Abstract:
BACKGROUND:Women generally report greater sensitivity to pain than do men, and healthy young women require 20% more anesthetic than healthy age-matched men to prevent movement in response to noxious electrical stimulation. In contrast, minimum alveolar concentration (MAC) for xenon is 26% less in elderly Japanese women than in elderly Japanese men. Whether anesthetic requirement is similar in men and women thus remains in dispute. The authors therefore tested the hypothesis that the desflurane concentration required to prevent movement in response to skin incision (MAC) differs between men and women. METHODS:Using the Dixon "up and down" method, the authors determined MAC for desflurane in 15 female and 15 male patients (18-40 yr old) undergoing surgery. RESULTS:MAC was 6.2 +/- 0.4% desflurane for women versus 6.0 +/- 0.3% for men (P = 0.31), a difference of only 3%. These data provide 90% power to detect a 9% difference between the groups. CONCLUSIONS:The MAC of desflurane did not differ between young men and women undergoing surgery with a true surgical incision. Although pain sensitivity may differ in women versus men, MAC of desflurane does not.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Wadhwa A,Durrani J,Sengupta P,Doufas AG,Sessler DIdoi
10.1097/00000542-200311000-00010subject
Has Abstractpub_date
2003-11-01 00:00:00pages
1062-5issue
5eissn
0003-3022issn
1528-1175pii
00000542-200311000-00010journal_volume
99pub_type
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