Differential effects of halothane and isoflurane on contractile force and calcium transients in cardiac Purkinje fibers.

Abstract:

BACKGROUND:Halothane and isoflurane have been shown to differentially effect mechanisms of contraction in working myocardial fibers. The aim of this study was to compare effects of halothane and isoflurane on contractile force (CF) and Ca2+ transients in canine cardiac Purkinje fiber preparations. METHODS:Fiber preparations (n = 29) were superfused with Krebs-Ringer solution and stimulated at 40-60 pulses/min at 30 degrees C in the absence and presence of 0.55% and 1.01% isoflurane or 0.27% and 0.78% halothane. Isometric tension (CF), and intracellular Ca2+ transients (luminescence, L) were measured after microinjecting the Ca2+ sensitive photoprotein aequorin into Purkinje fibers. Peak CF and peak L, rate of rise (slope) of CF and L, time to attain peak CF and L, and duration of CF and L at half-peak CF and L, were measured at 5 mM extracellular CaCl2. Changes in peak CF and peak L also were measured during incremental increases in CaCl2 from 3.6 to 9.0 mM. RESULTS:Both anesthetics depressed peak CF and peak L and the rate of increase in peak CF and L in a concentration-dependent fashion, and effects of halothane were greater than those of isoflurane. Time to attain peak L and duration of L at half-peak L was decreased or unchanged by isoflurane and was increased by halothane, whereas time to attain peak CF and duration of CF at half-peak CF was shortened by both. The change in peak CF response as a function of the change in peak L with increasing extracellular CaCl2 was attenuated similarly by both halothane and isoflurane. CONCLUSIONS:Halothane depresses peak CF and Ca2+ transients and prolongs Ca2+ transients more than does isoflurane at equivalent minimum alveolar concentration in Purkinje fibers. This suggests Ca2+ concentration is differentially altered by anesthetics in this tissue. Peak CF at equivalent peak Ca2+ transients, however, appears to be attenuated similarly by both anesthetics. These differences in anesthetic effect are qualitatively similar to those found in cardiac tissue of other species. These findings add to our understanding of effects of volatile anesthetics on contractile properties and myoplasmic Ca2+ in cardiac Purkinje fibers.

journal_name

Anesthesiology

journal_title

Anesthesiology

authors

Stowe DF,Sprung J,Turner LA,Kampine JP,Bosnjak ZJ

doi

10.1097/00000542-199406000-00024

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

1360-8

issue

6

eissn

0003-3022

issn

1528-1175

journal_volume

80

pub_type

杂志文章
  • Electroacupuncture improves survival in rats with lethal endotoxemia via the autonomic nervous system.

    abstract:BACKGROUND:Recent advances have indicated a complex interplay between the autonomic nervous system and the innate immune system. Targeting neural networks for the treatment of sepsis is being developed as a therapeutic strategy. Because electroacupuncture at select acupoints can modulate activities of the autonomic ner...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e3182426ebd

    authors: Song JG,Li HH,Cao YF,Lv X,Zhang P,Li YS,Zheng YJ,Li Q,Yin PH,Song SL,Wang HY,Wang XR

    更新日期:2012-02-01 00:00:00

  • Acute pain management. Programs in U.S. hospitals and experiences and attitudes among U.S. adults.

    abstract:BACKGROUND:The objective of the survey was to assess the status of acute pain management in U.S. hospitals and attitudes of adults in the U.S. toward postoperative pain management, information that has not been previously available. METHODS:Two telephone questionnaire surveys were conducted U.S. hospital participants,...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199511000-00023

    authors: Warfield CA,Kahn CH

    更新日期:1995-11-01 00:00:00

  • Effects of halothane on the sarcoplasmic reticulum Ca2+ stores and contractile proteins in rabbit pulmonary arteries.

