A brief regional ischemic-reperfusion enhances propofol-induced depression in left ventricular function of in situ rat hearts.

Abstract:

BACKGROUND:Propofol is short-acting intravenous general anesthetics that reduces cardiovascular hemodynamics. The effects of propofol on intrinsic myocardial contractility, however, remain debatable. The aim of the current study was to test the hypothesis that inhibitory effects of propofol on left ventricular (LV) contractility and mechanical work capability of in situ ejecting rat hearts are attenuated after a brief regional ischemia and reperfusion. METHODS:The authors obtained steady-state LV pressure-volume loops and intermittently obtained LV end-systolic pressure-volume relation and evaluated effects of propofol on LV function by end-systolic pressure (ESPmLVV), systolic pressure-volume area (PVAmLVV) at midrange LV volume (mLVV). RESULTS:Propofol (5.2 +/- 0.3 approximately 11.1 +/- 3.7 microg.ml) significantly decreased ESP0.08 to 78 +/- 12% approximately 64 +/- 13% of prepropofol and PVA0.08 to 76 +/- 13%approximately 63 +/- 16% of prepropofol in normal hearts, whereas propofol at a lower concentration (4.1 +/- 1.0 microg/ml) did not. Although brief ischemic-reperfusion per se did not affect LV function, propofol after that, even at a lower concentration (4.1 +/- 1.0 microg/ml), significantly decreased ESP0.08 to 70 +/- 27% of prepropofol and PVA0.08 to 68 +/- 33% of prepropofol. Pretreatment with a protein kinase C (PKC) inhibitor, bisindolylmaleimide reduced the propofol (4.1 +/- 1.0 microg/ml)-induced greater decreases in ESP0.08 and PVA0.08 after brief ischemic-reperfusion to 94 +/- 33% and 92 +/- 39% of prepropofol. In the propofol-infused hearts after brief ischemic-reperfusion, protein kinase C-epsilon translocation to the nucleus-myofibril fraction was found. CONCLUSION:In contrast to the study hypothesis, brief ischemic-reperfusion enhanced the inhibitory effects of propofol on LV systolic function; this enhancement is attributable to activation of protein kinase C.

journal_name

Anesthesiology

journal_title

Anesthesiology

authors

Kuzumoto N,Kitagawa Y,Uemura K,Ueyama T,Yoshida K,Furuya H,Takaki M

doi

10.1097/00000542-200410000-00012

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

879-87

issue

4

eissn

0003-3022

issn

1528-1175

pii

00000542-200410000-00012

journal_volume

101

pub_type

杂志文章
  • Sepsis is associated with a preferential diaphragmatic atrophy: a critically ill patient study using tridimensional computed tomography.

    abstract:BACKGROUND:Diaphragm and psoas are affected during sepsis in animal models. Whether diaphragm or limb muscle is preferentially affected during sepsis in the critically ill remains unclear. METHODS:Retrospective secondary analysis study including 40 patients, comparing control (n = 17) and critically ill patients, with...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000000201

    authors: Jung B,Nougaret S,Conseil M,Coisel Y,Futier E,Chanques G,Molinari N,Lacampagne A,Matecki S,Jaber S

    更新日期:2014-05-01 00:00:00

  • Plastic change of N-type Ca channel expression after preconditioning is responsible for prostaglandin E2-induced long-lasting allodynia.

    abstract:BACKGROUND:Although considerable evidence indicates neuronal Ca channels play significant roles in pain perception, their possible importance in hypersensitization after acute inflammation has not been investigated. METHODS:Using carrageenan for inducing hypersensitization, the authors investigated the analgesic effec...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200312000-00019

    authors: Yokoyama K,Kurihara T,Makita K,Tanabe T

    更新日期:2003-12-01 00:00:00

  • Cerebral oxygen saturation measured by near-infrared spectroscopy and jugular venous bulb oxygen saturation during arthroscopic shoulder surgery in beach chair position under sevoflurane-nitrous oxide or propofol-remifentanil anesthesia.

