Abstract:
BACKGROUND:The diagnosis of an acute malignant hyperthermia reaction by clinical criteria can be difficult because of the nonspecific nature and variable incidence of many of the clinical signs and laboratory findings. Development of a standardized means for estimating the qualitative likelihood of malignant hyperthermia in a given patient without the use of specialized diagnostic testing would be useful for patient management and would promote research into improved means for diagnosing this disease. METHODS:Using the Delphi method and an international panel of 11 experts on malignant hyperthermia, a multifactor malignant hyperthermia clinical grading scale comprising standardized clinical diagnostic criteria was developed for classification of existing records and for application to new patients. RESULTS:This scale ranks the qualitative likelihood that an adverse anesthetic event represents malignant hyperthermia (malignant hyperthermia event rank) and that, with further investigation of family history, an individual patient will be diagnosed as malignant hyperthermia susceptible (malignant hyperthermia susceptibility rank). The assigned rank represents a lower bound on the likelihood of malignant hyperthermia. The clinical grading scale requires the anesthesiologist to judge whether specific clinical signs are appropriate for the patient's medical condition, anesthetic technique, and surgical procedure. CONCLUSIONS:The malignant hyperthermia clinical grading scale is recommended for use as an aid to the objective definition of this disease. It use may improve malignant hyperthermia research by allowing comparisons among well-defined groups of patients. This clinical grading system provides a new and comprehensive clinical case definition for the malignant hyperthermia syndrome.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Larach MG,Localio AR,Allen GC,Denborough MA,Ellis FR,Gronert GA,Kaplan RF,Muldoon SM,Nelson TE,Ording Hdoi
10.1097/00000542-199404000-00008subject
Has Abstract,Author List Incompletepub_date
1994-04-01 00:00:00pages
771-9issue
4eissn
0003-3022issn
1528-1175journal_volume
80pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract:BACKGROUND:The authors sought to determine whether subjects with pathophysiological conditions that are characterized by increased concentrations of aldosterone have increased susceptibility to the side effects of neonatal anesthesia with sevoflurane. METHODS:Postnatal day 4-20 (P4-P20) rats were exposed to sevofluran...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e318266c62d
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Because patients may be taking clonidine chronically or may be receiving it as a premedication before surgery, the authors investigated its effect on cerebral hemodynamics. METHODS:In nine volunteers, middle cerebral artery mean blood flow velocity (Vm) was measured using transcranial Doppler ultrasonograph...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199709000-00015
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Cerebral embolization is a primary cause of cardiac surgical neurologic morbidity. During cardiopulmonary bypass (CPB), there are well-defined periods of embolic risk. In theory, cerebral embolization might be reduced by an increase in pump flow during these periods. The purpose of this study was to determin...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199911000-00031
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Propofol (2,6-diisopropylphenol) is one of the most frequently used anesthetic agents. One of the main side effects of propofol is to reduce blood pressure, which is thought to occur by inhibiting the release of catecholamines from sympathetic neurons. Here, the authors hypothesized that propofol-induced hyp...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001015
更新日期:2016-04-01 00:00:00
abstract::Using a randomized double-blind protocol, the authors prospectively compared three nondepolarizing muscle relaxants with respect to their influence on hemodynamics and on the electrocardiogram. Thirty-three patients undergoing elective coronary artery bypass grafting (CABG) with high-dose (100 micrograms/kg) fentanyl ...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-198506000-00003
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND:Sugammadex (Org 25969) forms a complex with steroidal neuromuscular blocking agents, thereby reversing neuromuscular block. This study investigated the dose-response relation, safety, and pharmacokinetics of sugammadex to reverse rocuronium-induced block. METHODS:Twenty-seven male surgical patients aged 18-...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/00000542-200604000-00009
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:A decrease in radial artery blood pressure relative to central arterial blood pressure is commonly associated with the rewarming phase of cardiopulmonary bypass. Decreased hand vascular resistance has been suggested as a possible mechanism. Although decreased blood viscosity due to hemodilution may contribut...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199412000-00016
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Halothane and isoflurane have been shown to differentially effect mechanisms of contraction in working myocardial fibers. The aim of this study was to compare effects of halothane and isoflurane on contractile force (CF) and Ca2+ transients in canine cardiac Purkinje fiber preparations. METHODS:Fiber prepar...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199406000-00024
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:The authors explored the database of the first International Study of Postoperative Cognitive Dysfunction study to specify the domains of cognitive function that were most vulnerable and to determine the pattern of deterioration in patients with preoperative cognitive impairment. METHODS:One thousand two hu...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/00000542-200703000-00006
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:The general anesthetics, isoflurane and sevoflurane, cause developmental abnormalities in neonatal animal models via incompletely understood mechanisms. Despite many common molecular targets, isoflurane and sevoflurane exhibit substantial differences in their actions. The authors sought to determine whether ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e318291c04e
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Physiologic data that is automatically collected during anesthesia is widely used for medical record keeping and clinical research. These data contain artifacts, which are not relevant in clinical care, but may influence research results. The aim of this study was to explore the effect of different methods o...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000003131
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:The aim of this study was to characterize cervical cord, root, and bony spine claims in the American Society of Anesthesiologists Closed Claims database to formulate hypotheses regarding mechanisms of injury. METHODS:All general anesthesia claims (1970-2007) in the Closed Claims database were searched to id...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3182104859
