were investigated in three healthy male volunteers, during 26-h observation sessions. Peak blood concentrations of morphine were 44 +/- 12.9 ng/ml after plain morphine and 13.7 +/- 6.7 ng/ml after epinephrine-morphine. Cutaneous hypalgesia was mo...


    pub_type: 杂志文章


    authors: Bromage PR,Camporesi EM,Durant PA,Nielsen CH

    更新日期:1983-03-01 00:00:00

  • The effect of halothane on the steady-state levels of high-energy phosphates in the neonatal heart.

    abstract::The neonatal heart is especially vulnerable to cardiac depression caused by halothane. The cause of this sensitivity is uncertain. Isolated, perfused, isovolumic, contracting neonatal rabbit hearts were studied using 31P NMR to determine whether changes in concentrations of high energy phosphates (HEP) or intracellula...


    pub_type: 杂志文章


    authors: McAuliffe JJ,Hickey PR

    更新日期:1987-08-01 00:00:00

  • Psychedelic effects of ketamine in healthy volunteers: relationship to steady-state plasma concentrations.

    abstract:BACKGROUND:Ketamine has been associated with a unique spectrum of subjective "psychedelic" effects in patients emerging from anesthesia. This study quantified these effects of ketamine and related them to steady-state plasma concentrations. METHODS:Ketamine or saline was administered in a single-blinded crossover prot...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bowdle TA,Radant AD,Cowley DS,Kharasch ED,Strassman RJ,Roy-Byrne PP

    更新日期:1998-01-01 00:00:00

  • Propofol-induced Changes in α-β Sensorimotor Cortical Connectivity.

    abstract:BACKGROUND:Anesthetics are believed to alter functional connectivity across brain regions. However, network-level analyses of anesthesia, particularly in humans, are sparse. The authors hypothesized that propofol-induced loss of consciousness results in functional disconnection of human sensorimotor cortices underlying...


    pub_type: 杂志文章


    authors: Malekmohammadi M,AuYong N,Price CM,Tsolaki E,Hudson AE,Pouratian N

    更新日期:2018-02-01 00:00:00

  • Does perioperative myocardial ischemia lead to postoperative myocardial infarction?

    abstract::To determine if a relationship exists between perioperative myocardial ischemia (ST segment depression greater than or equal to 0.1 mV) and postoperative myocardial infarction (PMI), nonparticipating observers recorded all ECG, hemodynamic, and other events between arrival of patients in the operating room and onset o...


    pub_type: 杂志文章


    authors: Slogoff S,Keats AS

    更新日期:1985-02-01 00:00:00

  • Propofol has no direct effect on sinoatrial node function or on normal atrioventricular and accessory pathway conduction in Wolff-Parkinson-White syndrome during alfentanil/midazolam anesthesia.

    abstract:BACKGROUND:Propofol has been implicated as causing intraoperative bradyarrhythmias. Furthermore, the effects of propofol on the electrophysiologic properties of the sinoatrial (SA) node and on normal atrioventricular (AV) and accessory pathways in patients with Wolff-Parkinson-White syndrome are unknown. Therefore, thi...


    pub_type: 临床试验,杂志文章


    authors: Sharpe MD,Dobkowski WB,Murkin JM,Klein G,Yee R

    更新日期:1995-04-01 00:00:00

  • Intracranial pressure during hypotension and subsequent vasopressor therapy in anesthetized cats.

    abstract::The effects of vasopressor therapy on intracranial pressure (ICP) during hypotension were evaluated in 45 adult cats anesthetized with pentobarbital and hyperventilated via an endotracheal tube with nitrous oxide, 70 per cent, and oxygen, 30 per cent, to maintain Paco2 25 plus or minus 5 torr. Hypotension was induced ...


    pub_type: 杂志文章


    authors: Stullken EH Jr,Sokoll MD

    更新日期:1975-04-01 00:00:00

  • Automated echocardiographic analysis. Examination of serial intraoperative measurements.