    abstract:BACKGROUND:We examined the effects of different anesthetics on cerebral oxygenation and systemic hemodynamics in patients undergoing surgery in beach chair position (BCP). Jugular venous bulb oxygen saturation (SjvO2) and regional cerebral tissue oxygen saturation (SctO2) were determined while patients were placed from...

    journal_title:Anesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ALN.0b013e31825154d2

    authors: Jeong H,Jeong S,Lim HJ,Lee J,Yoo KY

    更新日期:2012-05-01 00:00:00

  • Intravenous lidocaine and bupivacaine dose-dependently attenuate bronchial hyperreactivity in awake volunteers.

    abstract:BACKGROUND:In standard textbooks, intravenous lidocaine is recommended for intubation of patients with bronchial hyperreactivity. However, whether and to what extent intravenous local anesthetics attenuate bronchial hyperreactivity in humans is unknown. Accordingly, nine awake volunteers with known bronchial hyperreact...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000542-199603000-00007

    authors: Groeben H,Schwalen A,Irsfeld S,Stieglitz S,Lipfert P,Hopf HB

    更新日期:1996-03-01 00:00:00

  • Evaluation of Seldinger technique emergency cricothyroidotomy versus standard surgical cricothyroidotomy in 200 cadavers.

    abstract:BACKGROUND:Percutaneous cricothyroidotomy is a lifesaving procedure for airway obstruction in trauma victims who need airway establishment and cannot be intubated or in whom intubation has failed. METHODS:The purpose of this study was to examine whether there is a training effect using Seldinger technique emergency cr...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200501000-00005

    authors: Schaumann N,Lorenz V,Schellongowski P,Staudinger T,Locker GJ,Burgmann H,Pikula B,Hofbauer R,Schuster E,Frass M

    更新日期:2005-01-01 00:00:00

  • Mucociliary clearance in the canine lung during and after general anesthesia.

    abstract::Central and peripheral pulmonary mucociliary clearance was assessed by tantalum bronchography and serial chest roentgenograms in dogs. Thiopental, 25 mg/kg, did not change clearance from awake values. Halothane 1.2 MAC, for six hours, delayed both central and peripheral clearance by at least three hours. After halotha...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-197901000-00006

    authors: Forbes AR,Gamsu G

    更新日期:1979-01-01 00:00:00

  • Effects of succinylcholine and d-tubocurarine on epinephrine-induced arrhythmias during halothane anesthesia in dogs.

    abstract::The effects of subparalytic doses of succinylcholine and d-tubocurarine on epinephrine-induced cardiac arrhythmias during halothane anesthesia were evaluated in dogs. Succinylcholine markedly increased (P is less than .05) the arrhythmogenicity of epinephrine and d-tubocurarine slightly decreased (P is less than .05) ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-197501000-00008

    authors: Tucker WK,Munson ES

    更新日期:1975-01-01 00:00:00

  • Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of alfentanil.

    abstract:BACKGROUND:Although respiratory depression is the most well-known and dangerous side effect of opioids, no pharmacokinetic-pharmacodynamic model exists for its quantitative analysis. The development of such a model was the aim of this study. METHODS:After institutional approval approval and informed consent were obtai...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199907000-00023

    authors: Bouillon T,Schmidt C,Garstka G,Heimbach D,Stafforst D,Schwilden H,Hoeft A

    更新日期:1999-07-01 00:00:00

  • Ventilator-associated pneumonia leading to acute lung injury after trauma: importance of Haemophilus influenzae.

    abstract:BACKGROUND:Ventilator-associated pneumonia is a clear risk factor for acute lung injury which has been poorly described in trauma patients. This prospective study was undertaken to estimate the incidence of such ventilator-associated pneumonia leading to acute lung injury, the risk factors, and the associated morbidity...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200602000-00006

    authors: Stéphan F,Mabrouk N,Decailliot F,Delclaux C,Legrand P

    更新日期:2006-02-01 00:00:00

  • Treatment of iron deficiency anemia in orthopedic surgery with intravenous iron: efficacy and limits: a prospective study.

