Abstract:
:To assess the effect of a glucose infusion on brain extracellular fluid (ECF) during systemic hypoxia, changes in glucose and lactate concentrations in cerebral ECF during and after moderate hypoxic hypoxia were measured in adult, conscious, unrestrained rats, with a microdialysis probe in the posterior hippocampus. The rats were given either saline (n = 6) or 50% glucose solution (n = 6) for 3 h, starting 60 min before the onset of hypoxia. Hypoxia was produced by circulating 7% O2 gas in a plastic chamber for 90 min. In saline-infused animals, brain ECF glucose concentrations decreased slightly during hypoxia, although blood glucose concentrations did not change. Blood lactate concentrations increased to 6.28 +/- 0.91 mM, at 60 min after the onset of hypoxia (P less than 0.05). Brain ECF lactate concentrations increased to 3.53 +/- 0.20 mM and remained constant during 60 min of steady-state hypoxia (P less than 0.05) and decreased to the basal level within 60 min after the end of hypoxia. When sodium lactate solution was infused intravenously for 90 min (n = 4), blood lactate concentrations increased to a level as high as those found during hypoxia. However, the brain ECF lactate concentration increased only to 1.86 +/- 0.09 mM. In glucose-infused animals, the blood glucose concentration reached 339.1 +/- 32.3 mg/dl at the end of the glucose infusion, and the brain ECF glucose concentration increased to 54.7 +/- 7.3 mg/dl.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Harada M,Okuda C,Sawa T,Murakami Tdoi
10.1097/00000542-199210000-00017subject
Has Abstractpub_date
1992-10-01 00:00:00pages
728-34issue
4eissn
0003-3022issn
1528-1175journal_volume
77pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract::To study the effect of halothane on the coronary circulation, the circumflex diastolic coronary vascular resistance was measured in the working heart and total mean coronary resistance (TCR) in the isolated nonworking heart of the dog during administration of 100 per cent oxygen and during administration of 2--3 per c...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197704000-00002
更新日期:1977-04-01 00:00:00
abstract::The relationship of train-of-four (TOF) ratio to the depression of the first twitch (TD) was investigated in 16 patients given pancuronium in doses insufficient to eliminate the fourth response in the train. In ten patients the block was allowed to spontaneously recover (Group 1) and in six it was reversed with neosti...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198612000-00003
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:Ca is the dominant second messenger in primary sensory neurons. In addition, disrupted Ca signaling is a prominent feature in pain models involving peripheral nerve injury. Standard cytoplasmic Ca recording techniques use high K or field stimulation and dissociated neurons. To compare findings in intact dors...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181e0ef3f
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Electrical stimulation of acupuncture point P6 reduces the incidence of postoperative nausea or vomiting (PONV) in adult patients. However, acupressure, laser stimulation of P6, and acupuncture during anesthesia have not been effective for reducing PONV in the pediatric population. The authors studied the ef...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200202000-00013
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Pain and nausea are the most common challenges in postoperative recovery after mastectomy. Preventive measures include multimodal analgesia with preoperative glucocorticoid. The aim of this study was to investigate whether 24 mg of preoperative dexamethasone was superior to 8 mg on early recovery after maste...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000003112
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Studies have shown that long-term increase in the excitability of single wide dynamic range neurones in the spinal dorsal horn of rats may be induced after tetanic stimulation to the sciatic nerve. This sensory event is possibly an in vivo counterpart of long-term potentiation, described in the brain. This s...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200001000-00025
更新日期:2000-01-01 00:00:00
abstract::No significant change in pseudocholinesterase levels was observed in random specimens of whole blood stored for as long as 30 days. Levels in plasma anticoagulated with heparin or ethylenediaminetetraacetic acid declined only slightly. Therefore, massive transfusions do not contraindicate succinylcholine administratio...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197605000-00014
更新日期:1976-05-01 00:00:00
abstract:BACKGROUND:Propofol and isoflurane anesthesia were studied previously with functional brain imaging in humans to begin identifying key brain areas involved with mediating anesthetic-induced unconsciousness. The authors describe an additional positron emission tomography study of halothane's in vivo cerebral metabolic e...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199903000-00011
更新日期:1999-03-01 00:00:00
abstract::Groups of rats were exposed to air or 80 per cent nitrous oxide for 30 min or 18 h, following which the brainstem opiate receptor density and the apparent affinity of these receptors to the radiolabeled agonist, 3H-dihydromorphine, were assayed, Thirty-minute exposure to nitrous oxide did not change opiate receptor ch...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198207000-00008
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND:Lamotrigine is a sodium channel blocker that inhibits the neuronal release of glutamate. Systemic administration of lamotrigine induces analgesia in short- and long-term models of hyperalgesia in rats. Considering the key role of N-methyl-D-aspartate receptors in the sensitization of dorsal horn neurons that...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199802000-00028
更新日期:1998-02-01 00:00:00
abstract::Transient hyperreflexia, the Babinski reflex, and other transient neurologic signs may follow anesthesia in healthy persons. The authors describe the appearance and durations of these signs and relate them to anesthetic agent, time following cessation of anesthesia, and state of arousal. Twenty-nine neurologically nor...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198102000-00005
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:Tracheal intubation frequently results in reversible bronchoconstriction. Propofol has been reported to minimize this response in healthy patients and in asthma patients, but may be unsuitable for hemodynamically unstable patients for whom etomidate may be preferable. The current study examined respiratory r...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199606000-00005
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:The neural mechanisms underlying the modulation of pain perception by hypnosis remain obscure. In this study, we used positron emission tomography in 11 healthy volunteers to identify the brain areas in which hypnosis modulates cerebral responses to a noxious stimulus. METHODS:The protocol used a factorial ...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1097/00000542-200005000-00013