    abstract:BACKGROUND:The authors' purpose of this study was to elucidate the mechanisms of direct effects of halothane on the contractile proteins and Ca2+ release from the sarcoplasmic reticulum Ca2+ stores using isolated skinned strips (sarcolemma permealized with saponin) from rabbit pulmonary arteries. METHODS:The sarcoplas...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199804000-00031

    authors: Su JY,Tang LJ

    更新日期:1998-04-01 00:00:00

  • Hypothermic modulation of cerebral ischemic injury during cardiopulmonary bypass in pigs.

    abstract:BACKGROUND:The aim of this study was to determine whether progressive levels of hypothermia (37, 34, 31, or 28 degrees C) during cardiopulmonary bypass (CPB) in pigs reduce the physiologic and metabolic consequences of global cerebral ischemia. METHODS:Sagittal sinus and cortical microdialysis catheters were inserted ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199802000-00018

    authors: Conroy BP,Lin CY,Jenkins LW,DeWitt DS,Zornow MH,Uchida T,Johnston WE

    更新日期:1998-02-01 00:00:00

  • Response to mivacurium in a patient compound heterozygous for a novel and a known silent mutation in the butyrylcholinesterase gene: genotyping by sequencing.

    abstract:BACKGROUND:Patients who are homozygous for the atypical mutation, compound heterozygous for atypical and silent mutations, or homozygous for silent mutations (SS) respond to mivacurium with extensively prolonged neuromuscular block. Although important, exact phenotyping of these patients is difficult. This article pres...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200109000-00010

    authors: Gätke MR,Ostergaard D,Bundgaard JR,Varin F,Viby-Mogensen J

    更新日期:2001-09-01 00:00:00

  • Brain stem opioidergic and GABAergic neurons mediate the antinociceptive effect of nitrous oxide in Fischer rats.

    abstract:BACKGROUND:Recent studies have revealed that N2O exerts its antinociceptive effect by inducing opioid peptide release in the brain stem, thereby activating the descending noradrenergic inhibitory neurons, which modulate pain processing in the spinal cord. However, the precise neuronal pathways that mediate these events...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200310000-00030

    authors: Ohashi Y,Guo T,Orii R,Maze M,Fujinaga M

    更新日期:2003-10-01 00:00:00

  • Assessment of competency in anesthesiology.

    abstract::Assessment of competency in traditional graduate medical education has been based on observation of clinical care and classroom teaching. In anesthesiology, this has been relatively easy because of the high volume of care provided by residents under the direct observation of faculty in the operating room. With the mov...

    journal_title:Anesthesiology

    pub_type: 杂志文章,评审

    doi:10.1097/01.anes.0000264778.02286.4d

    authors: Tetzlaff JE

    更新日期:2007-04-01 00:00:00

  • Association between Neuraxial Labor Analgesia and Neonatal Morbidity after Operative Vaginal Delivery.

    abstract:BACKGROUND:Up to 84% of women who undergo operative vaginal delivery receive neuraxial analgesia. However, little is known about the association between neuraxial analgesia and neonatal morbidity in women who undergo operative vaginal delivery. The authors hypothesized that neuraxial analgesia is associated with a redu...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000003589

    authors: Butwick AJ,Wong CA,Lee HC,Blumenfeld YJ,Guo N

    更新日期:2021-01-01 00:00:00

  • Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat.

    abstract:BACKGROUND:Repetitive C-fiber stimulation induces a state of facilitated processing of sensory information in the dorsal horn, while chronic nerve compression gives rise to a hyperalgesic state, characterized by spontaneous neuronal activity generated by voltage-sensitive sodium channels, as well as spinal facilitation...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:

    authors: Abram SE,Yaksh TL

    更新日期:1994-02-01 00:00:00

  • Lidocaine and pentylenetetrazol seizure thresholds in cats are not reduced after enflurane anesthesia.