    abstract:BACKGROUND:Preoperative anemia is frequent in patients undergoing orthopedic surgery. The purpose of this study was to assess the preoperative increase of hemoglobin in iron deficiency anemia patients treated with intravenous iron. METHODS:After obtaining written informed consent, 20 patients with iron deficiency anem...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/01.anes.0000291441.10704.82

    authors: Theusinger OM,Leyvraz PF,Schanz U,Seifert B,Spahn DR

    更新日期:2007-12-01 00:00:00

  • Regional gas exchange and cellular metabolic activity in ventilator-induced lung injury.

    abstract:BACKGROUND:Alveolar overdistension and repetitive derecruitment-recruitment contribute to ventilator-induced lung injury (VILI). The authors investigated (1) whether inflammatory cell activation due to VILI was assessable by positron emission tomography and (2) whether cell activation due to dynamic overdistension alon...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/01.anes.0000264748.86145.ac

    authors: Musch G,Venegas JG,Bellani G,Winkler T,Schroeder T,Petersen B,Harris RS,Melo MF

    更新日期:2007-04-01 00:00:00

  • Cerebral blood flow and metabolism in dogs with chronic diabetes.

    abstract:BACKGROUND:Previously, the authors found that anesthetized diabetic dogs had increased cerebral blood flow (CBF) and oxygen consumption (CMRO2). These results may have been influenced by anesthesia or surgery. The aim of this study was to determine whether CBF and CMRO2 are increased in the awake or anesthetized state ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199311000-00020

    authors: Sieber FE,Brown PR,Wu Y,Koehler RC,Traystman RJ

    更新日期:1993-11-01 00:00:00

  • "Opt Out" and Access to Anesthesia Care for Elective and Urgent Surgeries among U.S. Medicare Beneficiaries.

    abstract:BACKGROUND:In 2001, the Centers for Medicare and Medicaid Services issued a rule allowing U.S. states to "opt out" of the regulations requiring physician supervision of nurse anesthetists in an effort to increase access to anesthesia care. Whether "opt out" has successfully achieved this goal remains unknown. METHODS:...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000001504

    authors: Sun EC,Dexter F,Miller TR,Baker LC

    更新日期:2017-03-01 00:00:00

  • Improved postoperative outcomes associated with preoperative statin therapy.

    abstract::Statin therapy is well established for prevention of cardiovascular disease. Statins may also reduce postoperative mortality and morbidity via a pleiotropic (non-lipid-lowering) effect. The authors conducted a meta-analysis to determine the influence of statin treatment on adverse postoperative outcomes in patients un...

    journal_title:Anesthesiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/00000542-200612000-00027

    authors: Hindler K,Shaw AD,Samuels J,Fulton S,Collard CD,Riedel B

    更新日期:2006-12-01 00:00:00

  • Dextrose affects gravitational spread of epidural anesthesia.

    abstract::Chloroprocaine, 0.5 per cent, with physiologic saline solution, has a specific gravity of 1.007 and a osmolarity of 283 mOsm/l, which increase to a specific gravity of 1.025 and an osmolarity of 542 mOsm/l when chloroprocaine is prepared in dextrose, 5 per cent. Chloroprocaine, 2.7 per cent, shows similar increases in...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198005000-00014

    authors: Park YR,Eastwood DW

    更新日期:1980-05-01 00:00:00

  • Newborn blood levels of lidocaine and mepivacaine in the first postnatal day following maternal epidural anesthesia.

    abstract::Distribution and elimination of lidocaine and mepivacaine were studies in 114 subjects after obstetric epidural anesthesia, Epinephrine significantly lowered the concentrations of lidocaine in the mothers' circulations by about 33 per cent, and the concentrations of mepivacaine by about 22 per cent. It also significan...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-197506000-00014

    authors: Brown WU,Bell GC,Lurie AO,Weiss B,Scanlon JW,Alper MH

    更新日期:1975-06-01 00:00:00

  • Nitrogen analyzer adaptation for use in the presence of halogenated anesthetics.