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:To compare continuous cardiac output obtained by simulation of an aortic input impedance model to bolus injection thermodilution (TDCO) in critically ill patients with septic shock. METHODS:In an open study, mechanically ventilated patients with septic shock were monitored for 1 (32 patients), 2 (15 patient...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199905000-00016
更新日期:1999-05-01 00:00:00
abstract::Hepatic venous oxygen saturation (ShvO2) was continuously monitored in 33 consecutive patients undergoing hepatic lobectomy. Fiberoptic pulmonary artery catheters were inserted into the hepatic vein (HV) and in the pulmonary artery through the right internal jugular vein before anesthetic induction. The success rate a...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199101000-00009
更新日期:1991-01-01 00:00:00
abstract::In order to determine whether or not irritation of the nasal passage with commonly used volatile anesthetics can elicit airway reflexes, we investigated respiratory, laryngeal, and tracheal responses to nasal insufflation of three volatile anesthetics (enflurane, isoflurane, and halothane) in 13 patients anesthetized ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199109000-00010
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Medical errors exact an inordinate toll on healthcare costs. One of the most publicized and analyzed type of medical error is wrong-site surgery. Yet, despite the burgeoning number of procedures performed, no literature exists on wrong-site pain management injections. The purpose of this study was to estimat...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/ALN.0b013e3181cf892d
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Positive end expiratory pressure (PEEP) is an important component of therapy in patients with acute lung injury or acute respiratory distress syndrome. The independent effect of PEEP on mortality is currently unknown. METHODS:A systematic review and meta-analysis of randomized controlled clinical trials com...
journal_title:Anesthesiology
pub_type: 杂志文章,meta分析,评审
doi:10.1097/ALN.0b013e31819fae06
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Hemodilution (HD) with oxyhemoglobin colloid (oxyHb) provides a greater arterial oxygen content (CaO2) than HD with conventional colloids; however, oxygen delivery (DO2) is essentially the same, because, in contrast to conventional HD, cardiac output (CO) is not augmented. This study seeks to elucidate the m...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199307000-00011
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:The dorsal horn of the spinal cord is a pivotal point for transmission of neuronal pain. During spinal and epidural anesthesia, the neurons of the dorsal horn are exposed to local anesthetics. Unfortunately, little is known about the action of local anesthetics on the major ionic conductances in dorsal horn ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199801000-00025
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Plasminogen activator inhibitor 1 (PAI-1) attenuates the conversion of plasminogen to plasmin. Polymorphisms of the PAI-1 gene are associated with varying PAI-1 levels and risk of prothrombotic events in nonsurgical patients. The purpose of this study, a secondary analysis of a clinical trial, was to investi...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e318167aecc
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:The concept of the axillary "sheath" has been a central tenet of brachial plexus regional anesthesia for many years. Recent investigations have cast doubt on its nature and existence. This study further examines the issue. METHODS:Computerized axial tomographic dye studies were performed using continuous ca...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200609000-00021
更新日期:2006-09-01 00:00:00
abstract::Substance abuse is a major socioeconomic problem. However, the ready availability of potent narcotic and sedative drugs probably constitutes a unique risk for anesthesiologists. Until recently, few anesthesia departments were prepared to recognize or safely manage afflicted colleagues. Because we felt it important to ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198610000-00011
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:Our objective was to elucidate the direct effects of fentanyl and morphine on cardiac excitation-contraction coupling using individual, field-stimulated rat ventricular myocytes. METHODS:Freshly isolated myocytes were loaded with fura-2 and field stimulated (0.3 Hz) at 28 degrees C. Amplitude and timing of ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199812000-00033
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:Anesthesia personnel are at risk for occupational infection with bloodborne pathogens from contaminated percutaneous injuries (CPIs). Additional information is needed to formulate methods to reduce risk. METHODS:The authors analyzed CPIs collected during a 2-yr period at 11 hospitals, assessed CPI underrepo...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00000542-199812000-00013
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:N-methyl-D-aspartate (NDMA) antagonists have minimal effects on acute nociception but block facilitated states of processing. In contrast, the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) antagonists decrease acute noxious responses. Morphine (a mu-opioid agonist) can also decrease acute n...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199809000-00023
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Mortality after noncardiac surgery has been associated with the "triple low state," a combination of low mean arterial blood pressure (<75 mmHg), low bispectral index (<45), and low minimum alveolar concentration of volatile anesthesia (<0.70). The authors set out to determine whether duration of a triple lo...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000281
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Cerebrospinal fluid (CSF) outflow to intra- and extracranial subarachnoid spaces caused by arterial inflow to the brain predominantly compensates systolic increases in cerebral blood volume. Phase-contrast magnetic resonance imaging is a new tool for noninvasive assessment of CSF displacement by measuring CS...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199906000-00008
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:While persistent opioid use after surgery has been the subject of a large number of studies, it is unknown how much variability in the definition of persistent use impacts the reported incidence across studies. The objective was to evaluate the incidence of persistent use estimated with different definitions...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000003265
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Recent evidence indicates that vascular adenosine triphosphate-sensitive potassium (K(ATP)) channels in vascular smooth muscle cells are critical in the regulation of vascular tonus under both physiologic and pathophysiologic conditions. Studies of the interaction of volatile anesthetics with vascular K(ATP)...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/01.anes.0000265158.47556.73
更新日期:2007-05-01 00:00:00