Abstract:
:Local glucose consumption within specific brain structures in awake and halothane-anesthetized primates was studied using a quantitative autoradiographic technique for glucose (14C-deoxyglucose). In both awake and anesthetized animals, significant heterogeneity (one-way analysis of variance) in uptake of glucose was found in the cortex, subcortical grey matter, and brainstem nuclei. No significant variability was found for any of the white matter areas sampled under either experimental condition. Halothane produced significant decreases in glucose metabolic rates in the occipital cortex, brainstem nuclei, cerebellar cortex, cerebellar white matter, and anterior commissure, compared with the awake state. The greatest decrease in cerebral metabolic rate was found in the occipital lobes of halothaneanesthetized animals. Results of this study suggest that neurophysiologic and behavioral changes that occur with anesthetic agents can, for the first time, be correlated with alterations in local cerebral glucose metabolism.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Shapiro HM,Greenberg JH,Reivich M,Ashmead G,Sokoloff Ldoi
10.1097/00000542-197802000-00004subject
Has Abstractpub_date
1978-02-01 00:00:00pages
97-103issue
2eissn
0003-3022issn
1528-1175journal_volume
48pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract:BACKGROUND:The effects of triiodothyronine (T3) on systemic hemodynamics, myocardial contractility (preload recruitable stroke work slope; Mw), and left ventricular (LV) isovolumic relaxation (time constant; tau) were examined before and after the development of pacing-induced cardiomyopathy in conscious dogs. METHODS...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199707000-00014
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Breastfeeding is an important public health concern. High cumulative doses of epidural fentanyl administered for labor analgesia have been reported to be associated with early termination of breastfeeding. We tested the hypothesis that breastfeeding success is adversely influenced by the cumulative epidural ...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000001793
更新日期:2017-10-01 00:00:00
abstract::Fentanyl is used as an analgesic in small doses (1-2 micrograms X kg-1) and as an anesthetic in very large doses (greater than 150 micrograms X kg-1). It has been demonstrated that the effects of fentanyl correlate with its concentrations in plasma. It is important, therefore, to know whether or not the pharmacokineti...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198312000-00009
更新日期:1983-12-01 00:00:00
abstract:BACKGROUND:It is increasingly important to evaluate patients' recovery after ambulatory surgery. The authors developed the Functional Recovery Index (FRI) to assess postdischarge functional recovery for ambulatory surgical patients. METHODS:The scale development involved four phases: item generation, item selection, r...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/ALN.0b013e318197a16d
更新日期:2009-03-01 00:00:00
abstract::Administration of the oxidant lipid peroxide tertiary butyl hydroperoxide (t-bu-OOH) in the isolated rabbit lung leads to acute pulmonary vasoconstriction, which is caused by the synthesis of thromboxane. The inhalational anesthetics, halothane, nitrous oxide, and cyclopropane, markedly enhance t-bu-OOH-induced pulmon...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198905000-00012
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:The tuberomammillary histaminergic neurons are involved in the sedative component of anesthetic action. The nucleus basalis magnocellularis (NBM) in the basal forebrain receives dense excitatory innervation from the tuberomammillary nucleus and is recognized as an important site of sleep-wake regulation. Thi...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181b061a0
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:We have previously shown that intralipid (lipid emulsion) protects the heart against ischemia/reperfusion injury and bupivacaine-induced cardiotoxicity. However, the precise underlying mechanisms are not fully understood. Here we explored the hypothesis that free fatty acid receptor-1 or G-protein-coupled re...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002195
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Lamotrigine is a sodium channel blocker that inhibits the neuronal release of glutamate. Systemic administration of lamotrigine induces analgesia in short- and long-term models of hyperalgesia in rats. Considering the key role of N-methyl-D-aspartate receptors in the sensitization of dorsal horn neurons that...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199802000-00028
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:Acid-sensing ion channel 3 (ASIC3) upregulation has been reported in dorsal root ganglion neurons after incision and contributes to postoperative nociception. This study hypothesized that upregulation of ASIC3 in incised tissues is induced by nerve growth factor through the phosphoinositide 3-kinase/protein ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000003576
更新日期:2020-12-01 00:00:00
abstract::Cardiac output and myocardial blood flow decrease dramatically in a dose-dependent pattern in the young lamb during isoflurane anesthesia. This raises important questions about the ability of the young lamb to increase myocardial performance if oxygen delivery were compromised by a decrease in oxygen content during an...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198911000-00020
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:Postoperative delirium is one of the most common complications in the elderly surgical population. However, its long-term outcomes remain largely to be determined. Therefore a prospective cohort study was conducted to determine the association between postoperative delirium and long-term decline in activitie...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002849
更新日期:2019-09-01 00:00:00
abstract::Deliberate hypotension was induced with isoflurane (mean inspired concentration 2.3 +/- 1.0%) in 12 patients undergoing craniotomy for clipping of cerebral aneurysms. Global cerebral blood flow (CBF) was measured before, during, and after hypotension. Arterio-venous O2 content difference was measured concomitantly, an...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198603000-00001
更新日期:1986-03-01 00:00:00
abstract:BACKGROUND:Perioperative thoracic epidural analgesia reduces stress response and pain scores and may improve outcome after cardiac surgery. This prospective, randomized trial was designed to compare the effectiveness of patient-controlled thoracic epidural analgesia with patient-controlled analgesia with intravenous mo...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/00000542-200601000-00020