    abstract::Interposition of activated carbon between a nitrogen analyzer needle valve and gas mixtures containing halothane, methoxyflurane, enflurane, or isoflurane eliminated the interfering effects of these agents, but added sampling delays. Placement of a carbon-filled Swinney adaptor in the sampling line between the needle ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-197512000-00014

    authors: Gilmour IJ,Holland R,Craig DB

    更新日期:1975-12-01 00:00:00

  • A Clinical Trial to Detect Subclinical Transfusion-induced Lung Injury during Surgery.

    abstract:BACKGROUND:Transfusion-related acute lung injury incidence remains the leading cause of posttransfusion mortality. The etiology may be related to leukocyte antibodies or biologically active compounds in transfused plasma, injuring susceptible recipient's lungs. The authors have hypothesized that transfusion could have ...

    journal_title:Anesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ALN.0000000000000689

    authors: Feiner JR,Gropper MA,Toy P,Lieberman J,Twiford J,Weiskopf RB

    更新日期:2015-07-01 00:00:00

  • The well-being model: a new drug interaction model for positive and negative effects.

    abstract:BACKGROUND:Drugs are routinely combined in anesthesia and pain management to obtain an enhancement of the desired effects. However, a parallel enhancement of the undesired effects might take place as well, resulting in a limited therapeutic usefulness. Therefore, when addressing the question of optimal drug combination...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200604000-00019

    authors: Zanderigo E,Sartori V,Sveticic G,Bouillon T,Schumacher P,Morari M,Curatolo M

    更新日期:2006-04-01 00:00:00

  • Factors associated with postoperative exacerbation of sleep-disordered breathing.

    abstract:INTRODUCTION:The knowledge on the mechanism of the postoperative exacerbation of sleep-disordered breathing may direct the perioperative management of patients with obstructive sleep apnea. The objective of this study is to investigate the factors associated with postoperative severity of sleep-disordered breathing. M...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000000041

    authors: Chung F,Liao P,Elsaid H,Shapiro CM,Kang W

    更新日期:2014-02-01 00:00:00

  • Cerebral extracellular glucose and lactate concentrations during and after moderate hypoxia in glucose- and saline-infused rats.

    abstract::To assess the effect of a glucose infusion on brain extracellular fluid (ECF) during systemic hypoxia, changes in glucose and lactate concentrations in cerebral ECF during and after moderate hypoxic hypoxia were measured in adult, conscious, unrestrained rats, with a microdialysis probe in the posterior hippocampus. T...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199210000-00017

    authors: Harada M,Okuda C,Sawa T,Murakami T

    更新日期:1992-10-01 00:00:00

  • Development and feasibility of a scale to assess postoperative recovery: the post-operative quality recovery scale.

    abstract:BACKGROUND:Good postoperative recovery is increasingly recognized as an important outcome after surgery. The authors created a new Post-operative Quality Recovery Scale (PQRS) that tracks multiple domains of recovery from immediate to long-term time periods in patients of varying ages, languages, and cultures. METHODS...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e3181d960a9

    authors: Royse CF,Newman S,Chung F,Stygall J,McKay RE,Boldt J,Servin FS,Hurtado I,Hannallah R,Yu B,Wilkinson DJ

    更新日期:2010-10-01 00:00:00

  • Endothelial glycocalyx as an additional barrier determining extravasation of 6% hydroxyethyl starch or 5% albumin solutions in the coronary vascular bed.

    abstract:BACKGROUND:The impact on the endothelial glycocalyx for the extravasation of colloidal infusion solutions has not been investigated sufficiently. METHODS:Isolated guinea pig hearts were perfused with Krebs-Henseleit buffer in a Langendorff mode. Solutions of 0.9% saline, 5% albumin (70 kd), or 6% hydroxyethyl starch (...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200405000-00025

    authors: Rehm M,Zahler S,Lötsch M,Welsch U,Conzen P,Jacob M,Becker BF

    更新日期:2004-05-01 00:00:00

  • Electrophysiologic characteristics of large neurons in dorsal root ganglia during development and after hind paw incision in the rat.