    abstract::Some previous reports indicate that the excitability of the brain may be increased for days following enflurane anesthesia. The authors investigated this possibility in cats by determining whether or not pentylenetetrazol- (Metrazol) or lidocaine-seizure thresholds decreased after repeated enflurane exposure. The lido...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198105000-00010

    authors: Heavner JE,Amory DW

    更新日期:1981-05-01 00:00:00

  • Cerebral cortex activation during experimentally induced ventilator fighting in normal humans receiving noninvasive mechanical ventilation.

    abstract:BACKGROUND:Mechanical ventilation is delivered to sedated patients during anesthesia, but also to nonsedated patients (ventilator weaning, noninvasive ventilation). In these circumstances, patient-ventilator asynchrony may occur, provoking discomfort and unduly increasing work of breathing. In certain cases, it is asso...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/01.anes.0000287005.58761.e8

    authors: Raux M,Ray P,Prella M,Duguet A,Demoule A,Similowski T

    更新日期:2007-11-01 00:00:00

  • Association between Use of Angiotensin-converting Enzyme Inhibitors or Angiotensin Receptor Blockers and Postoperative Delirium.

    abstract:BACKGROUND:Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers improve cognitive function. The authors therefore tested the primary hypothesis that preoperative use of angiotensin inhibitors is associated with less delirium in critical care patients. Post hoc, the association between postoperativ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000003329

    authors: Farag E,Liang C,Mascha EJ,Argalious MY,Ezell J,Maheshwari K,Esa WAS,Troianos CA,Sessler DI

    更新日期:2020-07-01 00:00:00

  • Effects of halothane and isoflurane on hyperexcitability of spinal dorsal horn neurons after incision in the rat.

    abstract:BACKGROUND:The aim of this study was to determine whether halothane and isoflurane used during and after surgical injury attenuate subsequent hyperexcitability of spinal dorsal horn (SDH) neurons by preventing development of central sensitization. METHODS:Activity of a wide-dynamic-range neuron of the SDH was isolated...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200501000-00025

    authors: Kawamata M,Narimatsu E,Kozuka Y,Takahashi T,Sugino S,Niiya T,Namiki A

    更新日期:2005-01-01 00:00:00

  • Transcutaneous cardiac pacing during thoracic surgery. Feasibility and hemodynamic evaluation by transesophageal echocardiography.

    abstract:BACKGROUND:Occasionally, emergency perioperative pacing is necessary. Transcutaneous cardiac pacing is noninvasive, safe, and readily available. Its feasibility and hemodynamic effects during thoracic surgery and one-lung ventilation have not been established. METHODS:Twenty anesthetized patients (aged 25-70 yr) witho...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000542-199310000-00013

    authors: Amar D,Gross JN,Burt M,Schwinger ME,Rusch VW,Reinsel RA

    更新日期:1993-10-01 00:00:00

  • Effects of propofol and thiopental in isolated rat aorta and pulmonary artery.

    abstract::This study was performed to determine if direct arterial dilating actions of propofol contribute to the drug's hypotensive actions. The effects of propofol were compared with those of thiopental on isolated vascular ring preparations from rat thoracic aorta and pulmonary artery. Thoracic aortic ring responses were eva...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199211000-00019

    authors: Park WK,Lynch C 3rd,Johns RA

    更新日期:1992-11-01 00:00:00

  • Are all preterm infants younger than 60 weeks postconceptual age at risk for postanesthetic apnea?

    abstract:BACKGROUND:Preterm and ex-preterm infants are at risk for life-threatening apnea after general anesthesia. The authors attempted to define the postconceptual age beyond which apnea is less likely to occur and to identify the factors that predispose to postanesthetic apnea. METHODS:Ninety-one infants younger than 60 we...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199306000-00009

    authors: Malviya S,Swartz J,Lerman J

    更新日期:1993-06-01 00:00:00

  • Anesthetic-induced improvement of the inflammatory response to one-lung ventilation.