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:This study investigated the ability of the modified continual reassessment method (MCRM) to determine the maximum tolerated dose of the opioid antagonist nalmefene, which does not reverse analgesia in an acceptable number of postoperative patients receiving epidural fentanyl in 0.075% bupivacaine. METHODS:I...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1097/00000542-200004000-00018
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:Fluid resuscitation in hemorrhagic shock aims to restore hemodynamics and repair altered microcirculation. Hemodynamic coherence is the concordant performance of macro- and microcirculation. The present study on fluid therapy in hemorrhagic shock hypothesized that the choice of fluid (0.9% sodium chloride [s...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002998
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Knowledge of normal front teeth-to-carina distance (FT-C) might prevent accidental bronchial intubation. The aim of the current study was to measure FT-C and to examine whether the Morgan formula for oral intubation depth, i.e., endotracheal tube (ETT) position at front teeth (cm) = 0.10 x height (cm) + 5, g...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181730288
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Ketamine is often administered to patients in whom hemodynamic instability is suspected. This study was designed to investigate the effect and possible site of action of ketamine on baroreflex response in rats. The site focused upon was the N-methyl-D-aspartate (NMDA) receptor of the nucleus tractus solitari...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199301000-00022
更新日期:1993-01-01 00:00:00
abstract::It is now well established that the pathophysiology of the malignant hyperthermia (MH) syndrome is related to a malfunction of intracellular calcium homeostasis. Magnesium plays important roles in the basic contractile properties of muscle, and many of its actions are antagonistic to those of calcium. The aim of this ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199007000-00016
更新日期:1990-07-01 00:00:00
abstract::The neuromuscular and cardiovascular effects of mivacurium chloride (BW B1090U) were evaluated in 90 children (2-12 yr) during N2O:O2 halothane or N2O:O2 narcotic anesthesia. Neuromuscular response was evaluated by recording the force of contraction of the adductor of the thumb during train-of-four stimulation at 0.1 ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198902000-00010
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:Nonimmobilizers are agents that lack anesthetic properties, although their chemical structure is very similar to known anesthetics. The primary action site of both agents, whether at the membrane or target protein level, is still a matter of debate. However, increasing evidence points to the distinct modific...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200210000-00016
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:In vitro studies have shown that isoflurane, enflurane, and halothane inhibit the hypoxic pulmonary vasoconstriction (HPV) with essentially the same potency. The aim of this study is to compare the effects of sevoflurane and isoflurane on HPV in constant-flow perfused rabbit lungs. METHODS:Constant-flow per...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199312000-00026
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Anesthetics are protective during ischemic-reperfusion injury and associated inflammation; therefore, the authors hypothesized that anesthetic pretreatment may provide protection in culture from cytokine-induced cell death. METHODS:Rat vascular smooth muscle (VSM) cell and human umbilical vascular endotheli...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200207000-00005
更新日期:2002-07-01 00:00:00
abstract::The effect of halothane, at clinically relevant concentrations on the ability of human polymorphonuclear leukocytes (PMNL) to kill the most frequently isolated gram-negative organisms responsible for human bacteremias, Escherichia coli and Klebsiella pneumoniae, was studied. Exposure of PMNL to 0.75 per cent halothane...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198155060-00009
更新日期:1981-12-01 00:00:00
abstract:BACKGROUND:Propofol has not been studied directly in animals subject to cerebral ischemia in the conscious state. Strokes are usually induced in animals while they are anesthetized, making it difficult to eliminate anesthetic interactions as a complicating factor. Therefore, to compare the neuroprotective effects of pr...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200205000-00023
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:Controversy exists regarding the effectiveness of propofol to prevent postoperative nausea and vomiting. This prospective, randomized, single-blinded study was designed to evaluate the antiemetic effectiveness of 0.5 mg/kg propofol when administered intravenously after sevoflurane- compared with desflurane-b...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199810000-00007
更新日期:1998-10-01 00:00:00
abstract:INTRODUCTION:The knowledge on the mechanism of the postoperative exacerbation of sleep-disordered breathing may direct the perioperative management of patients with obstructive sleep apnea. The objective of this study is to investigate the factors associated with postoperative severity of sleep-disordered breathing. M...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000041
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Patient blood management combines the use of several transfusion alternatives. Integrated use of erythropoietin, cell saver, and/or postoperative drain reinfusion devices on allogeneic erythrocyte use was evaluated using a restrictive transfusion threshold. METHODS:In a factorial design, adult elective hip-...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/ALN.0000000000000134
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:It is not always possible to predict when tracheal intubation will be difficult or impossible. The authors wanted to determine whether indirect laryngoscopy could identify patients in whom intubation was difficult. METHODS:Indirect laryngoscopy was done in 2,504 patients. The Wilson risk sum score and the m...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199702000-00007
更新日期:1997-02-01 00:00:00
abstract::The effects of anesthetic drugs on lipid order were evaluated by the fluorescence polarization of the probe molecule, 1,6-diphenyl-1,3,5-hexatriene (DPH) incorporated into vesicles of dimyristoylphosphatidylcholine (DMPC) and DMPC with 10 mol% ganglioside (GD1a). Anesthetics (enflurane, chloroform, diethylether, pento...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198502000-00003
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:Preterm and ex-preterm infants are at risk for life-threatening apnea after general anesthesia. The authors attempted to define the postconceptual age beyond which apnea is less likely to occur and to identify the factors that predispose to postanesthetic apnea. METHODS:Ninety-one infants younger than 60 we...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199306000-00009
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:Acid aspiration into one lung causes contralateral lung injury and systemic organ injury; this injury is thought to be mediated by the sequestration of activated neutrophils. Recombinant human soluble complement receptor 1 (sCR1) inhibits both the classical and alternative complement pathways; this study inv...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199611000-00021
更新日期:1996-11-01 00:00:00