    abstract:BACKGROUND:Withdrawal thresholds in the paw are lower in younger animals, and incision further reduces these thresholds. The authors hypothesized that these differences result in part from changes in intrinsic electrophysiologic properties of large neurons. METHODS:Using isolated whole dorsal root ganglion, current cl...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e31817c1ab9

    authors: Ririe DG,Liu B,Clayton B,Tong C,Eisenach JC

    更新日期:2008-07-01 00:00:00

  • Effects of nitrous oxide on human regional cerebral blood flow and isolated pial arteries.

    abstract:BACKGROUND:Results from previous studies on the effect of nitrous oxide (N2O) on the cerebral circulation are conflicting. Early reports claim N2O to have no effect whereas recent findings demonstrate a cerebral cortical vasodilatation during N2O inhalation, but the regional cerebral blood flow (CBF) in the subcortical...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199408000-00018

    authors: Reinstrup P,Ryding E,Algotsson L,Berntman L,Uski T

    更新日期:1994-08-01 00:00:00

  • Identification of two mutations (F758W and F758Y) in the N-methyl-D-aspartate receptor glycine-binding site that selectively prevent competitive inhibition by xenon without affecting glycine binding.

    abstract:BACKGROUND:Xenon is a general anesthetic with neuroprotective properties. Xenon inhibition at the glycine-binding site of the N-Methyl-D-aspartate (NMDA) receptor mediates xenon neuroprotection against ischemic injury in vitro. Here we identify specific amino acids important for xenon binding to the NMDA receptor, with...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e31825ada2e

    authors: Armstrong SP,Banks PJ,McKitrick TJ,Geldart CH,Edge CJ,Babla R,Simillis C,Franks NP,Dickinson R

    更新日期:2012-07-01 00:00:00

  • Effect of halothane anesthesia on glucose utilization and production in adolescents.

    abstract:BACKGROUND:It should be possible to avoid variations in plasma glucose concentration during anesthesia by adjusting glucose infusion rate to whole-body glucose uptake. To study this hypothesis, we measured glucose utilization and production, before and during halothane anesthesia. METHODS:After an overnight fast, six ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199505000-00010

    authors: Sbaï D,Jouvet P,Soulier A,Pénicaud L,Merckx J,Bresson JL

    更新日期:1995-05-01 00:00:00

  • Recurrent hypoxia in rats during development increases subsequent respiratory sensitivity to fentanyl.

    abstract:BACKGROUND:In children with a history of significant obstructive sleep apnea who undergo adenotonsillectomy, postsurgical administration of opiates has been alleged to be associated with an increased risk for respiratory complications, including respiratory depression. The authors hypothesize that this association is d...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200610000-00017

    authors: Moss IR,Brown KA,Laferrière A

    更新日期:2006-10-01 00:00:00

  • Primer of postoperative pruritus for anesthesiologists.

    abstract::Postoperative itching is an important problem in the postoperative care unit. Pruritus after surgery may be drug induced (including intrathecal opioids) or secondary to a preexisting systemic disease. Mechanisms of itching are complex and not completely understood. The purpose of this review is to highlight new discov...

    journal_title:Anesthesiology

    pub_type: 杂志文章,评审

    doi:10.1097/00000542-200507000-00025

    authors: Waxler B,Dadabhoy ZP,Stojiljkovic L,Rabito SF

    更新日期:2005-07-01 00:00:00

  • Noninvasive Tracking of Anesthesia Neurotoxicity in the Developing Rodent Brain.

    abstract:BACKGROUND:Potential deleterious effect of multiple anesthesia exposures on the developing brain remains a clinical concern. We hypothesized that multiple neonatal anesthesia exposures are more detrimental to brain maturation than an equivalent single exposure, with more pronounced long-term behavioral consequences. We...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000002229

    authors: Makaryus R,Lee H,Robinson J,Enikolopov G,Benveniste H

    更新日期:2018-07-01 00:00:00