    abstract:BACKGROUND:Although one-lung ventilation (OLV) has become an established procedure during thoracic surgery, sparse data exist about inflammatory alterations in the deflated, reventilated lung. The aim of this study was to prospectively investigate the effect of OLV on the pulmonary inflammatory response and to assess p...

    journal_title:Anesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ALN.0b013e3181a10731

    authors: De Conno E,Steurer MP,Wittlinger M,Zalunardo MP,Weder W,Schneiter D,Schimmer RC,Klaghofer R,Neff TA,Schmid ER,Spahn DR,Z'graggen BR,Urner M,Beck-Schimmer B

    更新日期:2009-06-01 00:00:00

  • Volatile anesthetics depress Ca2+ transients and glutamate release in isolated cerebral synaptosomes.

    abstract:BACKGROUND:The current study was performed to determine whether volatile anesthetics may include as part of their action in the central nervous system the depression of presynaptic transmitter release by alteration in intrasynaptic [Ca2+] ([Ca2+]i). METHODS:Guinea pig cerebrocortical synaptosomes were studied at 37 de...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199509000-00019

    authors: Miao N,Frazer MJ,Lynch C 3rd

    更新日期:1995-09-01 00:00:00

  • Complications of different ventilation strategies in endoscopic laryngeal surgery: a 10-year review.

    abstract:BACKGROUND:Spontaneous ventilation, mechanical controlled ventilation, apneic intermittent ventilation, and jet ventilation are commonly used during interventional suspension microlaryngoscopy. The aim of this study was to investigate specific complications of each technique, with special emphasis on transtracheal and ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200601000-00010

    authors: Jaquet Y,Monnier P,Van Melle G,Ravussin P,Spahn DR,Chollet-Rivier M

    更新日期:2006-01-01 00:00:00

  • Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery.

    abstract:BACKGROUND:Excessive bleeding often occurs during pediatric scoliosis surgery and is attributed to numerous factors, including accelerated fibrinolysis. The authors hypothesized that administration of tranexamic acid would reduce bleeding and transfusion requirements during scoliosis surgery. METHODS:Forty-four patien...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000542-200504000-00006

    authors: Sethna NF,Zurakowski D,Brustowicz RM,Bacsik J,Sullivan LJ,Shapiro F

    更新日期:2005-04-01 00:00:00

  • Pulmonary vascular effects of isoflurane anesthesia after left lung autotransplantation in chronically instrumented dogs.

    abstract:BACKGROUND:Single lung transplantation has become a viable therapy for treatment of end-stage pulmonary disease. We previously observed that left lung autotransplantation (LLA) results in a chronic increase in pulmonary vascular resistance and enhanced pulmonary vascular reactivity to sympathetic alpha adrenoreceptor a...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199609000-00019

    authors: Lennon PF,Murray PA

    更新日期:1996-09-01 00:00:00

  • Stability of pseudocholinesterase in stored blood.

    abstract::No significant change in pseudocholinesterase levels was observed in random specimens of whole blood stored for as long as 30 days. Levels in plasma anticoagulated with heparin or ethylenediaminetetraacetic acid declined only slightly. Therefore, massive transfusions do not contraindicate succinylcholine administratio...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-197605000-00014

    authors: Lanks KW,Sklar GS

    更新日期:1976-05-01 00:00:00

  • Xenon attenuates hippocampal long-term potentiation by diminishing synaptic and extrasynaptic N-methyl-D-aspartate receptor currents.

    abstract:BACKGROUND:The memory-blocking properties of general anesthetics are of high clinical relevance and scientific interest. The inhalational anesthetic xenon antagonizes N-methyl-D-aspartate (NMDA) receptors. It is unknown if xenon affects long-term potentiation (LTP), a cellular correlate for memory formation. In hippoca...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e3182475d66

    authors: Kratzer S,Mattusch C,Kochs E,Eder M,Haseneder R,Rammes G

    更新日期:2012-03-01 00:00:00

  • Comparison of the effects of racemic bupivacaine, levobupivacaine, and ropivacaine on ventricular conduction, refractoriness, and wavelength: an epicardial mapping study.