    abstract:BACKGROUND:Although transesophageal echocardiography allows continuous intraoperative cardiac monitoring, the technique has been limited by the lack of a method for realtime, quantitative assessment of cardiac chamber size and systolic function. Automated border detection (ABD), based on an analysis of integrated backs...


    pub_type: 杂志文章


    authors: Perrino AC Jr,Luther MA,O'Connor TZ,Cohen IS

    更新日期:1995-08-01 00:00:00

  • Distinct roles for sarcolemmal and mitochondrial adenosine triphosphate-sensitive potassium channels in isoflurane-induced protection against oxidative stress.

    abstract:BACKGROUND:Cardiac preconditioning, including that induced by halogenated anesthetics, is an innate protective mechanism against ischemia-reperfusion injury. The adenosine triphosphate-sensitive potassium (K(ATP)) channels are considered essential in preconditioning mechanism. However, it is unclear whether K(ATP) chan...


    pub_type: 杂志文章


    authors: Marinovic J,Bosnjak ZJ,Stadnicka A

    更新日期:2006-07-01 00:00:00

  • Anesthesia-related cardiac arrest in children: initial findings of the Pediatric Perioperative Cardiac Arrest (POCA) Registry.

    abstract:BACKGROUND:The Pediatric Perioperative Cardiac Arrest (POCA) Registry was formed in 1994 in an attempt to determine the clinical factors and outcomes associated with cardiac arrest in anesthetized children. METHODS:Institutions that provide anesthesia for children are voluntarily enrolled in the POCA Registry. A repre...


    pub_type: 杂志文章


    authors: Morray JP,Geiduschek JM,Ramamoorthy C,Haberkern CM,Hackel A,Caplan RA,Domino KB,Posner K,Cheney FW

    更新日期:2000-07-01 00:00:00

  • On-demand rather than daily-routine chest radiography prescription may change neither the number nor the impact of chest computed tomography and ultrasound studies in a multidisciplinary intensive care unit.

    abstract:BACKGROUND:Elimination of daily-routine chest radiographs (CXRs) may influence chest computed tomography (CT) and ultrasound practice in critically ill patients. METHODS:This was a retrospective cohort study including all patients admitted to a university-affiliated intensive care unit during two consecutive periods o...


    pub_type: 杂志文章


    authors: Kröner A,Binnekade JM,Graat ME,Vroom MB,Stoker J,Spronk PE,Schultz MJ

    更新日期:2008-01-01 00:00:00

  • Effects of volatile anesthetics on store-operated Ca(2+) influx in airway smooth muscle.

    abstract:BACKGROUND:In airway smooth muscle (ASM), volatile anesthetics deplete sarcoplasmic reticulum (SR) Ca(2+) stores by increasing Ca(2+) "leak." Accordingly, SR replenishment becomes dependent on Ca(2+) influx. Depletion of SR Ca(2+) stores triggers Ca(2+) influx via specific plasma membrane channels, store-operated Ca(2+...


    pub_type: 杂志文章


    authors: Pabelick CM,Ay B,Prakash YS,Sieck GC

    更新日期:2004-08-01 00:00:00

  • Interaction of intravenous anesthetics with human neuronal potassium currents in relation to clinical concentrations.

    abstract:BACKGROUND:Neuronal voltage-dependent potassium (K) currents are crucial for various cellular functions, such as the integration of temporal information in the central nervous system. Data for the effects of intravenous anesthetics on human neuronal K currents are limited. It was the authors' aim to evaluate the concen...


    pub_type: 杂志文章


    authors: Friederich P,Urban BW

    更新日期:1999-12-01 00:00:00

  • Pulmonary shunting during alveolar hypoventilation in the dog.

    abstract::Pulmonary shunting (Qs/Qt) was measured in 16 anesthetized and paralyzed healthy beagle puppies during a control period when the end-expired CO2 concentration was 5 per cent and during alveolar hypoventilation, when the PaCO2 increased to 100 plus or minus 13 torr (mean plus or minus SE) and the ;Ha vecame 7.04 plus o...


