Abstract:
:Evidence of developmental toxicity of clinically used nondepolarizing muscle relaxants was sought in rat embryos grown in culture. Embryos were explanted at 8 AM on day 9 of gestation (presomite stage, plug day = day 0), and were cultured in rotating bottles with medium containing various concentrations of d-tubocurarine, pancuronium, atracurium, and vecuronium. At 10 AM on day 11 of gestation (forelimb bud stage), culture was terminated and embryos were examined for general morphology. Treatment with tested agents resulted in dose-dependent developmental toxicity; namely, growth retardation seen as decreased crown-rump length, decreased number of somite pairs, and morphologic abnormalities. However, the concentrations that caused toxicity were at least 30-fold greater than serum concentrations clinically achieved in the mother. We conclude that these muscle relaxants have a low potential for causing developmental toxicity during organogenesis.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Fujinaga M,Baden JM,Mazze RIdoi
10.1097/00000542-199206000-00021subject
Has Abstractpub_date
1992-06-01 00:00:00pages
999-1003issue
6eissn
0003-3022issn
1528-1175journal_volume
76pub_type
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