    abstract:BACKGROUND:The study was designed to compare the effects of equimolar concentrations of racemic bupivacaine, levobupivacaine, and ropivacaine on ventricular conduction, anisotropy, duration and homogeneity of refractoriness, and wavelengths, and to provide a potency ratio for effects on conduction velocity. METHODS:Is...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200203000-00021

    authors: Aya AG,de la Coussaye JE,Robert E,Ripart J,Cuvillon P,Mazoit JX,Jeannes P,Fabbro-Péray P,Eledjam JJ

    更新日期:2002-03-01 00:00:00

  • Ketanserin pretreatment reverses alfentanil-induced muscle rigidity.

    abstract::Systemic pretreatment with ketanserin, a relatively specific type-2 serotonin receptor antagonist, significantly attenuated the muscle rigidity produced in rats by the potent short-acting opiate agonist alfentanil. Following placement of subcutaneous electrodes in each animal's left gastrocnemius muscle, rigidity was ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198709000-00012

    authors: Weinger MB,Cline EJ,Smith NT,Koob GF

    更新日期:1987-09-01 00:00:00

  • Intranasal nicotine for postoperative pain treatment.

    abstract:BACKGROUND:Despite pharmacological treatment, 70-80% of patients report moderate to severe pain after surgery. Because nicotine has been reported to have analgesic properties in animal and human volunteer studies, the authors assessed the analgesic efficacy of a single 3 mg dose of nicotine nasal spray administered bef...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000542-200412000-00023

    authors: Flood P,Daniel D

    更新日期:2004-12-01 00:00:00

  • Anesthesia for creation of a forearm fistula in patients with endstage renal failure.

    abstract::The effects of local infiltration anesthesia, brachial plexus blockade, isoflurane, or halothane anesthesia on blood flow through the brachial artery and through a newly created forearm arteriovenous fistula (AVF) were compared in 36 patients with endstage renal failure. Brachial artery blood flow was measured at two ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198906000-00005

    authors: Mouquet C,Bitker MO,Bailliart O,Rottembourg J,Clergue F,Montejo LS,Martineaud JP,Viars P

    更新日期:1989-06-01 00:00:00

  • Sodium channel in human malignant hyperthermia.

    abstract:BACKGROUND:The abundance of a specific sodium channel subunit (SkM2) appeared to be altered in vitro in cell cultures from persons susceptible to malignant hyperthermia. This study sought to determine whether these findings are artifacts of cell culture or whether they may be relevant to malignant hyperthermia. METHOD...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199705000-00004

    authors: Fletcher JE,Wieland SJ,Karan SM,Beech J,Rosenberg H

    更新日期:1997-05-01 00:00:00

  • Propofol: its role in changing the practice of anesthesia.

    abstract::Pharmacokinetics and pharmacodynamics of propofol infusions during general anesthesia. By Audrey Shafer, Van A. Doze, Steven L. Shafer, and Paul F. White. Anesthesiology 1988; 69:348-56. Reprinted with permission.The pharmacokinetic and pharmacodynamic properties of propofol (Diprivan) were studied in 50 elective surg...

    journal_title:Anesthesiology

    pub_type: 古典文章,评论,杂志文章

    doi:10.1097/ALN.0b013e31818ddba8

    authors: White PF

    更新日期:2008-12-01 00:00:00

  • Radiologic localization of the laryngeal mask airway in children.

    abstract::In the absence of data on the anatomic localization of the cuff of the laryngeal mask airway (LMA) in children, radiologic images were obtained from 50 infants and children (aged 1 month to 15 yr) undergoing diagnostic radiologic procedures during halothane and N2O:O2 anesthesia. In 46 patients, the cuff of the LMA wa...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199212000-00007

    authors: Goudsouzian NG,Denman W,Cleveland R,Shorten G

    更新日期:1992-12-01 00:00:00