    pub_type: 杂志文章


    authors: Stone JG,Sullivan SF

    更新日期:1975-04-01 00:00:00

  • Isoflurane activates intestinal sphingosine kinase to protect against renal ischemia-reperfusion-induced liver and intestine injury.

    abstract:BACKGROUND:Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury and often leads to multiorgan dysfunction and systemic inflammation. Volatile anesthetics have potent antiinflammatory effects. We aimed to determine whether the representative volatile anesthetic isoflurane protects against acut...


    pub_type: 杂志文章


    authors: Kim M,Park SW,Kim M,D'Agati VD,Lee HT

    更新日期:2011-02-01 00:00:00

  • Quantitative and qualitative effects of isoflurane on movement occurring after noxious stimulation.

    abstract:BACKGROUND:Anesthetic potency is assessed by determination of the anesthetic concentration that prevents gross, purposeful movement in response to noxious stimulation. It is unclear whether anesthetics cause a progressive decrease in the number and force of limb movements evoked by noxious stimulation, or a step decrea...


    pub_type: 杂志文章


    authors: Antognini JF,Wang XW,Carstens E

    更新日期:1999-10-01 00:00:00

  • Protective effect of hypothermia in cerebral oxygen deficiency caused by arterial hypoxia.

    abstract::To study the cerebral protective effects of hypothermia in arterial hypoxia, anesthetized (70% N2O), mechanically ventilated rats were cooled to a body temperature of 27 C. Hypoxia was induced by decreasing the oxygen content in the inspired gas mixture either to 6-7 per cent or to 2.5-3 per cent. This reduced mean Pa...


    pub_type: 杂志文章


    authors: Carlsson C,Hägerdal M,Siesjö BK

    更新日期:1976-01-01 00:00:00

  • Hamilton acute pain service safety study: using root cause analysis to reduce the incidence of adverse events.

    abstract:BACKGROUND:Although intravenous patient-controlled analgesia opioids and epidural analgesia offer improved analgesia for postoperative patients treated on an acute pain service, these modalities also expose patients to some risk of serious morbidity and even mortality. Root cause analysis, a process for identifying the...


    pub_type: 杂志文章,多中心研究


    authors: Paul JE,Buckley N,McLean RF,Antoni K,Musson D,Kampf M,Buckley D,Marcoux M,Frketich R,Thabane L,Cheng J

    更新日期:2014-01-01 00:00:00

  • Diagnosis of ventilator-associated pneumonia: an evaluation of direct examination and presence of intracellular organisms.

    abstract:BACKGROUND:Ventilator-associated pneumonia (VAP) requires early diagnosis and adequate antibiotic therapy. The aim of this prospective postmortem study was to assess the accuracy of direct examination and quantification of intracellular organisms (ICO) for the diagnosis of VAP. METHODS:Total and differential cell coun...


    pub_type: 杂志文章


    authors: Papazian L,Autillo-Touati A,Thomas P,Bregeon F,Garbe L,Saux P,Seite R,Gouin F

    更新日期:1997-08-01 00:00:00

  • Ketamine Alters Hippocampal Cell Proliferation and Improves Learning in Mice after Traumatic Brain Injury.

    abstract:WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Traumatic brain injury induces cellular proliferation in the hippocampus, which generates new neurons and glial cells during recovery. This process is regulated by N-methyl-D-aspartate-type glutamate receptors, which are inhibite...


    pub_type: 杂志文章


    authors: Peters AJ,Villasana LE,Schnell E

    更新日期:2018-08-01 00:00:00

  • Effects of neuromuscular blocking agents on excitatory transmission and gamma-aminobutyric acidA-mediated inhibition in the rat hippocampal slice.

    abstract:BACKGROUND:Although neuromuscular blocking agents do not cross the blood-brain barrier, they may penetrate the central nervous system under particular circumstances and eventually cause neurotoxic consequences. METHODS:The effects of neuromuscular blocking agents on excitatory and inhibitory transmission in area CA1 o...


    pub_type: 杂志文章


    authors: Chiodini FC,Tassonyi E,Fuchs-Buder T,Fathi M,Bertrand D,Muller D

    更新日期:1998-04-01 00:00:00