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The dose-response relation for spinal ropivacaine is undetermined, and there are few data available for obstetric patients. METHODS:In a prospective, randomized, double-blind investigation, the authors studied 72 patients undergoing elective cesarean delivery. An epidural catheter was placed at the L2-L3 ve...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200112000-00011
更新日期:2001-12-01 00:00:00
abstract::Postoperative adrenocortical function was compared in 23 out-patients receiving either thiopental, 4 mg/kg, for induction and a thiopental infusion, 0.26 mg . kg-1 . min-1, in combination with nitrous oxide 70% for maintenance of anesthesia (control); etomidate, 0.4 mg/kg, for induction followed by an etomidate infusi...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198412000-00003
更新日期:1984-12-01 00:00:00
abstract::Total lung capacity, vital capacity, residual volume, and functional residual capacity were determined by body plethysmography and the single-breath oxygen (SBO2) test was performed at 0, 5, and 11 cm H20 continuous positive airway pressure in healthy, awake, seated, spontaneously breathing subjects. Mean values for t...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197502000-00005
更新日期:1975-02-01 00:00:00
abstract:BACKGROUND:The chemokine family has been revealed to be involved in the pathogenesis of neuropathic pain. In this study, the authors investigated the role of chemokine (C-C motif) ligand 3 and its receptors chemokine (C-C motif) receptor 1 and chemokine (C-C motif) receptor (CCR) 5 in neuropathic pain. METHODS:A spina...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000190
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Clinical concentrations of volatile anesthetics significantly influence contractile response to the sympathetic neurotransmitter norepinephrine although its precise mechanisms remain unclarified. In this study, we investigated its possible alterations in diabetes, as well as its underlying mechanisms. METHO...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181ce9e80
更新日期:2010-03-01 00:00:00
abstract::The authors had previously observed a deleterious cerebrovascular effect of prolonged hypothermia in primates and cats. In this study they examined the systemic as well as cerebral hemodynamic and metabolic effects of 24 hours of hypothermia in the dog. With decreases in temperature to 29 C, cardiac output (Q) and who...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198003000-00007
更新日期:1980-03-01 00:00:00
abstract:BACKGROUND:Dynorphin A in the spinal cord is considered to contribute to nociceptive stimuli. However, it has not yet been determined whether activation of the spinal dynorphinergic system under nociceptive stimuli plays a role in direct acceleration of the ascending nociceptive pathway. In this study, the authors inve...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181ca31d9
更新日期:2010-02-01 00:00:00
abstract::Oral transmucosal fentanyl citrate (OTFC) is a novel, noninvasive dosage form of fentanyl used to provide children and adults with sedation, anxiolysis, and analgesia. In order to determine the bioavailability and absorption of fentanyl from OTFC, 12 volunteers were given intravenous fentanyl citrate or OTFC 15 microg...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1097/00000542-199108000-00009
更新日期:1991-08-01 00:00:00
abstract::Neuromuscular blockers may affect cerebral blood flow (CBF) regulation in the newborn. We studied the effects of d-tubocurarine (0.1 mg.kg-1, n = 8), pancuronium (0.1 and 0.4 mg.kg-1, n = 6 and 7), and vecuronium (0.1 and 0.4 mg.kg-1, n = 6 and 7) on CBF measured over the same range of mean systemic blood pressure ([B...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199202000-00013
更新日期:1992-02-01 00:00:00
abstract::The authors investigated the effects of a volatile anesthetic (isoflurane) on the functional properties of a well characterized membrane ion channel (the acetylcholine receptor channel), using the patch clamp electrophysiological method together with local microperfusion of isoflurane. They found that isoflurane cause...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198808000-00003
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:Diaphragm and psoas are affected during sepsis in animal models. Whether diaphragm or limb muscle is preferentially affected during sepsis in the critically ill remains unclear. METHODS:Retrospective secondary analysis study including 40 patients, comparing control (n = 17) and critically ill patients, with...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000201
更新日期:2014-05-01 00:00:00
abstract::Recovery from anesthesia was assessed in a controlled manner in 34 healthy student volunteers, using a psychomotor test battery 1 and 5 hours and a driving simulator 2, 4.5, and 7 hours after 3.5 minutes of anesthesia with halothane or enflurane combined with nitrous oxide and oxygen. Psychomotor performances remained...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197701000-00006
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:The degree to which intrathecally administered morphine can alleviate hypersensitivity in animals after peripheral nerve injury is controversial, and the mechanisms by which morphine works in these circumstances are uncertain. In normal animals, morphine induces adenosine release, and in vitro data suggest t...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200502000-00027
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Neosaxitoxin (NeoSTX) is a site-1 sodium channel blocker that produces prolonged local anesthesia in animals and humans. Under a Food and Drug Administration-approved phase 1 Investigational New Drug trial, the authors evaluated safety and efficacy of NeoSTX alone and combined with 0.2% bupivacaine (Bup) wit...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000000831
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Although automated closed-loop control systems may improve quality of care, their safety must be proved under extreme control conditions. This study describes a simulation methodology to test automated controllers and its application in a comparison of two published controllers for Bispectral Index (BIS)-gui...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200403000-00026
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:The authors hypothesized that low tidal volume (VT) would minimize ventilator-induced lung injury regardless of the degree of mechanical power. The authors investigated the impact of power, obtained by different combinations of VT and respiratory rate (RR), on ventilator-induced lung injury in experimental m...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002143
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Ten-eleven translocation methylcytosine dioxygenase converts 5-methylcytosine in DNA to 5-hydroxymethylcytosine, which plays an important role in gene transcription. Although 5-hydroxymethylcytosine is enriched in mammalian neurons, its regulatory function in nociceptive information processing is unknown. M...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001632
更新日期:2017-07-01 00:00:00